5UPT
 
 | | Acyl-CoA synthetase PtmA2 from Streptomyces platensis in complex with SBNP468 ligand | | Descriptor: | (7alpha,8alpha,10alpha,13alpha)-7,16-dihydroxykauran-18-oic acid, Acyl-CoA synthetase PtmA2, CHLORIDE ION, ... | | Authors: | Osipiuk, J, Hatzos-Skintges, C, Endres, M, Babnigg, G, Rudolf, J.D, Chang, C.Y, Ma, M, Shen, B, Phillips Jr, G.N, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro) | | Deposit date: | 2017-02-03 | | Release date: | 2017-02-22 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (1.92 Å) | | Cite: | Natural separation of the acyl-CoA ligase reaction results in a non-adenylating enzyme.
Nat. Chem. Biol., 14, 2018
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5VD6
 | | Crystal structure of a GNAT superfamily acetyltransferase PA4794 in complex with bisubstrate analog 6 | | Descriptor: | (3R,5S,9R,23S)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-10,14-dioxo-23-({[(phenylacetyl)amino]acetyl}amino)-2,4,6-trioxa-18-thia-11,15-diaza-3,5-diphosphatetracosan-24-oic acid 3,5-dioxide (non-preferred name), SULFATE ION, acetyltransferase PA4794 | | Authors: | Majorek, K.A, Joachimiak, A, Minor, W, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2017-04-01 | | Release date: | 2017-07-26 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.2 Å) | | Cite: | Generating enzyme and radical-mediated bisubstrates as tools for investigating Gcn5-related N-acetyltransferases.
FEBS Lett., 591, 2017
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6C9X
 | | THE CRYSTAL STRUCTURE OF THE alpha-Glucosidase (GH 31) FROM RUMINOCOCCUS OBEUM ATCC 29174 in complex with voglibose | | Descriptor: | (1S,2S,3R,4S,5S)-5-[(1,3-dihydroxypropan-2-yl)amino]-1-(hydroxymethyl)cyclohexane-1,2,3,4-tetrol, CHLORIDE ION, FORMIC ACID, ... | | Authors: | Tan, K, Tesar, C, Jedrzejczak, R, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2018-01-29 | | Release date: | 2018-03-07 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.457 Å) | | Cite: | THE CRYSTAL STRUCTURE OF THE alpha-Glucosidase (GH 31) FROM RUMINOCOCCUS OBEUM ATCC 29174 in complex with voglibose
To Be Published
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4MV2
 | | Crystal structure of plu4264 protein from Photorhabdus luminescens | | Descriptor: | NICKEL (II) ION, SODIUM ION, plu4264 | | Authors: | Michalska, K, Li, H, Jedrzejczak, R, Babnigg, G, Bingman, C.A, Yennamalli, R, Weerth, S, Thomas, M.G, Phillips Jr, G.N, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro) | | Deposit date: | 2013-09-23 | | Release date: | 2013-10-02 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.349 Å) | | Cite: | Structure of a cupin protein Plu4264 from Photorhabdus luminescens subsp. laumondii TTO1 at 1.35 angstrom resolution.
Proteins, 83, 2015
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4NEO
 | | Structure of BlmI, a type-II acyl-carrier-protein from Streptomyces verticillus involved in bleomycin biosynthesis | | Descriptor: | 1,2-ETHANEDIOL, 2-(2-METHOXYETHOXY)ETHANOL, Peptide synthetase NRPS type II-PCP | | Authors: | Cuff, M.E, Bigelow, L, Bearden, J, Babnigg, G, Bruno, C.J.P, Bingman, C.A, Yennamalli, R, Lohman, J, Ma, M, Shen, B, Phillips Jr, G.N, Joachimiak, A, Enzyme Discovery for Natural Product Biosynthesis (NatPro), Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2013-10-29 | | Release date: | 2014-01-29 | | Last modified: | 2023-03-22 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | The crystal structure of BlmI as a model for nonribosomal peptide synthetase peptidyl carrier proteins.
