6IVU
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6IVS
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8X4Z
| BA.2.86 Spike Trimer with ins483V mutation (3 RBD down) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Yue, C, Liu, P. | Deposit date: | 2023-11-16 | Release date: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.49 Å) | Cite: | Spike N354 glycosylation augments SARS-CoV-2 fitness for human adaptation through structural plasticity Natl Sci Rev, 2024
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8X50
| BA.2.86 Spike Trimer with ins483V mutation (1 RBD up) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Yue, C, Liu, P. | Deposit date: | 2023-11-16 | Release date: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.82 Å) | Cite: | Spike N354 glycosylation augments SARS-CoV-2 fitness for human adaptation through structural plasticity Natl Sci Rev, 2024
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8X55
| BA.2.86 Spike Trimer with T356K mutation (3 RBD down) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Yue, C, Liu, P. | Deposit date: | 2023-11-16 | Release date: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.75 Å) | Cite: | Spike N354 glycosylation augments SARS-CoV-2 fitness for human adaptation through structural plasticity Natl Sci Rev, 2024
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8X56
| BA.2.86 Spike Trimer with T356K mutation (1 RBD up) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Yue, C, Liu, P. | Deposit date: | 2023-11-16 | Release date: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.93 Å) | Cite: | Spike N354 glycosylation augments SARS-CoV-2 fitness for human adaptation through structural plasticity Natl Sci Rev, 2024
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7TW5
| Cryo-EM structure of human ankyrin complex (B2P1A2) from red blood cell | Descriptor: | Ankyrin-1, Band 3 anion transport protein, Protein 4.2 | Authors: | Xia, X, Liu, S.H, Zhou, Z.H. | Deposit date: | 2022-02-06 | Release date: | 2022-06-08 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (5.7 Å) | Cite: | Structure, dynamics and assembly of the ankyrin complex on human red blood cell membrane. Nat.Struct.Mol.Biol., 29, 2022
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7TW6
| Cryo-EM structure of human ankyrin complex (B4P1A1) from red blood cell | Descriptor: | Ankyrin-1, Band 3 anion transport protein, Protein 4.2 | Authors: | Xia, X, Liu, S.H, Zhou, Z.H. | Deposit date: | 2022-02-06 | Release date: | 2022-06-08 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (5.6 Å) | Cite: | Structure, dynamics and assembly of the ankyrin complex on human red blood cell membrane. Nat.Struct.Mol.Biol., 29, 2022
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7TW3
| Cryo-EM structure of human ankyrin complex (B2P1A1) from red blood cell | Descriptor: | Ankyrin-1, Band 3 anion transport protein, Protein 4.2 | Authors: | Xia, X, Liu, S.H, Zhou, Z.H. | Deposit date: | 2022-02-06 | Release date: | 2022-06-08 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Structure, dynamics and assembly of the ankyrin complex on human red blood cell membrane. Nat.Struct.Mol.Biol., 29, 2022
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7TVZ
| Cryo-EM structure of human band 3-protein 4.2 complex in diagonal conformation | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Band 3 anion transport protein, CHOLESTEROL, ... | Authors: | Xia, X, Liu, S.H, Zhou, Z.H. | Deposit date: | 2022-02-06 | Release date: | 2022-06-08 | Last modified: | 2022-07-27 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structure, dynamics and assembly of the ankyrin complex on human red blood cell membrane. Nat.Struct.Mol.Biol., 29, 2022
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7TW2
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7TW1
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7TW0
| Cryo-EM structure of human band 3-protein 4.2 complex in vertical conformation | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Band 3 anion transport protein, Protein 4.2 | Authors: | Xia, X, Liu, S.H, Zhou, Z.H. | Deposit date: | 2022-02-06 | Release date: | 2022-06-08 | Last modified: | 2022-07-27 | Method: | ELECTRON MICROSCOPY (4.6 Å) | Cite: | Structure, dynamics and assembly of the ankyrin complex on human red blood cell membrane. Nat.Struct.Mol.Biol., 29, 2022
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8WHZ
| BA.2.86 RBD in complex with hACE2 (local refinement) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Processed angiotensin-converting enzyme 2, ... | Authors: | Yue, C, Liu, P. | Deposit date: | 2023-09-23 | Release date: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.93 Å) | Cite: | Spike N354 glycosylation augments SARS-CoV-2 fitness for human adaptation through structural plasticity Natl Sci Rev, 2024
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8BAY
| Crystal Structure of IDH1 variant R132C S280F in complex with NADPH, Ca2+ and 3-butyl-2-oxoglutarate | Descriptor: | (R)-3-butyl-2-oxopentanedioic acid, (S)-3-butyl-2-oxopentanedioic acid, CALCIUM ION, ... | Authors: | Rabe, P, Schofield, C.J, Reinbold, R, Brewitz, L. | Deposit date: | 2022-10-12 | Release date: | 2022-11-02 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Natural and synthetic 2-oxoglutarate derivatives are substrates for oncogenic variants of human isocitrate dehydrogenase 1 and 2. J.Biol.Chem., 299, 2023
