4ZNM
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![BU of 4znm by Molmil](/molmil-images/mine/4znm) | Crystal structure of SgcC5 protein from Streptomyces globisporus (apo form) | Descriptor: | C-domain type II peptide synthetase, CHLORIDE ION, SODIUM ION | Authors: | Michalska, K, Bigelow, L, Jedrzejczak, R, Babnigg, G, Lohman, J, Ma, M, Rudolf, J, Chang, C.-Y, Shen, B, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro) | Deposit date: | 2015-05-04 | Release date: | 2015-05-27 | Last modified: | 2019-12-25 | Method: | X-RAY DIFFRACTION (1.998 Å) | Cite: | Crystal structure of SgcC5 protein from Streptomyces globisporus (apo form) To Be Published
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7XH2
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![BU of 7xh2 by Molmil](/molmil-images/mine/7xh2) | Dihydrofolate Reductase-like Protein SacH in safracin biosynthesis | Descriptor: | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Uncharacterized protein sfcH | Authors: | Ma, X, Shao, N, Ma, M, Tang, G. | Deposit date: | 2022-04-07 | Release date: | 2023-02-08 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Dihydrofolate reductase-like protein inactivates hemiaminal pharmacophore for self-resistance in safracin biosynthesis. Acta Pharm Sin B, 13, 2023
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7XH4
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![BU of 7xh4 by Molmil](/molmil-images/mine/7xh4) | Dihydrofolate Reductase-like Protein SacH in safracin biosynthesis complex with safracin A | Descriptor: | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Safracin A, Uncharacterized protein sfcH | Authors: | Ma, X, Shao, N, Zhang, Y, Yang, D, Ma, M, Tang, G. | Deposit date: | 2022-04-07 | Release date: | 2023-02-08 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Dihydrofolate reductase-like protein inactivates hemiaminal pharmacophore for self-resistance in safracin biosynthesis. Acta Pharm Sin B, 13, 2023
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7Y50
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![BU of 7y50 by Molmil](/molmil-images/mine/7y50) | Class I diterpene synthase (CyS) from Streptomyces cattleya | Descriptor: | Putative glutamate dehydrogenase/leucine dehydrogenase | Authors: | Xing, B, Ma, M. | Deposit date: | 2022-06-16 | Release date: | 2022-12-21 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal Structure Based Mutagenesis of Cattleyene Synthase Leads to the Generation of Rearranged Polycyclic Diterpenes. Angew.Chem.Int.Ed.Engl., 61, 2022
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7Y87
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7Y88
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![BU of 7y88 by Molmil](/molmil-images/mine/7y88) | class I diterpene synthase (CyS-GGPP-Mg2+) from Streptomyces cattleya | Descriptor: | GERANYLGERANYL DIPHOSPHATE, MAGNESIUM ION, Putative glutamate dehydrogenase/leucine dehydrogenase | Authors: | Xing, B, Ma, M. | Deposit date: | 2022-06-23 | Release date: | 2022-12-21 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.87 Å) | Cite: | Crystal Structure Based Mutagenesis of Cattleyene Synthase Leads to the Generation of Rearranged Polycyclic Diterpenes. Angew.Chem.Int.Ed.Engl., 61, 2022
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4ZXW
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![BU of 4zxw by Molmil](/molmil-images/mine/4zxw) | Crystal structure of SgcC5 protein from Streptomyces globisporus (complex with (R)-(-)-1-(2-naphthyl)-1,2-ethanediol and sucrose) | Descriptor: | (1R)-1-(naphthalen-2-yl)ethane-1,2-diol, 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, C-domain type II peptide synthetase, ... | Authors: | Michalska, K, Bigelow, L, Jedrzejczak, R, Babnigg, G, Lohman, J, Ma, M, Rudolf, J, Chang, C.-Y, Shen, B, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro) | Deposit date: | 2015-05-20 | Release date: | 2015-06-17 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.187 Å) | Cite: | Crystal structure of SgcC5 protein from Streptomyces globisporus To Be Published
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5CJ3
