7ULU
| Human DDAH1 soaked with its inhibitor ClPyrAA | Descriptor: | (2S)-2-amino-4-[(pyridin-2-yl)amino]butanoic acid, N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 | Authors: | Butrin, A, Zheng, Y, Tuley, A, Liu, D, Fast, W. | Deposit date: | 2022-04-05 | Release date: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Optimization of a switchable electrophile fragment into a potent and selective covalent inhibitor of human DDAH1 To Be Published
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7ULX
| Human DDAH1 soaked with its inhibitor N4-(4-chloropyridin-2-yl)-L-asparagine | Descriptor: | N(G),N(G)-dimethylarginine dimethylaminohydrolase 1, N-(pyridin-2-yl)-L-asparagine | Authors: | Zheng, Y, Butrin, A, Tuley, A, Liu, D, Fast, W. | Deposit date: | 2022-04-05 | Release date: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.707 Å) | Cite: | Optimization of a switchable electrophile fragment into a potent and selective covalent inhibitor of human DDAH1 To Be Published
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7ULV
| Human DDAH1 soaked with its inactivator S-((4-chloropyridin-2-yl)methyl)-L-cysteine | Descriptor: | N(G),N(G)-dimethylarginine dimethylaminohydrolase 1, S-[(pyridin-2-yl)methyl]-L-cysteine | Authors: | Zheng, Y, Butrin, A, Tuley, A, Liu, D, Fast, W. | Deposit date: | 2022-04-05 | Release date: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.37 Å) | Cite: | Optimization of a switchable electrophile fragment into a potent and selective covalent inhibitor of human DDAH1 To Be Published
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6DGE
| Crystal structure of the dimethylarginine dimethylaminohydrolase adduct with N5-(1-imino-2-chloroethyl)-L-lysine | Descriptor: | N(G),N(G)-dimethylarginine dimethylaminohydrolase 1, N~6~-[(1E)-2-chloroethanimidoyl]-L-lysine | Authors: | Monzingo, A.F, Burstein-Teitelbaum, G, Er, J.A.V, Tuley, A, Fast, W. | Deposit date: | 2018-05-17 | Release date: | 2018-07-25 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Dissection, Optimization, and Structural Analysis of a Covalent Irreversible DDAH1 Inhibitor. Biochemistry, 57, 2018
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