7CYC
 
 | | Cryo-EM structures of Alphacoronavirus spike glycoprotein | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | | Authors: | Song, X, Shi, Y, Ding, W, Liu, Z.J, Peng, G. | | Deposit date: | 2020-09-03 | | Release date: | 2020-12-23 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (3.21 Å) | | Cite: | Cryo-EM analysis of the HCoV-229E spike glycoprotein reveals dynamic prefusion conformational changes.
Nat Commun, 12, 2021
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7CYD
 | | Cryo-EM structures of Alphacoronavirus spike glycoprotein | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Song, X, Shi, Y, Ding, W, Liu, Z.J, Peng, G. | | Deposit date: | 2020-09-03 | | Release date: | 2020-12-23 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.55 Å) | | Cite: | Cryo-EM analysis of the HCoV-229E spike glycoprotein reveals dynamic prefusion conformational changes.
Nat Commun, 12, 2021
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8XAP
 | | Thermostable and acid-tolerant DNA-binding protein | | Descriptor: | DNA binding protein alba-1 | | Authors: | Chen, C.Y, Huang, C.H. | | Deposit date: | 2023-12-05 | | Release date: | 2024-12-11 | | Last modified: | 2025-06-25 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Dual dimeric interactions in the nucleic acid-binding protein Sac10b lead to multiple bridging of double-stranded DNA.
Heliyon, 10, 2024
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8XBQ
 | | Crystal structure of activity improved formolase variant K1 | | Descriptor: | Benzoylformate decarboxylase-K2, MAGNESIUM ION, THIAMINE DIPHOSPHATE | | Authors: | Wei, H.L, Cheng, Y.Y, Tang, Z.J, Tan, Z.J, Liu, W.D, Zhu, L.L. | | Deposit date: | 2023-12-06 | | Release date: | 2024-12-11 | | Last modified: | 2025-02-26 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Helix Zipper Regulating Formolase Activity.
Acs Catalysis, 15, 2025
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8XBR
 | | Crystal structure of activity improved formolase variant K3 | | Descriptor: | Benzoylformate decarboxylase, MAGNESIUM ION, THIAMINE DIPHOSPHATE | | Authors: | Wei, H.L, Cheng, Y.Y, Tang, Z.J, Tan, Z.J, Liu, W.D, Zhu, L.L. | | Deposit date: | 2023-12-06 | | Release date: | 2024-12-11 | | Last modified: | 2025-02-26 | | Method: | X-RAY DIFFRACTION (1.92 Å) | | Cite: | Helix Zipper Regulating Formolase Activity.
Acs Catalysis, 15, 2025
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8XAQ
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8XAO
 | | The thermostable and acid-tolerant DNA-binding protein | | Descriptor: | DNA/RNA-binding protein Alba, POTASSIUM ION | | Authors: | Chen, C.Y, Huang, C.H. | | Deposit date: | 2023-12-05 | | Release date: | 2024-12-11 | | Last modified: | 2025-06-25 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Dual dimeric interactions in the nucleic acid-binding protein Sac10b lead to multiple bridging of double-stranded DNA.
Heliyon, 10, 2024
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8XBO
 | | Crystal structure of activity improved formolase variant K6 | | Descriptor: | Benzoylformate decarboxylase, MAGNESIUM ION, THIAMINE DIPHOSPHATE | | Authors: | Wei, H.L, Cheng, Y.Y, Tang, Z.J, Tan, Z.J, Liu, W.D, Zhu, L.L. | | Deposit date: | 2023-12-06 | | Release date: | 2024-12-11 | | Last modified: | 2025-02-26 | | Method: | X-RAY DIFFRACTION (2.53 Å) | | Cite: | Helix Zipper Regulating Formolase Activity.
