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8V74
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BU of 8v74 by Molmil
Crystal structure of the core catalytic domain of human inositol phosphate multikinase in complex with compound 10
Descriptor: Inositol polyphosphate multikinase, N-{4-[(5P)-5-(1H-tetrazol-5-yl)-2,1-benzoxazol-3-yl]phenyl}cyclopropanecarboxamide
Authors:Wang, H, Shears, S.B.
Deposit date:2023-12-04
Release date:2024-12-11
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure-based development of IPMK kinase inhibitors.
To Be Published
8V6Y
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BU of 8v6y by Molmil
Crystal structure of the core catalytic domain of human inositol phosphate multikinase in complex with compound 3
Descriptor: 3-(3,5-dimethylphenyl)-2,1-benzoxazole-5-carboxylic acid, Inositol polyphosphate multikinase
Authors:Wang, H, Shears, S.B.
Deposit date:2023-12-04
Release date:2024-12-11
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure-based development of IPMK kinase inhibitors.
To Be Published
8V76
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BU of 8v76 by Molmil
Crystal structure of the core catalytic domain of human inositol phosphate multikinase in complex with compound 12
Descriptor: Inositol polyphosphate multikinase, N-{(3P)-3-[(5P)-5-(2H-tetrazol-5-yl)-2,1-benzoxazol-3-yl]phenyl}cyclopentanecarboxamide, SULFATE ION
Authors:Wang, H, Shears, S.B.
Deposit date:2023-12-04
Release date:2024-12-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure-based development of IPMK kinase inhibitors.
To Be Published
8V78
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BU of 8v78 by Molmil
Crystal structure of the core catalytic domain of human inositol phosphate multikinase in complex with compound 14
Descriptor: (3P,5M)-3-{3-[(3,5-dichloropyridin-2-yl)oxy]phenyl}-5-(1H-tetrazol-5-yl)-2,1-benzoxazole, Inositol polyphosphate multikinase
Authors:Wang, H, Shears, S.B.
Deposit date:2023-12-04
Release date:2024-12-11
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Structure-based development of IPMK kinase inhibitors.
To Be Published
5VJ6
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BU of 5vj6 by Molmil
BG505 SOSIP.664 in complex with broadly neutralizing antibodies PG9 and 8ANC195
Descriptor: 8ANC195 Fab heavy chain, 8ANC195 Fab light chain, Envelope glycoprotein gp160, ...
Authors:Wang, H, Bjorkman, P.J.
Deposit date:2017-04-18
Release date:2017-06-21
Last modified:2024-10-30
Method:ELECTRON MICROSCOPY (11.5 Å)
Cite:Asymmetric recognition of HIV-1 Envelope trimer by V1V2 loop-targeting antibodies.
Elife, 6, 2017
8H1M
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BU of 8h1m by Molmil
Crystal structure of glucose-2-epimerase mutant_D254A from Runella slithyformis Runsl_4512
Descriptor: FORMIC ACID, N-acylglucosamine 2-epimerase
Authors:Wang, H, Sun, X.M, Saburi, W, Yu, J, Yao, M.
Deposit date:2022-10-03
Release date:2023-07-12
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural insights into the substrate specificity and activity of a novel mannose 2-epimerase from Runella slithyformis.
Acta Crystallogr D Struct Biol, 79, 2023
8H1N
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BU of 8h1n by Molmil
Crystal structure of glucose-2-epimerase mutant_D254A in complex with D-Glucitol from Runella slithyformis Runsl_4512
Descriptor: FORMIC ACID, N-acylglucosamine 2-epimerase, sorbitol
Authors:Wang, H, Sun, X.M, Saburi, W, Yu, J, Yao, M.
Deposit date:2022-10-03
Release date:2023-07-12
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Structural insights into the substrate specificity and activity of a novel mannose 2-epimerase from Runella slithyformis.
Acta Crystallogr D Struct Biol, 79, 2023
5W2I
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BU of 5w2i by Molmil
Crystal structure of the core catalytic domain of human inositol phosphate multikinase soaked with C4-analogue of PtdIns(4,5)P2 and ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, Inositol polyphosphate multikinase,Inositol polyphosphate multikinase, ...
