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3BOF
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BU of 3bof by Molmil
Cobalamin-dependent methionine synthase (1-566) from Thermotoga maritima complexed with Zn2+ and Homocysteine
Descriptor: 2-AMINO-4-MERCAPTO-BUTYRIC ACID, 5-methyltetrahydrofolate S-homocysteine methyltransferase, POTASSIUM ION, ...
Authors:Koutmos, M, Smith, J.L, Ludwig, M.L.
Deposit date:2007-12-17
Release date:2008-03-11
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Metal active site elasticity linked to activation of homocysteine in methionine synthases.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3BOL
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BU of 3bol by Molmil
Cobalamin-dependent methionine synthase (1-566) from Thermotoga maritima complexed with Zn2+
Descriptor: 2-AMINO-4-MERCAPTO-BUTYRIC ACID, 5-methyltetrahydrofolate S-homocysteine methyltransferase, POTASSIUM ION, ...
Authors:Koutmos, M, Smith, J.L, Ludwig, M.L.
Deposit date:2007-12-17
Release date:2008-03-11
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Metal active site elasticity linked to activation of homocysteine in methionine synthases.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3PC4
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BU of 3pc4 by Molmil
Full length structure of cystathionine beta-synthase from Drosophila in complex with serine
Descriptor: (E)-N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-serine, CG1753, isoform A, ...
Authors:Koutmos, M, Smith, J.L.
Deposit date:2010-10-21
Release date:2010-12-01
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis for substrate activation and regulation by cystathionine beta-synthase (CBS) domains in cystathionine {beta}-synthase.
Proc.Natl.Acad.Sci.USA, 107, 2010
3PC2
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BU of 3pc2 by Molmil
Full length structure of cystathionine beta-synthase from Drosophila
Descriptor: CG1753, isoform A, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Koutmos, M, Smith, J.L.
Deposit date:2010-10-21
Release date:2010-12-01
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis for substrate activation and regulation by cystathionine beta-synthase (CBS) domains in cystathionine {beta}-synthase.
Proc.Natl.Acad.Sci.USA, 107, 2010
3PC3
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BU of 3pc3 by Molmil
Full length structure of cystathionine beta-synthase from Drosophila in complex with aminoacrylate
Descriptor: 2-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]ACRYLIC ACID, CG1753, isoform A, ...
Authors:Koutmos, M, Smith, J.L.
Deposit date:2010-10-21
Release date:2010-12-01
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural basis for substrate activation and regulation by cystathionine beta-synthase (CBS) domains in cystathionine {beta}-synthase.
Proc.Natl.Acad.Sci.USA, 107, 2010
3SBY
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BU of 3sby by Molmil
Crystal Structure of SeMet-Substituted Apo-MMACHC (1-244), a human B12 processing enzyme
Descriptor: Methylmalonic aciduria and homocystinuria type C protein
Authors:Koutmos, M, Gherasim, C, Smith, J.L, Banerjee, R.
Deposit date:2011-06-06
Release date:2011-06-22
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Structural basis of multifunctionality in a vitamin B12-processing enzyme.
J.Biol.Chem., 286, 2011
3SC0
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BU of 3sc0 by Molmil
Crystal Structure of MMACHC (1-238), a human B12 processing enzyme, complexed with MethylCobalamin
Descriptor: CO-METHYLCOBALAMIN, Methylmalonic aciduria and homocystinuria type C protein
Authors:Koutmos, M, Gherasim, C, Smith, J.L, Banerjee, R.
Deposit date:2011-06-06
Release date:2011-06-22
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural basis of multifunctionality in a vitamin B12-processing enzyme.
J.Biol.Chem., 286, 2011
3SBZ
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BU of 3sbz by Molmil
Crystal Structure of Apo-MMACHC (1-244), a human B12 processing enzyme
Descriptor: GLYCEROL, MALONATE ION, Methylmalonic aciduria and homocystinuria type C protein
Authors:Koutmos, M, Gherasim, C, Smith, J.L, Banerjee, R.
Deposit date:2011-06-06
Release date:2011-06-22
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis of multifunctionality in a vitamin B12-processing enzyme.
J.Biol.Chem., 286, 2011
4M3P
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BU of 4m3p by Molmil
Betaine-Homocysteine S-Methyltransferase from Homo sapiens complexed with Homocysteine
Descriptor: 2-AMINO-4-MERCAPTO-BUTYRIC ACID, Betaine--homocysteine S-methyltransferase 1, POTASSIUM ION, ...
Authors:Koutmos, M, Yamada, K, Mladkova, J, Paterova, J, Diamond, C.E, Tryon, K, Jungwirth, P, Garrow, T.A, Jiracek, J.
