8HGK
 
 | | Crystal structure of human ClpP in complex with ZK53 | | Descriptor: | 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide, ATP-dependent Clp protease proteolytic subunit, mitochondrial, ... | | Authors: | Yang, C.-G, Gan, J.H, Zhou, L.-L. | | Deposit date: | 2022-11-14 | | Release date: | 2023-09-27 | | Last modified: | 2024-04-17 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Selective activator of human ClpP triggers cell cycle arrest to inhibit lung squamous cell carcinoma.
Nat Commun, 14, 2023
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5ZVA
 | | APOBEC3F Chimeric Catalytic Domain in Complex with DNA(dC9) | | Descriptor: | APEBEC3F/ssDNA-C9, CACODYLATE ION, DNA (5'-D(*AP*TP*TP*TP*TP*CP*AP*AP*CP*T)-3'), ... | | Authors: | Cheng, C, Zhang, T.L, Wang, C.X, Lan, W.X, Ding, J.P, Cao, C.Y. | | Deposit date: | 2018-05-09 | | Release date: | 2018-11-21 | | Last modified: | 2018-11-28 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal Structure of Cytidine Deaminase Human APOBEC3F Chimeric Catalytic Domain in Complex with DNA
Chin.J.Chem., 36, 2018
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8YN5
 | | Cryo-EM structure of histamine H3 receptor in complex with histamine and Gi | | Descriptor: | Antibody fragment scFv16, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Zhang, X, Liu, G, Li, X, Gong, W. | | Deposit date: | 2024-03-10 | | Release date: | 2024-10-09 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Structural basis of ligand recognition and activation of the histamine receptor family.
Nat Commun, 15, 2024
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8YN9
 | | Cryo-EM structure of histamine H4 receptor in complex with histamine and Gi | | Descriptor: | Antibody fragment scFv16, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Zhang, X, Liu, G, Li, X, Gong, W. | | Deposit date: | 2024-03-10 | | Release date: | 2024-10-09 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (2.3 Å) | | Cite: | Structural basis of ligand recognition and activation of the histamine receptor family.
Nat Commun, 15, 2024
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8YNA
 | | Cryo-EM structure of histamine H4 receptor in complex with immepip and Gi | | Descriptor: | 4-(1H-imidazol-5-ylmethyl)piperidine, Antibody fragment scFv16, CHOLESTEROL, ... | | Authors: | Zhang, X, Liu, G, Li, X, Gong, W. | | Deposit date: | 2024-03-10 | | Release date: | 2024-10-09 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (2.63 Å) | | Cite: | Structural basis of ligand recognition and activation of the histamine receptor family.
Nat Commun, 15, 2024
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4UYU
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8YN2
 | | Cryo-EM structure of histamine H1 receptor in complex with histamine and miniGq | | Descriptor: | Antibody fragment scFv16, CHOLESTEROL, Engineered guanine nucleotide-binding protein G(q) subunit alpha, ... | | Authors: | Zhang, X, Liu, G, Li, X, Gong, W. | | Deposit date: | 2024-03-10 | | Release date: | 2024-10-09 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (2.66 Å) | | Cite: | Structural basis of ligand recognition and activation of the histamine receptor family.
Nat Commun, 15, 2024
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8YN4
 | | Cryo-EM structure of histamine H2 receptor in complex with histamine and miniGq | | Descriptor: | Antibody fragment scFv16, CHOLESTEROL, Engineered guanine nucleotide-binding protein G(q) subunit alpha, ... | | Authors: | Zhang, X, Liu, G, Li, X, Gong, W. | | Deposit date: | 2024-03-10 | | Release date: | 2024-10-09 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (2.97 Å) | | Cite: | Structural basis of ligand recognition and activation of the histamine receptor family.
Nat Commun, 15, 2024
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8YN6
 | | Cryo-EM structure of histamine H3 receptor in complex with imetit and Gi | | Descriptor: | 2-(1~{H}-imidazol-5-yl)ethyl carbamimidothioate, Antibody fragment scFv16, CHOLESTEROL, ... | | Authors: | Zhang, X, Liu, G, Li, X, Gong, W. | | Deposit date: | 2024-03-10 | | Release date: | 2024-10-09 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (2.77 Å) | | Cite: | Structural basis of ligand recognition and activation of the histamine receptor family.
Nat Commun, 15, 2024
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4UZ7
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4UZ5
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8YN3
 | | Cryo-EM structure of histamine H2 receptor in complex with histamine and miniGs | | Descriptor: | CHOLESTEROL, Engineered guanine nucleotide,binding protein G(s) subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Zhang, X, Liu, G, Li, X, Gong, W. | | Deposit date: | 2024-03-10 | | Release date: | 2024-10-09 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (2.56 Å) | | Cite: | Structural basis of ligand recognition and activation of the histamine receptor family.
Nat Commun, 15, 2024
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4UZ6
 | | STRUCTURE OF THE WNT DEACYLASE NOTUM - CRYSTAL FORM V - SOS COMPLEX - 1.9A | | Descriptor: | 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | | Authors: | Zebisch, M, Jones, E.Y. | | Deposit date: | 2014-09-04 | | Release date: | 2015-02-25 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Notum Deacylates Wnt Proteins to Suppress Signalling Activity.