Authors:Wang, H, Shears, S.B.
Deposit date:2017-06-06
Release date:2017-09-13
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural features of human inositol phosphate multikinase rationalize its inositol phosphate kinase and phosphoinositide 3-kinase activities.
J. Biol. Chem., 292, 2017
5W2H
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BU of 5w2h by Molmil
Crystal structure of the core catalytic domain of human inositol phosphate multikinase in complex with Ins(1,4,5)P3 and ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, Inositol polyphosphate multikinase,Inositol polyphosphate multikinase, ...
Authors:Wang, H, Shears, S.B.
Deposit date:2017-06-06
Release date:2017-09-13
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural features of human inositol phosphate multikinase rationalize its inositol phosphate kinase and phosphoinositide 3-kinase activities.
J. Biol. Chem., 292, 2017
7ZSA
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BU of 7zsa by Molmil
Yeast RNA polymerase II transcription pre-initiation complex with the +1 nucleosome and NTP (complex B)
Descriptor: DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ...
Authors:Wang, H, Cramer, P.
Deposit date:2022-05-06
Release date:2022-11-16
Last modified:2025-07-02
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structures of transcription preinitiation complex engaged with the +1 nucleosome.
Nat.Struct.Mol.Biol., 30, 2023
7ZSB
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BU of 7zsb by Molmil
Yeast RNA polymerase II transcription pre-initiation complex with the +1 nucleosome and NTP, complex C
Descriptor: DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ...
Authors:Wang, H, Cramer, P.
Deposit date:2022-05-06
Release date:2022-11-16
Last modified:2025-07-02
Method:ELECTRON MICROSCOPY (6.6 Å)
Cite:Structures of transcription preinitiation complex engaged with the +1 nucleosome.
Nat.Struct.Mol.Biol., 30, 2023
7ZS9
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BU of 7zs9 by Molmil
Yeast RNA polymerase II transcription pre-initiation complex with the +1 nucleosome (complex A)
Descriptor: DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ...
Authors:Wang, H, Cramer, P.
Deposit date:2022-05-06
Release date:2022-11-16
Last modified:2025-07-09
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structures of transcription preinitiation complex engaged with the +1 nucleosome.
Nat.Struct.Mol.Biol., 30, 2023
3T9A
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BU of 3t9a by Molmil
Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with AMPPNP at pH 7.0
Descriptor: CADMIUM ION, Inositol Pyrophosphate Kinase, MAGNESIUM ION, ...
Authors:Wang, H, Falck, J, Hall, T.M.T, Shears, S.B.
Deposit date:2011-08-02
Release date:2011-12-07
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding.
Nat.Chem.Biol., 8, 2011
3T9E
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BU of 3t9e by Molmil
Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with ADP, 5-(PP)-IP5 (5-IP7) and MgF3 (transition state mimic)
Descriptor: (1r,2R,3S,4s,5R,6S)-2,3,4,5,6-pentakis(phosphonooxy)cyclohexyl trihydrogen diphosphate, ADENOSINE-5'-DIPHOSPHATE, Inositol Pyrophosphate Kinase, ...
Authors:Wang, H, Falck, J, Hall, T.M.T, Shears, S.B.
Deposit date:2011-08-02
Release date:2011-12-07
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding.
Nat.Chem.Biol., 8, 2011
3T54
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BU of 3t54 by Molmil
Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with ATP and Cadmium
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CADMIUM ION, Inositol Pyrophosphate Kinase
Authors:Wang, H, Falck, J, Hall, T.M.T, Shears, S.B.
Deposit date:2011-07-26
Release date:2011-12-07
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding.
Nat.Chem.Biol., 8, 2011
3T9B
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BU of 3t9b by Molmil
Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with AMPPNP at pH 5.2
Descriptor: Inositol Pyrophosphate Kinase, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Wang, H, Falck, J, Hall, T.M.T, Shears, S.B.
Deposit date:2011-08-02
Release date:2011-12-07
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding.