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![BU of 5cj3 by Molmil](/molmil-images/mine/5cj3) | Crystal structure of the zorbamycin binding protein (ZbmA) from Streptomyces flavoviridis with zorbamycin | Descriptor: | CHLORIDE ION, COPPER (II) ION, Zbm binding protein, ... | Authors: | Chang, C, Bigelow, L, Clancy, S, Babnigg, G, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Rudolf, J.D, Ma, M, Chang, C.-Y, Lohman, J.R, Yang, D, Shen, B, Enzyme Discovery for Natural Product Biosynthesis, Enzyme Discovery for Natural Product Biosynthesis (NatPro) | Deposit date: | 2015-07-13 | Release date: | 2015-07-22 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.6499 Å) | Cite: | Crystal Structure of the Zorbamycin-Binding Protein ZbmA, the Primary Self-Resistance Element in Streptomyces flavoviridis ATCC21892. Biochemistry, 54, 2015
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7N7V
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![BU of 7n7v by Molmil](/molmil-images/mine/7n7v) | Crystal structure of TtnM, a Fe(II)-alpha-ketoglutarate-dependent hydroxylase from the tautomycetin biosynthesis pathway in Streptomyces griseochromogenes at 2 A. | Descriptor: | CHLORIDE ION, FE (II) ION, Predicted hydroxylase | Authors: | Han, L, Xu, W, Ma, M, Miller, M.D, Shen, B, Phillips Jr, G.N, Enzyme Discovery for Natural Product Biosynthesis (NatPro) | Deposit date: | 2021-06-11 | Release date: | 2022-07-06 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Structure of TtnM, a Fe(II)-alpha-ketoglutarate-dependent hydroxylase from the tautomycetin biosynthesis pathway in Streptomyces griseochromogenes. To Be Published
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4NEO
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![BU of 4neo by Molmil](/molmil-images/mine/4neo) | Structure of BlmI, a type-II acyl-carrier-protein from Streptomyces verticillus involved in bleomycin biosynthesis | Descriptor: | 1,2-ETHANEDIOL, 2-(2-METHOXYETHOXY)ETHANOL, Peptide synthetase NRPS type II-PCP | Authors: | Cuff, M.E, Bigelow, L, Bearden, J, Babnigg, G, Bruno, C.J.P, Bingman, C.A, Yennamalli, R, Lohman, J, Ma, M, Shen, B, Phillips Jr, G.N, Joachimiak, A, Enzyme Discovery for Natural Product Biosynthesis (NatPro), Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2013-10-29 | Release date: | 2014-01-29 | Last modified: | 2023-03-22 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The crystal structure of BlmI as a model for nonribosomal peptide synthetase peptidyl carrier proteins. Proteins, 82, 2014
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4OVM
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![BU of 4ovm by Molmil](/molmil-images/mine/4ovm) | Crystal structure of SgcJ protein from Streptomyces carzinostaticus | Descriptor: | uncharacterized protein SgcJ | Authors: | Chang, C, Bigelow, L, Clancy, S, Bingman, C.A, Yennamalli, R, Lohman, J.R, Ma, M, Shen, B, Phillips Jr, G.N, Babnigg, G, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro) | Deposit date: | 2013-11-20 | Release date: | 2013-12-25 | Last modified: | 2023-03-22 | Method: | X-RAY DIFFRACTION (2.719 Å) | Cite: | Crystal structure of SgcJ, an NTF2-like superfamily protein involved in biosynthesis of the nine-membered enediyne antitumor antibiotic C-1027. J.Antibiot., 2016
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4QA9
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![BU of 4qa9 by Molmil](/molmil-images/mine/4qa9) | Ensemble refinement of an epoxide hydrolase from Streptomyces carzinostaticus subsp. neocarzinostaticus. | Descriptor: | 1,2-ETHANEDIOL, Epoxide hydrolase, SULFATE ION | Authors: | Wang, F, Tan, K, Bigelow, L, Clancy, S, Babnigg, G, Bingman, C.A, Yennamalli, R, Lohman, J, Ma, M, Shen, B, Joachimiak, A, Phillips Jr, G.N, Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro) | Deposit date: | 2014-05-02 | Release date: | 2014-05-21 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.56 Å) | Cite: | Ensemble refinement of an epoxide hydrolase from Streptomyces carzinostaticus subsp. neocarzinostaticus. To be Published
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4R82
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![BU of 4r82 by Molmil](/molmil-images/mine/4r82) | Streptomyces globisporus C-1027 NADH:FAD oxidoreductase SgcE6 in complex with NAD and FAD fragments | Descriptor: | ACETATE ION, CALCIUM ION, CHLORIDE ION, ... | Authors: | Tan, K, Bigelow, L, Clancy, S, Babnigg, G, Bingman, C.A, Yennamalli, R, Lohman, J.R, Ma, M, Shen, B, Phillips Jr, G.N, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro) | Deposit date: | 2014-08-29 | Release date: | 2014-10-01 | Last modified: | 2016-11-02 | Method: | X-RAY DIFFRACTION (1.659 Å) | Cite: | Crystal Structures of SgcE6 and SgcC, the Two-Component Monooxygenase That Catalyzes Hydroxylation of a Carrier Protein-Tethered Substrate during the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus. Biochemistry, 55, 2016
