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1VCU
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BU of 1vcu by Molmil
Structure of the human cytosolic sialidase Neu2 in complex with the inhibitor DANA
Descriptor: 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Sialidase 2
Authors:Chavas, L.M.G, Fusi, P, Tringali, C, Venerando, B, Tettamanti, G, Kato, R, Monti, E, Wakatsuki, S.
Deposit date:2004-03-12
Release date:2004-11-02
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Crystal Structure of the Human Cytosolic Sialidase Neu2: EVIDENCE FOR THE DYNAMIC NATURE OF SUBSTRATE RECOGNITION
J.Biol.Chem., 280, 2005
1GME
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BU of 1gme by Molmil
Crystal structure and assembly of an eukaryotic small heat shock protein
Descriptor: HEAT SHOCK PROTEIN 16.9B
Authors:Van Montfort, R.L.M, Basha, E, Friedrich, K.L, Slingsby, C, Vierling, E.
Deposit date:2001-09-13
Release date:2001-11-29
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal Structure and Assembly of an Eukaryotic Small Heat Shock Protein
Nat.Struct.Biol., 8, 2001
2V9J
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BU of 2v9j by Molmil
Crystal structure of the regulatory fragment of mammalian AMPK in complexes with Mg.ATP-AMP
Descriptor: 5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-2, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1, ...
Authors:Xiao, B, Heath, R, Saiu, P, Leiper, F.C, Leone, P, Jing, C, Walker, P.A, Haire, L, Eccleston, J.F, Davis, C.T, Martin, S.R, Carling, D, Gamblin, S.J.
Deposit date:2007-08-23
Release date:2007-09-25
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Structural Basis for AMP Binding to Mammalian AMP-Activated Protein Kinase
Nature, 449, 2007
2WF0
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BU of 2wf0 by Molmil
Human BACE-1 in complex with 4-ethyl-N-((1S,2R)-2-hydroxy-1-(phenylmethyl)-3-(((3-(trifluoromethyl)phenyl)methyl)amino)propyl)-8-(2-oxo-1-pyrrolidinyl)-6-quinolinecarboxamide
Descriptor: BETA-SECRETASE 1, N-[(1S,2R)-1-BENZYL-2-HYDROXY-3-{[3-(TRIFLUOROMETHYL)BENZYL]AMINO}PROPYL]-4-ETHYL-8-(2-OXOPYRROLIDIN-1-YL)QUINOLINE-6-CARBOXAMIDE
Authors:Charrier, N, Clarke, B, Cutler, L, Demont, E, Dingwall, C, Dunsdon, R, Hawkins, J, Howes, C, Hubbard, J, Hussain, I, Maile, G, Matico, R, Mosley, J, Naylor, A, O'Brien, A, Redshaw, S, Rowland, P, Soleil, V, Smith, K.J, Sweitzer, S, Theobald, P, Vesey, D, Walter, D.S, Wayne, G.
Deposit date:2009-04-02
Release date:2009-05-19
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Second Generation of Bace-1 Inhibitors. Part 1: The Need for Improved Pharmacokinetics.
Bioorg.Med.Chem.Lett., 19, 2009
2FHS
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BU of 2fhs by Molmil
Structure of Acyl Carrier Protein Bound to FabI, the Enoyl Reductase from Escherichia Coli
Descriptor: Acyl carrier protein, enoyl-[acyl-carrier-protein] reductase, NADH-dependent
Authors:Kolappan, S, Novichenok, P, Rafi, S, Simmerling, C, Tonge, P.J, Kisker, C.
Deposit date:2005-12-27
Release date:2006-10-17
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of Acyl Carrier Protein Bound to FabI, the FASII Enoyl Reductase from Escherichia coli.
J.Biol.Chem., 281, 2006
2QIF
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BU of 2qif by Molmil
Crystal structure of a metallochaperone with a tetranuclear Cu(I) cluster
Descriptor: ACETATE ION, CALCIUM ION, COPPER (I) ION, ...
Authors:West, C, Singleton, C, Kihlken, M.A, Le Brun, N.E, Hemmings, A.M.
Deposit date:2007-07-04
Release date:2008-07-08
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:A tetranuclear Cu(I) cluster in the metallochaperone protein CopZ.
Biochemistry, 48, 2009
3TE5
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BU of 3te5 by Molmil
structure of the regulatory fragment of sacchromyces cerevisiae ampk in complex with NADH
Descriptor: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Carbon catabolite-derepressing protein kinase, Nuclear protein SNF4, ...
Authors:Mayer, F.V, Heath, R, Underwood, E, Sanders, M.J, Carmena, D, McCartney, R, Leiper, F.C, Xiao, B, Jing, C, Walker, P.A, Haire, L.F, Ogrodowicz, R, Martin, S.R, Schmidt, M.C, Gamblin, S.J, Carling, D.
