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4ZT7
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BU of 4zt7 by Molmil
Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor N-[(4R)-6,8-dichloro-1,2,3,4-tetrahydroquinolin-4-yl]-N'-(5-fluoro-3H-imidazo[4,5-b]pyridin-2-yl)propane-1,3-diamine (Chem 1717)
Descriptor: DIMETHYL SULFOXIDE, GLYCEROL, METHIONINE, ...
Authors:Koh, C.-Y, Hol, W.G.J.
Deposit date:2015-05-14
Release date:2016-05-04
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:5-Fluoroimidazo[4,5-b]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase Inhibitors.
Acs Infect Dis., 2, 2016
4YRK
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BU of 4yrk by Molmil
Crystal structure of T. cruzi Histidyl-tRNA synthetase in complex with (4-chlorophenyl)methanol (Chem 260)
Descriptor: (4-chlorophenyl)methanol, 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, ...
Authors:Koh, C.-Y, Hol, W.G.J.
Deposit date:2015-03-15
Release date:2015-08-12
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A binding hotspot in Trypanosoma cruzi histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens.
Acta Crystallogr. D Biol. Crystallogr., 71, 2015
4YRO
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BU of 4yro by Molmil
Crystal structure of T. cruzi Histidyl-tRNA synthetase in complex with 5-bromo-6-methylpyridin-2-amine (Chem 491)
Descriptor: 1,2-ETHANEDIOL, 5-bromo-6-methylpyridin-2-amine, DIMETHYL SULFOXIDE, ...
Authors:Koh, C.-Y, Hol, W.G.J.
Deposit date:2015-03-15
Release date:2015-08-12
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A binding hotspot in Trypanosoma cruzi histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens.
Acta Crystallogr. D Biol. Crystallogr., 71, 2015
4YRL
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BU of 4yrl by Molmil
Crystal structure of T. cruzi Histidyl-tRNA synthetase in complex with 4-(methylsulfanyl)aniline (Chem 262)
Descriptor: 1,2-ETHANEDIOL, 4-(methylsulfanyl)aniline, DIMETHYL SULFOXIDE, ...
Authors:Koh, C.-Y, Hol, W.G.J.
Deposit date:2015-03-15
Release date:2015-08-12
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A binding hotspot in Trypanosoma cruzi histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens.
Acta Crystallogr. D Biol. Crystallogr., 71, 2015
4ZT2
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BU of 4zt2 by Molmil
Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor N-(3,5-dichlorobenzyl)-N'-(1H-imidazo[4,5-b]pyridin-2-yl)propane-1,3-diamine (Chem 1575)
Descriptor: DIMETHYL SULFOXIDE, GLYCEROL, METHIONINE, ...
Authors:Koh, C.-Y, Hol, W.G.J.
Deposit date:2015-05-14
Release date:2016-05-04
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:5-Fluoroimidazo[4,5-b]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase Inhibitors.
Acs Infect Dis., 2, 2016
6AX8
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BU of 6ax8 by Molmil
Mycobacterium tuberculosis methionyl-tRNA synthetase in complex with methionyl-adenylate
Descriptor: Methionine-tRNA ligase, [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl] (2S)-2-azanyl-4-methylsulfanyl-butanoate
Authors:Barros-Alvarez, X, Hol, W.G.J.
Deposit date:2017-09-06
Release date:2018-04-11
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The crystal structure of the drug target Mycobacterium tuberculosis methionyl-tRNA synthetase in complex with a catalytic intermediate.
Acta Crystallogr F Struct Biol Commun, 74, 2018
6BQM
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BU of 6bqm by Molmil
Secreted serine protease VesC from Vibrio cholerae
Descriptor: serine protease VesC
Authors:Park, Y.J, Korotkov, K.V, Delarosa, J.R, Turley, S, DiMaio, F, Hol, W.G.J.
Deposit date:2017-11-28
Release date:2018-11-28
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Suppressor Mutations in Type II Secretion Mutants of Vibrio cholerae: Inactivation of the VesC Protease.
Msphere, 5, 2020
3BWC
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BU of 3bwc by Molmil
Crystal structure of spermidine synthase from Trypanosoma cruzi in complex with SAM at 2.3 A resolution
Descriptor: BETA-MERCAPTOETHANOL, S-ADENOSYLMETHIONINE, Spermidine synthase
Authors:Bosch, J, Arakaki, T.L, Le Trong, I, Merritt, E.A, Hol, W.G.J, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2008-01-09
Release date:2008-04-01
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of spermidine synthase from Trypanosoma cruzi.
