8XQA
 
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8XQ7
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8XPQ
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8XQ9
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5LRM
 | | Structure of di-zinc MCR-1 in P41212 space group | | Descriptor: | GLYCEROL, ZINC ION, phosphatidylethanolamine transferase Mcr-1 | | Authors: | Hinchliffe, P, Spencer, J. | | Deposit date: | 2016-08-19 | | Release date: | 2016-12-07 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Insights into the Mechanistic Basis of Plasmid-Mediated Colistin Resistance from Crystal Structures of the Catalytic Domain of MCR-1.
Sci Rep, 7, 2017
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8XJJ
 | | Co-crystal structure of SOS-1 and a potent, selective and orally bioavailable SOS1 inhibitor RGT-018 | | Descriptor: | 1,2-ETHANEDIOL, 5-[4-[[(1~{R})-1-[3-[bis(fluoranyl)methyl]-2-fluoranyl-phenyl]ethyl]amino]-2-methyl-6-morpholin-4-yl-7-oxidanylidene-pyrido[4,3-d]pyrimidin-8-yl]pyridine-2-carbonitrile, Son of sevenless homolog 1 | | Authors: | Ren, X. | | Deposit date: | 2023-12-21 | | Release date: | 2024-08-14 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Discovery of RGT-018: a Potent, Selective and Orally Bioavailable SOS1 Inhibitor for KRAS-driven Cancers.
Mol.Cancer Ther., 2024
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4R05
 | | Crystal structure of the refolded DENV3 methyltransferase | | Descriptor: | Nonstructural protein NS5 | | Authors: | Brecher, M.B, Li, Z, Zhang, J, Chen, H, Lin, Q, Liu, B, Li, H.M. | | Deposit date: | 2014-07-29 | | Release date: | 2014-11-12 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Refolding of a fully functional flavivirus methyltransferase revealed that S-adenosyl methionine but not S-adenosyl homocysteine is copurified with flavivirus methyltransferase.
Protein Sci., 24, 2015
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2OY0
 | | Crystal structure of the West Nile virus methyltransferase | | Descriptor: | Methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE | | Authors: | Li, H.M, Zhao, Y.W, Guo, Y, Shi, P.Y. | | Deposit date: | 2007-02-21 | | Release date: | 2007-04-03 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structure and Function of Flavivirus NS5 Methyltransferase.
J.Virol., 81, 2007
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6NPE
 | | C-abl Kinase domain with the activator(cmpd6), 2-cyano-N-(4-(3,4-dichlorophenyl)thiazol-2-yl)acetamide | | Descriptor: | 2-cyano-~{N}-[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]ethanamide, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, NONAETHYLENE GLYCOL, ... | | Authors: | campobasso, N. | | Deposit date: | 2019-01-17 | | Release date: | 2019-03-13 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Identification and Optimization of Novel Small c-Abl Kinase Activators Using Fragment and HTS Methodologies.
J. Med. Chem., 62, 2019
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6NPV
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6NPU
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8XZE
 | | Crystal structure of THF-II riboswitch with THF and soaked with Ir | | Descriptor: | (6S)-5,6,7,8-TETRAHYDROFOLATE, IRIDIUM ION, MAGNESIUM ION, ... | | Authors: | Li, C.Y, Ren, A.M. | | Deposit date: | 2024-01-21 | | Release date: | 2024-07-24 | | Last modified: | 2024-08-21 | | Method: | X-RAY DIFFRACTION (2.34 Å) | | Cite: | Structure-based characterization and compound identification of the wild-type THF class-II riboswitch.
Nucleic Acids Res., 52, 2024
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8XZR
 | | Crystal structure of folE riboswitch with 8-NH2 Guanine | | Descriptor: | 8-AMINOGUANINE, MAGNESIUM ION, RNA (53-MER), ... | | Authors: | Li, C.Y, Ren, A.M. | | Deposit date: | 2024-01-21 | | Release date: | 2024-07-24 | | Last modified: | 2024-08-21 | | Method: | X-RAY DIFFRACTION (1.83 Å) | | Cite: | Structure-based characterization and compound identification of the wild-type THF class-II riboswitch.
Nucleic Acids Res., 52, 2024
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8XZP
 | | Crystal structure of folE riboswitch with 8-CH3 Guanine | | Descriptor: | 2-azanyl-8-methyl-1,9-dihydropurin-6-one, MAGNESIUM ION, RNA (53-MER), ... | | Authors: | Li, C.Y, Ren, A.M. | | Deposit date: | 2024-01-21 | | Release date: | 2024-07-24 | | Last modified: | 2024-08-21 | | Method: | X-RAY DIFFRACTION (2.18 Å) | | Cite: | Structure-based characterization and compound identification of the wild-type THF class-II riboswitch.
