6ZVL

ARUK3000263 complex with Notum

Summary for 6ZVL

Entry DOI	10.2210/pdb6zvl/pdb
Related	6ZUV
Descriptor	Palmitoleoyl-protein carboxylesterase NOTUM, 2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, ... (7 entities in total)
Functional Keywords	notum, inhibitor, wnt, signaling protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	44655.53
Authors	Zhao, Y.,Ruza, R. (deposition date: 2020-07-24, release date: 2020-11-11, Last modification date: 2024-01-31)
Primary citation	Mahy, W.,Willis, N.J.,Zhao, Y.,Woodward, H.L.,Svensson, F.,Sipthorp, J.,Vecchia, L.,Ruza, R.R.,Hillier, J.,Kjaer, S.,Frew, S.,Monaghan, A.,Bictash, M.,Salinas, P.C.,Whiting, P.,Vincent, J.P.,Jones, E.Y.,Fish, P.V. 5-Phenyl-1,3,4-oxadiazol-2(3 H )-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit. J.Med.Chem., 63:12942-12956, 2020 Cited by PubMed: 33124429 DOI: 10.1021/acs.jmedchem.0c01391 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.3 Å)

Structure validation