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8UV0
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BU of 8uv0 by Molmil
Discovery of (4-Pyrazolyl)-2-Aminopyrimidines as Potent and Selective Inhibitors of Cyclin-Dependent Kinase 2
Descriptor: 1-{(4M)-4-[2-{[1-(cyclopropanesulfonyl)piperidin-4-yl]amino}-5-(trifluoromethyl)pyrimidin-4-yl]-1H-pyrazol-1-yl}-2-methylpropan-2-ol, Cyclin-dependent kinase 2
Authors:Deller, M.C, Epling, L.B.
Deposit date:2023-11-02
Release date:2024-02-14
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Discovery of (4-Pyrazolyl)-2-aminopyrimidines as Potent and Selective Inhibitors of Cyclin-Dependent Kinase 2.
J.Med.Chem., 67, 2024
6LFL
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BU of 6lfl by Molmil
Crystal structure of a class A GPCR
Descriptor: 4-[[3,4-bis(oxidanylidene)-2-[[(1~{R})-1-(4-propan-2-ylfuran-2-yl)propyl]amino]cyclobuten-1-yl]amino]-~{N},~{N}-dimethyl-3-oxidanyl-pyridine-2-carboxamide, C-X-C chemokine receptor type 2,GlgA glycogen synthase,C-X-C chemokine receptor type 2
Authors:Liu, Z.J, Hua, T, Liu, K.W, Wu, L.J.
Deposit date:2019-12-03
Release date:2020-09-02
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural basis of CXC chemokine receptor 2 activation and signalling.
Nature, 585, 2020
1RAC
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BU of 1rac by Molmil
CRYSTAL STRUCTURE OF CTP-LIGATED T STATE ASPARTATE TRANSCARBAMOYLASE AT 2.5 ANGSTROMS RESOLUTION: IMPLICATIONS FOR ATCASE MUTANTS AND THE MECHANISM OF NEGATIVE COOPERATIVITY
Descriptor: Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, CYTIDINE-5'-TRIPHOSPHATE, ...
Authors:Kosman, R.P, Gouaux, J.E, Lipscomb, W.N.
Deposit date:1992-08-14
Release date:1994-01-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of CTP-ligated T state aspartate transcarbamoylase at 2.5 A resolution: implications for ATCase mutants and the mechanism of negative cooperativity.
Proteins, 15, 1993
1O6D
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BU of 1o6d by Molmil
Crystal structure of a hypothetical protein
Descriptor: Hypothetical UPF0247 protein TM0844
Authors:Structural GenomiX
Deposit date:2003-11-03
Release date:2003-11-25
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Structural analysis of a set of proteins resulting from a bacterial genomics project
Proteins, 60, 2005
1O69
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BU of 1o69 by Molmil
Crystal structure of a PLP-dependent enzyme
Descriptor: (2-AMINO-4-FORMYL-5-HYDROXY-6-METHYLPYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE, BETA-MERCAPTOETHANOL, aminotransferase
Authors:Structural GenomiX
Deposit date:2003-10-23
Release date:2003-11-11
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Structural analysis of a set of proteins resulting from a bacterial genomics project
Proteins, 60, 2005
1O64
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BU of 1o64 by Molmil
Crystal structure of an ATP phosphoribosyltransferase
Descriptor: ATP phosphoribosyltransferase, PHOSPHATE ION
Authors:Structural GenomiX
Deposit date:2003-10-23
Release date:2003-11-11
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural analysis of a set of proteins resulting from a bacterial genomics project
Proteins, 60, 2005
1O62
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BU of 1o62 by Molmil
Crystal structure of the apo form of a PLP-dependent enzyme
Descriptor: ACETATE ION, BETA-MERCAPTOETHANOL, aminotransferase
Authors:Structural GenomiX
Deposit date:2003-10-23
Release date:2003-11-11
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural analysis of a set of proteins resulting from a bacterial genomics project.
Proteins, 60, 2005
1RAH
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BU of 1rah by Molmil
CRYSTAL STRUCTURE OF CTP-LIGATED T STATE ASPARTATE TRANSCARBAMOYLASE AT 2.5 ANGSTROMS RESOLUTION: IMPLICATIONS FOR ATCASE MUTANTS AND THE MECHANISM OF NEGATIVE COOPERATIVITY
Descriptor: Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, CYTIDINE-5'-TRIPHOSPHATE, ...
Authors:Kosman, R.P, Gouaux, J.E, Lipscomb, W.N.
Deposit date:1992-08-14
Release date:1994-01-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of CTP-ligated T state aspartate transcarbamoylase at 2.5 A resolution: implications for ATCase mutants and the mechanism of negative cooperativity.
