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Ankyrin repeat protein from Leishmania major
Descriptor:	hypothetical protein
Authors:	Holmes, M.A, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2010-01-26
Release date:	2010-02-09
Last modified:	2017-11-01
Method:	X-RAY DIFFRACTION (2.9 Å)
Cite:	Ankyrin repeat protein from Leishmania major To be Published

3LSS

Trypanosoma brucei seryl-tRNA synthetase in complex with ATP
Descriptor:	ADENOSINE-5'-TRIPHOSPHATE, MALONATE ION, SODIUM ION, ...
Authors:	Larson, E.T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:	2010-02-12
Release date:	2010-03-02
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	X-ray crystal structure of Seryl-tRNA synthetase from the eukaryotic parasite Trypanosoma brucei. to be published

3LX3

Plasmodium vivax 6-pyruvoyltetrahydropterin synthase (PTPS) in complex with xanthopterin
Descriptor:	2-amino-1,5-dihydropteridine-4,6-dione, 6-pyruvoyl tetrahydrobiopterin synthase, ZINC ION
Authors:	Larson, E.T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:	2010-02-24
Release date:	2010-03-09
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (1.55 Å)
Cite:	Structural analysis of the dual-functional 6-pyruvoyltetrahydropterin synthase from Malaria parasites. to be published

3M4P

Entamoeba histolytica asparaginyl-tRNA synthetase (AsnRS) in complex with asparaginyl-adenylate
Descriptor:	4-AMINO-1,4-DIOXOBUTAN-2-AMINIUM ADENOSINE-5'-MONOPHOSPHATE, Asparaginyl-tRNA synthetase, putative, ...
Authors:	Larson, E.T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:	2010-03-11
Release date:	2010-03-23
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (2.83 Å)
Cite:	X-ray crystal structure of asparaginyl-tRNA synthetase from the eukaryotic human pathogen Entamoeba histolytica. to be published

3M4Q

Entamoeba histolytica asparaginyl-tRNA synthetase (AsnRS)
Descriptor:	Asparaginyl-tRNA synthetase, putative
Authors:	Larson, E.T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:	2010-03-11
Release date:	2010-03-23
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (3 Å)
Cite:	X-ray crystal structure of asparaginyl-tRNA synthetase from the eukaryotic human pathogen Entamoeba histolytica. to be published

3KPA

Ubiquitin fold modifier conjugating enzyme from Leishmania major (probable)
Descriptor:	probable Ubiquitin fold modifier conjugating enzyme
Authors:	Han, G.W, Le Trong, I, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2009-11-16
Release date:	2009-12-01
Last modified:	2023-11-22
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Ubiquitin fold modifier conjugating enzyme from Leishmania major (probable) To be Published

6VYE

6-phosphogluconolactonase from Trypanosoma cruzi
Descriptor:	6-phosphogluconolactonase, GLYCEROL, PHOSPHATE ION
Authors:	Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2020-02-26
Release date:	2020-03-18
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	6-phosphogluconolactonase from Trypanosoma cruzi To be published

3LZE

Plasmodium vivax 6-pyruvoyltetrahydropterin synthase (PTPS), E37C catalytic residue mutant
Descriptor:	PTERINE, Putative 6-pyruvoyl tetrahydrobiopterin synthase, ZINC ION
Authors:	Larson, E.T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:	2010-03-01
Release date:	2010-04-07
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Structural analysis of the dual-functional 6-pyruvoyltetrahydropterin synthase from Malaria parasites. to be published

3KSV

Hypothetical protein from Leishmania major
Descriptor:	Uncharacterized protein, ZINC ION
Authors:	Han, G.W, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2009-11-23
Release date:	2010-01-12
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Hypothetical protein (HIT family) from Leishmania major To be Published

3M0N

Plasmodium vivax 6-pyruvoyltetrahydropterin synthase (PTPS), E37A catalytic residue mutant
Descriptor:	PTERINE, Putative 6-pyruvoyl tetrahydrobiopterin synthase, ZINC ION
Authors:	Larson, E.T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:	2010-03-03
Release date:	2010-04-07
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Structural analysis of the dual-functional 6-pyruvoyltetrahydropterin synthase from Malaria parasites. to be published