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7DMO
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7DMN
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![BU of 7dmn by Molmil](/molmil-images/mine/7dmn) | Crystal structure of two pericyclases catalyzing [4+2] cycloaddition | Descriptor: | Diels-Alderase fsa2, GLYCEROL | Authors: | Chi, C.B, Wang, Z.D, Liu, T, Zhang, Z.Y, Ma, M. | Deposit date: | 2020-12-04 | Release date: | 2021-10-06 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal Structures of Fsa2 and Phm7 Catalyzing [4 + 2] Cycloaddition Reactions with Reverse Stereoselectivities in Equisetin and Phomasetin Biosynthesis. Acs Omega, 6, 2021
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7C0N
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![BU of 7c0n by Molmil](/molmil-images/mine/7c0n) | Crystal structure of a self-assembling galactosylated peptide homodimer | Descriptor: | SULFATE ION, Self-assembling galactosylated tyrosine-rich peptide, beta-D-galactopyranose | Authors: | He, C, Wu, S, Chi, C, Zhang, W, Ma, M, Lai, L, Dong, S. | Deposit date: | 2020-05-01 | Release date: | 2020-10-07 | Last modified: | 2020-10-21 | Method: | X-RAY DIFFRACTION (1.552 Å) | Cite: | Glycopeptide Self-Assembly Modulated by Glycan Stereochemistry through Glycan-Aromatic Interactions. J.Am.Chem.Soc., 142, 2020
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7YUA
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7YV0
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5MTZ
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![BU of 5mtz by Molmil](/molmil-images/mine/5mtz) | Crystal structure of a long form RNase Z from yeast | Descriptor: | PHOSPHATE ION, Ribonuclease Z, ZINC ION | Authors: | Li de la Sierra-Gallay, I, Miao, M, van Tilbeurgh, H. | Deposit date: | 2017-01-11 | Release date: | 2017-06-21 | Last modified: | 2018-01-31 | Method: | X-RAY DIFFRACTION (2.99 Å) | Cite: | The crystal structure of Trz1, the long form RNase Z from yeast. Nucleic Acids Res., 45, 2017
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7XRF
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![BU of 7xrf by Molmil](/molmil-images/mine/7xrf) | Crystal structaure of DgpB/C complex | Descriptor: | AP_endonuc_2 domain-containing protein, DgpB, MANGANESE (II) ION | Authors: | Ma, M, He, P. | Deposit date: | 2022-05-10 | Release date: | 2023-02-15 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.137 Å) | Cite: | Structural mechanism of a dual-functional enzyme DgpA/B/C as both a C -glycoside cleaving enzyme and an O - to C -glycoside isomerase. Acta Pharm Sin B, 13, 2023
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5UPT
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![BU of 5upt by Molmil](/molmil-images/mine/5upt) | Acyl-CoA synthetase PtmA2 from Streptomyces platensis in complex with SBNP468 ligand | Descriptor: | (7alpha,8alpha,10alpha,13alpha)-7,16-dihydroxykauran-18-oic acid, Acyl-CoA synthetase PtmA2, CHLORIDE ION, ... | Authors: | Osipiuk, J, Hatzos-Skintges, C, Endres, M, Babnigg, G, Rudolf, J.D, Chang, C.Y, Ma, M, Shen, B, Phillips Jr, G.N, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro) | Deposit date: | 2017-02-03 | Release date: | 2017-02-22 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Natural separation of the acyl-CoA ligase reaction results in a non-adenylating enzyme. Nat. Chem. Biol., 14, 2018
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8I3D
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8I39
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![BU of 8i39 by Molmil](/molmil-images/mine/8i39) | Cryo-EM structure of abscisic acid transporter AtABCG25 with ABA | Descriptor: | (2Z,4E)-5-[(1S)-1-hydroxy-2,6,6-trimethyl-4-oxocyclohex-2-en-1-yl]-3-methylpenta-2,4-dienoic acid, ABC transporter G family member 25 | Authors: | Huang, X, Zhang, X, Zhang, P. | Deposit date: | 2023-01-16 | Release date: | 2023-09-13 | Last modified: | 2023-11-01 | Method: | ELECTRON MICROSCOPY (2.85 Å) | Cite: | Cryo-EM structure and molecular mechanism of abscisic acid transporter ABCG25. Nat.Plants, 9, 2023
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8I3B
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8I3C
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