Proteins, 82, 2014
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4O38
 | | Crystal structure of the human cyclin G associated kinase (GAK) | | Descriptor: | Cyclin-G-associated kinase, GLYCEROL, SUCCINIC ACID | | Authors: | Zhang, R, Hatzos-Skintges, C, Weger, A, Chaikuad, A, Eswaran, J, Fedorov, O, King, O, von Delft, F, Bountra, C, Arrowsmith, C.H, Weigelt, J, Edwards, A, Knapp, S, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Structural Genomics Consortium (SGC) | | Deposit date: | 2013-12-18 | | Release date: | 2014-01-01 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.097 Å) | | Cite: | Crystal structure of the human cyclin G associated kinase (GAK)
To be Published
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3EXC
 | | Structure of the RNA'se SSO8090 from Sulfolobus solfataricus | | Descriptor: | CHLORIDE ION, SODIUM ION, Uncharacterized protein | | Authors: | Singer, A.U, Skarina, T, Tan, K, Kagan, O, Onopriyenko, O, Edwards, A.M, Joachimiak, A, Yakunin, A.F, Savchenko, A, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2008-10-16 | | Release date: | 2008-11-11 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Structure of the RNA'se SSO8090 from Sulfolobus solfataricus
To be Published
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4KJM
 | | Crystal structure of the Staphylococcus aureus protein (NP_646141.1, domain 3912-4037) similar to streptococcal adhesins emb and ebhA/ebhB | | Descriptor: | ACETATE ION, CHLORIDE ION, Extracellular matrix-binding protein ebh, ... | | Authors: | Cymborowski, M, Shabalin, I.G, Joachimiak, G, Chruszcz, M, Gornicki, P, Zhang, R, Joachimiak, A, Minor, W, Midwest Center for Structural Genomics, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2013-05-03 | | Release date: | 2013-05-29 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure of the Staphylococcus aureus protein (NP_646141.1, domain 3912-4037) similar to streptococcal adhesins emb and ebhA/ebhB
To be Published
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6UHE
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6UHI
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5VUG
 | | Crystal Structure of Glycerophosphoryl Diester Phosphodiesterase Domain of Uncharacterized Protein Rv2277c from Mycobacterium tuberculosis | | Descriptor: | CALCIUM ION, GLYCEROL, Uncharacterized protein Rv2277c | | Authors: | Kim, Y, Li, H, Endres, M, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2017-05-19 | | Release date: | 2017-06-14 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Crystal Structure of Glycerophosphoryl Diester Phosphodiesterase Domain of Uncharacterized Protein Rv2277c from Mycobacterium tuberculosis
To Be Published
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6DM4
 | | Crystal structure of the SH2 domain from RavO (Lpg1129) from Legionella pneumophila in complex with Homo sapiens Shc1 phospho-Tyr317 peptide | | Descriptor: | RavO, SULFATE ION, Shc1 phospho-Tyr317 peptide | | Authors: | Stogios, P.J, Evdokimova, E, Di Leo, R, Kaneko, T, Li, S, Savchenko, A, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2018-06-04 | | Release date: | 2018-06-27 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structure of the SH2 domain from RavO (Lpg1129) from Legionella pneumophila in complex with Homo sapiens Shc1 phospho-Tyr317 peptide
To Be Published
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5VES
 | | The 2.4A crystal structure of OmpA domain of OmpA from Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S | | Descriptor: | Outer membrane protein A, SULFATE ION | | Authors: | Tan, K, Wu, R, Jedrzejczak, R, Adkins, J, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Program for the Characterization of Secreted Effector Proteins (PCSEP) | | Deposit date: | 2017-04-05 | | Release date: | 2017-04-19 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Insights into PG-binding, conformational change, and dimerization of the OmpA C-terminal domains from Salmonella enterica serovar Typhimurium and Borrelia burgdorferi.
Protein Sci., 26, 2017
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4M3S
 | | Crystal structure of a GNAT superfamily acetyltransferase PA4794 in complex with HEPES | | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, SULFATE ION, ... | | Authors: | Majorek, K.A, Chruszcz, M, Xu, X, Cymborowski, M, Zheng, H, Savchenko, A, Edwards, A, Joachimiak, A, Minor, W, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2013-08-06 | | Release date: | 2013-08-21 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Double trouble-Buffer selection and His-tag presence may be responsible for nonreproducibility of biomedical experiments.
Protein Sci., 23, 2014
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5UJP
 | | The crystal structure of a glyoxalase/bleomycin resistance protein from Streptomyces sp. CB03234 | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, Glyoxalase/bleomycin resisance protein/dioxygenase | | Authors: | Tan, K, Li, H, Endres, M, Phillips Jr, G.N, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro) | | Deposit date: | 2017-01-18 | | Release date: | 2017-02-22 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (1.42 Å) | | Cite: | The crystal structure of a glyoxalase/bleomycin resistance protein from Streptomyces sp. CB03234
To Be Published
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5UQP
 | | The crystal structure of cupin protein from Rhodococcus jostii RHA1 | | Descriptor: | CHLORIDE ION, Cupin, SULFATE ION, ... | | Authors: | Tan, K, Li, H, Clancy, S, Phillips Jr, G.N, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro) | | Deposit date: | 2017-02-08 | | Release date: | 2017-02-22 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | The crystal structure of cupin protein from Rhodococcus jostii RHA1
To Be Published
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5VVI
 | | Crystal Structure of the Ligand Binding Domain of LysR-type Transcriptional Regulator, OccR from Agrobacterium tumefaciens in the Complex with Octopine | | Descriptor: | 1,2-ETHANEDIOL, ACETIC ACID, CHLORIDE ION, ... | | Authors: | Kim, Y, Chhor, G, Jedrzejczak, R, Winans, S.C, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2017-05-19 | | Release date: | 2017-06-21 | | Last modified: | 2024-12-25 | | Method: | X-RAY DIFFRACTION (2.28 Å) | | Cite: | Crystal Structure of the Ligand-Binding Domain of a LysR-type Transcriptional Regulator: Transcriptional Activation via a Rotary Switch.