Deposit date:2011-08-12
Release date:2011-11-09
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:ADP Regulates SNF1, the Saccharomyces cerevisiae Homolog of AMP-Activated Protein Kinase.
Cell Metab, 14, 2011
3TDH
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BU of 3tdh by Molmil
Structure of the regulatory fragment of sccharomyces cerevisiae AMPK in complex with AMP
Descriptor: ADENOSINE MONOPHOSPHATE, Carbon catabolite-derepressing protein kinase, Nuclear protein SNF4, ...
Authors:Mayer, F.V, Heath, R, Underwood, E, Sanders, M.J, Carmena, D, McCartney, R, Leiper, F.C, Xiao, B, Jing, C, Walker, P.A, Haire, L.F, Ogrodowicz, R, Martin, S.R, Schmidt, M.C, Gamblin, S.J, Carling, D.
Deposit date:2011-08-11
Release date:2011-11-09
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:ADP Regulates SNF1, the Saccharomyces cerevisiae Homolog of AMP-Activated Protein Kinase.
Cell Metab, 14, 2011
1PKO
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BU of 1pko by Molmil
Myelin Oligodendrocyte Glycoprotein (MOG)
Descriptor: Myelin Oligodendrocyte Glycoprotein
Authors:Breithaupt, C, Schubart, A, Zander, H, Skerra, A, Huber, R, Linington, C, Jacob, U.
Deposit date:2003-06-06
Release date:2003-07-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structural insights into the antigenicity of myelin oligodendrocyte glycoprotein
Proc.Natl.Acad.Sci.USA, 100, 2003
1I0A
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BU of 1i0a by Molmil
CRYSTAL STRUCTURE OF WILD TYPE TURKEY DELTA 1 CRYSTALLIN (EYE LENS PROTEIN)
Descriptor: DELTA CRYSTALLIN I
Authors:Sampaleanu, L.M, Vallee, F, Slingsby, C, Howell, P.L.
Deposit date:2001-01-29
Release date:2001-04-21
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural studies of duck delta 1 and delta 2 crystallin suggest conformational changes occur during catalysis.
Biochemistry, 40, 2001
2XFI
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BU of 2xfi by Molmil
Human BACE-1 in complex with N-((1S,2R)-3-(((1S)-2-(cyclohexylamino)- 1-methyl-2-oxoethyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-3-((methylsulfonyl)(phenyl)amino)benzamide
Descriptor: BETA-SECRETASE 1, N-((1S,2R)-3-(((1S)-2-(CYCLOHEXYLAMINO)-1-METHYL-2-OXOETHYL)AMINO)-2-HYDROXY-1-( PHENYLMETHYL)PROPYL)-3-((METHYLSULFONYL)(PHENYL)AMINO) BENZAMIDE
Authors:Clarke, B, Cutler, L, Demont, E, Dingwall, C, Dunsdon, R, Hawkins, J, Howes, C, Hussain, I, Maile, G, Matico, R, Mosley, J, Naylor, A, O'Brien, A, Redshaw, S, Rowland, P, Soleil, V, Smith, K.J, Sweitzer, S, Theobald, P, Vesey, D, Walter, D.S, Wayne, G.
Deposit date:2010-05-24
Release date:2010-07-07
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Bace-1 Inhibitors Using Novel Edge-to-Face Interaction with Arg-296
Bioorg.Med.Chem.Lett., 20, 2010
1A45
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BU of 1a45 by Molmil
GAMMAF CRYSTALLIN FROM BOVINE LENS
Descriptor: GAMMAF CRYSTALLIN
Authors:Norledge, B.V, Hay, R, Bateman, O.A, Slingsby, C, White, H.E, Moss, D.S, Lindley, P.F, Driessen, H.P.C.
Deposit date:1998-02-10
Release date:1998-06-17
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Towards a molecular understanding of phase separation in the lens: a comparison of the X-ray structures of two high Tc gamma-crystallins, gammaE and gammaF, with two low Tc gamma-crystallins, gammaB and gammaD.
Exp.Eye Res., 65, 1997
5TIS
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BU of 5tis by Molmil
Room temperature XFEL structure of the native, doubly-illuminated photosystem II complex
Descriptor: 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, ...
