6SOG
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![BU of 6sog by Molmil](/molmil-images/mine/6sog) | BamABCDE in MSP1D1 nanodisc ensemble 1-6 | Descriptor: | Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamB, Outer membrane protein assembly factor BamC, ... | Authors: | Iadanza, M.G, Ranson, N.A, Radford, S.E, Higgins, A.J, Calabrese, A.N, Schiffrin, B, White, P. | Deposit date: | 2019-08-29 | Release date: | 2021-03-31 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (8.3 Å) | Cite: | BamABCDE in MSP1D1 nanodisc ensemble 1-6 To Be Published
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6SN8
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![BU of 6sn8 by Molmil](/molmil-images/mine/6sn8) | BamABCDE in MSP1D1 nanodisc ensemble 0-7 | Descriptor: | Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamB, Outer membrane protein assembly factor BamC, ... | Authors: | Iadanza, M.G, Ranson, N.A, Radford, S.E, Higgins, A.J, Calabrese, A.N, Schiffrin, B, White, P. | Deposit date: | 2019-08-23 | Release date: | 2021-03-31 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (8.4 Å) | Cite: | BamABCDE in MSP1D1 nanodisc ensemble 0-7 To Be Published
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6SOH
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![BU of 6soh by Molmil](/molmil-images/mine/6soh) | BamABCDE in MSP1D1 nanodisc ensemble 1-7 | Descriptor: | Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamB, Outer membrane protein assembly factor BamC, ... | Authors: | Iadanza, M.G, Ranson, N.A, Radford, S.E, Higgins, A.J, Calabrese, A.N, Schiffrin, B, White, P. | Deposit date: | 2019-08-29 | Release date: | 2021-03-31 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (9.5 Å) | Cite: | BamABCDE in MSP1D1 nanodisc ensemble 1-7 To Be Published
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6SN3
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![BU of 6sn3 by Molmil](/molmil-images/mine/6sn3) | BamABCDE in MSP1D1 nanodisc ensemble 0-3 | Descriptor: | Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamB, Outer membrane protein assembly factor BamC, ... | Authors: | Iadanza, M.G, Ranson, N.A, Radford, S.E, Higgins, A.J, Calabrese, A.N, Schiffrin, B, White, P. | Deposit date: | 2019-08-23 | Release date: | 2021-03-31 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (8.4 Å) | Cite: | BamABCDE in MSP1D1 nanodisc ensemble 0-3 To Be Published
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6SN2
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![BU of 6sn2 by Molmil](/molmil-images/mine/6sn2) | BamABCDE in MSP1D1 nanodisc ensemble 0-2 | Descriptor: | Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamB, Outer membrane protein assembly factor BamC, ... | Authors: | Iadanza, M.G, Ranson, N.A, Radford, S.E, Higgins, A.J, Calabrese, A.N, Schiffrin, B, White, P. | Deposit date: | 2019-08-23 | Release date: | 2021-03-31 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (9.5 Å) | Cite: | BamABCDE in MSP1D1 nanodisc ensemble 0-2 To Be Published
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6SN5
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![BU of 6sn5 by Molmil](/molmil-images/mine/6sn5) | BamABCDE in MSP1D1 nanodisc ensemble 0-5 | Descriptor: | Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamB, Outer membrane protein assembly factor BamC, ... | Authors: | Iadanza, M.G, Ranson, N.A, Radford, S.E, Higgins, A.J, Calabrese, A.N, Schiffrin, B, White, P. | Deposit date: | 2019-08-23 | Release date: | 2021-03-31 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (9.8 Å) | Cite: | BamABCDE in MSP1D1 nanodisc ensemble 0-5 To Be Published
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6SO8
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![BU of 6so8 by Molmil](/molmil-images/mine/6so8) | BamABCDE in MSP1D1 nanodisc ensemble 1-3 | Descriptor: | Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamB, Outer membrane protein assembly factor BamC, ... | Authors: | Iadanza, M.G, Ranson, N.A, Radford, S.E, Higgins, A.J, Calabrese, A.N, Schiffrin, B, White, P. | Deposit date: | 2019-08-29 | Release date: | 2021-03-31 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (9.8 Å) | Cite: | BamABCDE in MSP1D1 nanodisc ensemble 1-3 To Be Published
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6SOC
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![BU of 6soc by Molmil](/molmil-images/mine/6soc) | BamABCDE in MSP1D1 nanodisc ensemble 1-5 | Descriptor: | Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamB, Outer membrane protein assembly factor BamC, ... | Authors: | Iadanza, M.G, Ranson, N.A, Radford, S.E, Higgins, A.J, Calabrese, A.N, Schiffrin, B, White, P. | Deposit date: | 2019-08-29 | Release date: | 2021-03-31 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (9 Å) | Cite: | BamABCDE in MSP1D1 nanodisc ensemble 1-5 To Be Published
