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Porcine pancreatic elastase complexed with beta-casomorphin-7 and Lys-Ser at pH 5.0
Descriptor:	CALCIUM ION, Elastase-1, LYSINE, ...
Authors:	Liu, B, Schofield, C.J, Wilmouth, R.C.
Deposit date:	2005-10-20
Release date:	2006-05-30
Last modified:	2023-10-25
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	Structural analyses on intermediates in serine protease catalysis J.Biol.Chem., 281, 2006

7UQ3

JmjC domain-containing protein 5 (JMJD5) in complex with Mn and (S)-2-(1-hydroxy-2,5-dioxopyrrolidin-3-yl)acetic acid
Descriptor:	Bifunctional peptidase and arginyl-hydroxylase JMJD5, GLYCEROL, MANGANESE (II) ION, ...
Authors:	Chowdhury, R, Islam, M.S, Schofield, C.J.
Deposit date:	2022-04-19
Release date:	2022-12-21
Last modified:	2023-10-25
Method:	X-RAY DIFFRACTION (1.49 Å)
Cite:	Structural analysis of the 2-oxoglutarate binding site of the circadian rhythm linked oxygenase JMJD5. Sci Rep, 12, 2022

2BB4

Porcine pancreatic elastase complexed with beta-casomorphin-7 and Asp-Phe at pH 5.0
Descriptor:	ASPARTIC ACID, CALCIUM ION, Elastase-1, ...
Authors:	Liu, B, Schofield, C.J, Wilmouth, R.C.
Deposit date:	2005-10-17
Release date:	2006-05-30
Last modified:	2023-10-25
Method:	X-RAY DIFFRACTION (1.6 Å)
Cite:	Structural analyses on intermediates in serine protease catalysis J.Biol.Chem., 281, 2006

1YCI

Factor inhibiting HIF-1 alpha in complex with N-(carboxycarbonyl)-D-phenylalanine
Descriptor:	FE (II) ION, Hypoxia-inducible factor 1 alpha inhibitor, N-(CARBOXYCARBONYL)-D-PHENYLALANINE, ...
Authors:	McDonough, M.A, Schofield, C.J.
Deposit date:	2004-12-22
Release date:	2005-05-31
Last modified:	2023-10-25
Method:	X-RAY DIFFRACTION (2.7 Å)
Cite:	Selective inhibition of factor inhibiting hypoxia-inducible factor J.Am.Chem.Soc., 127, 2005

2ILM

Factor Inhibiting HIF-1 Alpha D201A Mutant in Complex with FE(II), Alpha-Ketoglutarate and HIF-1 Alpha 35mer
Descriptor:	2-OXOGLUTARIC ACID, BICARBONATE ION, FE (II) ION, ...
Authors:	Mcdonough, M.A, Schofield, C.J.
Deposit date:	2006-10-03
Release date:	2007-08-14
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Evidence that two enzyme-derived histidine ligands are sufficient for iron binding and catalysis by factor inhibiting HIF (FIH). J.Biol.Chem., 283, 2008

6QGV

HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with a Spiro[4.5]decanone inhibitor (JPHM-2-167)
Descriptor:	8-[(3-methylpyridin-2-yl)methyl]-3-(4-phenylphenyl)-1-pyrimidin-2-yl-1,3,8-triazaspiro[4.5]decane-2,4-dione, Egl nine homolog 1, GLYCEROL, ...
Authors:	Chowdhury, R, Holt-Martyn, J.P, Rahman, M.Z, Schofield, C.J.
Deposit date:	2019-01-13
Release date:	2020-02-05
Last modified:	2024-01-24
Method:	X-RAY DIFFRACTION (1.4 Å)
Cite:	Studies on spiro[4.5]decanone prolyl hydroxylase domain inhibitors. Medchemcomm, 10, 2019