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6JK8
| Cryo-EM structure of the full-length human IGF-1R in complex with insulin | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin, ... | Authors: | Zhang, X, Yu, D, Wang, T. | Deposit date: | 2019-02-27 | Release date: | 2020-03-04 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (4.7 Å) | Cite: | Visualization of Ligand-Bound Ectodomain Assembly in the Full-Length Human IGF-1 Receptor by Cryo-EM Single-Particle Analysis. Structure, 28, 2020
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7EZP
| Indole-2-carboxylic acid derivatives as allosteric inhibitors of fructose-1,6-bisphosphatase | Descriptor: | 1,6-di-O-phosphono-beta-D-fructofuranose, 3-(3-hydroxy-3-oxopropyl)-5-(2-methylpropyl)-7-nitro-1H-indole-2-carboxylic acid, Fructose-1,6-bisphosphatase 1 | Authors: | Wang, X.Y, Zhou, J, Xu, B.L. | Deposit date: | 2021-06-01 | Release date: | 2022-06-01 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Discovery of Novel Indole Derivatives as Fructose-1,6-bisphosphatase Inhibitors and X-ray Cocrystal Structures Analysis. Acs Med.Chem.Lett., 13, 2022
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7EZR
| Indole-2-carboxylic acid derivatives as allosteric inhibitors of fructose-1,6-bisphosphatase | Descriptor: | 1,6-di-O-phosphono-beta-D-fructofuranose, 5-ethyl-7-nitro-3-[3-oxidanylidene-3-(thiophen-2-ylsulfonylamino)propyl]-1H-indole-2-carboxylic acid, Fructose-1,6-bisphosphatase 1 | Authors: | Wang, X.Y, Zhou, J, Xu, B.L. | Deposit date: | 2021-06-01 | Release date: | 2022-06-01 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.27 Å) | Cite: | Discovery of Novel Indole Derivatives as Fructose-1,6-bisphosphatase Inhibitors and X-ray Cocrystal Structures Analysis. Acs Med.Chem.Lett., 13, 2022
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7EZF
| Indole-2-carboxylic acid derivatives as allosteric inhibitors of fructose-1,6-bisphosphatase | Descriptor: | 1,6-di-O-phosphono-beta-D-fructofuranose, 7-chloranyl-5-ethyl-3-(3-hydroxy-3-oxopropyl)-1H-indole-2-carboxylic acid, Fructose-1,6-bisphosphatase 1 | Authors: | Wang, X.Y, Zhou, J, Xu, B.L. | Deposit date: | 2021-06-01 | Release date: | 2022-06-01 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.76 Å) | Cite: | Discovery of Novel Indole Derivatives as Fructose-1,6-bisphosphatase Inhibitors and X-ray Cocrystal Structures Analysis. Acs Med.Chem.Lett., 13, 2022
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6Q9M
| Central Fibronectin-III array of RIM-binding protein | Descriptor: | PHOSPHATE ION, RIM-binding protein, isoform F | Authors: | Driller, J.D, Habibi, S, Wahl, M.C, Loll, B. | Deposit date: | 2018-12-18 | Release date: | 2020-01-15 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.453 Å) | Cite: | RIM-binding protein couples synaptic vesicle recruitment to release sites. J.Cell Biol., 219, 2020
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8BA4
| Crystal structure of JAK2 JH2-V617F in complex with Bemcentinib | Descriptor: | 1-(3,4-diazatricyclo[9.4.0.0^{2,7}]pentadeca-1(11),2(7),3,5,12,14-hexaen-5-yl)-~{N}3-[(7~{S})-7-pyrrolidin-1-yl-6,7,8,9-tetrahydro-5~{H}-benzo[7]annulen-3-yl]-1,2,4-triazole-3,5-diamine, Tyrosine-protein kinase JAK2 | Authors: | Haikarainen, T, Silvennoinen, O. | Deposit date: | 2022-10-11 | Release date: | 2023-02-01 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Identification of Novel Small Molecule Ligands for JAK2 Pseudokinase Domain. Pharmaceuticals, 16, 2023
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8BA3
| Crystal structure of JAK2 JH2 in complex with Bemcentinib | Descriptor: | 1-(3,4-diazatricyclo[9.4.0.0^{2,7}]pentadeca-1(11),2(7),3,5,12,14-hexaen-5-yl)-~{N}3-[(7~{S})-7-pyrrolidin-1-yl-6,7,8,9-tetrahydro-5~{H}-benzo[7]annulen-3-yl]-1,2,4-triazole-3,5-diamine, GLYCEROL, Tyrosine-protein kinase JAK2 | Authors: | Haikarainen, T, Silvennoinen, O. | Deposit date: | 2022-10-11 | Release date: | 2023-02-01 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Identification of Novel Small Molecule Ligands for JAK2 Pseudokinase Domain. Pharmaceuticals, 16, 2023
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8B99
| Crystal structure of JAK2 JH2-V617F in complex with JNJ-7706621 | Descriptor: | 4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1H-1,2,4-triazol-3-yl}amino)benzenesulfonamide, GLYCEROL, Tyrosine-protein kinase JAK2 | Authors: | Haikarainen, T, Silvennoinen, O. | Deposit date: | 2022-10-05 | Release date: | 2023-02-01 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Identification of Novel Small Molecule Ligands for JAK2 Pseudokinase Domain. Pharmaceuticals, 16, 2023
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8B8U
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8B9H
| Crystal structure of JAK2 JH2 in complex with Z902-A3 | Descriptor: | 6-[[methyl-[(3-methylthiophen-2-yl)methyl]amino]methyl]-~{N}4-phenyl-1,3,5-triazine-2,4-diamine, GLYCEROL, Tyrosine-protein kinase JAK2 | Authors: | Haikarainen, T, Silvennoinen, O. | Deposit date: | 2022-10-06 | Release date: | 2023-02-01 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Identification of Novel Small Molecule Ligands for JAK2 Pseudokinase Domain. Pharmaceuticals, 16, 2023
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