4OBA
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![BU of 4oba by Molmil](/molmil-images/mine/4oba) | Co-crystal structure of MDM2 with Inhibitor Compound 4 | Descriptor: | E3 ubiquitin-protein ligase Mdm2, [(2R,5R,6R)-4-[(1S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl]-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxomorpholin-2-yl]acetic acid | Authors: | Shaffer, P.L, Huang, X, Yakowec, P, Long, A.M. | Deposit date: | 2014-01-07 | Release date: | 2014-03-19 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.602 Å) | Cite: | Selective and Potent Morpholinone Inhibitors of the MDM2-p53 Protein-Protein Interaction. J.Med.Chem., 57, 2014
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4ODF
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![BU of 4odf by Molmil](/molmil-images/mine/4odf) | Co-Crystal Structure of MDM2 with Inhibitor Compound 47 | Descriptor: | 6-{[(2S,5R,6R)-4-[(1S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl]-6-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-3-oxomorpholin-2-yl]methyl}pyridine-3-carboxylic acid, E3 ubiquitin-protein ligase Mdm2 | Authors: | Shaffer, P.L, Huang, X, Yakowec, P, Long, A.M. | Deposit date: | 2014-01-10 | Release date: | 2014-04-02 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.2006 Å) | Cite: | Novel Inhibitors of the MDM2-p53 Interaction Featuring Hydrogen Bond Acceptors as Carboxylic Acid Isosteres. J.Med.Chem., 57, 2014
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4ODE
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![BU of 4ode by Molmil](/molmil-images/mine/4ode) | Co-Crystal Structure of MDM2 with Inhibitor Compound 4 | Descriptor: | (2-{[(3R,5R,6S)-1-[(1S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl]-6-(4-chloro-3-fluorophenyl)-5-(3-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]methyl}-1,3-thiazol-5-yl)acetic acid, E3 ubiquitin-protein ligase Mdm2, SULFATE ION | Authors: | Shaffer, P.L, Huang, X, Yakowec, P, Long, A.M. | Deposit date: | 2014-01-10 | Release date: | 2014-04-02 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Novel Inhibitors of the MDM2-p53 Interaction Featuring Hydrogen Bond Acceptors as Carboxylic Acid Isosteres. J.Med.Chem., 57, 2014
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1MAW
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![BU of 1maw by Molmil](/molmil-images/mine/1maw) | Crystal Structure of Tryptophanyl-tRNA Synthetase Complexed with ATP in an Open Conformation | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, TRYPTOPHAN-TRNA LIGASE | Authors: | Retailleau, P, Huang, X, Yin, Y, Hu, M, Weinreb, V, Vachette, P, Vonrhein, C, Bricogne, G, Roversi, P, Ilyin, V, Carter Jr, C.W. | Deposit date: | 2002-08-02 | Release date: | 2003-01-07 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Interconversion of ATP binding and conformational free energies by tryptophanyl-tRNA synthetase: structures of ATP bound to open and closed, pre-transition-state conformations. J.Mol.Biol., 325, 2003
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1M6V
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![BU of 1m6v by Molmil](/molmil-images/mine/1m6v) | Crystal Structure of the G359F (small subunit) Point Mutant of Carbamoyl Phosphate Synthetase | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, L-ornithine, ... | Authors: | Thoden, J.B, Huang, X, Raushel, F.M, Holden, H.M. | Deposit date: | 2002-07-17 | Release date: | 2002-07-31 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Carbamoyl-phosphate synthetase. Creation of an escape route for ammonia J.Biol.Chem., 277, 2002
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1M83
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![BU of 1m83 by Molmil](/molmil-images/mine/1m83) | Crystal Structure of Tryptophanyl-tRNA Synthetase Complexed with ATP in a Closed, Pre-transition State Conformation | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... | Authors: | Retailleau, P, Huang, X, Yin, Y, Hu, M, Weinreb, V, Vachette, P, Vonrhein, C, Bricogne, G, Roversi, P, Ilyin, V, Carter Jr, C.W. | Deposit date: | 2002-07-24 | Release date: | 2002-12-18 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Interconversion of ATP binding and conformational free energies by tryptophanyl-tRNA synthetase: structures of ATP bound to open and closed, pre-transition-state conformations. J.Mol.Biol., 325, 2003