3M3I

Hypothetical protein from Leishmania major
Descriptor:	Putative uncharacterized protein
Authors:	Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2010-03-09
Release date:	2010-03-23
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (2.35 Å)
Cite:	Hypothetical protein from Leishmania major To be Published

3HFD

Nucleosome Assembly Protein 1 from Plasmodium knowlesi
Descriptor:	Nucleosome assembly protein 1
Authors:	Arakaki, T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:	2009-05-11
Release date:	2009-05-26
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (2.8 Å)
Cite:	Nucleosome Assembly Protein 1 from Plasmodium knowlesi To be Published

3FOC

Tryptophanyl-tRNA synthetase from Giardia lamblia
Descriptor:	GLYCEROL, SULFATE ION, Tryptophanyl-tRNA synthetase
Authors:	Arakaki, T.L, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:	2008-12-29
Release date:	2009-01-13
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (2.09 Å)
Cite:	The structure of tryptophanyl-tRNA synthetase from Giardia lamblia reveals divergence from eukaryotic homologs. J.Struct.Biol., 171, 2010

2NPP

Structure of the Protein Phosphatase 2A Holoenzyme
Descriptor:	MANGANESE (II) ION, Protein Phosphatase 2, regulatory subunit A (PR 65), ...
Authors:	Xu, Y, Chen, Y, Xing, Y, Chao, Y, Shi, Y.
Deposit date:	2006-10-28
Release date:	2006-12-12
Last modified:	2023-11-15
Method:	X-RAY DIFFRACTION (3.3 Å)
Cite:	Structure of the protein phosphatase 2A holoenzyme Cell(Cambridge,Mass.), 127, 2006

3IAL

Giardia lamblia Prolyl-tRNA synthetase in complex with prolyl-adenylate
Descriptor:	5'-O-[(R)-hydroxy{[(2S)-pyrrolidin-2-ylcarbonyl]oxy}phosphoryl]adenosine, GLYCEROL, Prolyl-tRNA synthetase
Authors:	Larson, E.T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:	2009-07-14
Release date:	2009-08-11
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Structure of the prolyl-tRNA synthetase from the eukaryotic pathogen Giardia lamblia. Acta Crystallogr.,Sect.D, 68, 2012

3HRK

Histidyl-tRNA synthetase from Trypanosoma cruzi (Histidyl-adenylate complex)
Descriptor:	CHLORIDE ION, HISTIDYL-ADENOSINE MONOPHOSPHATE, Histidyl-tRNA synthetase
Authors:	Arakaki, T.L, Merritt, E.A, Larson, E.T, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:	2009-06-09
Release date:	2009-12-01
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (3.05 Å)
Cite:	Crystal structures of trypanosomal histidyl-tRNA synthetase illuminate differences between eukaryotic and prokaryotic homologs. J.Mol.Biol., 397, 2010

3HRI

Histidyl-tRNA synthetase (apo) from Trypanosoma brucei
Descriptor:	Histidyl-tRNA synthetase
Authors:	Arakaki, T.L, Merritt, E.A, Larson, E.T, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:	2009-06-09
Release date:	2009-12-01
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (2.85 Å)
Cite:	Crystal structures of trypanosomal histidyl-tRNA synthetase illuminate differences between eukaryotic and prokaryotic homologs. J.Mol.Biol., 397, 2010

2NYL

Crystal structure of Protein Phosphatase 2A (PP2A) holoenzyme with the catalytic subunit carboxyl terminus truncated
Descriptor:	MANGANESE (II) ION, Protein phosphatase 2, regulatory subunit A (PR 65), ...
Authors:	Xing, Y, Xu, Y, Chen, Y, Chao, Y, Lin, Z, Shi, Y.
Deposit date:	2006-11-20
Release date:	2006-12-12
Last modified:	2023-11-15
Method:	X-RAY DIFFRACTION (3.8 Å)
Cite:	Structure of the Protein Phosphatase 2A Holoenzyme. Cell(Cambridge,Mass.), 127, 2006