Nucleic Acids Res., 52, 2024
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8XZM
 | | Crystal structure of folE riboswitch with DHN | | Descriptor: | 2-AMINO-7,8-DIHYDRO-6-(1,2,3-TRIHYDROXYPROPYL)-4(1H)-PTERIDINONE, MAGNESIUM ION, RNA (53-MER), ... | | Authors: | Li, C.Y, Ren, A.M. | | Deposit date: | 2024-01-21 | | Release date: | 2024-07-24 | | Last modified: | 2024-08-21 | | Method: | X-RAY DIFFRACTION (1.98 Å) | | Cite: | Structure-based characterization and compound identification of the wild-type THF class-II riboswitch.
Nucleic Acids Res., 52, 2024
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8XZO
 | | Crystal structure of folE riboswitch with Guanine | | Descriptor: | GUANINE, MAGNESIUM ION, RNA (53-MER), ... | | Authors: | Li, C.Y, Ren, A.M. | | Deposit date: | 2024-01-21 | | Release date: | 2024-07-24 | | Last modified: | 2024-08-21 | | Method: | X-RAY DIFFRACTION (1.97 Å) | | Cite: | Structure-based characterization and compound identification of the wild-type THF class-II riboswitch.
Nucleic Acids Res., 52, 2024
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8XZK
 | | Crystal structure of folE riboswitch | | Descriptor: | RNA (53-MER) | | Authors: | Li, C.Y, Ren, A.M. | | Deposit date: | 2024-01-21 | | Release date: | 2024-07-24 | | Last modified: | 2024-08-21 | | Method: | X-RAY DIFFRACTION (2.58 Å) | | Cite: | Structure-based characterization and compound identification of the wild-type THF class-II riboswitch.
Nucleic Acids Res., 52, 2024
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8XZW
 | | Crystal structure of THF-II riboswitch with THF and soaked with Ir | | Descriptor: | (6S)-5,6,7,8-TETRAHYDROFOLATE, MAGNESIUM ION, RNA (53-MER), ... | | Authors: | Li, C.Y, Ren, A.M. | | Deposit date: | 2024-01-21 | | Release date: | 2024-07-24 | | Last modified: | 2024-08-21 | | Method: | X-RAY DIFFRACTION (1.91 Å) | | Cite: | Structure-based characterization and compound identification of the wild-type THF class-II riboswitch.
Nucleic Acids Res., 52, 2024
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8XZQ
 | | Crystal structure of folE riboswitch with 8-N Guanine | | Descriptor: | 5-AMINO-1H-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDIN-7-OL, MAGNESIUM ION, RNA (53-MER), ... | | Authors: | Li, C.Y, Ren, A.M. | | Deposit date: | 2024-01-21 | | Release date: | 2024-07-24 | | Last modified: | 2024-08-21 | | Method: | X-RAY DIFFRACTION (1.83 Å) | | Cite: | Structure-based characterization and compound identification of the wild-type THF class-II riboswitch.
Nucleic Acids Res., 52, 2024
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8XZL
 | | Crystal structure of folE riboswitch with DHF | | Descriptor: | DIHYDROFOLIC ACID, MAGNESIUM ION, RNA (53-MER), ... | | Authors: | Li, C.Y, Ren, A.M. | | Deposit date: | 2024-01-21 | | Release date: | 2024-07-24 | | Last modified: | 2024-08-21 | | Method: | X-RAY DIFFRACTION (2.13 Å) | | Cite: | Structure-based characterization and compound identification of the wild-type THF class-II riboswitch.
Nucleic Acids Res., 52, 2024
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8XZN
 | | Crystal structure of folE riboswitch with BH4 | | Descriptor: | 5,6,7,8-TETRAHYDROBIOPTERIN, MAGNESIUM ION, RNA (53-MER), ... | | Authors: | Li, C.Y, Ren, A.M. | | Deposit date: | 2024-01-21 | | Release date: | 2024-07-24 | | Last modified: | 2024-08-21 | | Method: | X-RAY DIFFRACTION (1.82 Å) | | Cite: | Structure-based characterization and compound identification of the wild-type THF class-II riboswitch.
Nucleic Acids Res., 52, 2024
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6ED3
 | | Mtb ClpB in complex with AMPPNP | | Descriptor: | Chaperone protein ClpB | | Authors: | Yu, H.J, Li, H.L. | | Deposit date: | 2018-08-08 | | Release date: | 2018-09-26 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (6.3 Å) | | Cite: | ATP hydrolysis-coupled peptide translocation mechanism ofMycobacterium tuberculosisClpB.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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8Y7L
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4MXM
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3DOY
 | | Crystal structure of (3R)-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ) from Helicobacter pylori in complex with compound 3i | | Descriptor: | (3R)-hydroxymyristoyl-acyl carrier protein dehydratase, 4-chloro-N'-[(1E)-(3,5-dibromo-2,4-dihydroxyphenyl)methylidene]benzohydrazide, BENZAMIDINE, ... | | Authors: | Zhang, L, He, L, Liu, X, Liu, H, Shen, X, Jiang, H. | | Deposit date: | 2008-07-07 | | Release date: | 2009-05-05 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Discovering potent inhibitors against the beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ) of Helicobacter pylori: structure-based design, synthesis, bioassay, and crystal structure determination.
J.Med.Chem., 52, 2009
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