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8I99
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BU of 8i99 by Molmil
N-carbamoyl-D-amino-acid hydrolase mutant - M4Th3
Descriptor: N-carbamoyl-D-amino-acid hydrolase
Authors:Hu, J.M, Ni, Y, Xu, G.C.
Deposit date:2023-02-06
Release date:2023-03-22
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (3.17 Å)
Cite:Engineering the Thermostability of a d-Carbamoylase Based on Ancestral Sequence Reconstruction for the Efficient Synthesis of d-Tryptophan.
J.Agric.Food Chem., 71, 2023
5YAK
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BU of 5yak by Molmil
The crystal structure of human IYD Thr239 mutant with ligand 3-Fluorotyrosine (F-Tyr)
Descriptor: 3-FLUOROTYROSINE, FLAVIN MONONUCLEOTIDE, Iodotyrosine deiodinase 1
Authors:Hu, J.M, Rokita, S.E, Schlessman, J.
Deposit date:2017-09-01
Release date:2018-08-08
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Redox control of iodotyrosine deiodinase
Protein Sci., 28, 2019
5JDK
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BU of 5jdk by Molmil
Crystal structure of the DNA binding domain of Sap1 in fission yeast S.pombe
Descriptor: GLYCEROL, Switch-activating protein 1
Authors:He, P, Wang, T.
Deposit date:2016-04-17
Release date:2017-02-22
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (0.998 Å)
Cite:Sap1 is a replication-initiation factor essential for the assembly of pre-replicative complex in the fission yeast Schizosaccharomyces pombe.
J. Biol. Chem., 292, 2017
6LKA
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BU of 6lka by Molmil
Crystal Structure of EV71-3C protease with a Novel Macrocyclic Compounds
Descriptor: 3C proteinase, ~{N}-[(2~{S})-1-[[(2~{S},3~{S},6~{S},7~{Z},12~{E})-4,9-bis(oxidanylidene)-6-[[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]methyl]-2-phenyl-1,10-dioxa-5-azacyclopentadeca-7,12-dien-3-yl]amino]-3-methyl-1-oxidanylidene-butan-2-yl]-5-methyl-1,2-oxazole-3-carboxamide
Authors:Li, P, Wu, S.Q, Xiao, T.Y.C, Li, Y.L, Su, Z.M, Hao, F, Hu, G.P, Hu, J, Lin, F.S, Chen, X.S, Gu, Z.X, He, H.Y, Li, J, Chen, S.H.
Deposit date:2019-12-18
Release date:2020-06-17
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.033 Å)
Cite:Design, synthesis, and evaluation of a novel macrocyclic anti-EV71 agent.
Bioorg.Med.Chem., 28, 2020
5WSH
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BU of 5wsh by Molmil
Structure of HLA-A2 P130
Descriptor: Beta-2-microglobulin, DI(HYDROXYETHYL)ETHER, GLY-VAL-TRP-ILE-ARG-THR-PRO-THR-ALA, ...
Authors:Zhang, Y, Wu, Y, Qi, J, Liu, J, Gao, G.F, Meng, S.
Deposit date:2016-12-07
Release date:2017-12-20
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:CD8+T-Cell Response-Associated Evolution of Hepatitis B Virus Core Protein and Disease Progress.
J. Virol., 92, 2018
5B7J
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BU of 5b7j by Molmil
Structure model of Sap1-DNA complex
Descriptor: DNA (5'-D(*AP*AP*TP*AP*TP*TP*GP*TP*TP*TP*TP*G)-3'), DNA (5'-D(*CP*AP*AP*AP*AP*CP*AP*AP*TP*AP*TP*T)-3'), Switch-activating protein 1
Authors:Jin, C, Hu, Y, Ding, J, Zhang, Y.
Deposit date:2016-06-07
Release date:2017-02-22
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Sap1 is a replication-initiation factor essential for the assembly of pre-replicative complex in the fission yeast Schizosaccharomyces pombe
J. Biol. Chem., 292, 2017
6LW2
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BU of 6lw2 by Molmil
The N-arylsulfonyl-indole-2-carboxamide-based inhibitors against fructose-1,6-bisphosphatase
Descriptor: 7-chloranyl-4-[(3-methoxyphenyl)amino]-N-(4-methoxyphenyl)sulfonyl-1-methyl-indole-2-carboxamide, Fructose-1,6-bisphosphatase 1
Authors:Wang, X.Y, Zhou, J, Xu, B.L.
