6M95
| Structure-based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-b]pyridine-2-one based p38 MAP Kinase Inhibitors by scaffold hopping: compound 1 | Descriptor: | (4-benzylpiperidin-1-yl)[2-methoxy-4-(methylsulfanyl)phenyl]methanone, Mitogen-activated protein kinase 14 | Authors: | Lane, W, Okada, K. | Deposit date: | 2018-08-22 | Release date: | 2019-04-17 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure-Based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-b]pyridin-2-one-Based p38 MAP Kinase Inhibitors: Part 1. Chemmedchem, 14, 2019
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5GKR
| Crystal structure of SLE patient-derived anti-DNA antibody in complex with oligonucleotide | Descriptor: | DNA (5'-D(P*TP*TP*TP*T)-3'), IgG2, Fab (heavy chain), ... | Authors: | Arimori, T, Sakakibara, S, Kikutani, H, Takagi, J. | Deposit date: | 2016-07-05 | Release date: | 2017-07-05 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Clonal evolution and antigen recognition of anti-nuclear antibodies in acute systemic lupus erythematosus Sci Rep, 7, 2017
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5GKS
| Crystal structure of SLE patient-derived anti-DNA antibody | Descriptor: | IgG2, Fab (heavy chain), PHOSPHATE ION, ... | Authors: | Arimori, T, Sakakibara, S, Kikutani, H, Takagi, J. | Deposit date: | 2016-07-05 | Release date: | 2017-07-05 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Clonal evolution and antigen recognition of anti-nuclear antibodies in acute systemic lupus erythematosus Sci Rep, 7, 2017
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3UG4
| Crystal structure of alpha-L-arabinofuranosidase from Thermotoga maritima arabinose complex | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Alpha-L-arabinofuranosidase, alpha-L-arabinofuranose | Authors: | Im, D.-H, Miyazaki, K, Wakagi, T, Fushinobu, S. | Deposit date: | 2011-11-02 | Release date: | 2012-03-07 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Crystal Structures of Glycoside Hydrolase Family 51 alpha-L-Arabinofuranosidase from Thermotoga maritima Biosci.Biotechnol.Biochem., 76, 2012
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3UG5
| Crystal structure of alpha-L-arabinofuranosidase from Thermotoga maritima xylose complex | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Alpha-L-arabinofuranosidase, beta-D-xylopyranose | Authors: | Im, D.-H, Miyazaki, K, Wakagi, T, Fushinobu, S. | Deposit date: | 2011-11-02 | Release date: | 2012-03-07 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal Structures of Glycoside Hydrolase Family 51 alpha-L-Arabinofuranosidase from Thermotoga maritima Biosci.Biotechnol.Biochem., 76, 2012
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3UG3
| Crystal structure of alpha-L-arabinofuranosidase from Thermotoga maritima ligand free form | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Alpha-L-arabinofuranosidase, ... | Authors: | Im, D.-H, Miyazaki, K, Wakagi, T, Fushinobu, S. | Deposit date: | 2011-11-02 | Release date: | 2012-03-07 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal Structures of Glycoside Hydrolase Family 51 alpha-L-Arabinofuranosidase from Thermotoga maritima Biosci.Biotechnol.Biochem., 76, 2012
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5OCT
| Discovery of small molecules binding to KRAS via high affinity antibody fragment competition method. | Descriptor: | DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, GTPase KRas, ... | Authors: | Cruz-Migoni, A, Ehebauer, M.T, Phillips, S.E.V, Quevedo, C.E, Rabbitts, T.H. | Deposit date: | 2017-07-03 | Release date: | 2018-08-22 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment. Nat Commun, 9, 2018
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5OCO
| Discovery of small molecules binding to KRAS via high affinity antibody fragment competition method. | Descriptor: | CITRIC ACID, DI(HYDROXYETHYL)ETHER, GTPase KRas, ... | Authors: | Cruz-Migoni, A, Ehebauer, M.T, Phillips, S.E.V, Quevedo, C.E, Rabbitts, T.H. | Deposit date: | 2017-07-03 | Release date: | 2018-08-22 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (1.66 Å) | Cite: | Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment. Nat Commun, 9, 2018
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5OCG
| Discovery of small molecules binding to KRAS via high affinity antibody fragment competition method. | Descriptor: | DI(HYDROXYETHYL)ETHER, GLYCEROL, GTPase KRas, ... | Authors: | Cruz-Migoni, A, Ehebauer, M.T, Phillips, S.E.V, Quevedo, C.E, Rabbitts, T.H. | Deposit date: | 2017-06-30 | Release date: | 2018-08-22 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.48 Å) | Cite: | Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment. Nat Commun, 9, 2018
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9JR2
| Cryo-EM structure of PTH-PTH1R-Gq (upright state) | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(q) subunit alpha-1 (miniGq), ... | Authors: | Sano, F.K, Hirano, H, Itoh, Y, Nureki, O. | Deposit date: | 2024-09-29 | Release date: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Insights into G-protein coupling preference from cryo-EM structures of Gq-bound PTH1R To Be Published
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9JR3
| Cryo-EM structure of PTH-PTH1R-Gq (tilted state) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Sano, F.K, Hirano, H, Itoh, Y, Nureki, O. | Deposit date: | 2024-09-29 | Release date: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Insights into G-protein coupling preference from cryo-EM structures of Gq-bound PTH1R To Be Published
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5H08
