7XJ2
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![BU of 7xj2 by Molmil](/molmil-images/mine/7xj2) | Structure of human TRPV3_G573S in complex with Trpvicin in C4 symmetry | Descriptor: | Fusion protein of Transient receptor potential cation channel subfamily V member 3 and 3C-GFP, N-[5-[2-(2-cyanopropan-2-yl)pyridin-4-yl]-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxy-pyrimidine-5-carboxamide | Authors: | Fan, J, Yue, Z, Jiang, D, Lei, X. | Deposit date: | 2022-04-14 | Release date: | 2022-11-09 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.64 Å) | Cite: | Structural basis of TRPV3 inhibition by an antagonist. Nat.Chem.Biol., 19, 2023
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7NW2
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![BU of 7nw2 by Molmil](/molmil-images/mine/7nw2) | Crystal Structure of SARS-CoV-2 main protease in complex with LON-WEI-adc59df6-47 | Descriptor: | 3C-like proteinase, CHLORIDE ION, DIMETHYL SULFOXIDE, ... | Authors: | Fearon, D, Douangamath, A, Aimon, A, Brandao-Neto, J, Dias, A, Dunnett, L, Gehrtz, P, Gorrie-Stone, T.J, Lukacik, P, Powell, A.J, Skyner, R, Strain-Damerell, C.M, Zaidman, D, London, N, Walsh, M.A, von Delft, F, Covid Moonshot Consortium | Deposit date: | 2021-03-16 | Release date: | 2021-07-07 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | An automatic pipeline for the design of irreversible derivatives identifies a potent SARS-CoV-2 M pro inhibitor. Cell Chem Biol, 28, 2021
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7XJ1
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![BU of 7xj1 by Molmil](/molmil-images/mine/7xj1) | Structure of human TRPV3_G573S in complex with Trpvicin in C2 symmetry | Descriptor: | Fusion protein of Transient receptor potential cation channel subfamily V member 3 and 3C-GFP, N-[5-[2-(2-cyanopropan-2-yl)pyridin-4-yl]-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxy-pyrimidine-5-carboxamide, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate | Authors: | Fan, J, Yue, Z, Jiang, D, Lei, X. | Deposit date: | 2022-04-14 | Release date: | 2022-11-09 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (2.93 Å) | Cite: | Structural basis of TRPV3 inhibition by an antagonist. Nat.Chem.Biol., 19, 2023
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7XJ3
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![BU of 7xj3 by Molmil](/molmil-images/mine/7xj3) | Structure of human TRPV3 | Descriptor: | [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate, fusion of transient receptor potential cation channel subfamily V member 3 and 3C-GFP | Authors: | Fan, J, Yue, Z, Jiang, D, Lei, X. | Deposit date: | 2022-04-14 | Release date: | 2022-11-09 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.54 Å) | Cite: | Structural basis of TRPV3 inhibition by an antagonist. Nat.Chem.Biol., 19, 2023
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3DGJ
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![BU of 3dgj by Molmil](/molmil-images/mine/3dgj) | NNFGAIL segment from Islet Amyloid Polypeptide (IAPP or amylin) | Descriptor: | NNFGAIL peptide | Authors: | Wiltzius, J.J, Sievers, S.A, Sawaya, M.R, Cascio, D, Eisenberg, D. | Deposit date: | 2008-06-13 | Release date: | 2008-07-01 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Atomic structure of the cross-beta spine of islet amyloid polypeptide (amylin). Protein Sci., 17, 2008
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7XJ0
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![BU of 7xj0 by Molmil](/molmil-images/mine/7xj0) | Structure of human TRPV3 in complex with Trpvicin | Descriptor: | Fusion protein of Transient receptor potential cation channel subfamily V member 3 and 3C-GFP, N-[5-[2-(2-cyanopropan-2-yl)pyridin-4-yl]-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxy-pyrimidine-5-carboxamide, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate | Authors: | Fan, J, Yue, Z, Jiang, D, Lei, X. | Deposit date: | 2022-04-14 | Release date: | 2022-11-09 | Last modified: | 2023-01-11 | Method: | ELECTRON MICROSCOPY (2.53 Å) | Cite: | Structural basis of TRPV3 inhibition by an antagonist. Nat.Chem.Biol., 19, 2023
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7XNK