Proteins, 15, 1993
1O68
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BU of 1o68 by Molmil
Crystal structure of 3-methyl-2-oxobutanoate hydroxymethyltransferase
Descriptor: 3-METHYL-2-OXOBUTANOIC ACID, 3-methyl-2-oxobutanoate hydroxymethyltransferase, SODIUM ION
Authors:Structural GenomiX
Deposit date:2003-10-23
Release date:2003-11-11
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural analysis of a set of proteins resulting from a bacterial genomics project
Proteins, 60, 2005
1RAB
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BU of 1rab by Molmil
CRYSTAL STRUCTURE OF CTP-LIGATED T STATE ASPARTATE TRANSCARBAMOYLASE AT 2.5 ANGSTROMS RESOLUTION: IMPLICATIONS FOR ATCASE MUTANTS AND THE MECHANISM OF NEGATIVE COOPERATIVITY
Descriptor: Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, CYTIDINE-5'-TRIPHOSPHATE, ...
Authors:Kosman, R.P, Gouaux, J.E, Lipscomb, W.N.
Deposit date:1992-08-14
Release date:1994-01-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of CTP-ligated T state aspartate transcarbamoylase at 2.5 A resolution: implications for ATCase mutants and the mechanism of negative cooperativity.
Proteins, 15, 1993
8YZK
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BU of 8yzk by Molmil
Orphan receptor GPRC5D in complex with scFv150-18
Descriptor: Soluble cytochrome b562,G-protein coupled receptor family C group 5 member D, scFv
Authors:Yan, P, Lin, X, Xu, F.
Deposit date:2024-04-07
Release date:2024-07-03
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:The binding mechanism of an anti-multiple myeloma antibody to the human GPRC5D homodimer.
Nat Commun, 15, 2024
1RAA
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BU of 1raa by Molmil
CRYSTAL STRUCTURE OF CTP-LIGATED T STATE ASPARTATE TRANSCARBAMOYLASE AT 2.5 ANGSTROMS RESOLUTION: IMPLICATIONS FOR ATCASE MUTANTS AND THE MECHANISM OF NEGATIVE COOPERATIVITY
Descriptor: Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, CYTIDINE-5'-TRIPHOSPHATE, ...
Authors:Kosman, R.P, Gouaux, J.E, Lipscomb, W.N.
Deposit date:1992-08-14
Release date:1994-01-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of CTP-ligated T state aspartate transcarbamoylase at 2.5 A resolution: implications for ATCase mutants and the mechanism of negative cooperativity.
Proteins, 15, 1993
1RAI
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BU of 1rai by Molmil
CRYSTAL STRUCTURE OF CTP-LIGATED T STATE ASPARTATE TRANSCARBAMOYLASE AT 2.5 ANGSTROMS RESOLUTION: IMPLICATIONS FOR ATCASE MUTANTS AND THE MECHANISM OF NEGATIVE COOPERATIVITY
Descriptor: Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, CYTIDINE-5'-TRIPHOSPHATE, ...
Authors:Kosman, R.P, Gouaux, J.E, Lipscomb, W.N.
Deposit date:1992-08-14
Release date:1994-01-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of CTP-ligated T state aspartate transcarbamoylase at 2.5 A resolution: implications for ATCase mutants and the mechanism of negative cooperativity.
Proteins, 15, 1993
8XS3
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BU of 8xs3 by Molmil
Structure of MPXV B6 and D68 fab complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, D68_heavy chain, ...
Authors:wu, L.L, Sun, J.Q.
Deposit date:2024-01-08
Release date:2024-06-12
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (3.46 Å)
Cite:Two noncompeting human neutralizing antibodies targeting MPXV B6 show protective effects against orthopoxvirus infections.
Nat Commun, 15, 2024
1O6B
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BU of 1o6b by Molmil
Crystal structure of phosphopantetheine adenylyltransferase with ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Structural GenomiX
Deposit date:2003-11-03
Release date:2003-11-25
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural analysis of a set of proteins resulting from a bacterial genomics project
Proteins, 60, 2005
1O63
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BU of 1o63 by Molmil
Crystal structure of an ATP phosphoribosyltransferase
Descriptor: ATP phosphoribosyltransferase
Authors:Structural GenomiX
Deposit date:2003-10-23
Release date:2003-11-11
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural analysis of a set of proteins resulting from a bacterial genomics project
Proteins, 60, 2005
1O6C
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BU of 1o6c by Molmil
Crystal structure of UDP-N-acetylglucosamine 2-epimerase
Descriptor: UDP-N-acetylglucosamine 2-epimerase
Authors:Structural GenomiX
Deposit date:2003-11-03
Release date:2003-11-25
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural analysis of a set of proteins resulting from a bacterial genomics project
Proteins, 60, 2005
5YGF
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BU of 5ygf by Molmil
Crystal structure of Drosophila melanogaster Papi extended Tudor domain (D287A) in complex with Piwi N-terminal R10-unme peptide
Descriptor: ASP-GLN-GLY-ARG-GLY-ARG-ARG-ARG-PRO, GH18329p
Authors:Zhang, Y.H, Huang, Y.