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1KSW
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![BU of 1ksw by Molmil](/molmil-images/mine/1ksw) | Structure of Human c-Src Tyrosine Kinase (Thr338Gly Mutant) in Complex with N6-benzyl ADP | Descriptor: | N6-BENZYL ADENOSINE-5'-DIPHOSPHATE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC | Authors: | Witucki, L.A, Huang, X, Shah, K, Liu, Y, Kyin, S, Eck, M.J, Shokat, K.M. | Deposit date: | 2002-01-14 | Release date: | 2002-02-27 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Mutant tyrosine kinases with unnatural nucleotide specificity retain the structure and phospho-acceptor specificity of the wild-type enzyme. Chem.Biol., 9, 2002
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1MAU
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![BU of 1mau by Molmil](/molmil-images/mine/1mau) | Crystal structure of Tryptophanyl-tRNA Synthetase Complexed with ATP and Tryptophanamide in a Pre-Transition state Conformation | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CITRIC ACID, GLYCEROL, ... | Authors: | Retailleau, P, Huang, X, Yin, Y, Hu, M, Weinreb, V, Vachette, P, Vonrhein, C, Bricogne, G, Roversi, P, Ilyin, V, Carter Jr, C.W. | Deposit date: | 2002-08-02 | Release date: | 2003-01-07 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Interconversion of ATP binding and conformational free energies by tryptophanyl-tRNA synthetase: structures of ATP bound to open and closed, pre-transition-state conformations. J.Mol.Biol., 325, 2003
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1MB2
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![BU of 1mb2 by Molmil](/molmil-images/mine/1mb2) | Crystal Structure of Tryptophanyl-tRNA Synthetase Complexed with Tryptophan in an Open Conformation | Descriptor: | TRYPTOPHAN, TRYPTOPHAN-TRNA LIGASE | Authors: | Retailleau, P, Huang, X, Yin, Y, Hu, M, Weinreb, V, Vachette, P, Vonrhein, C, Bricogne, G, Roversi, P, Ilyin, V, Carter Jr, C.W. | Deposit date: | 2002-08-02 | Release date: | 2003-01-07 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Interconversion of ATP binding and conformational free energies by tryptophanyl-tRNA synthetase: structures of ATP bound to open and closed, pre-transition-state conformations. J.Mol.Biol., 325, 2003
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3GTL
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![BU of 3gtl by Molmil](/molmil-images/mine/3gtl) | Backtracked RNA polymerase II complex with 13mer with G<>U mismatch | Descriptor: | DNA (28-MER), DNA (5'-D(*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*G)-3'), DNA-directed RNA polymerase II subunit RPB1, ... | Authors: | Wang, D, Bushnell, D.A, Huang, X, Westover, K.D, Levitt, M, Kornberg, R.D. | Deposit date: | 2009-03-27 | Release date: | 2009-06-09 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.38 Å) | Cite: | Structural basis of transcription: backtracked RNA polymerase II at 3.4 angstrom resolution. Science, 324, 2009
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3GTK
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![BU of 3gtk by Molmil](/molmil-images/mine/3gtk) | Backtracked RNA polymerase II complex with 18mer RNA | Descriptor: | DNA (29-MER), DNA (5'-D(*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*G)-3'), DNA-directed RNA polymerase II subunit RPB1, ... | Authors: | Wang, D, Bushnell, D.A, Huang, X, Westover, K.D, Levitt, M, Kornberg, R.D. | Deposit date: | 2009-03-27 | Release date: | 2009-06-09 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Structural basis of transcription: backtracked RNA polymerase II at 3.4 angstrom resolution. Science, 324, 2009
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3GTP
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![BU of 3gtp by Molmil](/molmil-images/mine/3gtp) | Backtracked RNA polymerase II complex with 24mer RNA | Descriptor: | DNA (28-MER), DNA (5'-D(*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*G)-3'), DNA-directed RNA polymerase II subunit RPB1, ... | Authors: | Wang, D, Bushnell, D.A, Huang, X, Westover, K.D, Levitt, M, Kornberg, R.D. | Deposit date: | 2009-03-27 | Release date: | 2009-06-09 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.9 Å) | Cite: | Structural basis of transcription: backtracked RNA polymerase II at 3.4 angstrom resolution. Science, 324, 2009
