2JZY
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7UIN
| CryoEM Structure of an Group II Intron Retroelement | Descriptor: | AMMONIUM ION, DNA (37-MER), E.r IIC Intron, ... | Authors: | Chung, K, Xu, L. | Deposit date: | 2022-03-29 | Release date: | 2022-11-23 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structures of a mobile intron retroelement poised to attack its structured DNA target Science, 378, 2022
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7UIM
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6E6Z
| Structure of Wild Type Human Transthyretin in Complex with Tafamidis | Descriptor: | 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid, Transthyretin | Authors: | Chung, K, Saelices, L, Sawaya, M.R, Cascio, D, Eisenberg, D. | Deposit date: | 2018-07-25 | Release date: | 2019-07-31 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structural Variants of Transthyretin To Be Published
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6E73
| Structure of Human Transthyretin Val30Met Mutant in Complex with Diflunisal | Descriptor: | 5-(2,4-DIFLUOROPHENYL)-2-HYDROXY-BENZOIC ACID, ACETATE ION, Transthyretin | Authors: | Chung, K, Saelices, L, Sawaya, M.R, Cascio, D, Eisenberg, D.S. | Deposit date: | 2018-07-25 | Release date: | 2019-07-31 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.797 Å) | Cite: | Structural Variants of Transthyretin to be published
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6E72
| Structure of Human Transthyretin Val30Met Mutant in Complex with Tafamidis | Descriptor: | 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid, Transthyretin | Authors: | Chung, K, Saelices, L, Sawaya, M.R, Cascio, D, Eisenberg, D. | Deposit date: | 2018-07-25 | Release date: | 2019-07-31 | Last modified: | 2019-12-18 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Structural Variants of Transthyretin To Be Published
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6E78
| Structure of Human Transthyretin Asp38Ala Mutant in Complex with Diflunisal | Descriptor: | 5-(2,4-DIFLUOROPHENYL)-2-HYDROXY-BENZOIC ACID, Transthyretin | Authors: | Chung, K, Saelices, L, Sawaya, M.R, Cascio, D, Eisenberg, D. | Deposit date: | 2018-07-25 | Release date: | 2019-07-31 | Last modified: | 2019-12-18 | Method: | X-RAY DIFFRACTION (1.499 Å) | Cite: | Structural Variants of Transthyretin To Be Published
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6E70
| Structure of Wild Type Human Transthyretin in Complex with Diflunisal | Descriptor: | 5-(2,4-DIFLUOROPHENYL)-2-HYDROXY-BENZOIC ACID, CALCIUM ION, Transthyretin | Authors: | Chung, K, Saelices, L, Sawaya, M.R, Cascio, D, Eisenberg, D. | Deposit date: | 2018-07-25 | Release date: | 2019-07-31 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.992 Å) | Cite: | Structural Variants of Transthyretin To Be Published
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6E75
| Structure of Human Transthyretin Asp38Ala Mutant | Descriptor: | ACETATE ION, Transthyretin | Authors: | Chung, K, Saelices, L, Sawaya, M.R, Cascio, D, Eisenberg, D. | Deposit date: | 2018-07-25 | Release date: | 2019-07-31 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structural Variants of Transthyretin To Be Published
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4AUA
| Liganded X-ray crystal structure of cyclin dependent kinase 6 (CDK6) | Descriptor: | 1H-benzimidazol-2-yl(1H-pyrrol-2-yl)methanone, CYCLIN-DEPENDENT KINASE 6 | Authors: | Cho, Y.S, Angove, H, Brain, C, Chen, C.H.T, Cheng, R, Chopra, R, Chung, K, Congreve, M, Dagostin, C, Davis, D, Feltell, R, Giraldes, J, Hiscock, S, Kim, S, Kovats, S, Lagu, B, Lewry, K, Loo, A, Lu, Y, Luzzio, M, Maniara, W, Mcmenamin, R, Mortenson, P, Benning, R, O'Reilly, M, Rees, D, Shen, J, Smith, T, Wang, Y, Williams, G, Woolford, A, Wrona, W, Xu, M, Yang, F, Howard, S. | Deposit date: | 2012-05-15 | Release date: | 2013-02-06 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Fragment-Based Discovery of 7-Azabenzimidazoles as Potent, Highly Selective, and Orally Active CDK4/6 Inhibitors. ACS Med Chem Lett, 3, 2012
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8T2T
| Structure of a group II intron ribonucleoprotein in the post-ligation (post-2F) state | Descriptor: | AMMONIUM ION, Group II intron reverse transcriptase/maturase, MAGNESIUM ION, ... | Authors: | Xu, L, Liu, T, Chung, K, Pyle, A.M. | Deposit date: | 2023-06-06 | Release date: | 2023-11-22 | Last modified: | 2024-01-03 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural insights into intron catalysis and dynamics during splicing. Nature, 624, 2023
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8T2R
| Structure of a group II intron ribonucleoprotein in the pre-ligation (pre-2F) state | Descriptor: | 5'exon, AMMONIUM ION, CALCIUM ION, ... | Authors: | Xu, L, Liu, T, Chung, K, Pyle, A.M. | Deposit date: | 2023-06-06 | Release date: | 2023-11-22 | Last modified: | 2024-01-03 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural insights into intron catalysis and dynamics during splicing. Nature, 624, 2023