To be Published
3BWB
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BU of 3bwb by Molmil
Crystal structure of the apo form of spermidine synthase from Trypanosoma cruzi at 2.5 A resolution
Descriptor: Spermidine synthase
Authors:Bosch, J, Hol, W.G.J, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2008-01-08
Release date:2008-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of spermidine synthase from Trypanosoma cruzi.
To be Published
1QCB
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BU of 1qcb by Molmil
ESCHERICHIA COLI HEAT LABILE ENTEROTOXIN TYPE IIB B-PENTAMER
Descriptor: PROTEIN (HEAT LABILE ENTEROTOXIN TYPE IIB B-PENTAMER)
Authors:Merritt, E.A, Hol, W.G.J.
Deposit date:1999-04-30
Release date:2003-06-10
Last modified:2021-07-28
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structures of the B-Pentamer from E. coli Enterotoxin LT-IIb
To be Published
1QB5
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BU of 1qb5 by Molmil
ESCHERICHIA COLI HEAT LABILE ENTEROTOXIN TYPE IIB B-PENTAMER
Descriptor: PROTEIN (HEAT LABILE ENTEROTOXIN TYPE IIB B-PENTAMER)
Authors:Merritt, E.A, Hol, W.G.J.
Deposit date:1999-04-30
Release date:2003-06-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structures of the B-Pentamer from E. coli Enterotoxin LT-IIb
To be Published
2BP2
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BU of 2bp2 by Molmil
THE STRUCTURE OF BOVINE PANCREATIC PROPHOSPHOLIPASE A2 AT 3.0 ANGSTROMS RESOLUTION
Descriptor: PHOSPHOLIPASE A2
Authors:Dijkstra, B.W, Vannes, G.J.H, Kalk, K.H, Brandenburg, N.P, Hol, W.G.J, Drenth, J.
Deposit date:1981-06-05
Release date:1981-07-16
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (3 Å)
Cite:The Structure of Bovine Pancreatic Prophospholipase A2 at 3.0 Angstroms Resolution
Acta Crystallogr.,Sect.B, 38, 1982
1LTS
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BU of 1lts by Molmil
REFINED STRUCTURE OF E. COLI HEAT LABILE ENTEROTOXIN, A CLOSE RELATIVE OF CHOLERA TOXIN
Descriptor: HEAT-LABILE ENTEROTOXIN, SUBUNIT A, SUBUNIT B
Authors:Sixma, T.K, Hol, W.G.J.
Deposit date:1992-07-15
Release date:1994-01-31
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Refined structure of Escherichia coli heat-labile enterotoxin, a close relative of cholera toxin.
J.Mol.Biol., 230, 1993
1UV7
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BU of 1uv7 by Molmil
periplasmic domain of EpsM from Vibrio cholerae
Descriptor: GENERAL SECRETION PATHWAY PROTEIN M
Authors:Abendroth, J, Hol, W.G.J.
Deposit date:2004-01-15
Release date:2004-04-23
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Crystal Structure of the Periplasmic Domain of the Type II Secretion System Protein Epsm from Vibrio Cholerae: The Simplest Version of the Ferredoxin Fold
J.Mol.Biol., 338, 2004
1W97
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BU of 1w97 by Molmil
cyto-EpsL: the cytoplasmic domain of EpsL, an inner membrane component of the type II secretion system of Vibrio cholerae
Descriptor: TYPE II SECRETION SYSTEM PROTEIN L
Authors:Abendroth, J, Bagdasarian, M, Sansdkvist, M, Hol, W.G.J.
