6EIZ
 
 | | A de novo designed hexameric coiled coil CC-Hex2 with farnesol bound in the channel. | | Descriptor: | (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol, CC-Hex2 | | Authors: | Rhys, G.G, Burton, A.J, Dawson, W.M, Thomas, F, Woolfson, D.N. | | Deposit date: | 2017-09-19 | | Release date: | 2018-07-11 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | De Novo-Designed alpha-Helical Barrels as Receptors for Small Molecules.
ACS Synth Biol, 7, 2018
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6EIK
 | | A de novo designed heptameric coiled coil CC-Hept-I24E | | Descriptor: | CC-Hept-I24E, FORMIC ACID, GLYCEROL | | Authors: | Rhys, G.G, Burton, A.J, Dawson, W.M, Thomas, F, Woolfson, D.N. | | Deposit date: | 2017-09-19 | | Release date: | 2018-07-18 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.52 Å) | | Cite: | De Novo-Designed alpha-Helical Barrels as Receptors for Small Molecules.
ACS Synth Biol, 7, 2018
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7QWC
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7QWD
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7QWE
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7QWB
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7QWA
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5LO2
 | | Engineering protein stability with atomic precision in a monomeric miniprotein | | Descriptor: | PPaTyr | | Authors: | Baker, E.G, Hudson, K.L, Williams, C, Bartlett, G.G, Heal, J.W, Sessions, R.B, Crump, M.P, Woolfson, D.N. | | Deposit date: | 2016-08-08 | | Release date: | 2017-05-17 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Engineering protein stability with atomic precision in a monomeric miniprotein.
Nat. Chem. Biol., 13, 2017
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5LO3
 | | Engineering protein stability with atomic precision in a monomeric miniprotein | | Descriptor: | PPaOMe | | Authors: | Baker, E.G, Hudson, K.L, Williams, C, Bartlett, G.G, Heal, J.W, Sessions, R.B, Crump, M.P, Woolfson, D.N. | | Deposit date: | 2016-08-08 | | Release date: | 2017-05-17 | | Last modified: | 2023-11-15 | | Method: | SOLUTION NMR | | Cite: | Engineering protein stability with atomic precision in a monomeric miniprotein.
Nat. Chem. Biol., 13, 2017
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1EYM
 | | FK506 BINDING PROTEIN MUTANT, HOMODIMERIC COMPLEX | | Descriptor: | FK506 BINDING PROTEIN | | Authors: | Rollins, C.T, Rivera, V.M, Woolfson, D.N, Keenan, T, Hatada, M, Adams, S.E, Andrade, L.J, Yaeger, D, van Schravendijk, M.R, Holt, D.A, Gilman, M, Clackson, T. | | Deposit date: | 2000-05-07 | | Release date: | 2000-08-09 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | A ligand-reversible dimerization system for controlling protein-protein interactions.
Proc.Natl.Acad.Sci.USA, 97, 2000
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5LO4
 | | Engineering protein stability with atomic precision in a monomeric miniprotein | | Descriptor: | PPa-CH3 | | Authors: | Baker, E.G, Williams, C, Hudson, K.L, Bartlett, G.G, Heal, J.W, Sessions, R.B, Crump, M.P, Woolfson, D.N. | | Deposit date: | 2016-08-08 | | Release date: | 2017-05-17 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Engineering protein stability with atomic precision in a monomeric miniprotein.
Nat. Chem. Biol., 13, 2017
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1SIF
 | | Crystal structure of a multiple hydrophobic core mutant of ubiquitin | | Descriptor: | ubiquitin | | Authors: | Benitez-Cardoza, C.G, Stott, K, Hirshberg, M, Went, H.M, Woolfson, D.N, Jackson, S.E. | | Deposit date: | 2004-02-29 | | Release date: | 2004-07-27 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.18 Å) | | Cite: | Exploring sequence/folding space: folding studies on multiple hydrophobic core mutants of ubiquitin
Biochemistry, 43, 2004
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2G0L
 | | Solution Structure of Neocarzinostatin Apo-Protein with bound Flavone | | Descriptor: | 2-PHENYL-4H-CHROMEN-4-ONE, NEOCARZINOSTATIN | | Authors: | Muskett, F.W, Stoneman, R.G, Caddick, S, Woolfson, D.N. | | Deposit date: | 2006-02-13 | | Release date: | 2006-03-28 | | Last modified: | 2022-03-09 | | Method: | SOLUTION NMR | | Cite: | Synthetic Ligands for Apo-Neocarzinostatin
J.Am.Chem.Soc., 128, 2006
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2G0K
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1J5H
 | | Solution Structure of Apo-Neocarzinostatin | | Descriptor: | Apo-Neocarzinostatin | | Authors: | Urbaniak, M.D, Muskett, F.W, Finucane, M.D, Caddick, S, Woolfson, D.N. | | Deposit date: | 2002-05-02 | | Release date: | 2002-09-11 | | Last modified: | 2023-12-27 | | Method: | SOLUTION NMR | | Cite: | Solution Structure of a Novel Chromoprotein Derived from Apo-Neocarzinostatin and a Synthetic Chromophore
Biochemistry, 41, 2002
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1J5I
 | | Solution Structure of a Novel Chromoprotein Derived from Apo-Neocarzinostatin and a Synthetic Chromophore | | Descriptor: | 2-HYDROXY-7-METHOXY-5-METHYL-NAPHTHALENE-1-CARBOXYLIC ACID MESO-2,5-DIHYDROXY-CYCLOPENT-3-ENYL ESTER, PROTEIN (Apo-Neocarzinostatin) | | Authors: | Urbaniak, M.D, Muskett, F.W, Finucane, M.D, Caddick, S, Woolfson, D.N. | | Deposit date: | 2002-05-02 | | Release date: | 2002-09-11 | | Last modified: | 2024-10-16 | | Method: | SOLUTION NMR | | Cite: | Solution Structure of a Novel Chromoprotein Derived from Apo-Neocarzinostatin and a Synthetic Chromophore
Biochemistry, 41, 2002
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4KVV
 | | Crystal structure of an alkylated Cys mutant of CC-Hex | | Descriptor: | 6-HELIX COILED COIL CC-HEX-L24C PEPTIDE with an alkylated Cys mutation | | Authors: | Burton, A.J, Agnew, C, Brady, R.L, Woolfson, D.N. | | Deposit date: | 2013-05-23 | | Release date: | 2013-08-21 | | Last modified: | 2013-09-11 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Accessibility, Reactivity, and Selectivity of Side Chains within a Channel of de Novo Peptide Assembly.
