8UZB
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![BU of 8uzb by Molmil](/molmil-images/mine/8uzb) | Cryo-EM structure of iGeoCas9 in complex with sgRNA and target DNA | Descriptor: | CRISPR-associated endonuclease Cas9, Non-target strand DNA, RNA (107-MER), ... | Authors: | Eggers, A.R, Soczek, K.M, Tuck, O.T, Doudna, J.A. | Deposit date: | 2023-11-14 | Release date: | 2024-05-29 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (2.63 Å) | Cite: | Rapid DNA unwinding accelerates genome editing by engineered CRISPR-Cas9. Cell, 2024
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9AXF
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![BU of 9axf by Molmil](/molmil-images/mine/9axf) | Structure of human calcium-sensing receptor in complex with chimeric Gq (miniGisq) protein in detergent | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(2-chlorophenyl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]propan-1-amine, ... | Authors: | Zuo, H, Park, J, Frangaj, A, Ye, J, Lu, G, Manning, J.J, Asher, W.B, Lu, Z, Hu, G, Wang, L, Mendez, J, Eng, E, Zhang, Z, Lin, X, Grasucci, R, Hendrickson, W.A, Clarke, O.B, Javitch, J.A, Conigrave, A.D, Fan, Q.R. | Deposit date: | 2024-03-06 | Release date: | 2024-04-17 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Promiscuous G-protein activation by the calcium-sensing receptor. Nature, 629, 2024
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8UZA
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![BU of 8uza by Molmil](/molmil-images/mine/8uza) | Cryo-EM structure of GeoCas9 in complex with sgRNA and target DNA | Descriptor: | CRISPR-associated endonuclease Cas9, Non-target strand DNA, Target strand DNA, ... | Authors: | Eggers, A.R, Soczek, K.M, Tuck, O.T, Doudna, J.A. | Deposit date: | 2023-11-14 | Release date: | 2024-05-29 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.17 Å) | Cite: | Rapid DNA unwinding accelerates genome editing by engineered CRISPR-Cas9. Cell, 2024
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8V11
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![BU of 8v11 by Molmil](/molmil-images/mine/8v11) | |
9AVG
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![BU of 9avg by Molmil](/molmil-images/mine/9avg) | Structure of human calcium-sensing receptor in complex with chimeric Gs (miniGis) protein in nanodiscs | Descriptor: | (19R,22S,25R)-22,25,26-trihydroxy-16,22-dioxo-17,21,23-trioxa-22lambda~5~-phosphahexacosan-19-yl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Zuo, H, Park, J, Frangaj, A, Ye, J, Lu, G, Manning, J.J, Asher, W.B, Lu, Z, Hu, G, Wang, L, Mendez, J, Eng, E, Zhang, Z, Lin, X, Grasucci, R, Hendrickson, W.A, Clarke, O.B, Javitch, J.A, Conigrave, A.D, Fan, Q.R. | Deposit date: | 2024-03-02 | Release date: | 2024-04-17 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Promiscuous G-protein activation by the calcium-sensing receptor. Nature, 629, 2024
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9ASB
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![BU of 9asb by Molmil](/molmil-images/mine/9asb) | Structure of human calcium-sensing receptor in complex with chimeric Gq (miniGisq) protein in nanodiscs | Descriptor: | (19R,22S,25R)-22,25,26-trihydroxy-16,22-dioxo-17,21,23-trioxa-22lambda~5~-phosphahexacosan-19-yl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Zuo, H, Park, J, Frangaj, A, Ye, J, Lu, G, Manning, J.J, Asher, W.B, Lu, Z, Hu, G, Wang, L, Mendez, J, Eng, E, Zhang, Z, Lin, X, Grasucci, R, Hendrickson, W.A, Clarke, O.B, Javitch, J.A, Conigrave, A.D, Fan, Q.R. | Deposit date: | 2024-02-24 | Release date: | 2024-04-17 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Promiscuous G-protein activation by the calcium-sensing receptor. Nature, 629, 2024
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9AZI
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![BU of 9azi by Molmil](/molmil-images/mine/9azi) | |
1MDU
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![BU of 1mdu by Molmil](/molmil-images/mine/1mdu) | Crystal structure of the chicken actin trimer complexed with human gelsolin segment 1 (GS-1) | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, ... | Authors: | Dawson, J.F, Sablin, E.P, Spudich, J.A, Fletterick, R.J. | Deposit date: | 2002-08-07 | Release date: | 2003-01-07 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure of an F-actin trimer disrupted by gelsolin and implications for the mechanism of severing J.Biol.Chem., 278, 2003
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5JGY