Mol. Microbiol., 2018
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4F4I
 | | Crystal structure of Thymidylate Kinase from Staphylococcus aureus in apo-form | | Descriptor: | Thymidylate kinase | | Authors: | Filippova, E.V, Minasov, G, Shuvalova, L, Kiryukhina, O, Jedrzejczak, R, Babnigg, G, Rubin, E, Sacchettini, J, Joachimiak, A, Anderson, W.F, Midwest Center for Structural Genomics (MCSG), Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors (MTBI) | | Deposit date: | 2012-05-10 | | Release date: | 2012-05-23 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | Crystal structure of Thymidylate Kinase from Staphylococcus aureus in apo-form
To be Published
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1EX2
 | | CRYSTAL STRUCTURE OF BACILLUS SUBTILIS MAF PROTEIN | | Descriptor: | PHOSPHATE ION, PROTEIN MAF, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose | | Authors: | Minasov, G, Teplova, M, Stewart, G.C, Koonin, E.V, Anderson, W.F, Egli, M, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2000-04-28 | | Release date: | 2000-06-14 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Functional implications from crystal structures of the conserved Bacillus subtilis protein Maf with and without dUTP.
Proc.Natl.Acad.Sci.USA, 97, 2000
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6DM3
 | | Crystal structure of the SH2 domain from RavO (Lpg1129) from Legionella pneumophila, apoprotein | | Descriptor: | RavO | | Authors: | Stogios, P.J, Evdokimova, E, Di Leo, R, Kaneko, T, Li, S, Savchenko, A, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2018-06-04 | | Release date: | 2018-06-27 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Crystal structure of the SH2 domain from RavO (Lpg1129) from Legionella pneumophila, apoprotein
To Be Published
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5VVH
 | | Crystal Structure of the Effector Binding Domain of LysR-type Transcriptional Regulator, OccR from Agrobacterium tumefaciens | | Descriptor: | FORMIC ACID, Octopine catabolism/uptake operon regulatory protein OccR, SULFATE ION | | Authors: | Kim, Y, Chhor, G, Jedrzejczak, R, Winans, S.C, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2017-05-19 | | Release date: | 2017-06-21 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal Structure of the Ligand-Binding Domain of a LysR-type Transcriptional Regulator: Transcriptional Activation via a Rotary Switch.
Mol. Microbiol., 2018
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4MY0
 | | Crystal Structure of GCN5-related N-acetyltransferase from Kribbella flavida | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETYL COENZYME *A, GCN5-related N-acetyltransferase, ... | | Authors: | Kim, Y, Mack, J, Endres, M, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2013-09-26 | | Release date: | 2013-11-06 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (2.101 Å) | | Cite: | Crystal Structure of GCN5-related N-acetyltransferase from Kribbella flavida
To be Published
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4DQD
 | | The crystal structure of a transporter in complex with 3-phenylpyruvic acid | | Descriptor: | 3-HYDROXYPYRUVIC ACID, 3-PHENYLPYRUVIC ACID, Extracellular ligand-binding receptor, ... | | Authors: | Tan, K, Mack, J.C, Zerbs, S, Collart, F, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2012-02-15 | | Release date: | 2012-02-29 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.601 Å) | | Cite: | Structural and functional characterization of solute binding proteins for aromatic compounds derived from lignin: p-Coumaric acid and related aromatic acids.
Proteins, 81, 2013
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6CP9
 | | Contact-dependent growth inhibition toxin - immunity protein complex from Klebsiella pneumoniae 342 | | Descriptor: | CdiA, CdiI | | Authors: | Michalska, K, Stols, L, Eschenfeldt, W, Hayes, C.S, Goulding, C.W, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Structure-Function Analysis of Polymorphic CDI Toxin-Immunity Protein Complexes (UC4CDI) | | Deposit date: | 2018-03-13 | | Release date: | 2019-03-13 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Convergent Evolution of the Barnase/EndoU/Colicin/RelE (BECR) Fold in Antibacterial tRNase Toxins.
Structure, 27, 2019
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4NHE
 | | The crystal structure of oxidoreductase (Gfo/Idh/MocA family) from Streptococcus pneumoniae TIGR4 in complex with NADP | | Descriptor: | ACETATE ION, FORMIC ACID, GLYCEROL, ... | | Authors: | Tan, K, Hatzos-Skintges, C, Jedrzejczak, R, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2013-11-04 | | Release date: | 2013-11-27 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | The crystal structure of oxidoreductase (Gfo/Idh/MocA family) from Streptococcus pneumoniae TIGR4 in complex with NADP.
To be Published
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