Authors:Young, I.D, Ibrahim, M, Chatterjee, R, Gul, S, Fuller, F, Koroidov, S, Brewster, A.S, Tran, R, Alonso-Mori, R, Kroll, T, Michels-Clark, T, Laksmono, H, Sierra, R.G, Stan, C.A, Hussein, R, Zhang, M, Douthit, L, Kubin, M, de Lichtenberg, C, Pham, L.V, Nilsson, H, Cheah, M.H, Shevela, D, Saracini, C, Bean, M.A, Seuffert, I, Sokaras, D, Weng, T.-C, Pastor, E, Weninger, C, Fransson, T, Lassalle, L, Braeuer, P, Aller, P, Docker, P.T, Andi, B, Orville, A.M, Glownia, J.M, Nelson, S, Sikorski, M, Zhu, D, Hunter, M.S, Aquila, A, Koglin, J.E, Robinson, J, Liang, M, Boutet, S, Lyubimov, A.Y, Uervirojnangkoorn, M, Moriarty, N.W, Liebschner, D, Afonine, P.V, Watermann, D.G, Evans, G, Wernet, P, Dobbek, H, Weis, W.I, Brunger, A.T, Zwart, P.H, Adams, P.D, Zouni, A, Messinger, J, Bergmann, U, Sauter, N.K, Kern, J, Yachandra, V.K, Yano, J.
Deposit date:2016-10-03
Release date:2016-11-23
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.25000381 Å)
Cite:Structure of photosystem II and substrate binding at room temperature.
Nature, 540, 2016
1MKK
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BU of 1mkk by Molmil
Disulfide deficient mutant of vascular endothelial growth factor A (C61A and C104A)
Descriptor: Vascular Endothelial Growth Factor A
Authors:Muller, Y.A, Heiring, C, Misselwitz, R, Welfle, K, Welfle, H.
Deposit date:2002-08-29
Release date:2002-12-11
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (1.32 Å)
Cite:The cystine knot promotes folding and not thermodynamic stability in vascular endothelial growth factor
J.Biol.Chem., 277, 2002
1MKG
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BU of 1mkg by Molmil
DISULFIDE DEFICIENT MUTANT OF VASCULAR ENDOTHELIAL GROWTH FACTOR A (C57A and C102A)
Descriptor: Vascular Endothelial Growth Factor A
Authors:Muller, Y.A, Heiring, C, Misselwitz, R, Welfle, K, Welfle, H.
Deposit date:2002-08-29
Release date:2002-12-11
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The cystine knot promotes folding and not thermodynamic stability in vascular endothelial growth factor
J.Biol.Chem., 277, 2002
1Z60
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BU of 1z60 by Molmil
Solution structure of the carboxy-terminal domain of human TFIIH P44 subunit
Descriptor: TFIIH basal transcription factor complex p44 subunit, ZINC ION
Authors:Kellenberger, E, Dominguez, C, Fribourg, S, Wasielewski, E, Moras, D, Poterszman, A, Boelens, R, Kieffer, B.
Deposit date:2005-03-21
Release date:2005-04-12
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Solution structure of the C-terminal domain of TFIIH P44 subunit reveals a novel type of C4C4 ring domain involved in protein-protein interactions.
J.Biol.Chem., 280, 2005
2BB2
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BU of 2bb2 by Molmil
X-RAY ANALYSIS OF BETA B2-CRYSTALLIN AND EVOLUTION OF OLIGOMERIC LENS PROTEINS
Descriptor: BETA B2-CRYSTALLIN, BETA-MERCAPTOETHANOL
Authors:Bax, B, Lapatto, R, Nalini, V, Driessen, H, Lindley, P.F, Mahadevan, D, Blundell, T.L, Slingsby, C.
Deposit date:1992-09-21
Release date:1993-10-31
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:X-ray analysis of beta B2-crystallin and evolution of oligomeric lens proteins.
Nature, 347, 1990
6FAH
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BU of 6fah by Molmil
Molecular basis of the flavin-based electron-bifurcating caffeyl-CoA reductase reaction
Descriptor: Caffeyl-CoA reductase-Etf complex subunit CarC, Caffeyl-CoA reductase-Etf complex subunit CarD, Caffeyl-CoA reductase-Etf complex subunit CarE, ...
Authors:Demmer, J.K, Bertsch, J, Oeppinger, C, Wohlers, H, Kayastha, K, Demmer, U, Ermler, U, Mueller, V.
Deposit date:2017-12-15
Release date:2018-01-24
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.133 Å)
Cite:Molecular basis of the flavin-based electron-bifurcating caffeyl-CoA reductase reaction.