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6SN4
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![BU of 6sn4 by Molmil](/molmil-images/mine/6sn4) | BamABCDE in MSP1D1 nanodisc ensemble 0-4 | Descriptor: | Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamB, Outer membrane protein assembly factor BamC, ... | Authors: | Iadanza, M.G, Ranson, N.A, Radford, S.E, Higgins, A.J, Calabrese, A.N, Schiffrin, B, White, P. | Deposit date: | 2019-08-23 | Release date: | 2021-03-31 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (9.5 Å) | Cite: | BamABCDE in MSP1D1 nanodisc ensemble 0-4 To Be Published
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6SMX
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![BU of 6smx by Molmil](/molmil-images/mine/6smx) | BamABCDE in MSP1D1 nanodisc | Descriptor: | Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamB, Outer membrane protein assembly factor BamC, ... | Authors: | Iadanza, M.G, Ranson, N.A, Radford, S.E, Higgins, A.J, Calabrese, A.N, Schiffrin, B, White, P. | Deposit date: | 2019-08-23 | Release date: | 2021-03-31 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (6.65 Å) | Cite: | BamABCDE in MSP1D1 nanodisc To Be Published
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6SN7
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![BU of 6sn7 by Molmil](/molmil-images/mine/6sn7) | BamABCDE in MSP1D1 nanodisc ensemble 0-6 | Descriptor: | Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamB, Outer membrane protein assembly factor BamC, ... | Authors: | Iadanza, M.G, Ranson, N.A, Radford, S.E, Higgins, A.J, Calabrese, A.N, Schiffrin, B, White, P. | Deposit date: | 2019-08-23 | Release date: | 2021-03-31 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (8.9 Å) | Cite: | BamABCDE in MSP1D1 nanodisc ensemble 0-6 To Be Published
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6SOA
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![BU of 6soa by Molmil](/molmil-images/mine/6soa) | BamABCDE in MSP1D1 nanodisc ensemble 0-9 | Descriptor: | Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamB, Outer membrane protein assembly factor BamC, ... | Authors: | Iadanza, M.G, Ranson, N.A, Radford, S.E, Higgins, A.J, Calabrese, A.N, Schiffrin, B, White, P. | Deposit date: | 2019-08-29 | Release date: | 2021-03-31 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (10.8 Å) | Cite: | BamABCDE in MSP1D1 nanodisc ensemble 0-9 To Be Published
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7PJR
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![BU of 7pjr by Molmil](/molmil-images/mine/7pjr) | Notum_ARUK3000438 | Descriptor: | 1-[4-chloranyl-3-(trifluoromethyl)phenyl]-1,2,3-triazole, 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, ... | Authors: | Vecchia, L, Zhao, Y, Fish, P, Jones, E.Y. | Deposit date: | 2021-08-24 | Release date: | 2022-09-07 | Last modified: | 2023-03-22 | Method: | X-RAY DIFFRACTION (1.51 Å) | Cite: | Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit. J.Med.Chem., 65, 2022
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7PK3
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![BU of 7pk3 by Molmil](/molmil-images/mine/7pk3) | Notum_ARUK3001185 | Descriptor: | 1-[2,4-bis(chloranyl)-3-(trifluoromethyl)phenyl]-1,2,3-triazole, 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, ... | Authors: | Vecchia, L, Hillier, J, Zhao, Y, Fish, P, Jones, E.Y. | Deposit date: | 2021-08-25 | Release date: | 2022-09-07 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.41 Å) | Cite: | Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit. J.Med.Chem., 65, 2022
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7PKV
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![BU of 7pkv by Molmil](/molmil-images/mine/7pkv) | Notum_Inhibitor ARUK3000223 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, Palmitoleoyl-protein carboxylesterase NOTUM, ... | Authors: | Ruza, R, Zhao, Y, Fish, P, Jones, E.Y. | Deposit date: | 2021-08-26 | Release date: | 2022-09-07 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.68 Å) | Cite: | Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit. J.Med.Chem., 65, 2022
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6ZVL
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![BU of 6zvl by Molmil](/molmil-images/mine/6zvl) | ARUK3000263 complex with Notum | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-[4-chloranyl-3-(trifluoromethyl)phenyl]-3~{H}-1,3,4-oxadiazol-2-one, ... | Authors: | Zhao, Y, Ruza, R. | Deposit date: | 2020-07-24 | Release date: | 2020-11-11 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | 5-Phenyl-1,3,4-oxadiazol-2(3 H )-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit. J.Med.Chem., 63, 2020
