7LT0

Hsp90a N-terminal inhibitor

Summary for 7LT0

• Entry DOI: 10.2210/pdb7lt0/pdb
• Descriptor: Heat shock protein HSP 90-alpha, (1,3-dihydro-2H-isoindol-2-yl){3-[(3,4-dimethylphenyl)sulfanyl]-4-hydroxyphenyl}methanone (3 entities in total)
• Functional Keywords: inhibitor, hsp90, chaperone
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 33875.72

Authors

Balch, M.,Peng, S.,Deng, J.,Matts, R. (deposition date: 2021-02-18, release date: 2021-03-03, Last modification date: 2023-10-18)

• Primary citation: Mishra, S.J.,Khandelwal, A.,Banerjee, M.,Balch, M.,Peng, S.,Davis, R.E.,Merfeld, T.,Munthali, V.,Deng, J.,Matts, R.L.,Blagg, B.S.J.; Selective Inhibition of the Hsp90 alpha Isoform.; Angew.Chem.Int.Ed.Engl., 60:10547-10551, 2021; PubMed: 33621416; DOI: 10.1002/anie.202015422

Experimental method

X-RAY DIFFRACTION (1.697 Å)