3GJJ
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![BU of 3gjj by Molmil](/molmil-images/mine/3gjj) | crystal structure of a DNA duplex containing 7,8-dihydropyridol[2,3-d]pyrimidin-2-one | Descriptor: | 2'-(4-HYDROXYPHENYL)-5-(4-METHYL-1-PIPERAZINYL)-2,5'-BI-BENZIMIDAZOLE, 5'-D(*CP*GP*CP*GP*AP*AP*TP*(B7C)P*CP*GP*CP*G)-3' | Authors: | Takenaka, A, Juan, E.C.M, Shimizu, S, Haraguchi, T, Xiao, M, Kurose, T, Ohkubo, A, Sekine, M, Shibata, T, Millington, C.L, Williams, D.M. | Deposit date: | 2009-03-09 | Release date: | 2010-03-31 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Insights into the stabilizing contributions of bicyclic cytosine analogues: crystal structures of DNA duplexes containing 7,8-dihydropyridol[2,3-d]pyrimidin-2-one To be Published
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3GJL
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![BU of 3gjl by Molmil](/molmil-images/mine/3gjl) | crystal structure of a DNA duplex containing 7,8-dihydropyridol[2,3-d]pyrimidin-2-one | Descriptor: | 5'-D(*CP*GP*CP*GP*AP*A)-3', 5'-D(P*TP*TP*(B7C)P*GP*CP*G)-3', SODIUM ION | Authors: | Takenaka, A, Juan, E.C.M, Shimizu, S, Haraguchi, T, Xiao, M, Kurose, T, Ohkubo, A, Sekine, M, Shibata, T, Millington, C.L, Williams, D.M. | Deposit date: | 2009-03-09 | Release date: | 2010-03-31 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Insights into the stabilizing contributions of bicyclic cytosine analogues: crystal structures of DNA duplexes containing 7,8-dihydropyridol[2,3-d]pyrimidin-2-one To be Published
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3GJK
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![BU of 3gjk by Molmil](/molmil-images/mine/3gjk) | crystal structure of a DNA duplex containing 7,8-dihydropyridol[2,3-d]pyrimidin-2-one | Descriptor: | 5'-D(*CP*GP*CP*GP*AP*A)-3', 5'-D(P*TP*TP*(B7C)P*GP*CP*G)-3', POTASSIUM ION | Authors: | Takenaka, A, Juan, E.C.M, Shimizu, S, Haraguchi, T, Xiao, M, Kurose, T, Ohkubo, A, Sekine, M, Shibata, T, Millington, C.L, Williams, D.M. | Deposit date: | 2009-03-09 | Release date: | 2010-03-31 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Insights into the stabilizing contributions of bicyclic cytosine analogues: crystal structures of DNA duplexes containing 7,8-dihydropyridol[2,3-d]pyrimidin-2-one To be Published
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3GJH
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![BU of 3gjh by Molmil](/molmil-images/mine/3gjh) | Crystal structure of a DNA duplex containing 7,8-dihydropyridol[2,3-d]pyrimidin-2-one | Descriptor: | 5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*(B7C)P*GP*CP*G)-3', 6-AMIDINE-2-(4-AMIDINO-PHENYL)INDOLE | Authors: | Takenaka, A, Juan, E.C.M, Shimizu, S, Haraguchi, T, Xiao, M, Kurose, T. | Deposit date: | 2009-03-09 | Release date: | 2010-03-31 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Insights into the stabilizing contributions of bicyclic cytosine analogues: crystal structures of DNA duplexes containing 7,8-dihydropyridol[2,3-d]pyrimidin-2-one To be Published
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8HI8
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![BU of 8hi8 by Molmil](/molmil-images/mine/8hi8) | |
8HCI
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![BU of 8hci by Molmil](/molmil-images/mine/8hci) | |
8HI7
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![BU of 8hi7 by Molmil](/molmil-images/mine/8hi7) | |
7CL0
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![BU of 7cl0 by Molmil](/molmil-images/mine/7cl0) | Crystal structure of human SIRT6 | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, NAD-dependent protein deacetylase sirtuin-6, ... | Authors: | Song, K, Zhang, J. | Deposit date: | 2020-07-20 | Release date: | 2021-02-24 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.53 Å) | Cite: | Reply to: Binding site for MDL-801 on SIRT6. Nat.Chem.Biol., 17, 2021
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7CL1
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![BU of 7cl1 by Molmil](/molmil-images/mine/7cl1) | Human SIRT6 in complex with allosteric activator MDL-801 (3.2A) | Descriptor: | 5-[[3,5-bis(chloranyl)phenyl]sulfonylamino]-2-[(5-bromanyl-4-fluoranyl-2-methyl-phenyl)sulfamoyl]benzoic acid, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | Authors: | Song, K, Zhang, J. | Deposit date: | 2020-07-20 | Release date: | 2021-02-24 | Last modified: | 2021-05-12 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Reply to: Binding site for MDL-801 on SIRT6. Nat.Chem.Biol., 17, 2021
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4X3X
