6EKO
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![BU of 6eko by Molmil](/molmil-images/mine/6eko) | Crystal structure of Type IIP restriction endonuclease PfoI with cognate DNA | Descriptor: | CALCIUM ION, DNA (5'-D(*CP*GP*CP*TP*CP*CP*CP*GP*GP*AP*GP*CP*GP*T)-3'), Restriction endonuclease PfoI | Authors: | Tamulaitiene, G, Manakova, E, Jovaisaite, V, Grazulis, S, Siksnys, V. | Deposit date: | 2017-09-26 | Release date: | 2018-10-10 | Last modified: | 2019-04-24 | Method: | X-RAY DIFFRACTION (2.284 Å) | Cite: | Unique mechanism of target recognition by PfoI restriction endonuclease of the CCGG-family. Nucleic Acids Res., 47, 2019
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6EKR
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4QDL
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![BU of 4qdl by Molmil](/molmil-images/mine/4qdl) | Crystal structure of E.coli Cas1-Cas2 complex | Descriptor: | CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2 | Authors: | Tamulaitiene, G, Sinkunas, T, Silanskas, A, Gasiunas, G, Grazulis, S, Siksnys, V. | Deposit date: | 2014-05-14 | Release date: | 2014-05-28 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structure of E.coli Cas1-Cas2 complex To be Published
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2IXS
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![BU of 2ixs by Molmil](/molmil-images/mine/2ixs) | Structure of SdaI restriction endonuclease | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, SDAI RESTRICTION ENDONUCLEASE, ... | Authors: | Tamulaitiene, G, Jakubauskas, A, Urbanke, C, Huber, R, Grazulis, S, Siksnys, V. | Deposit date: | 2006-07-11 | Release date: | 2006-09-14 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The Crystal Structure of the Rare-Cutting Restriction Enzyme Sdai Reveals Unexpected Domain Architecture Structure, 14, 2006
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5DWB
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![BU of 5dwb by Molmil](/molmil-images/mine/5dwb) | Crystal structure of specific restriction endonuclease AgeI-DNA complex | Descriptor: | DNA (5'-D(*TP*TP*CP*GP*AP*CP*CP*GP*GP*TP*CP*GP*A*)-3'), Type-2 restriction enzyme AgeI | Authors: | Tamulaitiene, G, Jovaisaite, V, Grazulis, S, Siksnys, V. | Deposit date: | 2015-09-22 | Release date: | 2016-09-28 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Restriction endonuclease AgeI is a monomer which dimerizes to cleave DNA. Nucleic Acids Res., 45, 2017
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5DWA
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![BU of 5dwa by Molmil](/molmil-images/mine/5dwa) | Crystal structure of pre-specific restriction endonuclease AgeI-DNA complex | Descriptor: | DNA (5'-D(*TP*CP*GP*AP*CP*CP*GP*GP*TP*CP*G*)-3'), Type-2 restriction enzyme AgeI | Authors: | Tamulaitiene, G, Jovaisaite, V, Grazulis, S, Siksnys, V. | Deposit date: | 2015-09-22 | Release date: | 2016-10-05 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Restriction endonuclease AgeI is a monomer which dimerizes to cleave DNA. Nucleic Acids Res., 45, 2017
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5DWC
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8BTO
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![BU of 8bto by Molmil](/molmil-images/mine/8bto) | Helical structure of BcThsA in complex with 1''-3'gcADPR | Descriptor: | (2R,3R,3aS,5S,6R,7S,8R,11R,13S,15aR)-2-(6-amino-9H-purin-9-yl)-3,6,7,11,13-pentahydroxyoctahydro-2H,5H,11H,13H-5,8-epoxy-11lambda~5~,13lambda~5~-furo[2,3-g][1,3,5,9,2,4]tetraoxadiphosphacyclotetradecine-11,13-dione, NAD(+) hydrolase ThsA, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | Authors: | Tamulaitiene, G, Sasnauskas, G, Sabonis, D. | Deposit date: | 2022-11-29 | Release date: | 2024-02-21 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (2.96 Å) | Cite: | Activation of Thoeris antiviral system via SIR2 effector filament assembly. Nature, 627, 2024
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8BTN
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![BU of 8btn by Molmil](/molmil-images/mine/8btn) | Crystal structure of BcThsB | Descriptor: | TIR domain-containing protein | Authors: | Tamulaitiene, G, Sabonis, D. | Deposit date: | 2022-11-29 | Release date: | 2024-02-21 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Activation of Thoeris antiviral system via SIR2 effector filament assembly. Nature, 627, 2024
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8BTP