Deposit date:2020-02-07
Release date:2020-05-13
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Discovery of N -Arylsulfonyl-Indole-2-Carboxamide Derivatives as Potent, Selective, and Orally Bioavailable Fructose-1,6-Bisphosphatase Inhibitors-Design, Synthesis, In Vivo Glucose Lowering Effects, and X-ray Crystal Complex Analysis.
J.Med.Chem., 63, 2020
6U2D
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BU of 6u2d by Molmil
PmtCD peptide exporter basket domain
Descriptor: ABC transporter ATP-binding protein, IODIDE ION, SULFATE ION
Authors:Zeytuni, N, Strynadka, N.C.J.
Deposit date:2019-08-19
Release date:2020-10-14
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Structural insight into the Staphylococcus aureus ATP-driven exporter of virulent peptide toxins
Sci Adv, 6, 2020
7X31
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BU of 7x31 by Molmil
solution structure of an anti-CRISPR protein
Descriptor: Anti-CRISPR protein (AcrIIC1)
Authors:Zhao, Y, Yang, F.
Deposit date:2022-02-27
Release date:2022-10-26
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:A redox switch regulates the assembly and anti-CRISPR activity of AcrIIC1.
Nat Commun, 13, 2022
8J2F
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BU of 8j2f by Molmil
Human neutral shpingomyelinase
Descriptor: HEPTANE, MAGNESIUM ION, Sphingomyelin phosphodiesterase 2, ...
Authors:Zhang, S.S.
Deposit date:2023-04-14
Release date:2023-12-06
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (3.07 Å)
Cite:Molecular basis for the catalytic mechanism of human neutral sphingomyelinases 1 (hSMPD2).
Nat Commun, 14, 2023
6DL2
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BU of 6dl2 by Molmil
BRD4 bromodomain 1 in complex with HYB157
Descriptor: 1,2-ETHANEDIOL, 3-benzyl-2,9-dimethyl-4H,6H-thieno[2,3-e][1,2,4]triazolo[3,4-c][1,4]oxazepine, Bromodomain-containing protein 4
Authors:Meagher, J.L, Stuckey, J.A.
Deposit date:2018-05-31
Release date:2019-04-17
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression.
J. Med. Chem., 61, 2018
4N7S
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BU of 4n7s by Molmil
Crystal structure of Tse3-Tsi3 complex with Zinc ion
Descriptor: ACETATE ION, CALCIUM ION, CHLORIDE ION, ...
Authors:Shang, G.J.
Deposit date:2013-10-16
Release date:2014-04-23
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.101 Å)
Cite:Structural insights into the T6SS effector protein Tse3 and the Tse3-Tsi3 complex from Pseudomonas aeruginosa reveal a calcium-dependent membrane-binding mechanism
Mol.Microbiol., 92, 2014
4N88
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BU of 4n88 by Molmil
Crystal structure of Tse3-Tsi3 complex with calcium ion
Descriptor: CALCIUM ION, Uncharacterized protein
Authors:Shang, G.J.
Deposit date:2013-10-17
Release date:2014-04-23
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural insights into the T6SS effector protein Tse3 and the Tse3-Tsi3 complex from Pseudomonas aeruginosa reveal a calcium-dependent membrane-binding mechanism
Mol.Microbiol., 92, 2014
4N80
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BU of 4n80 by Molmil
Crystal structure of Tse3-Tsi3 complex
Descriptor: CALCIUM ION, Uncharacterized protein, ZINC ION
Authors:Shang, G.J.
Deposit date:2013-10-16
Release date:2014-04-23
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural insights into the T6SS effector protein Tse3 and the Tse3-Tsi3 complex from Pseudomonas aeruginosa reveal a calcium-dependent membrane-binding mechanism
Mol.Microbiol., 92, 2014
5CA9
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BU of 5ca9 by Molmil
Structures of the candida albicans sey1p GTPase in complex with GDPAlF4-
Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Protein SEY1, ...
Authors:Yan, L.
Deposit date:2015-06-29
Release date:2015-09-23
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structures of the yeast dynamin-like GTPase Sey1p provide insight into homotypic ER fusion
J.Cell Biol., 210, 2015
5CA8
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BU of 5ca8 by Molmil
Structures of the yeast dynamin-like GTPase Sey1p in complex with GDP
Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Protein SEY1
Authors:Yan, L.
Deposit date:2015-06-29
Release date:2015-09-16
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of the yeast dynamin-like GTPase Sey1p provide insight into homotypic ER fusion
J.Cell Biol., 210, 2015
4M5E
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BU of 4m5e by Molmil
Tse3 structure
Descriptor: CADMIUM ION, CALCIUM ION, GLYCEROL, ...
Authors:Qian, Y.