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![BU of 5jgy by Molmil](/molmil-images/mine/5jgy) | Crystal structure of maize AKR4C13 in P21 space group | Descriptor: | 1,2-ETHANEDIOL, 4-{[(2R,3R,4S,5R)-5-({[(R)-{[(R)-{[(2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxy-4-(phosphonooxy)tetrahydrofuran-2-yl]methoxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}methyl)-3,4-dihydroxytetrahydrofuran-2-yl]oxy}butanoic acid (non-preferred name), Aldose reductase, ... | Authors: | Santos, M.L, Giuseppe, P.O, Kiyota, E, Sousa, S.M, Schmelz, E.A, Yunes, J.A, Koch, K.E, Murakami, M.T, Aparicio, R. | Deposit date: | 2016-04-20 | Release date: | 2017-05-03 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Crystal structure of maize AKR4C13 in P21 space group To Be Published
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5JCG
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![BU of 5jcg by Molmil](/molmil-images/mine/5jcg) | |
5JH1
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![BU of 5jh1 by Molmil](/molmil-images/mine/5jh1) | Crystal structure of the apo form of AKR4C7 from maize | Descriptor: | Aldose reductase, AKR4C7 | Authors: | Giuseppe, P.O, Santos, M.L, Sousa, S.M, Koch, K.E, Yunes, J.A, Aparicio, R, Murakami, M.T. | Deposit date: | 2016-04-20 | Release date: | 2016-11-09 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | A comparative structural analysis reveals distinctive features of co-factor binding and substrate specificity in plant aldo-keto reductases. Biochem.Biophys.Res.Commun., 474, 2016
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1MTP
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![BU of 1mtp by Molmil](/molmil-images/mine/1mtp) | The X-ray crystal structure of a serpin from a thermophilic prokaryote | Descriptor: | Serine Proteinase Inhibitor (SERPIN), Chain A, Chain B | Authors: | Irving, J.A, Cabrita, L.D, Rossjohn, J, Pike, R.N, Bottomley, S.P, Whisstock, J.C. | Deposit date: | 2002-09-21 | Release date: | 2003-04-15 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | The 1.5 A crystal structure of a prokaryote serpin: controlling conformational change in a heated environment Structure, 11, 2003
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1N19
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![BU of 1n19 by Molmil](/molmil-images/mine/1n19) | Structure of the HSOD A4V mutant | Descriptor: | COPPER (I) ION, SULFATE ION, Superoxide Dismutase [Cu-Zn], ... | Authors: | Cardoso, R.M.F, Thayer, M.M, DiDonato, M, Lo, T.P, Bruns, C.K, Getzoff, E.D, Tainer, J.A. | Deposit date: | 2002-10-16 | Release date: | 2002-11-27 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Insights into Lou Gehrig's disease from the structure and instability of the A4V mutant of human Cu,Zn superoxide dismutase. J.Mol.Biol., 324, 2002
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1N0N
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![BU of 1n0n by Molmil](/molmil-images/mine/1n0n) | Catalytic and Structural Effects of Amino-Acid Substitution at His30 in Human Manganese Superoxide Dismutase | Descriptor: | MANGANESE (II) ION, SULFATE ION, Superoxide dismutase [Mn] | Authors: | Borgstahl, G.E.O, Parge, H.E, Hickey, M.J, Beyer Jr, W.F, Hallewell, R.A, Tainer, J.A. | Deposit date: | 2002-10-14 | Release date: | 2002-11-06 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | Catalytic and Structural Effects of Amino-Acid Substitution at His30 in Human Manganese Superoxide Dismutase to be published
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5JFT
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![BU of 5jft by Molmil](/molmil-images/mine/5jft) | Zebra Fish Caspase-3 | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, ACE-ASP-GLU-VAL-ASK, ... | Authors: | Tucker, M.B, MacKenzie, S.H, Maciag, J.J, Dirscherl, H, Swartz, P.D, Yoder, J.A, Hamilton, P.T, Clark, A.C. | Deposit date: | 2016-04-19 | Release date: | 2016-10-26 | Last modified: | 2016-11-02 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | Phage display and structural studies reveal plasticity in substrate specificity of caspase-3a from zebrafish. Protein Sci., 25, 2016
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1MUD
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![BU of 1mud by Molmil](/molmil-images/mine/1mud) | CATALYTIC DOMAIN OF MUTY FROM ESCHERICHIA COLI, D138N MUTANT COMPLEXED TO ADENINE | Descriptor: | ADENINE, Adenine DNA glycosylase, GLYCEROL, ... | Authors: | Guan, Y, Tainer, J.A. | Deposit date: | 1998-08-20 | Release date: | 1999-09-20 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | MutY catalytic core, mutant and bound adenine structures define specificity for DNA repair enzyme superfamily. Nat.Struct.Biol., 5, 1998
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5J8K
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![BU of 5j8k by Molmil](/molmil-images/mine/5j8k) | Architecture of supercomplex I-III2 | Descriptor: | COMPLEX I 13KDA/NDUFS6, COMPLEX I 15KDA/NDUFS5, COMPLEX I 18KDA/NDUFS6, ... | Authors: | Letts, J.A, Fiedorczuk, K, Sazanov, L.A. | Deposit date: | 2016-04-08 | Release date: | 2016-09-21 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (7.8 Å) | Cite: | The architecture of respiratory supercomplexes. Nature, 537, 2016
