3ZBS
| Catalytic domain of mouse 2',3'-cyclic nucleotide 3'- phosphodiesterase, with mutation V321A, crystallized with 2'-AMPS | Descriptor: | 2', 3'-CYCLIC NUCLEOTIDE 3'-PHOSPHODIESTERASE, 2'-O-(sulfidophosphinato)adenosine, ... | Authors: | Myllykoski, M, Raasakka, A, Lehtimaki, M, Han, H, Kursula, P. | Deposit date: | 2012-11-13 | Release date: | 2013-07-10 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Crystallographic Analysis of the Reaction Cycle of 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase, a Unique Member of the 2H Phosphoesterase Family J.Mol.Biol., 425, 2013
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3ZBZ
| Catalytic domain of mouse 2',3'-cyclic nucleotide 3'- phosphodiesterase, with mutation V321A, crystallized with 2'-AMPS | Descriptor: | 2', 3'-CYCLIC-NUCLEOTIDE 3'-PHOSPHODIESTERASE, 2'-O-(sulfidophosphinato)adenosine, ... | Authors: | Myllykoski, M, Raasakka, A, Lehtimaki, M, Han, H, Kursula, P. | Deposit date: | 2012-11-14 | Release date: | 2013-07-10 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystallographic Analysis of the Reaction Cycle of 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase, a Unique Member of the 2H Phosphoesterase Family J.Mol.Biol., 425, 2013
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1YP5
| Yeast Myo5 SH3 domain, tetragonal crystal form | Descriptor: | Myosin-5 isoform | Authors: | Gonfloni, S, Kursula, P, Sacco, R, Cesareni, G, Wilmanns, M. | Deposit date: | 2005-01-29 | Release date: | 2006-01-17 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.68 Å) | Cite: | Yeast Myo5 SH3 domain, tetragonal crystal form To be Published
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3ZBR
| Catalytic domain of mouse 2',3'-cyclic nucleotide 3'- phosphodiesterase, with mutation H230S, crystallized with NADP | Descriptor: | 2', 3'-CYCLIC-NUCLEOTIDE 3'-PHOSPHODIESTERASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Myllykoski, M, Raasakka, A, Lehtimaki, M, Han, H, Kursula, P. | Deposit date: | 2012-11-13 | Release date: | 2013-07-10 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.304 Å) | Cite: | Crystallographic Analysis of the Reaction Cycle of 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase, a Unique Member of the 2H Phosphoesterase Family J.Mol.Biol., 425, 2013
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2J9Q
| A novel conformation for the TPR domain of pex5p | Descriptor: | PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR, STRONTIUM ION | Authors: | Stanley, W.A, Wilmanns, M, Kursula, P. | Deposit date: | 2006-11-15 | Release date: | 2007-04-17 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | A Previously Unobserved Conformation for the Human Pex5P Receptor Suggests Roles for Intrinsic Flexibility and Rigid Domain Motions in Ligand Binding Bmc Struct.Biol., 7, 2007
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6TU2
| Crystal structure of rat annexin A11 | Descriptor: | Annexin, CALCIUM ION | Authors: | Raasakka, A, Lillebostad, P, Vedeler, A, Kursula, P. | Deposit date: | 2020-01-01 | Release date: | 2020-05-06 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure of the ALS Mutation Target Annexin A11 Reveals a Stabilising N-Terminal Segment. Biomolecules, 10, 2020
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2BZN
| Crystal structure of human guanosine monophosphate reductase 2 GMPR2 in complex with IMP | Descriptor: | GMP REDUCTASE 2, INOSINIC ACID | Authors: | Stenmark, P, Kursula, P, Arrowsmith, C, Berglund, H, Edwards, A, Ehn, M, Graslund, S, Hammarstrom, M, Hallberg, B.M, Kotenyova, T, Nilsson-Ehle, P, Nordlund, P, Ogg, D, Persson, C, Sagemark, J, Schuler, H, Sundstrom, M, Thorsell, A, Weigelt, J. | Deposit date: | 2005-08-19 | Release date: | 2005-09-02 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Cofactor Mobility Determines Reaction Outcome in the Impdh and Gmpr (Beta-Alpha)(8) Barrel Enzymes. Nat.Chem.Biol., 7, 2011
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2CAR
| Crystal Structure Of Human Inosine Triphosphatase | Descriptor: | INOSINE TRIPHOSPHATE PYROPHOSPHATASE | Authors: | Stenmark, P, Kursula, P, Arrowsmith, C, Berglund, H, Edwards, A, Ehn, M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Hallberg, B.M, Hogbom, M, Holmberg Schiavone, L, Kotenyova, T, Nilsson-Ehle, P, Nyman, T, Ogg, D, Persson, C, Sagemark, J, Schuler, H, Sundstrom, M, Thorsell, A.G, van den Berg, S, Weigelt, J, Nordlund, P. | Deposit date: | 2005-12-22 | Release date: | 2006-01-04 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.09 Å) | Cite: | Crystal Structure of Human Inosine Triphosphatase. Substrate Binding and Implication of the Inosine Triphosphatase Deficiency Mutation P32T. J.Biol.Chem., 282, 2007
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5O99
| Unconventional SH3 domain from the postsynaptic density scaffold protein Shank3 | Descriptor: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, SH3 and multiple ankyrin repeat domains protein 3 | Authors: | Ponna, S.K, Myllykoski, M, Boeckers, T.M, Kursula, P. | Deposit date: | 2017-06-16 | Release date: | 2017-07-05 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (0.871 Å) | Cite: | Structure of an unconventional SH3 domain from the postsynaptic density protein Shank3 at ultrahigh resolution. Biochem. Biophys. Res. Commun., 490, 2017