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![BU of 7xnk by Molmil](/molmil-images/mine/7xnk) | human KCNQ1-CaM in complex with ML277 | Descriptor: | (2R)-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-1-(4-methylbenzene-1-sulfonyl)piperidine-2-carboxamide, Calmodulin-3, POTASSIUM ION, ... | Authors: | Ma, D, Guo, J. | Deposit date: | 2022-04-29 | Release date: | 2022-12-14 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Structural mechanisms for the activation of human cardiac KCNQ1 channel by electro-mechanical coupling enhancers. Proc.Natl.Acad.Sci.USA, 119, 2022
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7XNI
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![BU of 7xni by Molmil](/molmil-images/mine/7xni) | human KCNQ1-CaM in apo state | Descriptor: | Calmodulin-3, Potassium voltage-gated channel subfamily KQT member 1 | Authors: | Ma, D, Guo, J. | Deposit date: | 2022-04-28 | Release date: | 2022-12-14 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structural mechanisms for the activation of human cardiac KCNQ1 channel by electro-mechanical coupling enhancers. Proc.Natl.Acad.Sci.USA, 119, 2022
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7XNL
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![BU of 7xnl by Molmil](/molmil-images/mine/7xnl) | human KCNQ1-CaM-ML277-PIP2 complex in state A | Descriptor: | (2R)-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-1-(4-methylbenzene-1-sulfonyl)piperidine-2-carboxamide, Calmodulin-3, POTASSIUM ION, ... | Authors: | Ma, D, Guo, J. | Deposit date: | 2022-04-29 | Release date: | 2022-12-14 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural mechanisms for the activation of human cardiac KCNQ1 channel by electro-mechanical coupling enhancers. Proc.Natl.Acad.Sci.USA, 119, 2022
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7XNN
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![BU of 7xnn by Molmil](/molmil-images/mine/7xnn) | human KCNQ1-CaM-ML277-PIP2 complex in state B | Descriptor: | (2R)-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-1-(4-methylbenzene-1-sulfonyl)piperidine-2-carboxamide, Calmodulin-3, POTASSIUM ION, ... | Authors: | Ma, D, Guo, J. | Deposit date: | 2022-04-29 | Release date: | 2022-12-14 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Structural mechanisms for the activation of human cardiac KCNQ1 channel by electro-mechanical coupling enhancers. Proc.Natl.Acad.Sci.USA, 119, 2022
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5N18
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![BU of 5n18 by Molmil](/molmil-images/mine/5n18) | Second Bromodomain (BD2) from Candida albicans Bdf1 bound to an imidazopyridine (compound 2) | Descriptor: | 4-[8-methyl-3-[(4-methylphenyl)amino]imidazo[1,2-a]pyridin-2-yl]phenol, Bromodomain-containing factor 1, GLYCEROL | Authors: | Mietton, F, Ferri, E, Champleboux, M, Zala, N, Maubon, D, Zhou, Y, Harbut, M, Spittler, D, Garnaud, C, Courcon, M, Chauvel, M, d'Enfert, C, Kashemirov, B.A, Hull, M, Cornet, M, McKenna, C.E, Govin, J, Petosa, C. | Deposit date: | 2017-02-05 | Release date: | 2017-05-31 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Selective BET bromodomain inhibition as an antifungal therapeutic strategy. Nat Commun, 8, 2017
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7TV3
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![BU of 7tv3 by Molmil](/molmil-images/mine/7tv3) | LH2-LH3 antenna in parallel configuration embedded in a nanodisc | Descriptor: | BACTERIOCHLOROPHYLL A, LYCOPENE, Light-harvesting protein B-800/850 alpha chain, ... | Authors: | Toporik, H, Harris, D, Schlau-Cohen, G.S, Mazor, Y. | Deposit date: | 2022-02-03 | Release date: | 2023-02-15 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (11.4 Å) | Cite: | Elucidating interprotein energy transfer dynamics within the antenna network from purple bacteria. Proc.Natl.Acad.Sci.USA, 120, 2023
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7OY2
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![BU of 7oy2 by Molmil](/molmil-images/mine/7oy2) | High resolution structure of cytochrome bd-II oxidase from E. coli | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-[(2~{E},6~{E},10~{Z},14~{E},18~{E},22~{E},26~{E})-3,7,11,15,19,23,27,31-octamethyldotriaconta-2,6,10,14,18,22,26,30-octaenyl]naphthalene-1,4-dione, CARDIOLIPIN, ... | Authors: | Grund, T.N, Wu, D, Bald, D, Michel, H, Safarian, S. | Deposit date: | 2021-06-23 | Release date: | 2021-12-15 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (2.06 Å) | Cite: | Mechanistic and structural diversity between cytochrome bd isoforms of Escherichia coli . Proc.Natl.Acad.Sci.USA, 118, 2021