Deposit date:2017-09-22
Release date:2018-03-14
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.698 Å)
Cite:Structural insights into the sequence-specific recognition of Piwi byDrosophilaPapi
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5YGD
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BU of 5ygd by Molmil
Crystal structure of Drosophila melanogaster Papi extended Tudor domain (D287A) in complex with Piwi N-terminal R10me2s peptide
Descriptor: ASP-GLN-GLY-ARG-GLY-ARG-2MR-ARG-PRO-LEU-ASN, GH18329p
Authors:Zhang, Y.H, Huang, Y.
Deposit date:2017-09-22
Release date:2018-03-14
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.551 Å)
Cite:Structural insights into the sequence-specific recognition of Piwi byDrosophilaPapi
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5YGB
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BU of 5ygb by Molmil
Crystal structure of drosophila melanogaster Papi extended Tudor domain mutant - D287A
Descriptor: GH18329p
Authors:Zhang, Y.H, Huang, Y.
Deposit date:2017-09-22
Release date:2018-03-14
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural insights into the sequence-specific recognition of Piwi byDrosophilaPapi
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5YGC
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BU of 5ygc by Molmil
Crystal structure of Drosophila melanogaster Papi extended Tudor domain
Descriptor: GH18329p
Authors:Zhang, Y.H, Huang, Y.
Deposit date:2017-09-22
Release date:2018-03-14
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural insights into the sequence-specific recognition of Piwi byDrosophilaPapi
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6DQA
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BU of 6dqa by Molmil
Linked KDM5A JMJ Domain Bound to Inhibitor N70 i.e.[2-((3-aminophenyl)(2-(piperidin-1-yl)ethoxy)methyl)thieno[3,2-b]pyridine-7-carboxylic acid]
Descriptor: 1,2-ETHANEDIOL, 2-{(R)-(3-aminophenyl)[2-(piperidin-1-yl)ethoxy]methyl}thieno[3,2-b]pyridine-7-carboxylic acid, GLYCEROL, ...
Authors:Horton, J.R, Cheng, X.
Deposit date:2018-06-10
Release date:2018-11-21
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.888 Å)
Cite:Structure-Based Engineering of Irreversible Inhibitors against Histone Lysine Demethylase KDM5A.
J. Med. Chem., 61, 2018
6DQ6
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BU of 6dq6 by Molmil
LINKED KDM5A JMJ DOMAIN BOUND TO THE INHIBITOR N44 i.e. 3-((2-(pyridin-2-yl)-6-(4-(vinylsulfonyl)-1,4-diazepan-1-yl)pyrimidin-4-yl)amino)propanoic acid
Descriptor: DIMETHYL SULFOXIDE, GLYCEROL, Linked KDM5A Jmj Domain, ...
Authors:Horton, J.R, Cheng, X.
Deposit date:2018-06-10
Release date:2018-11-21
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.587 Å)
Cite:Structure-Based Engineering of Irreversible Inhibitors against Histone Lysine Demethylase KDM5A.
J. Med. Chem., 61, 2018
6DQF
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BU of 6dqf by Molmil
LINKED KDM5A JMJ DOMAIN BOUND TO THE INHIBITOR N68 i.e. 2-(1-(2-(piperidin-1-yl)ethyl)-1H-benzo[d]imidazol-2-yl)thieno[3,2-b]pyridine-7-carboxylic acid
Descriptor: 2-{1-[2-(piperidin-1-yl)ethyl]-1H-benzimidazol-2-yl}thieno[3,2-b]pyridine-7-carboxylic acid, Linked KDM5A Jmj Domain, MANGANESE (II) ION
Authors:Horton, J.R, Cheng, X.
Deposit date:2018-06-10
Release date:2019-06-12
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.688 Å)
Cite:To be determined
To Be Published
5Z2H
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BU of 5z2h by Molmil
Structure of Dictyostelium discoideum mitochondrial calcium uniporter N-terminal domain(DdMCU-NTD)
Descriptor: Dictyostelium discoideum mitochondrial calcium uniporter
Authors:Yuan, Y, Wen, M, Chou, J.J, Li, D, Bo, O.
Deposit date:2018-01-02
Release date:2019-01-02
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.674 Å)
Cite:Structural Characterization of the N-Terminal Domain of theDictyostelium discoideumMitochondrial Calcium Uniporter.
Acs Omega, 5, 2020

223532

数据于2024-08-07公开中

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