5F17
 
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8IO5
 | | Herg1a-herg1b closed state 2 | | Descriptor: | Potassium voltage-gated channel subfamily H member 2 | | Authors: | Zhang, M.F. | | Deposit date: | 2023-03-10 | | Release date: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Structure of Herg1a-herg1b open state
To Be Published
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8IOB
 | | Herg1a-herg1b closed state 1 | | Descriptor: | Potassium voltage-gated channel subfamily H member 2 | | Authors: | Zhang, M.F. | | Deposit date: | 2023-03-10 | | Release date: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structure of Herg1a-herg1b closed state 1
To Be Published
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8IO4
 | | Herg1a-herg1b open state | | Descriptor: | Potassium voltage-gated channel subfamily H member 2 | | Authors: | Zhang, M.F. | | Deposit date: | 2023-03-10 | | Release date: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structure of Herg1a-herg1b open state
To Be Published
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8JXO
 | | Cryo-EM structure of BlCHR2 class one | | Descriptor: | BlCHR2, POTASSIUM ION, RETINAL | | Authors: | Zhang, M.F. | | Deposit date: | 2023-07-01 | | Release date: | 2024-07-10 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Structure of BlCHR2 class one
To Be Published
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8JXP
 | | Cryo-EM structure of BlCHR2 class one | | Descriptor: | BlCHR2, POTASSIUM ION, RETINAL | | Authors: | Zhang, M.F. | | Deposit date: | 2023-07-01 | | Release date: | 2024-07-10 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Structure of BlCHR2 class one
To Be Published
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8IFU
 | | HcCCR in NaCl | | Descriptor: | (1S)-2-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(octadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, HcCCR, RETINAL, ... | | Authors: | Zhang, M.F. | | Deposit date: | 2023-02-19 | | Release date: | 2024-02-28 | | Method: | ELECTRON MICROSCOPY (2.37 Å) | | Cite: | Structure of HcCCR
To Be Published
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8WXJ
 | | human CLC-1 D136G closed state | | Descriptor: | Chloride channel protein 1, THIOCYANATE ION | | Authors: | Zhang, M.F. | | Deposit date: | 2023-10-29 | | Release date: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (2.68 Å) | | Cite: | CLC-1 in SCN environment
To Be Published
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7XTK
 | | Cryo-EM structure of SLC19A1 | | Descriptor: | Reduced folate transporter | | Authors: | Zhang, M.F, Shan, Y.Y. | | Deposit date: | 2022-05-17 | | Release date: | 2023-06-21 | | Last modified: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (2.89 Å) | | Cite: | Structure of human SLC19A1.
To Be Published
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7XYM
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5HBZ
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7V1U
 | | Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor ZJ12 | | Descriptor: | 1,2-ETHANEDIOL, Bromodomain-containing protein 4, ~{N}-(3-ethyl-6-methoxy-1,2-benzoxazol-5-yl)-2-methoxy-benzenesulfonamide | | Authors: | Zhang, M, Wang, C, Zhang, C, Zhang, Y, Xu, Y. | | Deposit date: | 2021-08-06 | | Release date: | 2022-08-10 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.82 Å) | | Cite: | Design, synthesis and pharmacological characterization of N-(3-ethylbenzo[d]isoxazol-5-yl) sulfonamide derivatives as BRD4 inhibitors against acute myeloid leukemia.
Acta Pharmacol.Sin., 43, 2022
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7V2J
 | | Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor 33 | | Descriptor: | Bromodomain-containing protein 4, ~{N}-(3-ethyl-6-methoxy-1,2-benzoxazol-5-yl)-4-methoxy-benzenesulfonamide | | Authors: | Zhang, M, Wang, C, Zhang, C, Zhang, Y, Xu, Y. | | Deposit date: | 2021-08-09 | | Release date: | 2022-08-17 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.24 Å) | | Cite: | Design, synthesis and pharmacological characterization of N-(3-ethylbenzo[d]isoxazol-5-yl) sulfonamide derivatives as BRD4 inhibitors against acute myeloid leukemia.
Acta Pharmacol.Sin., 43, 2022
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5EYI
 | | Structure of PRRSV apo-NSP11 at 2.16A | | Descriptor: | 2-(2-METHOXYETHOXY)ETHANOL, CHLORIDE ION, Non-structural protein 11, ... | | Authors: | Zhang, M.F, Chen, Z. | | Deposit date: | 2015-11-25 | | Release date: | 2016-10-12 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.16 Å) | | Cite: | Structural Biology of the Arterivirus nsp11 Endoribonucleases.
J. Virol., 91, 2017
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5HC1
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8W6A
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8W6B
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8YMO
 | | OSCA1.1-F516A pre-open 1 | | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Protein OSCA1 | | Authors: | Zhang, M.F. | | Deposit date: | 2024-03-09 | | Release date: | 2024-10-02 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Activation mechanisms of dimeric mechanosensitive OSCA/TMEM63 channels.
Nat Commun, 15, 2024
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8YMN
 | | OSCA1.1-F516A pre-open 2 | | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Protein OSCA1 | | Authors: | Zhang, M.F. | | Deposit date: | 2024-03-09 | | Release date: | 2024-10-02 | | Method: | ELECTRON MICROSCOPY (2.5 Å) | | Cite: | Activation mechanisms of dimeric mechanosensitive OSCA/TMEM63 channels.
Nat Commun, 15, 2024
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8YMQ
 | | OSCA1.1-F516A nanodisc | | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Protein OSCA1 | | Authors: | Zhang, M.F. | | Deposit date: | 2024-03-09 | | Release date: | 2024-10-02 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Activation mechanisms of dimeric mechanosensitive OSCA/TMEM63 channels.
Nat Commun, 15, 2024
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8YMP
 | | OSCA1.1-F516A nanodisc in LPC | | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Protein OSCA1 | | Authors: | Zhang, M.F. | | Deposit date: | 2024-03-09 | | Release date: | 2024-10-02 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Activation mechanisms of dimeric mechanosensitive OSCA/TMEM63 channels.
Nat Commun, 15, 2024
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8YMM
 | | OSCA1.1-F516A open | | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Protein OSCA1 | | Authors: | Zhang, M.F. | | Deposit date: | 2024-03-09 | | Release date: | 2024-10-02 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Activation mechanisms of dimeric mechanosensitive OSCA/TMEM63 channels.
Nat Commun, 15, 2024
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8GRS
 | | human TMEM63A | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CSC1-like protein 1 | | Authors: | Zhang, M.F. | | Deposit date: | 2022-09-02 | | Release date: | 2023-06-14 | | Last modified: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | A mechanical-coupling mechanism in OSCA/TMEM63 channel mechanosensitivity.
Nat Commun, 14, 2023
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8GRN
 | | AtOSCA1.1 extended state | | Descriptor: | Protein OSCA1, [1-MYRISTOYL-GLYCEROL-3-YL]PHOSPHONYLCHOLINE | | Authors: | Zhang, M.F. | | Deposit date: | 2022-09-02 | | Release date: | 2023-06-14 | | Last modified: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (2.5 Å) | | Cite: | A mechanical-coupling mechanism in OSCA/TMEM63 channel mechanosensitivity.
Nat Commun, 14, 2023
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8GRO
 | | AtOSCA3.1 contracted state | | Descriptor: | CSC1-like protein ERD4 | | Authors: | Zhang, M.F. | | Deposit date: | 2022-09-02 | | Release date: | 2023-06-14 | | Last modified: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | A mechanical-coupling mechanism in OSCA/TMEM63 channel mechanosensitivity.
Nat Commun, 14, 2023
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