Acs Catalysis, 15, 2025
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3DBS
 | | Structure of PI3K gamma in complex with GDC0941 | | Descriptor: | 2-(1H-indazol-4-yl)-6-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-4-morpholin-4-yl-thieno[3,2-d]pyrimidine, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | | Authors: | Wiesmann, C, Ultsch, M. | | Deposit date: | 2008-06-02 | | Release date: | 2008-06-17 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer
J.Med.Chem., 51, 2008
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7V27
 | | RBD/XG005 local refinement | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, XG005-VH, ... | | Authors: | Zhan, W.Q, Zhang, X, Sun, L, Chen, Z.G. | | Deposit date: | 2021-08-07 | | Release date: | 2022-08-10 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (4.18 Å) | | Cite: | RBD/XG005 local refinement
To Be Published
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7KLP
 | | Crystal structure of a three-tetrad, parallel, K+ stabilized human telomeric G-quadruplex | | Descriptor: | HEXAETHYLENE GLYCOL, POTASSIUM ION, telomeric DNA | | Authors: | Yatsunyk, L.A, Li, K.S, Chen, E.V. | | Deposit date: | 2020-10-30 | | Release date: | 2020-12-30 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.35 Å) | | Cite: | Water spines and networks in G-quadruplex structures.
Nucleic Acids Res., 49, 2021
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6XT7
 | | Tel25 Hybrid Four-quartet G-quadruplex with K+ | | Descriptor: | DNA (25-MER), MAGNESIUM ION, POTASSIUM ION, ... | | Authors: | Yatsunyk, L.A, McCarthy, S.E. | | Deposit date: | 2020-07-17 | | Release date: | 2020-12-30 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.56 Å) | | Cite: | The first crystal structures of hybrid and parallel four-tetrad intramolecular G-quadruplexes.
Nucleic Acids Res., 50, 2022
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7RC9
 | | Crystal structure of human TLR8 ectodomain bound to small molecule antagonist 21 | | Descriptor: | 2-(2,6-dimethylpyridin-4-yl)-5-(piperidin-4-yl)-3-(propan-2-yl)-1H-indole, 2-acetamido-2-deoxy-beta-D-glucopyranose, Toll-like receptor 8, ... | | Authors: | Critton, D.A. | | Deposit date: | 2021-07-07 | | Release date: | 2022-05-04 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.76 Å) | | Cite: | Identification of 2-Pyridinylindole-Based Dual Antagonists of Toll-like Receptors 7 and 8 (TLR7/8).
Acs Med.Chem.Lett., 13, 2022
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6V9U
 | | Crystal structure of human TLR8 ectodomain bound to small molecule antagonist 14c | | Descriptor: | 2-(3,4-dimethoxyphenyl)-5-(piperidin-4-yl)-3-(propan-2-yl)-1H-indole, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Critton, D.A. | | Deposit date: | 2019-12-16 | | Release date: | 2020-08-12 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | Discovery of Potent and Orally Bioavailable Small Molecule Antagonists of Toll-like Receptors 7/8/9 (TLR7/8/9).
Acs Med.Chem.Lett., 11, 2020
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4EPU
 | | Ang1 fibrinogen-related domain (FReD) | | Descriptor: | Angiopoietin-1, CALCIUM ION | | Authors: | Yeykal, C.C, Adams, E.J. | | Deposit date: | 2012-04-17 | | Release date: | 2013-04-17 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.098 Å) | | Cite: | Biochemical and structural characterization of the Ang1 fibrinogen-related domain
To be Published
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5CT7
 | | BRAF in Complex with RAF265 | | Descriptor: | 1-methyl-5-({2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl}oxy)-N-[4-(trifluoromethyl)phenyl]-1H-benzimidazol-2-amine, Serine/threonine-protein kinase B-raf | | Authors: | Appleton, B.A. | | Deposit date: | 2015-07-23 | | Release date: | 2015-09-09 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (3.17 Å) | | Cite: | Discovery of RAF265: A Potent mut-B-RAF Inhibitor for the Treatment of Metastatic Melanoma.
Acs Med.Chem.Lett., 6, 2015
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