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1CDZ
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![BU of 1cdz by Molmil](/molmil-images/mine/1cdz) | BRCT DOMAIN FROM DNA-REPAIR PROTEIN XRCC1 | Descriptor: | PROTEIN (DNA-REPAIR PROTEIN XRCC1) | Authors: | Zhang, X, Morera, S, Bates, P, Whitehead, P, Coffer, A, Hainbucher, K, Nash, R, Sternberg, M, Lindahl, T, Freemont, P. | Deposit date: | 1999-03-04 | Release date: | 2000-02-28 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structure of an XRCC1 BRCT domain: a new protein-protein interaction module. EMBO J., 17, 1998
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2VJ3
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![BU of 2vj3 by Molmil](/molmil-images/mine/2vj3) | Human Notch-1 EGFs 11-13 | Descriptor: | CALCIUM ION, CHLORIDE ION, NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1, ... | Authors: | Johnson, S, Cordle, J, Tay, J.Z, Roversi, P, Lea, S.M. | Deposit date: | 2007-12-06 | Release date: | 2008-07-29 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | A Conserved Face of the Jagged/Serrate Dsl Domain is Involved in Notch Trans-Activation and Cis-Inhibition. Nat.Struct.Mol.Biol., 15, 2008
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2VJ2
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![BU of 2vj2 by Molmil](/molmil-images/mine/2vj2) | Human Jagged-1, domains DSL and EGFs1-3 | Descriptor: | D-MALATE, JAGGED-1 | Authors: | Johnson, S, Cordle, J, Tay, J.Z, Roversi, P, Handford, P.A, Lea, S.M. | Deposit date: | 2007-12-06 | Release date: | 2008-07-29 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | A Conserved Face of the Jagged/Serrate Dsl Domain is Involved in Notch Trans-Activation and Cis-Inhibition. Nat.Struct.Mol.Biol., 15, 2008
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7B4X
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![BU of 7b4x by Molmil](/molmil-images/mine/7b4x) | Notum complex with ARUK3002697 | Descriptor: | 1,2-ETHANEDIOL, 6-(4-methylphenyl)sulfanyl-2~{H}-[1,2,4]triazolo[4,3-b]pyridazin-3-one, DIMETHYL SULFOXIDE, ... | Authors: | Jones, E.Y, Fish, P. | Deposit date: | 2020-12-02 | Release date: | 2022-01-12 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.24 Å) | Cite: | Structural Analysis and Development of Notum Fragment Screening Hits. Acs Chem Neurosci, 13, 2022
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5MWF
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![BU of 5mwf by Molmil](/molmil-images/mine/5mwf) | Human Jagged2 C2-EGF2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ... | Authors: | Suckling, R.J, Handford, P.A, Lea, S.M. | Deposit date: | 2017-01-18 | Release date: | 2017-06-14 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands. EMBO J., 36, 2017
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5MVX
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![BU of 5mvx by Molmil](/molmil-images/mine/5mvx) | Human DLL4 C2-EGF3 | Descriptor: | Delta-like protein 4, alpha-L-fucopyranose | Authors: | Suckling, R.J, Handford, P.A, Lea, S.M. | Deposit date: | 2017-01-17 | Release date: | 2017-06-14 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.17 Å) | Cite: | Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands. EMBO J., 36, 2017
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5MW7
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![BU of 5mw7 by Molmil](/molmil-images/mine/5mw7) | Human Jagged2 C2-EGF3 | Descriptor: | Protein jagged-2, alpha-L-fucopyranose | Authors: | Suckling, R.J, Handford, P.A, Lea, S.M. | Deposit date: | 2017-01-18 | Release date: | 2017-06-14 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands. EMBO J., 36, 2017
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5MWB
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![BU of 5mwb by Molmil](/molmil-images/mine/5mwb) | Human Notch-2 EGF11-13 | Descriptor: | CALCIUM ION, Neurogenic locus notch homolog protein 2, alpha-L-fucopyranose, ... | Authors: | Suckling, R.J, Handford, P.A, Lea, S.M. | Deposit date: | 2017-01-18 | Release date: | 2017-06-14 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands. EMBO J., 36, 2017
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5MW5
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![BU of 5mw5 by Molmil](/molmil-images/mine/5mw5) | Human Jagged2 C2-EGF2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Protein jagged-2 | Authors: | Suckling, R.J, Handford, P.A, Lea, S.M. | Deposit date: | 2017-01-18 | Release date: | 2017-06-14 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands. EMBO J., 36, 2017
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