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![BU of 8btp by Molmil](/molmil-images/mine/8btp) | Helical structure of BcThsA in complex with 1''-3'gc(etheno)ADPR | Descriptor: | (1S,3S,4R,5R,7R,15R,16S,17R)-5-imidazo[2,1-f]purin-3-yl-10,12-bis(oxidanyl)-10,12-bis(oxidanylidene)-2,6,9,11,13,18-hexaoxa-10$l^{5},12$l^{5}-diphosphatricyclo[13.2.1.0^{3,7}]octadecane-4,16,17-triol, ETHENO-NAD, NAD(+) hydrolase ThsA | Authors: | Tamulaitiene, G, Sasnauskas, G, Sabonis, D. | Deposit date: | 2022-11-29 | Release date: | 2024-02-21 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (2.75 Å) | Cite: | Activation of Thoeris antiviral system via SIR2 effector filament assembly. Nature, 627, 2024
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6EK1
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![BU of 6ek1 by Molmil](/molmil-images/mine/6ek1) | Crystal structure of Type IIP restriction endonuclease PfoI | Descriptor: | 1,2-ETHANEDIOL, restriction endonuclease PfoI | Authors: | Tamulaitiene, G, Manakova, E, Jovaisaite, V, Grazulis, S, Siksnys, V. | Deposit date: | 2017-09-25 | Release date: | 2018-10-10 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.601 Å) | Cite: | Unique mechanism of target recognition by PfoI restriction endonuclease of the CCGG-family. Nucleic Acids Res., 47, 2019
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4RCT
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![BU of 4rct by Molmil](/molmil-images/mine/4rct) | Crystal structure of R-protein of NgoAVII restriction endonuclease | Descriptor: | Restriction endonuclease R.NgoVII | Authors: | Tamulaitiene, G, Silanskas, A, Grazulis, S, Zaremba, M, Siksnys, V. | Deposit date: | 2014-09-17 | Release date: | 2014-12-24 | Last modified: | 2014-12-31 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Crystal structure of the R-protein of the multisubunit ATP-dependent restriction endonuclease NgoAVII. Nucleic Acids Res., 42, 2014
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4RD5
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![BU of 4rd5 by Molmil](/molmil-images/mine/4rd5) | Crystal structure of R.NgoAVII restriction endonuclease B3 domain with cognate DNA | Descriptor: | DNA (5'-D(*CP*CP*CP*TP*AP*AP*GP*CP*GP*GP*CP*AP*AP*TP*CP*C)-3'), DNA (5'-D(*GP*GP*GP*AP*TP*TP*GP*CP*CP*GP*CP*TP*TP*AP*GP*G)-3'), Restriction endonuclease R.NgoVII | Authors: | Tamulaitiene, G, Silanskas, A, Grazulis, S, Zaremba, M, Siksnys, V. | Deposit date: | 2014-09-18 | Release date: | 2014-12-24 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structure of the R-protein of the multisubunit ATP-dependent restriction endonuclease NgoAVII. Nucleic Acids Res., 42, 2014
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4RDM
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![BU of 4rdm by Molmil](/molmil-images/mine/4rdm) | Crystal structure of R.NgoAVII restriction endonuclease B3 domain with cognate DNA | Descriptor: | DNA (5'-D(*CP*CP*TP*AP*AP*GP*CP*GP*GP*CP*AP*AP*TP*CP*C)-3)', DNA (5'-D(*GP*GP*GP*AP*TP*TP*GP*CP*CP*GP*CP*TP*TP*AP*G)-3)', Restriction endonuclease R.NgoVII, ... | Authors: | Tamulaitiene, G, Silanskas, A, Grazulis, S, Zaremba, M, Siksnys, V. | Deposit date: | 2014-09-19 | Release date: | 2014-12-24 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structure of the R-protein of the multisubunit ATP-dependent restriction endonuclease NgoAVII. Nucleic Acids Res., 42, 2014
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8PHB
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![BU of 8phb by Molmil](/molmil-images/mine/8phb) | Crystal structure of apo Cami1 | Descriptor: | CRISPR-associated protein, APE2256 family | Authors: | Tamulaitiene, G, Tamulaitis, G, Mogila, I, Keda, K. | Deposit date: | 2023-06-19 | Release date: | 2023-12-13 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Ribosomal stalk-captured CARF-RelE ribonuclease inhibits translation following CRISPR signaling. Science, 382, 2023
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8PHJ
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![BU of 8phj by Molmil](/molmil-images/mine/8phj) | cA4-bound Cami1 in complex with 70S ribosome | Descriptor: | 16S rRNA, 23S rRNA (2862-MER), 5S rRNA, ... | Authors: | Tamulaitiene, G, Mogila, I, Sasnauskas, G, Tamulaitis, G. | Deposit date: | 2023-06-20 | Release date: | 2023-12-13 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (3.67 Å) | Cite: | Ribosomal stalk-captured CARF-RelE ribonuclease inhibits translation following CRISPR signaling. Science, 382, 2023
