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7WQZ
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BU of 7wqz by Molmil
Structure of Active-mutEP
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Enteropeptidase catalytic light chain, Enteropeptidase non-catalytic heavy chain
Authors:Yang, X.L, Ding, Z.Y, Huang, H.J.
Deposit date:2022-01-26
Release date:2022-10-26
Last modified:2022-11-23
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Cryo-EM structures reveal the activation and substrate recognition mechanism of human enteropeptidase.
Nat Commun, 13, 2022
7WDK
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BU of 7wdk by Molmil
The structure of PldA-PA3488 complex
Descriptor: Phospholipase D, Tli4_C domain-containing protein
Authors:Zhao, L, Yang, X.Y, Li, Z.Q.
Deposit date:2021-12-21
Release date:2022-10-26
Last modified:2022-11-09
Method:ELECTRON MICROSCOPY (3.05 Å)
Cite:Structural insights into PA3488-mediated inactivation of Pseudomonas aeruginosa PldA
Nat Commun, 13, 2022
7WR7
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BU of 7wr7 by Molmil
Structure of Inhibited-EP
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-carbamimidamidobenzoic acid, Enteropeptidase catalytic light chain, ...
Authors:Yang, X.L, Ding, Z.Y, Huang, H.J.
Deposit date:2022-01-26
Release date:2022-10-26
Last modified:2022-11-23
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Cryo-EM structures reveal the activation and substrate recognition mechanism of human enteropeptidase.
Nat Commun, 13, 2022
7WQW
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BU of 7wqw by Molmil
Structure of Active-EP
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Enteropeptidase catalytic light chain, Enteropeptidase non-catalytic heavy chain
Authors:Yang, X.L, Ding, Z.Y, Huang, H.J.
Deposit date:2022-01-26
Release date:2022-10-26
Last modified:2022-11-23
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM structures reveal the activation and substrate recognition mechanism of human enteropeptidase.
Nat Commun, 13, 2022
7WQX
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BU of 7wqx by Molmil
Structure of Inactive-EP
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Enteropeptidase
Authors:Yang, X.L, Ding, Z.Y, Huang, H.J.
Deposit date:2022-01-26
Release date:2022-10-26
Last modified:2022-11-23
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Cryo-EM structures reveal the activation and substrate recognition mechanism of human enteropeptidase.
Nat Commun, 13, 2022
8H3U
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BU of 8h3u by Molmil
Inhibitor-bound EP, polyA model
Descriptor: Enteropeptidase catalytic light chain, Enteropeptidase non-catalytic heavy chain
Authors:Ding, Z.Y, Huang, H.J.
Deposit date:2022-10-09
Release date:2022-11-23
Method:ELECTRON MICROSCOPY (4.7 Å)
Cite:Cryo-EM structures reveal the activation and substrate recognition mechanism of human enteropeptidase.
Nat Commun, 13, 2022
8H3S
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BU of 8h3s by Molmil
Substrate-bound EP, polyA model
Descriptor: Enteropeptidase catalytic light chain, Enteropeptidase non-catalytic heavy chain, Serine protease 1
Authors:Ding, Z.Y, Huang, H.J.
Deposit date:2022-10-09
Release date:2022-11-23
Method:ELECTRON MICROSCOPY (4.9 Å)
Cite:Cryo-EM structures reveal the activation and substrate recognition mechanism of human enteropeptidase.
Nat Commun, 13, 2022
7FCZ
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BU of 7fcz by Molmil
Crystal Structure of human RIPK1 kinase domain in complex with a novel inhibitor
Descriptor: N-[(3S)-7-(2-cyclopropylethynyl)-5-methyl-4-oxidanylidene-2,3-dihydro-1,5-benzoxazepin-3-yl]-5-(phenylmethyl)-4H-1,2,4-triazole-3-carboxamide, Receptor-interacting serine/threonine-protein kinase 1
Authors:Su, H.X, Xie, H, Nie, T.Q, Li, M.J, Xu, Y.C.
Deposit date:2021-07-15
Release date:2022-01-19
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Potent and Selective RIPK1 Inhibitors Targeting Dual-Pockets for the Treatment of Systemic Inflammatory Response Syndrome and Sepsis.
Angew.Chem.Int.Ed.Engl., 61, 2022
7FD0
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BU of 7fd0 by Molmil
Crystal Structure of human RIPK1 kinase domain in complex with a novel inhibitor
Descriptor: N-[(3S)-5-methyl-7-[2-(oxan-4-yl)ethynyl]-4-oxidanylidene-2,3-dihydro-1,5-benzoxazepin-3-yl]-5-(phenylmethyl)-4H-1,2,4-triazole-3-carboxamide, Receptor-interacting serine/threonine-protein kinase 1
Authors:Su, H.X, Xie, H, Nie, T.Q, Li, M.J, Xu, Y.C.