Deposit date:2013-08-08
Release date:2014-04-23
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Structural insights into the T6SS effector protein Tse3 and the Tse3-Tsi3 complex from Pseudomonas aeruginosa reveal a calcium-dependent membrane-binding mechanism
Mol.Microbiol., 92, 2014
4M5F
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BU of 4m5f by Molmil
complex structure of Tse3-Tsi3
Descriptor: CALCIUM ION, PHOSPHATE ION, Uncharacterized protein
Authors:Gu, L.C.
Deposit date:2013-08-08
Release date:2014-04-23
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural insights into the T6SS effector protein Tse3 and the Tse3-Tsi3 complex from Pseudomonas aeruginosa reveal a calcium-dependent membrane-binding mechanism
Mol.Microbiol., 92, 2014
8XJV
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BU of 8xjv by Molmil
Structural basis for the linker histone H5-nucleosome binding and chromatin compaction
Descriptor: DNA, Histone H2A, Histone H2B 1.1, ...
Authors:Li, W.Y, Song, F, Zhu, P.
Deposit date:2023-12-22
Release date:2024-09-11
Last modified:2024-10-09
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural basis for linker histone H5-nucleosome binding and chromatin fiber compaction.
Cell Res., 34, 2024
8YZ7
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BU of 8yz7 by Molmil
Crystal structure of DdrI, a CRP family protein from Deinococcus radiodurans
Descriptor: POTASSIUM ION, Transcriptional regulator, FNR/CRP family
Authors:Zhao, Y, Wang, Y.
Deposit date:2024-04-06
Release date:2024-07-03
Last modified:2024-09-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:cAMP-independent DNA binding of the CRP family protein DdrI from Deinococcus radiodurans.
Mbio, 15, 2024
8YE4
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BU of 8ye4 by Molmil
The complex of TCR NYN-I and HLA-A24 bound to SARS-CoV-2 Spike448-456 peptide NYNYLYRLF
Descriptor: Beta-2-microglobulin, MHC class I antigen precusor, Spike protein S1, ...
Authors:Deng, S.S, Jin, T.C, Xu, Z.H, Wang, M.H.
Deposit date:2024-02-21
Release date:2024-08-21
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural insights into immune escape at killer T cell epitope by SARS-CoV-2 Spike Y453F variants.
J.Biol.Chem., 300, 2024
8ZV9
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BU of 8zv9 by Molmil
Complex structure of HLA2402 with recognizing SARS-CoV-2 Y453F epitope NYNYLFRLF
Descriptor: 1,2-ETHANEDIOL, Beta-2-microglobulin, MHC class I antigen, ...
Authors:Deng, S.S, Jin, T.C, Xu, Z.H, Wang, M.H.
Deposit date:2024-06-11
Release date:2024-08-21
Last modified:2024-08-28
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural insights into immune escape at killer T cell epitope by SARS-CoV-2 Spike Y453F variants.
J.Biol.Chem., 300, 2024
5N21
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BU of 5n21 by Molmil
Crystal structure of the BCL6 BTB domain in complex with pyrazolo-pyrimidine ligand
Descriptor: 2-[(2~{S})-1-[3-cyano-7-[(2-oxidanylidene-3,4-dihydro-1~{H}-quinolin-6-yl)amino]pyrazolo[1,5-a]pyrimidin-5-yl]pyrrolidin-2-yl]ethanoic acid, B-cell lymphoma 6 protein, CHLORIDE ION
Authors:Robb, G, Ferguson, A, Hargreaves, D.
Deposit date:2017-02-06
Release date:2017-05-17
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors.
J. Med. Chem., 60, 2017
5N1Z
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BU of 5n1z by Molmil
Crystal structure of the BCL6 BTB domain in complex with pyrazolo-pyrimidine macrocyclic ligand
Descriptor: B-cell lymphoma 6 protein, CHLORIDE ION, pyrazolo-pyrimidine macrocycle
Authors:Robb, G, Ferguson, A, Hargreaves, D.
Deposit date:2017-02-06
Release date:2017-05-17
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors.
J. Med. Chem., 60, 2017
5N1X
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BU of 5n1x by Molmil
Crystal structure of the BCL6 BTB domain in complex with pyrazolo-pyrimidine ligand
Descriptor: B-cell lymphoma 6 protein, ~{N}-ethyl-5-pyridin-3-yl-pyrazolo[1,5-a]pyrimidin-7-amine
Authors:Robb, G, Ferguson, A, Hargreaves, D.
Deposit date:2017-02-06
Release date:2017-05-17
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors.
J. Med. Chem., 60, 2017

226707

数据于2024-10-30公开中

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