Nat.Chem.Biol., 8, 2011
3T9D
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BU of 3t9d by Molmil
Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with AMPPNP and 5-(PP)-IP5 (5-IP7)
Descriptor: (1r,2R,3S,4s,5R,6S)-2,3,4,5,6-pentakis(phosphonooxy)cyclohexyl trihydrogen diphosphate, Inositol Pyrophosphate Kinase, MAGNESIUM ION, ...
Authors:Wang, H, Falck, J, Hall, T.M.T, Shears, S.B.
Deposit date:2011-08-02
Release date:2011-12-07
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding.
Nat.Chem.Biol., 8, 2011
3USI
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BU of 3usi by Molmil
Crystal structure of LeuT bound to L-leucine in space group P2 from lipid bicelles
Descriptor: LEUCINE, SODIUM ION, Transporter
Authors:Wang, H, Elferich, J, Gouaux, E.
Deposit date:2011-11-23
Release date:2012-01-11
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.106 Å)
Cite:Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context.
Nat.Struct.Mol.Biol., 19, 2012
3USK
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BU of 3usk by Molmil
Crystal structure of LeuT bound to L-leucine in space group P21 from lipid bicelles
Descriptor: LEUCINE, SODIUM ION, Transporter
Authors:Wang, H, Elferich, J, Gouaux, E.
Deposit date:2011-11-23
Release date:2012-01-11
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (4.5 Å)
Cite:Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context.
Nat.Struct.Mol.Biol., 19, 2012
3USL
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BU of 3usl by Molmil
Crystal Structure of LeuT bound to L-selenomethionine in space group C2 from lipid bicelles
Descriptor: ACETATE ION, IODIDE ION, PHOSPHOCHOLINE, ...
Authors:Wang, H, Elferich, J, Gouaux, E.
Deposit date:2011-11-23
Release date:2012-01-11
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context.
Nat.Struct.Mol.Biol., 19, 2012
3T7A
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BU of 3t7a by Molmil
Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with ADP at pH 5.2
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Wang, H, Falck, J, Hall, T.M.T, Shears, S.B.
Deposit date:2011-07-29
Release date:2011-12-07
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding.
Nat.Chem.Biol., 8, 2011
3T9F
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BU of 3t9f by Molmil
Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with ADP and 1,5-(PP)2-IP4 (1,5-IP8)
Descriptor: (1R,3S,4R,5S,6R)-2,4,5,6-tetrakis(phosphonooxy)cyclohexane-1,3-diyl bis[trihydrogen (diphosphate)], ADENOSINE-5'-DIPHOSPHATE, CADMIUM ION, ...
Authors:Wang, H, Falck, J, Hall, T.M.T, Shears, S.B.
Deposit date:2011-08-02
Release date:2011-12-07
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding.
Nat.Chem.Biol., 8, 2011
3T9C
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BU of 3t9c by Molmil
Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with AMPPNP and inositol hexakisphosphate (IP6)
Descriptor: INOSITOL HEXAKISPHOSPHATE, Inositol Pyrophosphate Kinase, MAGNESIUM ION, ...
Authors:Wang, H, Falck, J, Hall, T.M.T, Shears, S.B.
Deposit date:2011-08-02
Release date:2011-12-07
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding.
Nat.Chem.Biol., 8, 2011
5YXA
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BU of 5yxa by Molmil
Crystal structure of the C-terminal fragment of NS1 protein from yellow fever virus
Descriptor: Non-structural protein 1
Authors:Wang, H, Song, H, Qi, J, Shi, Y, Gao, G.F.
Deposit date:2017-12-04
Release date:2018-01-24
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of the C-terminal fragment of NS1 protein from yellow fever virus.
Sci China Life Sci, 60, 2017
3USO
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BU of 3uso by Molmil
Crystal structure of LeuT bound to L-selenomethionine in space group P21212 from lipid bicelles
Descriptor: SELENOMETHIONINE, SODIUM ION, Transporter
Authors:Wang, H, Elferich, J, Gouaux, E.
Deposit date:2011-11-23
Release date:2012-01-11
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (4.5 Å)
Cite:Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context.
Nat.Struct.Mol.Biol., 19, 2012

238582

数据于2025-07-09公开中

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