Deposit date:2021-07-15
Release date:2022-01-19
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Potent and Selective RIPK1 Inhibitors Targeting Dual-Pockets for the Treatment of Systemic Inflammatory Response Syndrome and Sepsis.
Angew.Chem.Int.Ed.Engl., 61, 2022
6A0A
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BU of 6a0a by Molmil
Structure of a triple-helix region of human collagen type III
Descriptor: collagen type III peptide
Authors:Yang, X, Zhu, Y, Ye, S, Zhang, R.
Deposit date:2018-06-05
Release date:2018-12-26
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.502 Å)
Cite:Characterization by high-resolution crystal structure analysis of a triple-helix region of human collagen type III with potent cell adhesion activity.
Biochem. Biophys. Res. Commun., 508, 2019
6A0C
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BU of 6a0c by Molmil
Structure of a triple-helix region of human collagen type III
Descriptor: 1,2-ETHANEDIOL, GLYCEROL, collagen type III peptide
Authors:Yang, X, Zhu, Y, Ye, S, Zhang, R.
Deposit date:2018-06-05
Release date:2018-12-26
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.501 Å)
Cite:Characterization by high-resolution crystal structure analysis of a triple-helix region of human collagen type III with potent cell adhesion activity.
Biochem. Biophys. Res. Commun., 508, 2019
3FCO
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BU of 3fco by Molmil
Crystal Structure of 11beta-Hydroxysteroid Dehydrogenase 1 (11b-HSD1) in Complex with Benzamide Inhibitor
Descriptor: Corticosteroid 11-beta-dehydrogenase isozyme 1, N-cyclopropyl-N-(cis-4-cyclopropyl-4-hydroxycyclohexyl)-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamide, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Wang, Z, Sudom, A, Walker, N.P.
Deposit date:2008-11-21
Release date:2009-12-01
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Optimization of novel di-substituted cyclohexylbenzamide derivatives as potent 11 beta-HSD1 inhibitors.
Bioorg.Med.Chem.Lett., 19, 2009
4WT2
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BU of 4wt2 by Molmil
Co-crystal Structure of MDM2 in Complex with AM-7209
Descriptor: 4-({[(3R,5R,6S)-1-[(1S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl]-6-(4-chloro-3-fluorophenyl)-5-(3-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]acetyl}amino)-2-methoxybenzoic acid, E3 ubiquitin-protein ligase Mdm2, SULFATE ION
Authors:Shaffer, P.L, Huang, X, Yakowec, P, Long, A.M.
Deposit date:2014-10-30
Release date:2014-12-03
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Discovery of AM-7209, a Potent and Selective 4-Amidobenzoic Acid Inhibitor of the MDM2-p53 Interaction.
J.Med.Chem., 57, 2014
5UMY
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BU of 5umy by Molmil
Crystal structure of TnmS3 in complex with tiancimycin
Descriptor: (1aS,11S,11aR,14Z,18R)-3,8,18-trihydroxy-11a-[(1R)-1-hydroxyethyl]-7-methoxy-11,11a-dihydro-4H-11,1a-hept[3]ene[1,5]diynonaphtho[2,3-h]oxireno[c]quinoline-4,9(10H)-dione, Glyoxalase/bleomycin resisance protein/dioxygenase
Authors:Chang, C.Y, Chang, C, Nocek, B, Rudolf, J.D, Joachimiak, A, Phillips Jr, G.N, SHen, B, Enzyme Discovery for Natural Product Biosynthesis (NatPro), Midwest Center for Structural Genomics (MCSG)
Deposit date:2017-01-29
Release date:2018-07-04
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Resistance to Enediyne Antitumor Antibiotics by Sequestration.
Cell Chem Biol, 25, 2018
8IYX
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BU of 8iyx by Molmil
Cryo-EM structure of the GPR34 receptor in complex with the antagonist YL-365
Descriptor: 1-[4-(3-chlorophenyl)phenyl]carbonyl-4-[2-(4-phenylmethoxyphenyl)ethanoylamino]piperidine-4-carboxylic acid, Probable G-protein coupled receptor 34,YL-365
Authors:Jia, G.W, Wang, X, Zhang, C.B, Dong, H.H, Su, Z.M.
Deposit date:2023-04-06
Release date:2024-03-20
Method:ELECTRON MICROSCOPY (3.34 Å)
Cite:Cryo-EM structures of human GPR34 enable the identification of selective antagonists.
Proc.Natl.Acad.Sci.USA, 120, 2023
8X91
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BU of 8x91 by Molmil
P/Q type calcium channel in complex with omega-conotoxin MVIIC
Descriptor: 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Yan, N, Li, Z, Cong, Y, Wu, T, Wang, T.