Deposit date:2004-10-06
Release date:2004-11-30
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The Structure of the Cytoplasmic Domain of Epsl, an Inner Membrane Component of the Type II Secretion System of Vibrio Cholerae: An Unusual Member of the Actin-Like ATPase Superfamily
J.Mol.Biol., 344, 2004
1X6O
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BU of 1x6o by Molmil
Structural Analysis of Leishmania braziliensis eukaryotic initiation factor 5a
Descriptor: DI(HYDROXYETHYL)ETHER, eukaryotic initiation factor 5a
Authors:Bosch, J, Robien, M.A, Hol, W.G.J, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2004-08-11
Release date:2004-08-24
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural Analysis of Leishmania braziliensis eukaryotic initiation factor 5a
To be Published
1XO7
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BU of 1xo7 by Molmil
Crystal structure of cyclophilin from Trypanosoma cruzi
Descriptor: cyclophilin
Authors:Caruthers, J.M, Hol, W.G.J, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2004-10-05
Release date:2004-12-21
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Crystal structure of cyclophilin from Trypanosoma cruzi
TO BE PUBLISHED
1XQ7
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BU of 1xq7 by Molmil
Cyclophilin from Trypanosoma cruzi bound to cyclosporin A
Descriptor: CYCLOSPORIN A, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE
Authors:Caruthers, J.M, Hol, W.G.J, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2004-10-11
Release date:2004-12-21
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Cyclophilin from Trypanosoma Cruzi Bound to Cyclosporin A
To be Published
1XTD
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BU of 1xtd by Molmil
Structural Analysis of Leishmania mexicana eukaryotic initiation factor 5a
Descriptor: eukaryotic initiation factor 5a
Authors:Bosch, J, Hol, W.G.J, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2004-10-21
Release date:2004-10-26
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural Analysis of Leishmania mexicana eukaryotic initiation factor 5a
To be Published
1XTP
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BU of 1xtp by Molmil
Structural Analysis of Leishmania major LMAJ004091AAA, a SAM-dependent methyltransferase of the DUF858/Pfam05891 family
Descriptor: LMAJ004091AAA, S-ADENOSYL-L-HOMOSELENOCYSTEINE
Authors:Robien, M.A, Hol, W.G.J, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2004-10-22
Release date:2004-11-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Structural Analysis of Leishmania major LMAJ004091AAA
To be Published
1XQ9
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BU of 1xq9 by Molmil
Structure of Phosphoglycerate Mutase from Plasmodium falciparum at 2.6 Resolution
Descriptor: THIOCYANATE ION, phosphoglycerate mutase
Authors:Caruthers, J.M, Hol, W.G.J, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2004-10-11
Release date:2004-12-21
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Structure of Phosphoglycerate Mutase from Plasmodium falciparum at 2.6 Resolution
TO BE PUBLISHED
1XIQ
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BU of 1xiq by Molmil
Plasmodium falciparum Nucleoside diphosphate kinase B
Descriptor: Nucleoside diphosphate kinase B
Authors:Robien, M.A, Bosch, J, Hol, W.G.J, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2004-09-21
Release date:2004-10-12
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Crystal structure of Nucleoside diphosphate kinase B from Plasmodium falciparum
To be Published
1XUP
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BU of 1xup by Molmil
ENTEROCOCCUS CASSELIFLAVUS GLYCEROL KINASE COMPLEXED WITH GLYCEROL
Descriptor: GLYCEROL, Glycerol kinase
Authors:Yeh, J.I, Charrier, V, Paulo, J, Hou, L, Darbon, E, Hol, W.G.J, Deutscher, J.
Deposit date:2004-10-26
Release date:2004-12-14
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structures of Enterococcal Glycerol Kinase in the Absence and Presence of Glycerol: Correlation of Conformation to Substrate Binding and a Mechanism of Activation by Phosphorylation
Biochemistry, 43, 2004
1Y63
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BU of 1y63 by Molmil
Initial crystal structural analysis of a probable kinase from Leishmania major Friedlin
Descriptor: ADENOSINE-5'-DIPHOSPHATE, BROMIDE ION, Lmaj004144AAA protein, ...
Authors:Robien, M.A, Hol, W.G.J, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2004-12-03
Release date:2005-01-04
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structural analysis of a probable kinase from Leishmania major Friedlin
To be Published
1Y13
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BU of 1y13 by Molmil
Structural Analysis of Plasmodium falciparum 6-pyruvoyl tetrahydropterin synthase (PTPS)
Descriptor: 6-pyruvoyl tetrahydropterin synthase, BIOPTERIN, ZINC ION
Authors:Bosch, J, Hol, W.G.J, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2004-11-17
Release date:2005-01-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Analysis of Plasmodium falciparum 6-pyruvoyl tetrahydropterin synthase (PTPS)
To be Published

221716

數據於2024-06-26公開中

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