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5O63
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4ZSF
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![BU of 4zsf by Molmil](/molmil-images/mine/4zsf) | Crystal structure of pre-specific restriction endonuclease BsaWI-DNA complex | Descriptor: | BsaWI endonuclease, CALCIUM ION, DNA, ... | Authors: | Tamulaitiene, G, Rutkauskas, M, Grazulis, S, Siksnys, V. | Deposit date: | 2015-05-13 | Release date: | 2015-10-07 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Functional significance of protein assemblies predicted by the crystal structure of the restriction endonuclease BsaWI. Nucleic Acids Res., 43, 2015
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7AE9
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![BU of 7ae9 by Molmil](/molmil-images/mine/7ae9) | Crystal structure of mono-AMPylated HEPN(R46E) toxin in complex with MNT antitoxin | Descriptor: | 2',3'-DIDEOXYADENOSINE-5'-MONOPHOSPHATE, HEPN toxin, MNT ANTITOXIN | Authors: | Tamulaitiene, G, Sasnauskas, G, Songailiene, I, Juozapaitis, J, Siksnys, V. | Deposit date: | 2020-09-17 | Release date: | 2020-12-30 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | HEPN-MNT Toxin-Antitoxin System: The HEPN Ribonuclease Is Neutralized by OligoAMPylation. Mol.Cell, 80, 2020
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7AE8
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![BU of 7ae8 by Molmil](/molmil-images/mine/7ae8) | Crystal structure of HEPN(R102A) toxin | Descriptor: | ACETATE ION, HEPN toxin | Authors: | Tamulaitiene, G, Sasnauskas, G, Songailiene, I, Juozapaitis, J, Siksnys, V. | Deposit date: | 2020-09-17 | Release date: | 2020-12-30 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | HEPN-MNT Toxin-Antitoxin System: The HEPN Ribonuclease Is Neutralized by OligoAMPylation. Mol.Cell, 80, 2020
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7AER
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![BU of 7aer by Molmil](/molmil-images/mine/7aer) | Rebuilt and re-refined PDB entry 5yep: tri-AMPylated Shewanella oneidensis HEPN toxin in complex with MNT antitoxin | Descriptor: | ADENOSINE MONOPHOSPHATE, Toxin-antitoxin system antidote Mnt family, Toxin-antitoxin system toxin HepN family | Authors: | Tamulaitiene, G, Sasnauskas, G, Songailiene, I, Juozapaitis, J, Siksnys, V. | Deposit date: | 2020-09-18 | Release date: | 2020-12-30 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | HEPN-MNT Toxin-Antitoxin System: The HEPN Ribonuclease Is Neutralized by OligoAMPylation. Mol.Cell, 80, 2020
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6FJW
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7AE2
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![BU of 7ae2 by Molmil](/molmil-images/mine/7ae2) | Crystal structure of HEPN(H107A-Y109F) toxin in complex with MNT antitoxin | Descriptor: | HEPN toxin, MNT ANTITOXIN | Authors: | Tamulaitiene, G, Sasnauskas, G, Songailiene, I, Juozapaitis, J, Siksnys, V. | Deposit date: | 2020-09-17 | Release date: | 2020-12-30 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | HEPN-MNT Toxin-Antitoxin System: The HEPN Ribonuclease Is Neutralized by OligoAMPylation. Mol.Cell, 80, 2020
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7AE6
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![BU of 7ae6 by Molmil](/molmil-images/mine/7ae6) | Crystal structure of di-AMPylated HEPN(R102A) toxin | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE MONOPHOSPHATE, HEPN toxin | Authors: | Tamulaitiene, G, Sasnauskas, G, Songailiene, I, Juozapaitis, J, Siksnys, V. | Deposit date: | 2020-09-17 | Release date: | 2020-12-30 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | HEPN-MNT Toxin-Antitoxin System: The HEPN Ribonuclease Is Neutralized by OligoAMPylation. Mol.Cell, 80, 2020
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6F1S
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![BU of 6f1s by Molmil](/molmil-images/mine/6f1s) | C-terminal domain of CglI restriction endonuclease H subunit | Descriptor: | 1,2-ETHANEDIOL, CglIIR protein, FORMIC ACID | Authors: | Tamulaitiene, G, Grigaitis, R, Zaremba, M, Silanskas, A. | Deposit date: | 2017-11-23 | Release date: | 2018-02-14 | Last modified: | 2019-01-16 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | The H-subunit of the restriction endonuclease CglI contains a prototype DEAD-Z1 helicase-like motor. Nucleic Acids Res., 46, 2018
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