2KDQ
 
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2KHP
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2KM8
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2KGP
 | | Structural basis for stabilization of the tau pre-mRNA splicing regulatory element by Novantrone (Mitoxantrone) | | Descriptor: | 1,4-DIHYDROXY-5,8-BIS({2-[(2-HYDROXYETHYL)AMINO]ETHYL}AMINO)-9,10-ANTHRACENEDIONE, RNA (25-MER) | | Authors: | Zheng, S, Chen, Y, Donahue, C.P, Wolfe, M.S, Varani, G. | | Deposit date: | 2009-03-13 | | Release date: | 2009-06-02 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Structural basis for stabilization of the tau pre-mRNA splicing regulatory element by novantrone (mitoxantrone).
Chem.Biol., 16, 2009
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2KWL
 | | Solution Structure of acyl carrier protein from Borrelia burgdorferi | | Descriptor: | Acyl carrier protein | | Authors: | Barnwal, R, Vittal, V, Moody, J, Varani, G, Seattle Structural Genomics Center for Infectious Disease (SSGCID) | | Deposit date: | 2010-04-12 | | Release date: | 2010-04-28 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | NMR structure of an acyl-carrier protein from Borrelia burgdorferi.
Acta Crystallogr.,Sect.F, 67, 2011
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2KO7
 | | Solution structure of peptidyl-prolyl cis-trans isomerase from Burkholderia pseudomallei complexed with Cycloheximide-N-ethylethanoate | | Descriptor: | Peptidyl-prolyl cis-trans isomerase, ethyl (4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}-2,6-dioxopiperidin-1-yl)acetate | | Authors: | Zheng, S, Leeper, T, Varani, G, Seattle Structural Genomics Center for Infectious Disease (SSGCID) | | Deposit date: | 2009-09-11 | | Release date: | 2009-09-29 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | The structure of a Burkholderia pseudomallei immunophilin-inhibitor complex reveals new approaches to antimicrobial development.
Biochem.J., 437, 2011
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2KX5
 | | Recognition of HIV TAR RNA by peptide mimetic of Tat protein | | Descriptor: | Cyclic peptide mimetic of Tat protein, HIV TAR RNA | | Authors: | Davidson, A, Patora-Komisarska, K, Robinson, J, Varani, G. | | Deposit date: | 2010-04-26 | | Release date: | 2010-07-07 | | Last modified: | 2011-07-13 | | Method: | SOLUTION NMR | | Cite: | Essential structural requirements for specific recognition of HIV TAR RNA by peptide mimetics of Tat protein.
Nucleic Acids Res., 39, 2011
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2KLX
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2L2S
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2L8H
 | | Chemical probe bound to HIV TAR RNA | | Descriptor: | 4-methoxynaphthalen-2-amine, ARGININE, HIV TAR RNA | | Authors: | Davidson, A, Begley, D, Lau, C, Varani, G. | | Deposit date: | 2011-01-12 | | Release date: | 2011-03-23 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | A Small-Molecule Probe Induces a Conformation in HIV TAR RNA Capable of Binding Drug-Like Fragments.
J.Mol.Biol., 410, 2011
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2L2Q
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2L0I
 | | Solution structure of Rtt103 CTD-interacting domain bound to a Ser2 phosphorylated CTD peptide | | Descriptor: | DNA-directed RNA polymerase, Regulator of Ty1 transposition protein 103 | | Authors: | Lunde, B.M, Reichow, S.L, Kim, M, Suh, H, Leeper, T.C, Yang, F, Mutschler, H, Buratowski, S, Meinhart, A, Varani, G. | | Deposit date: | 2010-07-06 | | Release date: | 2010-09-08 | | Last modified: | 2011-07-13 | | Method: | SOLUTION NMR | | Cite: | Cooperative interaction of transcription termination factors with the RNA polymerase II C-terminal domain.
Nat.Struct.Mol.Biol., 17, 2010
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2LBB
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2LHJ
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2LOL
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2LJU
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2LWK
 | | Solution structure of small molecule-influenza RNA complex | | Descriptor: | 6,7-dimethoxy-2-(piperazin-1-yl)quinazolin-4-amine, RNA (32-MER) | | Authors: | Lee, M.-K, Varani, G, Choi, B.-S, Pellecchia, M, Seattle Structural Genomics Center for Infectious Disease (SSGCID) | | Deposit date: | 2012-08-01 | | Release date: | 2012-08-29 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | A novel small-molecule binds to the influenza A virus RNA promoter and inhibits viral replication.
Chem.Commun.(Camb.), 50, 2014
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2MJ3
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2MCQ
 | | NMR structure of a BolA-like hypothetical protein RP812 from Rickettsia prowazekii, Seattle structural genomics center for infectious disease (SSGCID) | | Descriptor: | Uncharacterized protein RP812 | | Authors: | Chen, Y, Barnwal, R, Yang, F, Varani, G, Seattle Structural Genomics Center for Infectious Disease (SSGCID) | | Deposit date: | 2013-08-22 | | Release date: | 2013-10-09 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | NMR structure of a BolA-like hypothetical protein RP812 from Rickettsia prowazekii, Seattle structural genomics center for infectious disease (SSGCID)
To be Published
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2M4Y
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2N6T
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2MRL
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2NAX
 | | Structure of CCHC zinc finger domain of Pcf11 | | Descriptor: | Protein PCF11, ZINC ION | | Authors: | Yang, F, Varani, G. | | Deposit date: | 2016-01-12 | | Release date: | 2016-11-23 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | The C terminus of Pcf11 forms a novel zinc-finger structure that plays an essential role in mRNA 3'-end processing.
RNA, 23, 2017
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2N82
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2N6X
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