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X-Ray Crystal Structure of Dihydrodipicolinate reductase from Burkholderia thailandensis
Descriptor:	CHLORIDE ION, Dihydrodipicolinate reductase, SODIUM ION, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2012-05-09
Release date:	2012-06-06
Last modified:	2023-09-13
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Combining functional and structural genomics to sample the essential Burkholderia structome. Plos One, 8, 2013

4F3P

Crystal structure of a Glutamine-binding periplasmic protein from Burkholderia pseudomallei in complex with glutamine
Descriptor:	Glutamine-binding periplasmic protein
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2012-05-09
Release date:	2012-05-23
Last modified:	2023-09-13
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Crystal structure of a Glutamine-binding periplasmic protein from Burkholderia pseudomallei in complex with glutamine To be Published

4F7D

Crystal structure of ferredoxin-NADP reductase from burkholderia thailandensis E264
Descriptor:	Ferredoxin--NADP reductase
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2012-05-15
Release date:	2012-05-30
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (2.35 Å)
Cite:	Combining functional and structural genomics to sample the essential Burkholderia structome. Plos One, 8, 2013

4FFC

Crystal structure of a 4-aminobutyrate aminotransferase (GabT) from Mycobacterium abscessus
Descriptor:	1,2-ETHANEDIOL, 4-aminobutyrate aminotransferase (GabT)
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2012-05-31
Release date:	2012-06-13
Last modified:	2023-12-06
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015

4YS8

Crystal Structure of 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (IspD) from Burkholderia thailandensis
Descriptor:	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, ACETATE ION, GLYCEROL
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2015-03-16
Release date:	2015-04-01
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.45 Å)
Cite:	Crystal Structure of 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (IspD) from Burkholderia thailandensis to be published

4ZR8

Structure of uroporphyrinogen decarboxylase from Acinetobacter baumannii
Descriptor:	1,2-ETHANEDIOL, CHLORIDE ION, MAGNESIUM ION, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2015-05-11
Release date:	2015-06-03
Last modified:	2024-03-06
Method:	X-RAY DIFFRACTION (1.5 Å)
Cite:	Structure of uroporphyrinogen decarboxylase from Acinetobacter baumannii To be Published

6OP0

Asymmetric hTNF-alpha
Descriptor:	(R)-{1-[(2,5-dimethylphenyl)methyl]-6-(1-methyl-1H-pyrazol-4-yl)-1H-benzimidazol-2-yl}(pyridin-4-yl)methanol, Tumor necrosis factor
Authors:	Arakaki, T.L, Edwards, T.E, Fairman, J.W, Davies, D.R, Foley, A, Ceska, T.
Deposit date:	2019-04-23
Release date:	2019-12-25
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (2.55 Å)
Cite:	Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer. Nat Commun, 10, 2019

5B8F

X-ray Crystal Structure of a 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase from Pseudomonas aeruginosa
Descriptor:	(4S)-2-METHYL-2,4-PENTANEDIOL, 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, CYTIDINE-5'-MONOPHOSPHATE, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2015-04-20
Release date:	2015-05-06
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (1.45 Å)
Cite:	X-ray Crystal Structure of a 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase from Pseudomonas aeruginosa to be published

5BR9

Crystal structure of an uncharacterized protein with similarity to peptidase YEAZ from Pseudomonas aeruginosa
Descriptor:	Uncharacterized protein
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2015-05-29
Release date:	2015-07-15
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.35 Å)
Cite:	Crystal structure of an uncharacterized protein with similarity to peptidase YEAZ from Pseudomonas aeruginosa to be published

5DLD

Crystal Structure of a UDP-N-acetylglucosamine 2-epimerase from Burkholderia vietnamiensis complexed with UDP-GlcNAc and UDP
Descriptor:	1,2-ETHANEDIOL, ACETATE ION, GLYCEROL, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2015-09-04
Release date:	2015-09-30
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (1.45 Å)
Cite:	Crystal Structure of a UDP-N-acetylglucosamine 2-epimerase from Burkholderia vietnamiensis complexed with UDP-GlcNAc and UDP to be published

5CY4

Crystal structure of an oligoribonuclease from Acinetobacter baumannii
Descriptor:	1,2-ETHANEDIOL, CALCIUM ION, Oligoribonuclease
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2015-07-30
Release date:	2015-08-19
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.25 Å)
Cite:	Crystal structure of an oligoribonuclease from Acinetobacter baumannii To Be Published