Deposit date:2023-11-29
Release date:2024-03-20
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (3.11 Å)
Cite:Structural basis for different omega-agatoxin IVA sensitivities of the P-type and Q-type Ca v 2.1 channels.
Cell Res., 34, 2024
8X90
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BU of 8x90 by Molmil
P/Q type calcium channel
Descriptor: 1,2-DIDECANOYL-SN-GLYCERO-3-[PHOSPHO-L-SERINE], 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Yan, N, Li, Z, Cong, Y, Wu, T, Wang, T.
Deposit date:2023-11-29
Release date:2024-03-20
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (2.95 Å)
Cite:Structural basis for different omega-agatoxin IVA sensitivities of the P-type and Q-type Ca v 2.1 channels.
Cell Res., 34, 2024
8X93
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BU of 8x93 by Molmil
P/Q type calcium channel in complex with omega-Agatoxin IVA
Descriptor: 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Yan, N, Li, Z, Cong, Y, Wu, T, Wang, T.
Deposit date:2023-11-29
Release date:2024-03-20
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (2.92 Å)
Cite:Structural basis for different omega-agatoxin IVA sensitivities of the P-type and Q-type Ca v 2.1 channels.
Cell Res., 34, 2024
7EQ1
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BU of 7eq1 by Molmil
GPR114-Gs-scFv16 complex
Descriptor: Adhesion G-protein coupled receptor G5, Gs protein alpha subunit, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Ping, Y.
Deposit date:2021-04-28
Release date:2022-05-11
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural basis for the tethered peptide activation of adhesion GPCRs.
Nature, 604, 2022
6IGF
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BU of 6igf by Molmil
Crystal structure of Human Papillomavirus type 52 pentamer
Descriptor: Major capsid protein L1
Authors:Li, Z.H, Song, S, He, M.Z, Gu, Y, Li, S.W.
Deposit date:2018-09-25
Release date:2018-11-28
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.751 Å)
Cite:Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity.
Nat Commun, 9, 2018
6IGE
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BU of 6ige by Molmil
Crystal structure of Human Papillomavirus type 33 pentamer
Descriptor: Major capsid protein L1
Authors:Li, Z.H, Song, S, He, M.Z, Gu, Y, Li, S.W.
Deposit date:2018-09-25
Release date:2018-12-05
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity.
Nat Commun, 9, 2018
6IO6
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BU of 6io6 by Molmil
Silver-bound Glyceraldehyde-3-phosphate dehydrogenase A at non-catalytic site
Descriptor: Glyceraldehyde-3-phosphate dehydrogenase A, SILVER ION
Authors:Wang, H, Sun, H, Wang, M.
Deposit date:2018-10-29
Release date:2019-07-03
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Antimicrobial silver targets glyceraldehyde-3-phosphate dehydrogenase in glycolysis ofE. coli.
Chem Sci, 10, 2019
6J72
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BU of 6j72 by Molmil
Crystal structure of IniA from Mycobacterium smegmatis with GTP bound
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, Isoniazid inducible gene protein IniA, L(+)-TARTARIC ACID, ...
Authors:Wang, M.F, Guo, X.Y, Hu, J.J, Li, J, Rao, Z.H.
Deposit date:2019-01-16
Release date:2019-09-11
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Mycobacterial dynamin-like protein IniA mediates membrane fission.
Nat Commun, 10, 2019
4AI5
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BU of 4ai5 by Molmil
Crystal structure of Y16F of 3-methyladenine DNA glycosylase I (TAG) in complex with 3-methyladenine
Descriptor: 3-METHYL-3H-PURIN-6-YLAMINE, DNA-3-METHYLADENINE GLYCOSYLASE I, SULFATE ION, ...
Authors:Zhu, X, Naismith, J.H.
Deposit date:2012-02-08
Release date:2012-02-15
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:A Model for 3-Methyladenine Recognition by 3-Methyladenine DNA Glycosylase I (Tag) from Staphylococcus Aureus.
Acta Crystallogr.,Sect.F, 68, 2012
4AI4
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BU of 4ai4 by Molmil
crystal structure of E38Q mutant of 3-methyladenine DNA glycosylase I from Staphylococcus aureus
Descriptor: DNA-3-METHYLADENINE GLYCOSYLASE I, SULFATE ION, ZINC ION
Authors:Zhu, X, Naismith, J.H.
Deposit date:2012-02-08
Release date:2012-02-15
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:A Model for 3-Methyladenine Recognition by 3-Methyladenine DNA Glycosylase I (Tag) from Staphylococcus Aureus.
Acta Crystallogr.,Sect.F, 68, 2012

221716

數據於2024-06-26公開中

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