1JN3
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4PPX
| DNA Polymerase Beta E295K with Spiroiminodihydantoin in Templating Position | Descriptor: | 5'-D(*CP*CP*GP*AP*CP*(SDH)P*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3', 5'-D(*GP*TP*CP*GP*G)-3', ... | Authors: | Eckenroth, B.E, Doublie, S. | Deposit date: | 2014-02-27 | Release date: | 2014-04-02 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | Crystal Structure of DNA Polymerase beta with DNA Containing the Base Lesion Spiroiminodihydantoin in a Templating Position. Biochemistry, 53, 2014
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6UOL
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6UOK
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6UOM
| Y271G DNA polymerase beta ternary complex with templating adenine and incoming r8-oxo-GTP | Descriptor: | 1,2-ETHANEDIOL, 2',3'-DIDEOXYCYTIDINE-5'-MONOPHOSPHATE, 8-OXO-GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Smith, M.R, Freudenthal, B.D. | Deposit date: | 2019-10-15 | Release date: | 2020-01-08 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Molecular and structural characterization of oxidized ribonucleotide insertion into DNA by human DNA polymerase beta. J.Biol.Chem., 295, 2020
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3UXO
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3UXP
| Co-crystal Structure of Rat DNA polymerase beta Mutator I260Q: Enzyme-DNA-ddTTP | Descriptor: | 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, DNA 5'-D(P*AP*CP*TP*CP*AP*CP*AP*TP*A)-3', DNA 5'-D(P*AP*TP*GP*TP*GP*AP*G)-3', ... | Authors: | Gridley, C.L, Jaeger, J. | Deposit date: | 2011-12-05 | Release date: | 2012-12-05 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.723 Å) | Cite: | Structural Changes in the Hydrophobic Hinge Region Adversely Affect the Activity and Fidelity of the I260Q Mutator DNA Polymerase beta. Biochemistry, 52, 2013
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3V7J
| Co-crystal structure of Wild Type Rat polymerase beta: Enzyme-DNA binary complex | Descriptor: | CHLORIDE ION, DNA (5'-D(P*AP*TP*GP*TP*GP*AP*GP*T)-3'), DNA (5'-D(P*CP*AP*AP*AP*CP*TP*CP*AP*CP*AP*TP*A)-3'), ... | Authors: | Rangarajan, S, Jaeger, J. | Deposit date: | 2011-12-21 | Release date: | 2013-01-16 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Crystallographic studies of K72E mutant DNA polymerase explain loss of lyase function and reveal changes in the overall conformational state of the polymerase domain To be Published
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3V7K
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3V7L
| Apo Structure of Rat DNA polymerase beta K72E variant | Descriptor: | CHLORIDE ION, DNA polymerase beta, SODIUM ION, ... | Authors: | Rangarajan, S, Jaeger, J. | Deposit date: | 2011-12-21 | Release date: | 2013-01-16 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.66 Å) | Cite: | Crystallographic studies of K72E mutant DNA polymerase explain loss of lyase function and reveal changes in the overall conformational state of the polymerase domain To be Published
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3UXN
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3V72
| Crystal Structure of Rat DNA polymerase beta Mutator E295K: Enzyme-dsDNA | Descriptor: | CHLORIDE ION, DNA 5'-D(P*AP*AP*AP*CP*TP*CP*AP*CP*AP*T)-3', DNA 5'-D(P*AP*TP*GP*TP*GP*AP*GP*T)-3', ... | Authors: | Gridley, C.L, Jaeger, J. | Deposit date: | 2011-12-20 | Release date: | 2012-07-04 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | Unfavorable Electrostatic and Steric Interactions in DNA Polymerase beta E295K Mutant Interfere with the Enzyme s Pathway J.Am.Chem.Soc., 134, 2012
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5U8G
| DNA Polymerase Beta crystallized in PEG 400 | Descriptor: | CHLORIDE ION, DNA (5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), ... | Authors: | Eckenroth, B.E, Doublie, S. | Deposit date: | 2016-12-14 | Release date: | 2017-04-26 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.166 Å) | Cite: | Remote Mutations Induce Functional Changes in Active Site Residues of Human DNA Polymerase beta. Biochemistry, 56, 2017
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5U8I
| DNA Polymerase Beta S229L crystallized in PEG 400 | Descriptor: | DNA (5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), DNA (5'-D(*GP*TP*CP*GP*G)-3'), ... | Authors: | Eckenroth, B.E, Doublie, S. | Deposit date: | 2016-12-14 | Release date: | 2017-04-26 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Remote Mutations Induce Functional Changes in Active Site Residues of Human DNA Polymerase beta. Biochemistry, 56, 2017
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5U8H
| DNA Polymerase Beta G231D crystallized in PEG 400 | Descriptor: | DNA (5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), DNA (5'-D(*GP*TP*CP*GP*G)-3'), ... | Authors: | Eckenroth, B.E, Doublie, S. | Deposit date: | 2016-12-14 | Release date: | 2017-04-26 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.155 Å) | Cite: | Remote Mutations Induce Functional Changes in Active Site Residues of Human DNA Polymerase beta. Biochemistry, 56, 2017
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6BTF
| DNA Polymerase Beta I260Q Ternary Complex | Descriptor: | 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, DNA Downstream Strand, DNA Primer Strand, ... | Authors: | Eckenroth, B.E, Doublie, S. | Deposit date: | 2017-12-06 | Release date: | 2018-09-26 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | I260Q DNA polymerase beta highlights precatalytic conformational rearrangements critical for fidelity. Nucleic Acids Res., 46, 2018
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6BTE
| DNA Polymerase Beta I260Q Binary Complex | Descriptor: | CHLORIDE ION, DNA Downstream Strand, DNA Primer Strand, ... | Authors: | Eckenroth, B.E, Doublie, S. | Deposit date: | 2017-12-06 | Release date: | 2018-09-26 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | I260Q DNA polymerase beta highlights precatalytic conformational rearrangements critical for fidelity. Nucleic Acids Res., 46, 2018
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6NKZ
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6NKX
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6NKT
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6NKY
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6NKV
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6NKR
| Ternary complex crystal structure of K289M variant of DNA polymerase Beta with dGTP | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, DNA (5'-D(*CP*CP*GP*AP*CP*CP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ... | Authors: | Batra, V.K, Wilson, S.H. | Deposit date: | 2019-01-07 | Release date: | 2020-01-08 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Revealing an Internal Stabilization Deficiency in the DNA Polymerase beta K289M Cancer Variant through the Combined Use of Chemical Biology and X-ray Crystallography. Biochemistry, 59, 2020
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6NKU
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6NKS
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