FEBS Lett., 592, 2018
2WEZ
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BU of 2wez by Molmil
Human BACE-1 in complex with 1-ethyl-N-((1S,2R)-2-hydroxy-3-(((3-(methyloxy)phenyl)methyl)amino)-1-(phenylmethyl)propyl)-4-(2-oxo-1- pyrrolidinyl)-1H-indole-6-carboxamide
Descriptor: BETA-SECRETASE 1, N-{(1S,2R)-1-BENZYL-2-HYDROXY-3-[(3-METHOXYBENZYL)AMINO]PROPYL}-1-ETHYL-4-(2-OXOPYRROLIDIN-1-YL)-1H-INDOLE-6-CARBOXAMIDE
Authors:Charrier, N, Clarke, B, Cutler, L, Demont, E, Dingwall, C, Dunsdon, R, Hawkins, J, Howes, C, Hubbard, J, Hussain, I, Maile, G, Matico, R, Mosley, J, Naylor, A, O'Brien, A, Redshaw, S, Rowland, P, Soleil, V, Smith, K.J, Sweitzer, S, Theobald, P, Vesey, D, Walter, D.S, Wayne, G.
Deposit date:2009-04-02
Release date:2009-05-19
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Second Generation of Bace-1 Inhibitors. Part 1: The Need for Improved Pharmacokinetics.
Bioorg.Med.Chem.Lett., 19, 2009
3CSP
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BU of 3csp by Molmil
Crystal structure of the DM2 mutant of myelin oligodendrocyte glycoprotein
Descriptor: Myelin-oligodendrocyte glycoprotein
Authors:Breithaupt, C, Schafer, B, Pellkofer, H, Huber, R, Linington, C, Jacob, U.
Deposit date:2008-04-10
Release date:2008-10-21
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Demyelinating myelin oligodendrocyte glycoprotein-specific autoantibody response is focused on one dominant conformational epitope region in rodents
J.Immunol., 181, 2008
2WJ7
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BU of 2wj7 by Molmil
human alphaB crystallin
Descriptor: ALPHA-CRYSTALLIN B CHAIN
Authors:Naylor, C.E, Bagneris, C, Bateman, O.A, Cronin, N, Keep, N.H, Slingsby, C.
Deposit date:2009-05-22
Release date:2009-08-11
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.631 Å)
Cite:Crystal Structures of Alpha-Crystallin Domain Dimers of Alphab-Crystallin and Hsp20.
J.Mol.Biol., 392, 2009
1HK0
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BU of 1hk0 by Molmil
Human GammaD Crystallin Structure at 1.25 A Resolution
Descriptor: Gamma-crystallin D
Authors:Basak, A.K, Slingsby, C.
Deposit date:2003-03-05
Release date:2003-05-08
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:High-Resolution X-Ray Crystal Structures of Human Gammad Crystallin (1.25A) and the R58H Mutant (1.15A) Associated with Aculeiform Cataract
J.Mol.Biol., 328, 2003
2Y8Q
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BU of 2y8q by Molmil
Structure of the regulatory fragment of mammalian AMPK in complex with one ADP
Descriptor: 5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-2, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1, ...
Authors:Xiao, B, Sanders, M.J, Underwood, E, Heath, R, Mayer, F, Carmena, D, Jing, C, Walker, P.A, Eccleston, J.F, Haire, L.F, Saiu, P, Howell, S.A, Aasland, R, Martin, S.R, Carling, D, Gamblin, S.J.
Deposit date:2011-02-09
Release date:2011-03-16
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of Mammalian Ampk and its Regulation by Adp
Nature, 472, 2011
2Y8L
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BU of 2y8l by Molmil
Structure of the regulatory fragment of mammalian aMPK in complex with two ADP
Descriptor: 5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-2, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1, ...
Authors:Xiao, B, Sanders, M.J, Underwood, E, Heath, R, Mayer, F, Carmena, D, Jing, C, Walker, P.A, Eccleston, J.F, Haire, L.F, Saiu, P, Howell, S.A, Aasland, R, Martin, S.R, Carling, D, Gamblin, S.J.
Deposit date:2011-02-07
Release date:2011-03-16
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of Mammalian Ampk and its Regulation by Adp
Nature, 472, 2011
2YA3
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BU of 2ya3 by Molmil
STRUCTURE OF THE REGULATORY FRAGMENT OF MAMMALIAN AMPK IN COMPLEX WITH COUMARIN ADP
Descriptor: 3'-(7-diethylaminocoumarin-3-carbonylamino)-3'-deoxy-ADP, 5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-2, ...
Authors:Xiao, B, Sanders, M.J, Underwood, E, Heath, R, Mayer, F, Carmena, D, Jing, C, Walker, P.A, Eccleston, J.F, Haire, L.F, Saiu, P, Howell, S.A, Aasland, R, Martin, S.R, Carling, D, Gamblin, S.J.
Deposit date:2011-02-17
Release date:2011-03-16
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Structure of Mammalian Ampk and its Regulation by Adp
Nature, 472, 2011

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