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1MUO
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![BU of 1muo by Molmil](/molmil-images/mine/1muo) | CRYSTAL STRUCTURE OF AURORA-2, AN ONCOGENIC SERINE-THREONINE KINASE | Descriptor: | ADENOSINE, Aurora-related kinase 1 | Authors: | Cheetham, G.M.T, Knegtel, R.M.A, Coll, J.T, Renwick, S.B, Swenson, L, Weber, P, Lippke, J.A, Austen, D.A. | Deposit date: | 2002-09-24 | Release date: | 2003-04-15 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Crystal Structure of Aurora-2, an Oncogenic Serine/Threonine Kinase J.Biol.Chem., 277, 2002
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1N0J
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![BU of 1n0j by Molmil](/molmil-images/mine/1n0j) | |
1N1D
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![BU of 1n1d by Molmil](/molmil-images/mine/1n1d) | Glycerol-3-phosphate cytidylyltransferase complexed with CDP-glycerol | Descriptor: | SULFATE ION, [CYTIDINE-5'-PHOSPHATE] GLYCERYLPHOSPHORIC ACID ESTER, glycerol-3-phosphate cytidylyltransferase | Authors: | Pattridge, K.A, Weber, C.H, Friesen, J.A, Sankar, S, Kent, C, Ludwig, M.L. | Deposit date: | 2002-10-17 | Release date: | 2003-11-11 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Glycerol-3-phosphate cytidylyltransferase. Structural changes induced by binding of CDP-glycerol and the role of lysine residues in catalysis J.Biol.Chem., 278, 2003
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1MRU
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![BU of 1mru by Molmil](/molmil-images/mine/1mru) | Intracellular Ser/Thr protein kinase domain of Mycobacterium tuberculosis PknB. | Descriptor: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Probable serine/threonine-protein kinase pknB | Authors: | Young, T.A, Delagoutte, B, Endrizzi, J.A, Alber, T, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2002-09-18 | Release date: | 2003-02-11 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structure of Mycobacterium tuberculosis PknB supports a universal activation mechanism for Ser/Thr protein kinases. Nat.Struct.Biol., 10, 2003
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1N25
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![BU of 1n25 by Molmil](/molmil-images/mine/1n25) | Crystal structure of the SV40 Large T antigen helicase domain | Descriptor: | Large T Antigen, ZINC ION | Authors: | Li, D, Zhao, R, Lilyestrom, W, Gai, D, Zhang, R, DeCaprio, J.A, Fanning, E, Jochimiak, A, Szakonyi, G, Chen, X.S. | Deposit date: | 2002-10-21 | Release date: | 2003-06-03 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure of the replicative helicase of the oncoprotein SV40 large tumour antigen Nature, 423, 2003
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1MXE
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![BU of 1mxe by Molmil](/molmil-images/mine/1mxe) | Structure of the Complex of Calmodulin with the Target Sequence of CaMKI | Descriptor: | CALCIUM ION, Calmodulin, Target Sequence of rat Calmodulin-Dependent Protein Kinase I | Authors: | Clapperton, J.A, Martin, S.R, Smerdon, S.J, Gamblin, S.J, Bayley, P.M. | Deposit date: | 2002-10-02 | Release date: | 2002-12-04 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structure of the Complex
of Calmodulin with the Target
Sequence of Calmodulin-Dependent
Protein Kinase I: Studies of the
Kinase Activation Mechanism Biochemistry, 41, 2002
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1N4C
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![BU of 1n4c by Molmil](/molmil-images/mine/1n4c) | NMR Structure of the J-Domain and Clathrin Substrate Binding Domain of Bovine Auxilin | Descriptor: | Auxilin | Authors: | Gruschus, J.M, Han, C.J, Greener, T, Greene, L.E, Ferretti, J.A, Eisenberg, E. | Deposit date: | 2002-10-30 | Release date: | 2003-11-11 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structure of the functional fragment of auxilin required for catalytic uncoating of clathrin-coated vesicles. Biochemistry, 43, 2004
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2QZ0
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![BU of 2qz0 by Molmil](/molmil-images/mine/2qz0) | Mature Q183E variant of Green Fluorescent Protein Chromophore | Descriptor: | Green fluorescent protein, MAGNESIUM ION | Authors: | Wood, T.I, Barondeau, D.P, Hitomi, C, Tainer, J.A, Getzoff, E.D. | Deposit date: | 2007-08-15 | Release date: | 2009-04-21 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Kinetically Isolated Reaction Intermediates Provide Structural Characterization of the GFP Fluorophore Biosynthesis Pathway To be Published
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