2NYM

Crystal Structure of Protein Phosphatase 2A (PP2A) with C-terminus truncated catalytic subunit
Descriptor:	MANGANESE (II) ION, Protein phosphatase 2, Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform, ...
Authors:	Chen, Y, Xing, Y, Xu, Y, Chao, Y, Lin, Z, Jeffrey, P.D, Shi, Y.
Deposit date:	2006-11-21
Release date:	2006-12-12
Last modified:	2023-11-15
Method:	X-RAY DIFFRACTION (3.6 Å)
Cite:	Structure of the Protein Phosphatase 2A Holoenzyme. Cell(Cambridge,Mass.), 127, 2006

4J75

Crystal Structure of a parasite tRNA synthetase, product-bound
Descriptor:	GLYCEROL, TRYPTOPHANYL-5'AMP, Tryptophanyl-tRNA synthetase
Authors:	Koh, C.Y, Kim, J.E, Verlinde, C.L.M.J, Hol, W.G.J.
Deposit date:	2013-02-12
Release date:	2013-05-22
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Crystal structures of Plasmodium falciparum cytosolic tryptophanyl-tRNA synthetase and its potential as a target for structure-guided drug design. Mol.Biochem.Parasitol., 189, 2013

4J76

Crystal Structure of a parasite tRNA synthetase, ligand-free
Descriptor:	GLYCEROL, Tryptophanyl-tRNA synthetase
Authors:	Koh, C.Y, Kim, J.E, Verlinde, C.L.M.J, Hol, W.G.J.
Deposit date:	2013-02-12
Release date:	2013-05-22
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (2.34 Å)
Cite:	Crystal structures of Plasmodium falciparum cytosolic tryptophanyl-tRNA synthetase and its potential as a target for structure-guided drug design. Mol.Biochem.Parasitol., 189, 2013

4YRI

Crystal structure of T. cruzi Histidyl-tRNA synthetase in complex with 1-(3-bromophenyl)methanamine (Chem 166)
Descriptor:	1,2-ETHANEDIOL, 1-(3-bromophenyl)methanamine, DIMETHYL SULFOXIDE, ...
Authors:	Koh, C.-Y, Hol, W.G.J.
Deposit date:	2015-03-15
Release date:	2015-08-12
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	A binding hotspot in Trypanosoma cruzi histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens. Acta Crystallogr. D Biol. Crystallogr., 71, 2015

4YRR

Crystal structure of T. cruzi Histidyl-tRNA synthetase in complex with N-(quinolin-3-yl)acetamide (Chem 1691)
Descriptor:	1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, HISTIDINE, ...
Authors:	Koh, C.-Y, Hol, W.G.J.
Deposit date:	2015-03-15
Release date:	2015-08-12
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	A binding hotspot in Trypanosoma cruzi histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens. Acta Crystallogr. D Biol. Crystallogr., 71, 2015

4YRP

Crystal structure of T. cruzi Histidyl-tRNA synthetase in complex with 1-(4-BROMOPHENYL)METHANAMINE (Chem 707)
Descriptor:	1,2-ETHANEDIOL, 1-(4-BROMOPHENYL)METHANAMINE, DIMETHYL SULFOXIDE, ...
Authors:	Koh, C.-Y, Hol, W.G.J.
Deposit date:	2015-03-15
Release date:	2015-08-12
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	A binding hotspot in Trypanosoma cruzi histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens. Acta Crystallogr. D Biol. Crystallogr., 71, 2015

4YRJ

Crystal structure of T. cruzi Histidyl-tRNA synthetase in complex with 4-chlorobenzene-1,2-diamine (Chem 256)
Descriptor:	1,2-ETHANEDIOL, 4-chlorobenzene-1,2-diamine, DIMETHYL SULFOXIDE, ...
Authors:	Koh, C.-Y, Hol, W.G.J.
Deposit date:	2015-03-15
Release date:	2015-08-12
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	A binding hotspot in Trypanosoma cruzi histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens. Acta Crystallogr. D Biol. Crystallogr., 71, 2015

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