7U8X
 
 | | hTRAP1 with inhibitors | | Descriptor: | Heat shock protein 75 kDa, mitochondrial, [5-(4-fluoro-2H-isoindole-2-carbonyl)-2-hydroxyphenyl](5-methoxy-2H-isoindol-2-yl)methanone | | Authors: | Deng, J, Matts, R, Peng, S. | | Deposit date: | 2022-03-09 | | Release date: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Elucidation of novel TRAP1-Selective inhibitors that regulate mitochondrial processes.
Eur.J.Med.Chem., 258, 2023
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7U8V
 | | hTRAP1 with inhibitors | | Descriptor: | (4-hydroxy-1,3-phenylene)bis[(2H-isoindol-2-yl)methanone], Heat shock protein 75 kDa, mitochondrial | | Authors: | Deng, J, Matts, R, Peng, S. | | Deposit date: | 2022-03-09 | | Release date: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (1.448 Å) | | Cite: | Elucidation of novel TRAP1-Selective inhibitors that regulate mitochondrial processes.
Eur.J.Med.Chem., 258, 2023
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7U8U
 | | hTRAP1 with inhibitors | | Descriptor: | Heat shock protein 75 kDa, mitochondrial, [2-hydroxy-5-(2H-isoindole-2-carbonyl)phenyl]{5-[3-(triphenyl-lambda~5~-phosphanyl)propoxy]-2H-isoindol-2-yl}methanone | | Authors: | Deng, J, Matts, R, Peng, S. | | Deposit date: | 2022-03-09 | | Release date: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (3.065 Å) | | Cite: | Elucidation of novel TRAP1-Selective inhibitors that regulate mitochondrial processes.
Eur.J.Med.Chem., 258, 2023
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7LSZ
 | | Hsp90a N-terminal inhibitor | | Descriptor: | Heat shock protein HSP 90-alpha, {3-[(2,3-dihydro-1,4-benzodioxin-6-yl)sulfanyl]-4-hydroxyphenyl}(1,3-dihydro-2H-isoindol-2-yl)methanone | | Authors: | Balch, M, Peng, S, Deng, J, Matts, R. | | Deposit date: | 2021-02-18 | | Release date: | 2021-03-03 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Selective Inhibition of the Hsp90 alpha Isoform.
Angew.Chem.Int.Ed.Engl., 60, 2021
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7LT0
 | | Hsp90a N-terminal inhibitor | | Descriptor: | (1,3-dihydro-2H-isoindol-2-yl){3-[(3,4-dimethylphenyl)sulfanyl]-4-hydroxyphenyl}methanone, Heat shock protein HSP 90-alpha | | Authors: | Balch, M, Peng, S, Deng, J, Matts, R. | | Deposit date: | 2021-02-18 | | Release date: | 2021-03-03 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.697 Å) | | Cite: | Selective Inhibition of the Hsp90 alpha Isoform.
Angew.Chem.Int.Ed.Engl., 60, 2021
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2PWH
 | | Crystal structure of the trehalulose synthase MutB from Pseudomonas mesoacidophila MX-45 | | Descriptor: | CALCIUM ION, Sucrose isomerase | | Authors: | Ravaud, S, Robert, X, Haser, R, Aghajari, N. | | Deposit date: | 2007-05-11 | | Release date: | 2007-06-26 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Trehalulose synthase native and carbohydrate complexed structures provide insights into sucrose isomerization.
J.Biol.Chem., 61, 2007
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1ZJB
 | | Crystal structure of the trehalulose synthase MutB from Pseudomonas mesoacidophila MX-45 (monoclinic form) | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, Trehalulose synthase | | Authors: | Ravaud, S, Robert, X, Haser, R, Aghajari, N. | | Deposit date: | 2005-04-28 | | Release date: | 2006-10-17 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Expression, purification, crystallization and preliminary X-ray crystallographic studies of the trehalulose synthase MutB from Pseudomonas mesoacidophila MX-45.
Acta Crystallogr.,Sect.F, 61, 2005
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2PWD
 | | Crystal Structure of the Trehalulose Synthase MUTB from Pseudomonas Mesoacidophila MX-45 Complexed to the Inhibitor Deoxynojirmycin | | Descriptor: | 1-DEOXYNOJIRIMYCIN, CALCIUM ION, Sucrose isomerase | | Authors: | Ravaud, S, Robert, X, Haser, R, Aghajari, N. | | Deposit date: | 2007-05-11 | | Release date: | 2007-06-26 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Trehalulose synthase native and carbohydrate complexed structures provide insights into sucrose isomerization.
J.Biol.Chem., 61, 2007
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2PWF
 | | Crystal structure of the MutB D200A mutant in complex with glucose | | Descriptor: | CALCIUM ION, Sucrose isomerase, beta-D-glucopyranose | | Authors: | Ravaud, S, Robert, X, Haser, R, Aghajari, N. | | Deposit date: | 2007-05-11 | | Release date: | 2007-06-26 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Trehalulose synthase native and carbohydrate complexed structures provide insights into sucrose isomerization.
J.Biol.Chem., 61, 2007
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2PWG
 | | Crystal Structure of the Trehalulose Synthase MutB From Pseudomonas Mesoacidophila MX-45 Complexed to the Inhibitor Castanospermine | | Descriptor: | CALCIUM ION, CASTANOSPERMINE, Sucrose isomerase | | Authors: | Ravaud, S, Robert, X, Haser, R, Aghajari, N. | | Deposit date: | 2007-05-11 | | Release date: | 2007-06-26 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Trehalulose synthase native and carbohydrate complexed structures provide insights into sucrose isomerization.