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3GTM
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![BU of 3gtm by Molmil](/molmil-images/mine/3gtm) | Co-complex of Backtracked RNA polymerase II with TFIIS | Descriptor: | DNA (28-MER), DNA (5'-D(*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*G)-3'), DNA-directed RNA polymerase II subunit RPB1, ... | Authors: | Wang, D, Bushnell, D.A, Huang, X, Westover, K.D, Levitt, M, Kornberg, R.D. | Deposit date: | 2009-03-27 | Release date: | 2009-06-09 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Structural basis of transcription: backtracked RNA polymerase II at 3.4 angstrom resolution. Science, 324, 2009
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3GTQ
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![BU of 3gtq by Molmil](/molmil-images/mine/3gtq) | Backtracked RNA polymerase II complex induced by damage | Descriptor: | DNA (5'-D(*CP*TP*AP*CP*CP*CP*AP*TP*AP*AP*CP*CP*AP*CP*AP*GP*GP*CP*TP*CP*CP*TP*CP*TP*CP*CP*AP*TP*C)-3'), DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, ... | Authors: | Wang, D, Bushnell, D.A, Huang, X, Westover, K.D, Levitt, M, Kornberg, R.D. | Deposit date: | 2009-03-27 | Release date: | 2009-06-09 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Structural basis of transcription: backtracked RNA polymerase II at 3.4 angstrom resolution. Science, 324, 2009
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3GTO
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![BU of 3gto by Molmil](/molmil-images/mine/3gto) | Backtracked RNA polymerase II complex with 15mer RNA | Descriptor: | DNA (28-MER), DNA (5'-D(*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*G)-3'), DNA-directed RNA polymerase II subunit RPB1, ... | Authors: | Wang, D, Bushnell, D.A, Huang, X, Westover, K.D, Levitt, M, Kornberg, R.D. | Deposit date: | 2009-03-27 | Release date: | 2009-06-09 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (4 Å) | Cite: | Structural basis of transcription: backtracked RNA polymerase II at 3.4 angstrom resolution. Science, 324, 2009
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3GTG
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![BU of 3gtg by Molmil](/molmil-images/mine/3gtg) | Backtracked RNA polymerase II complex with 12mer RNA | Descriptor: | DNA (28-MER), DNA (5'-D(*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*G)-3'), DNA-directed RNA polymerase II subunit RPB1, ... | Authors: | Wang, D, Bushnell, D.A, Huang, X, Westover, K.D, Levitt, M, Kornberg, R.D. | Deposit date: | 2009-03-27 | Release date: | 2009-06-09 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.78 Å) | Cite: | Structural basis of transcription: backtracked RNA polymerase II at 3.4 angstrom resolution. Science, 324, 2009
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3GTJ
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![BU of 3gtj by Molmil](/molmil-images/mine/3gtj) | Backtracked RNA polymerase II complex with 13mer RNA | Descriptor: | DNA (28-MER), DNA (5'-D(*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*G)-3'), DNA-directed RNA polymerase II subunit RPB1, ... | Authors: | Wang, D, Bushnell, D.A, Huang, X, Westover, K.D, Levitt, M, Kornberg, R.D. | Deposit date: | 2009-03-27 | Release date: | 2009-06-09 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.42 Å) | Cite: | Structural basis of transcription: backtracked RNA polymerase II at 3.4 angstrom resolution. Science, 324, 2009
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3IZ3
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![BU of 3iz3 by Molmil](/molmil-images/mine/3iz3) | CryoEM structure of cytoplasmic polyhedrosis virus | Descriptor: | Structural protein VP1, Structural protein VP3, Viral structural protein 5 | Authors: | Cheng, L, Sun, J, Zhang, K, Mou, Z, Huang, X, Ji, G, Sun, F, Zhang, J, Zhu, P. | Deposit date: | 2010-09-14 | Release date: | 2011-03-16 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Atomic model of a cypovirus built from cryo-EM structure provides insight into the mechanism of mRNA capping. Proc.Natl.Acad.Sci.USA, 108, 2011
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3RZD