| Human PTPRZ D1 domain complexed with NAZ2329 | Descriptor: | 3-{[2-Ethoxy-5-(trifluoromethyl)benzyl]sulfanyl}-N-(phenylsulfonyl)thiophene-2-carboxamide, Receptor-type tyrosine-protein phosphatase zeta | Authors: | Sugawara, H. | Deposit date: | 2016-10-04 | Release date: | 2017-07-26 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.53 Å) | Cite: | Targeting PTPRZ inhibits stem cell-like properties and tumorigenicity in glioblastoma cells Sci Rep, 7, 2017
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5WR3
| Thermolysin, SFX liganded form with water-based carrier | Descriptor: | CALCIUM ION, N-[(benzyloxy)carbonyl]-L-aspartic acid, Thermolysin, ... | Authors: | Kunishima, N, Naitow, H, Matsuura, Y. | Deposit date: | 2016-11-29 | Release date: | 2017-08-16 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Protein-ligand complex structure from serial femtosecond crystallography using soaked thermolysin microcrystals and comparison with structures from synchrotron radiation Acta Crystallogr D Struct Biol, 73, 2017
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5WR2
| Thermolysin, SFX liganded form with oil-based carrier | Descriptor: | CALCIUM ION, N-[(benzyloxy)carbonyl]-L-aspartic acid, Thermolysin, ... | Authors: | Kunishima, N, Naitow, H, Matsuura, Y. | Deposit date: | 2016-11-29 | Release date: | 2017-08-16 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Protein-ligand complex structure from serial femtosecond crystallography using soaked thermolysin microcrystals and comparison with structures from synchrotron radiation Acta Crystallogr D Struct Biol, 73, 2017
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5WR6
| Thermolysin, liganded form with cryo condition 2 | Descriptor: | CALCIUM ION, N-[(benzyloxy)carbonyl]-L-aspartic acid, Thermolysin, ... | Authors: | Kunishima, N, Naitow, H, Matsuura, Y. | Deposit date: | 2016-11-29 | Release date: | 2017-08-16 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Protein-ligand complex structure from serial femtosecond crystallography using soaked thermolysin microcrystals and comparison with structures from synchrotron radiation Acta Crystallogr D Struct Biol, 73, 2017
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5WR4
| Thermolysin, SFX unliganded form with oil-based carrier | Descriptor: | CALCIUM ION, Thermolysin, ZINC ION | Authors: | Kunishima, N, Naitow, H, Matsuura, Y. | Deposit date: | 2016-11-29 | Release date: | 2017-08-16 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Protein-ligand complex structure from serial femtosecond crystallography using soaked thermolysin microcrystals and comparison with structures from synchrotron radiation Acta Crystallogr D Struct Biol, 73, 2017
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5WR5
| Thermolysin, liganded form with cryo condition 1 | Descriptor: | CALCIUM ION, N-[(benzyloxy)carbonyl]-L-aspartic acid, TETRAETHYLENE GLYCOL, ... | Authors: | Kunishima, N, Naitow, H, Matsuura, Y. | Deposit date: | 2016-11-29 | Release date: | 2017-08-16 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Protein-ligand complex structure from serial femtosecond crystallography using soaked thermolysin microcrystals and comparison with structures from synchrotron radiation Acta Crystallogr D Struct Biol, 73, 2017
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3WUM
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3WXT
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3WUL
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3WXU
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5ZF0
| X-ray Structure of the Electron Transfer Complex between Ferredoxin and Photosystem I | Descriptor: | 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, BETA-CAROTENE, ... | Authors: | Kubota-Kawai, H, Mutoh, R, Shinmura, K, Setif, P, Nowaczyk, M, Roegner, M, Ikegami, T, Tanaka, T, Kurisu, G. | Deposit date: | 2018-03-01 | Release date: | 2018-04-11 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (4.2 Å) | Cite: | X-ray structure of an asymmetrical trimeric ferredoxin-photosystem I complex Nat Plants, 4, 2018
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2CY1
| Crystal structure of APE1850 | Descriptor: | NusA protein homolog | Authors: | Shibata, R, Bessho, Y, Umehara, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2005-07-04 | Release date: | 2006-01-04 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystallization of the archaeal transcription termination factor NusA: a significant decrease in twinning under microgravity conditions Acta Crystallogr.,Sect.F, 63, 2007
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5FVI
| Structure of IrisFP in mineral grease at 100 K. | Descriptor: | Green to red photoconvertible GFP-like protein EosFP, SULFATE ION | Authors: | Colletier, J.P, Gallat, F.X, Coquelle, N, Weik, M. | Deposit date: | 2016-02-07 | Release date: | 2016-04-13 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.397 Å) | Cite: | Serial Femtosecond Crystallography and Ultrafast Absorption Spectroscopy of the Photoswitchable Fluorescent Protein Irisfp. J.Phys.Chem.Lett., 7, 2016
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5FVG
| Structure of IrisFP at 100 K. | Descriptor: | Green to red photoconvertible GFP-like protein EosFP, SULFATE ION | Authors: | Colletier, J.P, Gallat, F.X, Coquelle, N, Weik, M. | Deposit date: | 2016-02-07 | Release date: | 2017-01-11 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Serial Femtosecond Crystallography and Ultrafast Absorption Spectroscopy of the Photoswitchable Fluorescent Protein Irisfp. J.Phys.Chem.Lett, 7, 2016
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