J.Biol.Chem., 61, 2007
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2PWE
 | | Crystal structure of the MutB E254Q mutant in complex with the substrate sucrose | | Descriptor: | CALCIUM ION, Sucrose isomerase, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose | | Authors: | Ravaud, S, Robert, X, Haser, R, Aghajari, N. | | Deposit date: | 2007-05-11 | | Release date: | 2007-06-26 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Trehalulose synthase native and carbohydrate complexed structures provide insights into sucrose isomerization.
J.Biol.Chem., 282, 2007
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4GIA
 | | Crystal structure of the MUTB F164L mutant from crystals soaked with isomaltulose | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, GLYCEROL, ... | | Authors: | Lipski, A, Haser, R, Aghajari, N. | | Deposit date: | 2012-08-08 | | Release date: | 2013-02-13 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.01 Å) | | Cite: | Mutations inducing an active-site aperture in Rhizobium sp. sucrose isomerase confer hydrolytic activity
Acta Crystallogr.,Sect.D, 69, 2013
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4GI9
 | | Crystal structure of the MUTB F164L mutant from crystals soaked with Trehalulose | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, GLYCEROL, ... | | Authors: | Lipski, A, Haser, R, Aghajari, N. | | Deposit date: | 2012-08-08 | | Release date: | 2013-02-13 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Mutations inducing an active-site aperture in Rhizobium sp. sucrose isomerase confer hydrolytic activity
Acta Crystallogr.,Sect.D, 69, 2013
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3GBE
 | | Crystal structure of the isomaltulose synthase SmuA from Protaminobacter rubrum in complex with the inhibitor deoxynojirimycin | | Descriptor: | 1,2-ETHANEDIOL, 1-DEOXYNOJIRIMYCIN, CITRATE ANION, ... | | Authors: | Ravaud, S, Robert, X, Haser, R, Aghajari, N. | | Deposit date: | 2009-02-19 | | Release date: | 2009-05-26 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structural determinants of product specificity of sucrose isomerases
Febs Lett., 583, 2009
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4GI8
 | | Crystal structure of the MUTB F164L mutant from crystals soaked with the substrate sucrose | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, GLYCEROL, ... | | Authors: | Lipski, A, Haser, R, Aghajari, N. | | Deposit date: | 2012-08-08 | | Release date: | 2013-02-13 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Mutations inducing an active-site aperture in Rhizobium sp. sucrose isomerase confer hydrolytic activity
Acta Crystallogr.,Sect.D, 69, 2013
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4GIN
 | | Crystal structure of the MUTB R284C mutant from crystals soaked with the inhibitor deoxynojirimycin | | Descriptor: | CALCIUM ION, GLYCEROL, Sucrose isomerase | | Authors: | Lipski, A, Ravaud, S, Robert, X, Haser, R, Aghajari, N. | | Deposit date: | 2012-08-08 | | Release date: | 2013-02-13 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Mutations inducing an active-site aperture in Rhizobium sp. sucrose isomerase confer hydrolytic activity
Acta Crystallogr.,Sect.D, 69, 2013
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3GBD
 | | Crystal structure of the isomaltulose synthase SmuA from Protaminobacter rubrum | | Descriptor: | 1,2-ETHANEDIOL, CITRATE ANION, Sucrose isomerase SmuA from Protaminobacter rubrum | | Authors: | Ravaud, S, Robert, X, Haser, R, Aghajari, N. | | Deposit date: | 2009-02-19 | | Release date: | 2009-05-26 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Structural determinants of product specificity of sucrose isomerases
Febs Lett., 583, 2009
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4H8V
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4H8H
 | | MUTB inactive double mutant E254Q-D415N | | Descriptor: | CALCIUM ION, GLYCEROL, SULFATE ION, ... | | Authors: | Lipski, A, Haser, R, Aghajari, N. | | Deposit date: | 2012-09-22 | | Release date: | 2013-09-25 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Insights into product binding in sucrose isomerases from crystal structures of MutB from Rhizobium sp.
To be Published
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4GO9
 | | CRYSTAL STRUCTURE of the TREHALULOSE SYNTHASE MUTANT, MUTB D415N, in COMPLEX with TRIS | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, Sucrose isomerase | | Authors: | Lipski, A, Ravaud, S, Robert, X, Haser, R, Aghajari, N. | | Deposit date: | 2012-08-19 | | Release date: | 2013-08-21 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | CRYSTAL STRUCTURE of the TREHALULOSE SYNTHASE MUTB, MUTANT D415N, in COMPLEX with TRIS
To be Published, 2013
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4H7V
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4H8U
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4GO8
 | | Crystal Structure of the TREHALULOSE SYNTHASE MUTB, MUTANT A258V, in complex with TRIS | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, Sucrose isomerase | | Authors: | Lipski, A, Haser, R, Aghajari, N. | | Deposit date: | 2012-08-19 | | Release date: | 2013-08-21 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Crystal structure of MUTB A258V mutant in complex with TRIS
To be Published, 2013
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4H2C
 | | Trehalulose synthase MutB R284C mutant | | Descriptor: | CALCIUM ION, GLYCEROL, Sucrose isomerase | | Authors: | Lipski, A, Ravaud, S, Robert, X, Haser, R, Aghajari, N. | | Deposit date: | 2012-09-12 | | Release date: | 2013-02-13 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Mutations inducing an active-site aperture in Rhizobium sp. sucrose isomerase confer hydrolytic activity
Acta Crystallogr.,Sect.D, 69, 2013
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4GI6
 | | Crystal structure of the MUTB F164L mutant in complex with glucose | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, GLYCEROL, ... | | Authors: | Lipski, A, Haser, R, Aghajari, N. | | Deposit date: | 2012-08-08 | | Release date: | 2013-02-13 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Mutations inducing an active-site aperture in Rhizobium sp. sucrose isomerase confer hydrolytic activity
Acta Crystallogr.,Sect.D, 69, 2013
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