6ST3

HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with 4-hydroxy-N-(4-phenoxybenzyl)-2-(1H-pyrazol-1-yl)pyrimidine-5-carboxamide
Descriptor:	4-oxidanyl-~{N}-[(4-phenoxyphenyl)methyl]-2-pyrazol-1-yl-pyrimidine-5-carboxamide, Egl nine homolog 1, FORMIC ACID, ...
Authors:	Chowdhury, R, Holt-Martyn, J.P, Schofield, C.J.
Deposit date:	2019-09-10
Release date:	2019-12-04
Last modified:	2024-01-24
Method:	X-RAY DIFFRACTION (2.426 Å)
Cite:	Structure-Activity Relationship and Crystallographic Studies on 4-Hydroxypyrimidine HIF Prolyl Hydroxylase Domain Inhibitors. Chemmedchem, 15, 2020

2ZGG

Asn-hydroxylation stabilises the ankyrin repeat domain fold
Descriptor:	3 repeat synthetic ankyrin, CADMIUM ION, COBALT (II) ION
Authors:	McDonough, M.A, Schofield, C.J.
Deposit date:	2008-01-21
Release date:	2008-02-05
Last modified:	2023-11-01
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Asparagine beta-hydroxylation stabilizes the ankyrin repeat domain fold Mol Biosyst, 5, 2009

2Y34

S-nitrosylated PHD2 (NO exposed) in complex with Fe(II) and UN9
Descriptor:	EGL NINE HOMOLOG 1, FE (II) ION, N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE
Authors:	Chowdhury, R, McDonough, M.A, Schofield, C.J.
Deposit date:	2010-12-18
Release date:	2010-12-29
Last modified:	2023-12-20
Method:	X-RAY DIFFRACTION (2.01 Å)
Cite:	Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1). J. Mol. Biol., 410, 2011

2Y33

S-nitrosylated PHD2 (GSNO soaked) in complex with Zn(II) and UN9
Descriptor:	EGL NINE HOMOLOG 1, N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE, ZINC ION
Authors:	Chowdhury, R, Clifton, I.J, Schofield, C.J.
Deposit date:	2010-12-18
Release date:	2010-12-29
Last modified:	2023-12-20
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Studies on the Reaction of Nitric Oxide with the Hypoxia-Inducible Factor Prolyl Hydroxylase Domain 2 (Egln1) J.Mol.Biol., 410, 2011

2ZGD

Asn-hydroxylation stabilises the ankyrin repeat domain fold
Descriptor:	3 repeat synthetic ankyrin, CADMIUM ION, CHLORIDE ION
Authors:	McDonough, M.A, Schofield, C.J.
Deposit date:	2008-01-21
Release date:	2008-02-05
Last modified:	2023-11-01
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Asparagine beta-hydroxylation stabilizes the ankyrin repeat domain fold Mol Biosyst, 5, 2009

5LAS

HIF prolyl hydroxylase 2 (PHD2-R281C/P317C/R396T) cross-linked to HIF-1alpha NODD-L397C/D412C and N-oxalylglycine (NOG) (complex-3)
Descriptor:	Egl nine homolog 1, Hypoxia-inducible factor 1-alpha, MANGANESE (II) ION, ...
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2016-06-14
Release date:	2016-08-31
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

5LB6

HIF prolyl hydroxylase 2 (PHD2/EGLN1) R371H variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/UN9)
Descriptor:	Egl nine homolog 1, GLYCEROL, MANGANESE (II) ION, ...
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2016-06-15
Release date:	2016-08-31
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

5LBE

HIF prolyl hydroxylase 2 (PHD2/EGLN1) G294E variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/FG2216)
Descriptor:	BICARBONATE ION, Egl nine homolog 1, MANGANESE (II) ION, ...
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2016-06-15
Release date:	2016-08-31
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (1.749 Å)
Cite:	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

5LBC

HIF prolyl hydroxylase 2 (PHD2/EGLN1) I280V/R281L/I292V variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/FG2216)
Descriptor:	BICARBONATE ION, CHLORIDE ION, Egl nine homolog 1, ...
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2016-06-15
Release date:	2016-08-31
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (1.816 Å)
Cite:	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