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![BU of 3rzd by Molmil](/molmil-images/mine/3rzd) | RNA Polymerase II Initiation Complex with a 5-nt RNA | Descriptor: | DNA (5'-D(*CP*TP*AP*CP*CP*GP*AP*TP*AP*AP*GP*CP*AP*GP*AP*CP*GP*AP*TP*CP*CP*TP*CP*TP*CP*GP*AP*TP*G)-3'), DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, ... | Authors: | Liu, X, Bushnell, D.A, Silva, D.A, Huang, X, Kornberg, R.D. | Deposit date: | 2011-05-11 | Release date: | 2011-08-10 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Initiation complex structure and promoter proofreading. Science, 333, 2011
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3J6Q
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![BU of 3j6q by Molmil](/molmil-images/mine/3j6q) | Identification of the active sites in the methyltransferases of a transcribing dsRNA virus | Descriptor: | S-ADENOSYL-L-HOMOCYSTEINE, Structural protein VP3 | Authors: | Zhu, B, Yang, C, Liu, H, Cheng, L, Song, F, Zeng, S, Huang, X, Ji, G, Zhu, P. | Deposit date: | 2014-03-20 | Release date: | 2014-10-08 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Identification of the active sites in the methyltransferases of a transcribing dsRNA virus. J.Mol.Biol., 426, 2014
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3RZO
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![BU of 3rzo by Molmil](/molmil-images/mine/3rzo) | RNA Polymerase II Initiation Complex with a 4-nt RNA | Descriptor: | DNA (5'-D(*CP*TP*AP*CP*CP*GP*AP*TP*AP*AP*GP*CP*AP*GP*AP*CP*GP*AP*TP*CP*CP*TP*CP*TP*CP*GP*AP*TP*G)-3'), DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, ... | Authors: | Liu, X, Bushnell, D.A, Silva, D.A, Huang, X, Kornberg, R.D. | Deposit date: | 2011-05-12 | Release date: | 2011-08-10 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Initiation complex structure and promoter proofreading. Science, 333, 2011
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3S1R
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![BU of 3s1r by Molmil](/molmil-images/mine/3s1r) | RNA Polymerase II Initiation Complex with a 5-nt 3'-deoxy RNA soaked with GTP | Descriptor: | DNA (5'-D(*CP*TP*AP*CP*CP*GP*AP*TP*AP*AP*GP*CP*AP*GP*AP*CP*GP*AP*TP*CP*CP*TP*CP*TP*CP*GP*AP*TP*G)-3'), DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, ... | Authors: | Liu, X, Bushnell, D.A, Silva, D.A, Huang, X, Kornberg, R.D. | Deposit date: | 2011-05-16 | Release date: | 2011-08-10 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Initiation complex structure and promoter proofreading. Science, 333, 2011
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3S16
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![BU of 3s16 by Molmil](/molmil-images/mine/3s16) | RNA Polymerase II Initiation Complex with an 8-nt RNA | Descriptor: | DNA (5'-D(*CP*TP*AP*CP*CP*GP*AP*TP*AP*AP*GP*CP*AP*GP*AP*CP*GP*AP*TP*CP*CP*TP*CP*TP*CP*GP*AP*TP*G)-3'), DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, ... | Authors: | Liu, X, Bushnell, D.A, Silva, D.A, Huang, X, Kornberg, R.D. | Deposit date: | 2011-05-14 | Release date: | 2011-08-10 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.241 Å) | Cite: | Initiation complex structure and promoter proofreading. Science, 333, 2011
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3S14
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![BU of 3s14 by Molmil](/molmil-images/mine/3s14) | RNA Polymerase II Initiation Complex with a 6-nt RNA | Descriptor: | DNA (5'-D(*CP*TP*AP*CP*CP*GP*AP*TP*AP*AP*GP*CP*AP*GP*AP*CP*GP*AP*TP*CP*CP*TP*CP*TP*CP*GP*AP*TP*G)-3'), DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, ... | Authors: | Liu, X, Bushnell, D.A, Silva, D.A, Huang, X, Kornberg, R.D. | Deposit date: | 2011-05-14 | Release date: | 2011-08-10 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Initiation complex structure and promoter proofreading. Science, 333, 2011
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3S1N
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![BU of 3s1n by Molmil](/molmil-images/mine/3s1n) | RNA Polymerase II Initiation Complex with a 5-nt RNA (variant 2) | Descriptor: | DNA (5'-D(*CP*TP*AP*CP*CP*GP*AP*TP*AP*AP*GP*CP*AP*GP*AP*CP*GP*AP*TP*GP*CP*TP*CP*TP*CP*GP*AP*TP*G)-3'), DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, ... | Authors: | Liu, X, Bushnell, D.A, Silva, D.A, Huang, X, Kornberg, R.D. | Deposit date: | 2011-05-15 | Release date: | 2011-08-10 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Initiation complex structure and promoter proofreading. Science, 333, 2011
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