Deposit date:2013-08-06
Release date:2014-06-18
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.895 Å)
Cite:Specific potassium ion interactions facilitate homocysteine binding to betaine-homocysteine S-methyltransferase.
Proteins, 82, 2014
3BUL
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BU of 3bul by Molmil
E. coli I690C/G743C MetH C-terminal fragment (649-1227)
Descriptor: COBALAMIN, Methionine synthase
Authors:Koutmos, M, Pattridge, K.A, Ludwig, M.L.
Deposit date:2008-01-03
Release date:2008-04-01
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A disulfide-stabilized conformer of methionine synthase reveals an unexpected role for the histidine ligand of the cobalamin cofactor.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3IV9
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BU of 3iv9 by Molmil
Structure of the B12-dependent Methionine Synthase (MetH) C-teminal half in a "His-On" conformation
Descriptor: COBALAMIN, Methionine synthase
Authors:Pattridge, K.A, Koutmos, M, Smith, J.L.
Deposit date:2009-08-31
Release date:2009-11-24
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Insights into the reactivation of cobalamin-dependent methionine synthase.
Proc.Natl.Acad.Sci.USA, 106, 2009
3IVA
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BU of 3iva by Molmil
Structure of the B12-dependent Methionine Synthase (MetH) C-teminal half with AdoHcy bound
Descriptor: COBALAMIN, Methionine synthase, NITRATE ION, ...
Authors:Pattridge, K.A, Koutmos, M, Smith, J.L.
Deposit date:2009-08-31
Release date:2009-11-24
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Insights into the reactivation of cobalamin-dependent methionine synthase.
Proc.Natl.Acad.Sci.USA, 106, 2009
4JYB
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BU of 4jyb by Molmil
MeaB, A Bacterial Homolog of MMAA, Bound to GMPPNP
Descriptor: Methylmalonyl-CoA mutase accessory protein, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Authors:Koutmos, M, Lofgren, M, Padovani, D, Banerjee, R.
Deposit date:2013-03-29
Release date:2013-07-24
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A switch III motif relays signaling between a B12 enzyme and its G-protein chaperone.
Nat.Chem.Biol., 9, 2013
4JYC
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BU of 4jyc by Molmil
MeaB, A Bacterial Homolog of MMAA, in its Apo form
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Methylmalonyl-CoA mutase accessory protein
Authors:Koutmos, M, Lofgren, M, Padovani, D, Banerjee, R.
Deposit date:2013-03-29
Release date:2013-07-24
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A switch III motif relays signaling between a B12 enzyme and its G-protein chaperone.
Nat.Chem.Biol., 9, 2013
4LC1
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BU of 4lc1 by Molmil
MeaB, A Bacterial Homolog of MMAA, Bound to GDP and crystallized in the presence of GDP and [AlF4]-
Descriptor: GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, Methylmalonyl-CoA mutase accessory protein
Authors:Koutmos, M, Padovani, D, Lofgren, M, Banerjee, R.
Deposit date:2013-06-21
Release date:2013-09-25
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Autoinhibition and Signaling by the Switch II Motif in the G-protein Chaperone of a Radical B12 Enzyme.
J.Biol.Chem., 288, 2013
4G25
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BU of 4g25 by Molmil
Crystal Structure of proteinaceous RNase P 1 (PRORP1) from A. thaliana, SeMet substituted form with Sr
Descriptor: Pentatricopeptide repeat-containing protein At2g32230, mitochondrial, STRONTIUM ION, ...
Authors:Koutmos, M, Howard, M.J, Fierke, C.A.
Deposit date:2012-07-11
Release date:2012-09-26
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Mitochondrial ribonuclease P structure provides insight into the evolution of catalytic strategies for precursor-tRNA 5' processing.
Proc.Natl.Acad.Sci.USA, 109, 2012
4G23
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BU of 4g23 by Molmil
Crystal Structure of proteinaceous RNase P 1 (PRORP1) from A. thaliana with Mn
Descriptor: Pentatricopeptide repeat-containing protein At2g32230, mitochondrial, ZINC ION
Authors:Koutmos, M, Howard, M.J, Fierke, C.A.
Deposit date:2012-07-11
Release date:2012-09-26
Last modified:2012-11-14
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Mitochondrial ribonuclease P structure provides insight into the evolution of catalytic strategies for precursor-tRNA 5' processing.
Proc.Natl.Acad.Sci.USA, 109, 2012
4JGT
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BU of 4jgt by Molmil
Structure and kinetic analysis of H2S production by human Mercaptopyruvate Sulfurtransferase
Descriptor: 3-mercaptopyruvate sulfurtransferase, GLYCEROL, PYRUVIC ACID, ...