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8T2S
| Structure of a group II intron ribonucleoprotein in the pre-branching (pre-1F) state | Descriptor: | AMMONIUM ION, CALCIUM ION, Group II intron reverse transcriptase/maturase, ... | Authors: | Xu, L, Liu, T, Chung, K, Pyle, A.M. | Deposit date: | 2023-06-06 | Release date: | 2023-11-22 | Last modified: | 2024-01-03 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural insights into intron catalysis and dynamics during splicing. Nature, 624, 2023
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6E77
| Structure of Human Transthyretin Asp38Ala Mutant in Complex with Tafamidis | Descriptor: | 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid, Transthyretin | Authors: | Saelices, L, Chung, K, Sawaya, M.R, Cascio, D, Eisenberg, D. | Deposit date: | 2018-07-25 | Release date: | 2019-07-31 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural Variants of Transthyretin To Be Published
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6E74
| Structure of Human Transthyretin Leu55Pro Mutant in Complex with Tafamidis | Descriptor: | 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid, Transthyretin | Authors: | Saelices, L, Chung, K, Sawaya, M.R, Cascio, D, Eisenberg, D. | Deposit date: | 2018-07-25 | Release date: | 2019-07-31 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural Variants of Transthyretin To Be Published
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6E71
| Structure of Human Transthyretin Val30Met/Thr119Met Mutant | Descriptor: | DI(HYDROXYETHYL)ETHER, Transthyretin | Authors: | Saelices, L, Chung, K, Sawaya, M.R, Cascio, D, Eisenberg, D. | Deposit date: | 2018-07-25 | Release date: | 2019-07-31 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structural Variants of Transthyretin To Be Published
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6E76
| Structure of Human Transthyretin Asp38Ala/Thr119Met Mutant | Descriptor: | ACETATE ION, GLYCEROL, SULFATE ION, ... | Authors: | Saelices, L, Chung, K, Sawaya, M.R, Cascio, D, Eisenberg, D. | Deposit date: | 2018-07-25 | Release date: | 2019-07-31 | Last modified: | 2019-12-18 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural Variants of Transthyretin To Be Published
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2K02
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4EZ5
| CDK6 (monomeric) in complex with inhibitor | Descriptor: | Cyclin-dependent kinase 6, {5-[4-(dimethylamino)piperidin-1-yl]-1H-imidazo[4,5-b]pyridin-2-yl}[2-(isoquinolin-4-yl)pyridin-4-yl]methanone | Authors: | Chopra, R, Xu, M. | Deposit date: | 2012-05-02 | Release date: | 2013-02-06 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Fragment-Based Discovery of 7-Azabenzimidazoles as Potent, Highly Selective, and Orally Active CDK4/6 Inhibitors. ACS Med Chem Lett, 3, 2012
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3NUP
| CDK6 (monomeric) in complex with inhibitor | Descriptor: | 4-[3-(1-methylethyl)-1H-pyrazol-4-yl]-N-(1-methylpiperidin-4-yl)pyrimidin-2-amine, Cell division protein kinase 6 | Authors: | Chopra, R. | Deposit date: | 2010-07-07 | Release date: | 2010-12-22 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | 4-(Pyrazol-4-yl)-pyrimidines as selective inhibitors of cyclin-dependent kinase 4/6. J.Med.Chem., 53, 2010
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3NUX
| CDK6 (monomeric) in complex with inhibitor | Descriptor: | 4-[5-chloro-3-(1-methylethyl)-1H-pyrazol-4-yl]-N-(5-piperazin-1-ylpyridin-2-yl)pyrimidin-2-amine, Cell division protein kinase 6 | Authors: | Chopra, R. | Deposit date: | 2010-07-07 | Release date: | 2010-12-22 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | 4-(Pyrazol-4-yl)-pyrimidines as selective inhibitors of cyclin-dependent kinase 4/6. J.Med.Chem., 53, 2010
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1L3X
| Solution Structure of Novel Disintegrin Salmosin | Descriptor: | platelet aggregation inhibitor disintegrin | Authors: | Shin, J, Lee, W. | Deposit date: | 2002-03-01 | Release date: | 2003-12-23 | Last modified: | 2012-11-21 | Method: | SOLUTION NMR | Cite: | Solution structure of a novel disintegrin, salmosin, from Agkistrondon halys venom Biochemistry, 42, 2003
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6G1T
| TraN, a repressor of an Enterococcus conjugative type IV secretion system | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, AM32, DNA (34-MER) | Authors: | Goessweiner-Mohr, N, Kohler, V, Keller, W. | Deposit date: | 2018-03-22 | Release date: | 2018-07-25 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | TraN: A novel repressor of an Enterococcus conjugative type IV secretion system. Nucleic Acids Res., 46, 2018
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