Nature, 519, 2015
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4UZQ
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6KDY
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6KEA
 | | crystal structure of MBP-tagged REV7-IpaB complex | | Descriptor: | Maltose-binding periplasmic protein,LINKER,hREV7,LINKER,Invasin IpaB,hREV3 | | Authors: | Wang, X, Pernicone, N, Pertz, L, Hua, D.P, Zhang, T.Q, Listovsky, T, Xie, W. | | Deposit date: | 2019-07-04 | | Release date: | 2019-09-11 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | REV7 has a dynamic adaptor region to accommodate small GTPase RAN/ShigellaIpaB ligands, and its activity is regulated by the RanGTP/GDP switch.
J.Biol.Chem., 294, 2019
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7XOZ
 | | Crystal structure of RPPT-TIR | | Descriptor: | ADENOSINE-5-DIPHOSPHORIBOSE, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase | | Authors: | Song, W, Jia, A, Huang, S, Chai, J. | | Deposit date: | 2022-05-02 | | Release date: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.52 Å) | | Cite: | TIR-catalyzed ADP-ribosylation reactions produce signaling molecules for plant immunity.
Science, 377, 2022
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8Y92
 | | structure of NET-Atomoxetine in outward-open state | | Descriptor: | (3R)-N-methyl-3-(2-methylphenoxy)-3-phenyl-propan-1-amine, CHLORIDE ION, SODIUM ION, ... | | Authors: | Zhang, H, Xu, E.H, Jiang, Y. | | Deposit date: | 2024-02-06 | | Release date: | 2024-05-29 | | Last modified: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (3.29 Å) | | Cite: | Dimerization and antidepressant recognition at noradrenaline transporter.
Nature, 630, 2024
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8Y91
 | | Structure of NET-nomifensine in outward-open state | | Descriptor: | (4S)-2-methyl-4-phenyl-3,4-dihydro-1H-isoquinolin-8-amine, CHLORIDE ION, SODIUM ION, ... | | Authors: | Zhang, H, Xu, E.H, Jiang, Y. | | Deposit date: | 2024-02-06 | | Release date: | 2024-05-29 | | Last modified: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (3.13 Å) | | Cite: | Dimerization and antidepressant recognition at noradrenaline transporter.
Nature, 630, 2024
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8Y90
 | | Structure of NET-Nefopam in outward-open state | | Descriptor: | (1S)-5-methyl-1-phenyl-1,3,4,6-tetrahydro-2,5-benzoxazocine, CHLORIDE ION, SODIUM ION, ... | | Authors: | Zhang, H, Xu, E.H, Jiang, Y. | | Deposit date: | 2024-02-06 | | Release date: | 2024-05-29 | | Last modified: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (3.15 Å) | | Cite: | Dimerization and antidepressant recognition at noradrenaline transporter.
Nature, 630, 2024
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5WXB
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8XV2
 | | Thiamine-bound human SLC19A3 | | Descriptor: | 3-(4-AMINO-2-METHYL-PYRIMIDIN-5-YLMETHYL)-5-(2-HYDROXY-ETHYL)-4-METHYL-THIAZOL-3-IUM, Soluble cytochrome b562,Thiamine transporter 2 | | Authors: | Dang, Y, Wang, G.P, Zhang, Z. | | Deposit date: | 2024-01-14 | | Release date: | 2024-03-27 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Substrate and drug recognition mechanisms of SLC19A3.
Cell Res., 34, 2024
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8XV5
 | | Pyridoxamine-bound human SLC19A3 | | Descriptor: | 4-(AMINOMETHYL)-5-(HYDROXYMETHYL)-2-METHYLPYRIDIN-3-OL, Soluble cytochrome b562,Thiamine transporter 2 | | Authors: | Dang, Y, Wang, G.P, Zhang, Z. | | Deposit date: | 2024-01-14 | | Release date: | 2024-03-27 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Substrate and drug recognition mechanisms of SLC19A3.
Cell Res., 34, 2024
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6JYJ
 | | Crystal structure of FAM46B (TENT5B) | | Descriptor: | CITRATE ANION, Terminal nucleotidyltransferase 5B | | Authors: | Zhang, H, Hu, J.L, Gao, S. | | Deposit date: | 2019-04-26 | | Release date: | 2020-03-04 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.693199 Å) | | Cite: | FAM46B is a prokaryotic-like cytoplasmic poly(A) polymerase essential in human embryonic stem cells.
Nucleic Acids Res., 48, 2020
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8GZ4
 | | Crystal structure of MPXV phosphatase | | Descriptor: | Dual specificity protein phosphatase H1, PHOSPHATE ION | | Authors: | Yang, H.T, Wang, W, Huang, H.J, Ji, X.Y. | | Deposit date: | 2022-09-25 | | Release date: | 2023-05-17 | | Last modified: | 2023-12-06 | | Method: | X-RAY DIFFRACTION (1.802 Å) | | Cite: | Crystal structure of monkeypox H1 phosphatase, an antiviral drug target.
Protein Cell, 14, 2023
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