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![BU of 4x3x by Molmil](/molmil-images/mine/4x3x) | The crystal structure of Arc C-lobe | Descriptor: | Activity-regulated cytoskeleton-associated protein | Authors: | Zhang, W, Ward, M, Leahy, D, Worley, P. | Deposit date: | 2014-12-01 | Release date: | 2015-06-03 | Last modified: | 2017-09-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis of arc binding to synaptic proteins: implications for cognitive disease. Neuron, 86, 2015
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4X3H
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![BU of 4x3h by Molmil](/molmil-images/mine/4x3h) | CRYSTAL STRUCTURE OF ARC N-LOBE COMPLEXED WITH STARGAZIN PEPTIDE | Descriptor: | Activity-regulated cytoskeleton-associated protein, VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-2 SUBUNIT | Authors: | zhang, W, ward, m, leahy, d, worley, p. | Deposit date: | 2014-11-30 | Release date: | 2015-06-03 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.401 Å) | Cite: | Structural basis of arc binding to synaptic proteins: implications for cognitive disease. Neuron, 86, 2015
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4X3I
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![BU of 4x3i by Molmil](/molmil-images/mine/4x3i) | The crystal structure of Arc N-lobe complexed with CAMK2A fragment | Descriptor: | Activity-regulated cytoskeleton-associated protein, CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT ALPHA | Authors: | Zhang, W, Ward, M, Leahy, D, Worley, P. | Deposit date: | 2014-11-30 | Release date: | 2015-06-03 | Last modified: | 2017-09-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural basis of arc binding to synaptic proteins: implications for cognitive disease. Neuron, 86, 2015
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3CST
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![BU of 3cst by Molmil](/molmil-images/mine/3cst) | |
3CSF
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![BU of 3csf by Molmil](/molmil-images/mine/3csf) | |
5Y2F
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![BU of 5y2f by Molmil](/molmil-images/mine/5y2f) | Human SIRT6 in complex with allosteric activator MDL-801 | Descriptor: | 5-[[3,5-bis(chloranyl)phenyl]sulfonylamino]-2-[(5-bromanyl-4-fluoranyl-2-methyl-phenyl)sulfamoyl]benzoic acid, 9-mer peptide QTARKSTGG, DI(HYDROXYETHYL)ETHER, ... | Authors: | Zhang, J, Huang, Z, Song, K. | Deposit date: | 2017-07-25 | Release date: | 2018-11-07 | Last modified: | 2018-11-28 | Method: | X-RAY DIFFRACTION (2.53 Å) | Cite: | Identification of a cellularly active SIRT6 allosteric activator. Nat. Chem. Biol., 14, 2018
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6J14
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![BU of 6j14 by Molmil](/molmil-images/mine/6j14) | Complex structure of GY-14 and PD-1 | Descriptor: | GY-14 heavy chain V fragment, GY-14 light chain V fragment, Programmed cell death protein 1 | Authors: | Chen, D, Tan, S, Whang, H, Zhang, H, Chai, Y, Qi, J, Yan, J, Gao, G.F. | Deposit date: | 2018-12-27 | Release date: | 2019-11-06 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | The FG Loop of PD-1 Serves as a "Hotspot" for Therapeutic Monoclonal Antibodies in Tumor Immune Checkpoint Therapy. Iscience, 14, 2019
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6J15
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![BU of 6j15 by Molmil](/molmil-images/mine/6j15) | Complex structure of GY-5 Fab and PD-1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, GY-5 heavy chain Fab, ... | Authors: | Chen, D, Tan, S, Zhang, H, Wang, H, Chai, Y, Qi, J, Yan, J, Gao, G.F. | Deposit date: | 2018-12-27 | Release date: | 2019-11-06 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | The FG Loop of PD-1 Serves as a "Hotspot" for Therapeutic Monoclonal Antibodies in Tumor Immune Checkpoint Therapy. Iscience, 14, 2019
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8IMS
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![BU of 8ims by Molmil](/molmil-images/mine/8ims) | Crystal structure of TRAF7 coiled-coil domain | Descriptor: | E3 ubiquitin-protein ligase TRAF7 | Authors: | Hu, R, Lin, L, Lu, Q. | Deposit date: | 2023-03-07 | Release date: | 2024-01-24 | Last modified: | 2024-07-17 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | The structure of TRAF7 coiled-coil trimer provides insight into its function in zebrafish embryonic development. J Mol Cell Biol, 16, 2024
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8J4T
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![BU of 8j4t by Molmil](/molmil-images/mine/8j4t) | GajA-GajB complex | Descriptor: | Endonuclease GajA, Gabija protein GajB | Authors: | Wei, T, Ma, J, Huo, Y. | Deposit date: | 2023-04-20 | Release date: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structural and biochemical insights into the mechanism of the Gabija bacterial immunity system. Nat Commun, 15, 2024
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