5LBB

HIF prolyl hydroxylase 2 (PHD2/EGLN1) R396T variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/UN9)
Descriptor:	BICARBONATE ION, Egl nine homolog 1, MANGANESE (II) ION, ...
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2016-06-15
Release date:	2016-08-31
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

5L9R

HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with N-oxalylglycine (NOG)
Descriptor:	Egl nine homolog 1, GLYCEROL, MANGANESE (II) ION, ...
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2016-06-10
Release date:	2016-08-31
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (1.81 Å)
Cite:	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

5LBF

HIF prolyl hydroxylase 2 (PHD2/EGLN1) K293K/G294E variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/FG2216)
Descriptor:	BICARBONATE ION, Egl nine homolog 1, MANGANESE (II) ION, ...
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2016-06-16
Release date:	2016-08-31
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (1.8995 Å)
Cite:	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

5LAT

HIF prolyl hydroxylase 2 (PHD2/EGLN1) P317R variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/UN9)
Descriptor:	BICARBONATE ION, Egl nine homolog 1, GLYCEROL, ...
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2016-06-15
Release date:	2016-08-31
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

5L9B

HIF PROLYL HYDROXYLASE 2 (PHD2/ EGLN1) IN COMPLEX WITH 2-OXOGLUTARATE (2OG) AND HIF-1ALPHA CODD (556-574)
Descriptor:	2-OXOGLUTARIC ACID, Egl nine homolog 1, Hypoxia-inducible factor 1-alpha, ...
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2016-06-10
Release date:	2016-08-31
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

5LA9

HIF prolyl hydroxylase 2 (PHD2-R281C/V314C) cross-linked to HIF-1alpha NODD-L397C/D412C and N-oxalylglycine (NOG) (complex-2)
Descriptor:	Egl nine homolog 1, Hypoxia-inducible factor 1-alpha, MANGANESE (II) ION, ...
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2016-06-14
Release date:	2016-08-31
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (2.813 Å)
Cite:	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

7YXI

Drosophila melanogaster JMJD7 (dmJMJD7) in complex with Mn and N-oxalylglycine (NOG)
Descriptor:	1,2-ETHANEDIOL, GH14974p, MANGANESE (II) ION, ...
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2022-02-16
Release date:	2022-04-27
Last modified:	2024-01-31
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Conservation of the unusual dimeric JmjC fold of JMJD7 from Drosophila melanogaster to humans. Sci Rep, 12, 2022

7YXL

Drosophila melanogaster JMJD7 (dmJMJD7) in complex with Mn and N-oxalyl-D-phenylalanine (NOFD)
Descriptor:	1,2-ETHANEDIOL, ACETATE ION, GH14974p, ...
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2022-02-16
Release date:	2022-04-27
Last modified:	2024-01-31
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Conservation of the unusual dimeric JmjC fold of JMJD7 from Drosophila melanogaster to humans. Sci Rep, 12, 2022

7YXG

Drosophila melanogaster JMJD7 (dmJMJD7) in complex with Mn and 2OG
Descriptor:	1,2-ETHANEDIOL, 2-OXOGLUTARIC ACID, GH14974p, ...
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2022-02-16
Release date:	2022-04-27
Last modified:	2024-01-31
Method:	X-RAY DIFFRACTION (1.641 Å)
Cite:	Conservation of the unusual dimeric JmjC fold of JMJD7 from Drosophila melanogaster to humans. Sci Rep, 12, 2022

7YXK

Drosophila melanogaster JMJD7 (dmJMJD7) in complex with Mn and N-oxalyl-D-alanine (NODA)
Descriptor:	(2~{R})-2-(carboxycarbonylamino)propanoic acid, 1,2-ETHANEDIOL, ACETATE ION, ...
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2022-02-16
Release date:	2022-04-27
Last modified:	2024-01-31
Method:	X-RAY DIFFRACTION (2.43 Å)
Cite:	Conservation of the unusual dimeric JmjC fold of JMJD7 from Drosophila melanogaster to humans. Sci Rep, 12, 2022

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