J.Am.Chem.Soc., 135, 2013
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4KVU
 | | Crystal structure of a 6-helix coiled coil CC-Hex-L17C-W224BF | | Descriptor: | 6-helix coiled coil CC-Hex-L17C-W224BF, GLYCEROL | | Authors: | Burton, A.J, Agnew, C, Brady, R.L, Woolfson, D.N. | | Deposit date: | 2013-05-23 | | Release date: | 2013-08-21 | | Last modified: | 2013-09-11 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Accessibility, Reactivity, and Selectivity of Side Chains within a Channel of de Novo Peptide Assembly.
J.Am.Chem.Soc., 135, 2013
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4KVT
 | | Crystal structure of a 6-helix coiled coil CC-Hex-L24C | | Descriptor: | 6-helix coiled coil CC-Hex-L24C peptide | | Authors: | Burton, A.J, Agnew, C, Brady, R.L, Woolfson, D.N. | | Deposit date: | 2013-05-23 | | Release date: | 2013-08-21 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Accessibility, Reactivity, and Selectivity of Side Chains within a Channel of de Novo Peptide Assembly.
J.Am.Chem.Soc., 135, 2013
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8A09
 | | A hexameric barrel state of a de novo coiled-coil assembly: CC-Type2-(QgLaId)4 | | Descriptor: | A hexameric barrel state of a de novo coiled-coil assembly: CC-Type2-(QgLaId)4, GLYCEROL | | Authors: | Martin, F.J.O, Rhys, G.G, Dawson, W.M, Woolfson, D.N. | | Deposit date: | 2022-05-27 | | Release date: | 2022-06-15 | | Last modified: | 2024-06-19 | | Method: | X-RAY DIFFRACTION (1.35 Å) | | Cite: | Differential sensing with arrays of de novo designed peptide assemblies.
Nat Commun, 14, 2023
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7QDI
 | | Structure of octameric left-handed 310-helix bundle: D-310HD | | Descriptor: | 1,2-ETHANEDIOL, 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, 2-(2-METHOXYETHOXY)ETHANOL, ... | | Authors: | Kumar, P, Paterson, N.G, Woolfson, D.N. | | Deposit date: | 2021-11-27 | | Release date: | 2022-04-27 | | Last modified: | 2022-07-27 | | Method: | X-RAY DIFFRACTION (2.34 Å) | | Cite: | De novo design of discrete, stable 3 10 -helix peptide assemblies.
Nature, 607, 2022
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7QDJ
 | | Racemic structure of PK-10 and PK-11 | | Descriptor: | GLYCEROL, MALONATE ION, PK-10+PK-11, ... | | Authors: | Kumar, P, Paterson, N.G, Woolfson, D.N. | | Deposit date: | 2021-11-27 | | Release date: | 2022-04-27 | | Last modified: | 2022-07-27 | | Method: | X-RAY DIFFRACTION (1.44 Å) | | Cite: | De novo design of discrete, stable 3 10 -helix peptide assemblies.
Nature, 607, 2022
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7QDK
 | | A trimeric de novo coiled-coil assembly: CC-TypeN-LaLd | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CC-TypeN-LaLd, GLYCEROL, ... | | Authors: | Kumar, P, Paterson, N.G, Woolfson, D.N. | | Deposit date: | 2021-11-27 | | Release date: | 2022-04-27 | | Last modified: | 2022-07-27 | | Method: | X-RAY DIFFRACTION (1.41 Å) | | Cite: | De novo design of discrete, stable 3 10 -helix peptide assemblies.
Nature, 607, 2022
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8A3G
 | | X-ray crystal structure of a de novo designed antiparallel coiled-coil homotetramer with 4 heptad repeats, apCC-Tet* | | Descriptor: | ACETATE ION, SODIUM ION, apCC-Tet* | | Authors: | Naudin, E.A, Mylemans, B, Albanese, K.I, Woolfson, D.N. | | Deposit date: | 2022-06-08 | | Release date: | 2022-10-05 | | Last modified: | 2022-11-23 | | Method: | X-RAY DIFFRACTION (0.96 Å) | | Cite: | From peptides to proteins: coiled-coil tetramers to single-chain 4-helix bundles.
Chem Sci, 13, 2022
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8A3J
 | | X-ray crystal structure of a de novo designed antiparallel coiled-coil heterotetramer with 3 heptad repeats, apCC-Tet*3-A2B2 | | Descriptor: | apCC-Tet*3-A, apCC-Tet*3-B | | Authors: | Naudin, E.A, Mylemans, B, Albanese, K.I, Woolfson, D.N. | | Deposit date: | 2022-06-08 | | Release date: | 2022-10-05 | | Last modified: | 2022-11-23 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | From peptides to proteins: coiled-coil tetramers to single-chain 4-helix bundles.
Chem Sci, 13, 2022
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