7TI2

Structure of KPC-2 bound to RPX-7063 at 1.75A
Descriptor:	1,2-ETHANEDIOL, Carbapenem-hydrolyzing beta-lactamase KPC, {(3R,7S)-2-hydroxy-3-[2-(thiophen-2-yl)acetamido]-2,3,4,7-tetrahydro-1,2-oxaborepin-7-yl}acetic acid
Authors:	Clifton, M.C, Fairman, J.W, Edwards, T.E, Hecker, S.J.
Deposit date:	2022-01-12
Release date:	2022-10-12
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (1.75 Å)
Cite:	Broad-spectrum cyclic boronate beta-lactamase inhibitors featuring an intramolecular prodrug for oral bioavailability. Bioorg.Med.Chem., 62, 2022

5SCR

Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-735
Descriptor:	(2R)-3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)-2-methylpropanoic acid, Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2021-12-20
Release date:	2022-02-09
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-735 to be published

5SCW

Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-916
Descriptor:	(2S)-4-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)butane-1,2-diol, 1,2-ETHANEDIOL, CHLORIDE ION, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2021-12-20
Release date:	2022-02-09
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (1.75 Å)
Cite:	Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-916 to be published

5SCT

Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-783
Descriptor:	3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)-N-(dimethylsulfamoyl)propanamide, Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2021-12-20
Release date:	2022-02-09
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (1.55 Å)
Cite:	Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-783 to be published

5SD7

Crystal Structure of Dihydrofolate Reductase from Homo sapiens bound to NADP and SDDC Inhibitor SDDC-735
Descriptor:	(2S)-3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)-2-methylpropanoic acid, 1,2-ETHANEDIOL, CHLORIDE ION, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2021-12-20
Release date:	2022-02-09
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Crystal Structure of Dihydrofolate Reductase from Homo sapiens bound to NADP and SDDC Inhibitor SDDC-735 to be published

5SD0

Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-1225
Descriptor:	1,2-ETHANEDIOL, 3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}pyridin-3-yl)propan-1-ol, CHLORIDE ION, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2021-12-20
Release date:	2022-02-09
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (1.75 Å)
Cite:	Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-1225 to be published

5SCZ

Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-1224
Descriptor:	(2E)-3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}pyridin-3-yl)prop-2-en-1-ol, 1,2-ETHANEDIOL, CHLORIDE ION, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2021-12-20
Release date:	2022-02-09
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (1.75 Å)
Cite:	Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-1224 to be published

5SD3

Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-1088
Descriptor:	1,2-ETHANEDIOL, 3-{2-[(3-{[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]methyl}oxetan-3-yl)methoxy]phenyl}propanoic acid, Dihydrofolate reductase, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2021-12-20
Release date:	2022-02-09
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (1.3 Å)
Cite:	Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-1088 to be published

5SD4

Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-1218
Descriptor:	1,2-ETHANEDIOL, 3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}pyridin-3-yl)prop-2-yn-1-ol, CHLORIDE ION, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2021-12-20
Release date:	2022-02-09
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (1.25 Å)
Cite:	Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-1218 to be published

5SCP

Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-23
Descriptor:	1,2-ETHANEDIOL, 3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)propanamide, CHLORIDE ION, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2021-12-20
Release date:	2022-02-09
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-23 to be published

5SD9

Crystal Structure of Dihydrofolate Reductase from Homo sapiens bound to NADP and SDDC Inhibitor SDDC-1096
Descriptor:	(2S)-2-[(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)methyl]-3-fluoropropanoic acid, 1,2-ETHANEDIOL, Dihydrofolate reductase, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2021-12-20
Release date:	2022-02-09
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Crystal Structure of Dihydrofolate Reductase from Homo sapiens bound to NADP and SDDC Inhibitor SDDC-1096 to be published

5SDA

Crystal Structure of Dihydrofolate Reductase from Homo sapiens bound to NADP and SDDC Inhibitor SDDC-774
Descriptor:	(2R)-3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)-2-methylpropanamide, 1,2-ETHANEDIOL, CHLORIDE ION, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2021-12-20
Release date:	2022-02-09
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (2.45 Å)
Cite:	Crystal Structure of Dihydrofolate Reductase from Homo sapiens bound to NADP and SDDC Inhibitor SDDC-774 to be published

5SDB

Crystal Structure of Human DHFR complexed with NADP and N10-formyl-tetrahydrofolate
Descriptor:	1,2-ETHANEDIOL, Dihydrofolate reductase, N-(4-{[(2,4-diaminopteridin-6-yl)methyl](hydroxymethyl)amino}benzene-1-carbonyl)-L-glutamic acid, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2021-12-20
Release date:	2022-02-09
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (1.55 Å)
Cite:	Crystal Structure of Human DHFR complexed with NADP and N10-formyl-tetrahydrofolate to be published

5SCO

Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-M7
Descriptor:	2-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)-N,N-dimethylethane-1-sulfonamide, BROMIDE ION, Dihydrofolate reductase, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2021-12-20
Release date:	2022-02-09
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (1.3 Å)
Cite:	Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-M7 to be published

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