Authors:Koutmos, M, Yamada, K, Yadav, P.K, Chiku, T, Banerjee, R.
Deposit date:2013-03-03
Release date:2013-05-29
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.161 Å)
Cite:Structure and Kinetic Analysis of H2S Production by Human Mercaptopyruvate Sulfurtransferase.
J.Biol.Chem., 288, 2013
4G24
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BU of 4g24 by Molmil
Crystal Structure of proteinaceous RNase P 1 (PRORP1) from A. thaliana with Mn
Descriptor: 6-AMINOHEXANOIC ACID, MANGANESE (II) ION, Pentatricopeptide repeat-containing protein At2g32230, ...
Authors:Koutmos, M, Howard, M.J, Fierke, C.A.
Deposit date:2012-07-11
Release date:2012-09-26
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Mitochondrial ribonuclease P structure provides insight into the evolution of catalytic strategies for precursor-tRNA 5' processing.
Proc.Natl.Acad.Sci.USA, 109, 2012
4G26
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BU of 4g26 by Molmil
Crystal Structure of proteinaceous RNase P 1 (PRORP1) from A. thaliana with Ca
Descriptor: CALCIUM ION, Pentatricopeptide repeat-containing protein At2g32230, mitochondrial, ...
Authors:Koutmos, M, Howard, M.J, Fierke, C.A.
Deposit date:2012-07-11
Release date:2012-09-26
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Mitochondrial ribonuclease P structure provides insight into the evolution of catalytic strategies for precursor-tRNA 5' processing.
Proc.Natl.Acad.Sci.USA, 109, 2012
5VOO
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BU of 5voo by Molmil
Methionine synthase folate-binding domain with methyltetrahydrofolate from Thermus thermophilus HB8
Descriptor: 5-METHYL-5,6,7,8-TETRAHYDROFOLIC ACID, 5-methyltetrahydrofolate homocysteine S-methyltransferase, CHLORIDE ION, ...
Authors:Koutmos, M, Yamada, K.
Deposit date:2017-05-03
Release date:2018-01-17
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The folate-binding module of Thermus thermophilus cobalamin-dependent methionine synthase displays a distinct variation of the classical TIM barrel: a TIM barrel with a `twist'.
Acta Crystallogr D Struct Biol, 74, 2018
5VOP
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BU of 5vop by Molmil
Methionine synthase folate-binding domain from Thermus thermophilus HB8 native
Descriptor: 5-METHYL-5,6,7,8-TETRAHYDROFOLIC ACID, 5-methyltetrahydrofolate homocysteine S-methyltransferase, CITRATE ANION, ...
Authors:Koutmos, M, Yamada, K.
Deposit date:2017-05-03
Release date:2018-01-17
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The folate-binding module of Thermus thermophilus cobalamin-dependent methionine synthase displays a distinct variation of the classical TIM barrel: a TIM barrel with a `twist'.
Acta Crystallogr D Struct Biol, 74, 2018
8D32
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BU of 8d32 by Molmil
Mycobacterium tuberculosis pduO-type ATP:cobalamin adenosyltransferase bound to 5-deoxyadenosylrhodibalamin and PPPi
Descriptor: 5'-DEOXYADENOSINE, Corrinoid adenosyltransferase, MAGNESIUM ION, ...
Authors:Mascarenhas, R.N, Ruetz, M, Koutmos, M, Banerjee, R.
Deposit date:2022-05-31
Release date:2023-05-10
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:A noble substitution leads to the cofactor mimicry by rhodibalamin
To Be Published
8EAC
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BU of 8eac by Molmil
Thermus thermophilus methylenetetrahydrofolate reductase
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, Methylenetetrahydrofolate reductase
Authors:Yamada, K, Koutmos, M.
Deposit date:2022-08-28
Release date:2023-01-18
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:5-Formyltetrahydrofolate promotes conformational remodeling in a methylenetetrahydrofolate reductase active site and inhibits its activity.
J.Biol.Chem., 299, 2022
6U1R
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BU of 6u1r by Molmil
SxtG an amidinotransferase from the Microseira wollei in Saxitoxin biosynthetic pathway
Descriptor: FORMIC ACID, SxtG
Authors:Mallik, L, Lukowski, A.L, Narayan, A.R.H, Koutmos, M.
Deposit date:2019-08-16
Release date:2020-03-18
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.792 Å)
Cite:Substrate Promiscuity of a Paralytic Shellfish Toxin Amidinotransferase.
Acs Chem.Biol., 15, 2020

 

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