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5OVC
| PDZ domain from rat Shank3 bound to the C terminus of GKAP | Descriptor: | CHLORIDE ION, GKAP C terminus, synthetic peptide, ... | Authors: | Ponna, S.K, Myllykoski, M, Boeckers, T.M, Kursula, P. | Deposit date: | 2017-08-28 | Release date: | 2018-03-07 | Last modified: | 2018-07-11 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Structural basis for PDZ domain interactions in the post-synaptic density scaffolding protein Shank3. J. Neurochem., 145, 2018
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2VK3
| Crystal structure of rat profilin 2a | Descriptor: | (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, GLYCEROL, PROFILIN-2, ... | Authors: | Haikarainen, T, Kursula, P. | Deposit date: | 2007-12-17 | Release date: | 2009-02-10 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structure, Modifications and Ligand-Binding Properties of Rat Profilin 2A. Acta Crystallogr.,Sect.D, 65, 2009
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5OVV
| PDZ domain from rat Shank3 bound to the C terminus of ProSAPiP1 | Descriptor: | Leucine zipper putative tumor suppressor 3, SH3 and multiple ankyrin repeat domains protein 3, THIOCYANATE ION | Authors: | Ponna, S.K, Myllykoski, M, Boeckers, T.M, Kursula, P. | Deposit date: | 2017-08-29 | Release date: | 2018-03-07 | Last modified: | 2018-07-11 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Structural basis for PDZ domain interactions in the post-synaptic density scaffolding protein Shank3. J. Neurochem., 145, 2018
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5OVA
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5OVP
| PDZ domain from rat Shank3 bound to the C terminus of CIRL | Descriptor: | Adhesion G protein-coupled receptor L1, SH3 and multiple ankyrin repeat domains protein 3 | Authors: | Ponna, S.K, Myllykoski, M, Boeckers, T.M, Kursula, P. | Deposit date: | 2017-08-29 | Release date: | 2018-03-07 | Last modified: | 2018-07-11 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structural basis for PDZ domain interactions in the post-synaptic density scaffolding protein Shank3. J. Neurochem., 145, 2018
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2W73
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6S2M
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6S2S
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6SID
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6SIE
| Crystal structure of the C-lobe of drosophila Arc 2 | Descriptor: | Activity-regulated cytoskeleton associated protein 2, SULFATE ION | Authors: | Hallin, E.I, Kursula, P. | Deposit date: | 2019-08-09 | Release date: | 2019-08-28 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal and solution structures reveal oligomerization of individual capsid homology domains of Drosophila Arc. Plos One, 16, 2021
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6SIB
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6STS
| Human myelin protein P2 mutant R30Q | Descriptor: | Myelin P2 protein, PALMITIC ACID, SULFATE ION | Authors: | Ruskamo, S, Lehtimaki, M, Kursula, P. | Deposit date: | 2019-09-11 | Release date: | 2020-04-08 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Cryo-EM, X-ray diffraction, and atomistic simulations reveal determinants for the formation of a supramolecular myelin-like proteolipid lattice. J.Biol.Chem., 295, 2020
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6TA2
| Human NAMPT in complex with nicotinic acid mononucleotide and phosphate | Descriptor: | CHLORIDE ION, GLYCEROL, NICOTINATE MONONUCLEOTIDE, ... | Authors: | Houry, D, Raasakka, A, Kursula, P, Ziegler, M. | Deposit date: | 2019-10-29 | Release date: | 2020-11-18 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.68 Å) | Cite: | Identification of structural determinants of NAMPT activity and substrate selectivity To Be Published
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6TA0
| Human NAMPT in complex with nicotinic acid and phosphoribosyl pyrophosphate | Descriptor: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, GLYCEROL, NICOTINIC ACID, ... | Authors: | Houry, D, Raasakka, A, Kursula, P, Ziegler, M. | Deposit date: | 2019-10-29 | Release date: | 2020-11-18 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Identification of structural determinants of NAMPT activity and substrate selectivity To Be Published
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6TAC
| Human NAMPT deletion mutant in complex with nicotinamide mononucleotide, pyrophosphate, and Mg2+ | Descriptor: | BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... | Authors: | Houry, D, Raasakka, A, Kursula, P, Ziegler, M. | Deposit date: | 2019-10-29 | Release date: | 2020-11-18 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Identification of structural determinants of NAMPT activity and substrate selectivity To Be Published
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6TQ0
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