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7TUW
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![BU of 7tuw by Molmil](/molmil-images/mine/7tuw) | LH2-LH3 antenna in anti parallel configuration embedded in a nanodisc | Descriptor: | BACTERIOCHLOROPHYLL A, LYCOPENE, Light-harvesting protein B-800/850 alpha chain, ... | Authors: | Toporik, H, Harris, D, Schlau-Cohen, G.S, Mazor, Y. | Deposit date: | 2022-02-03 | Release date: | 2023-02-15 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (8.2 Å) | Cite: | Elucidating interprotein energy transfer dynamics within the antenna network from purple bacteria. Proc.Natl.Acad.Sci.USA, 120, 2023
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5N82
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![BU of 5n82 by Molmil](/molmil-images/mine/5n82) | Crystal structure of an engineered TycA variant in complex with an beta-Phe-AMP analog | Descriptor: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, SULFATE ION, Tyrocidine synthase 1, ... | Authors: | Niquille, D.L, Hansen, D.L, Mori, T, Fercher, D, Kries, H, Hilvert, D. | Deposit date: | 2017-02-22 | Release date: | 2017-12-13 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.708 Å) | Cite: | Nonribosomal biosynthesis of backbone-modified peptides. Nat Chem, 10, 2018
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7W3J
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![BU of 7w3j by Molmil](/molmil-images/mine/7w3j) | Structure of USP14-bound human 26S proteasome in substrate-inhibited state SC_USP14 | Descriptor: | 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... | Authors: | Zhang, S, Zou, S, Yin, D, Wu, Z, Mao, Y. | Deposit date: | 2021-11-25 | Release date: | 2022-05-04 | Last modified: | 2022-06-01 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | USP14-regulated allostery of the human proteasome by time-resolved cryo-EM. Nature, 605, 2022
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7W39
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![BU of 7w39 by Molmil](/molmil-images/mine/7w39) | Structure of USP14-bound human 26S proteasome in state EA2.1_UBL | Descriptor: | 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... | Authors: | Zhang, S, Zou, S, Yin, D, Wu, Z, Mao, Y. | Deposit date: | 2021-11-25 | Release date: | 2022-05-04 | Last modified: | 2022-06-01 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | USP14-regulated allostery of the human proteasome by time-resolved cryo-EM. Nature, 605, 2022
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7W3A
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![BU of 7w3a by Molmil](/molmil-images/mine/7w3a) | Structure of USP14-bound human 26S proteasome in substrate-engaged state ED4_USP14 | Descriptor: | 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... | Authors: | Zhang, S, Zou, S, Yin, D, Wu, Z, Mao, Y. | Deposit date: | 2021-11-25 | Release date: | 2022-05-04 | Last modified: | 2022-06-01 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | USP14-regulated allostery of the human proteasome by time-resolved cryo-EM. Nature, 605, 2022
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7W3B
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![BU of 7w3b by Molmil](/molmil-images/mine/7w3b) | Structure of USP14-bound human 26S proteasome in substrate-engaged state ED5_USP14 | Descriptor: | 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... | Authors: | Zhang, S, Zou, S, Yin, D, Wu, Z, Mao, Y. | Deposit date: | 2021-11-25 | Release date: | 2022-05-04 | Last modified: | 2022-06-01 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | USP14-regulated allostery of the human proteasome by time-resolved cryo-EM. Nature, 605, 2022
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7W37
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![BU of 7w37 by Molmil](/molmil-images/mine/7w37) | Structure of USP14-bound human 26S proteasome in state EA1_UBL | Descriptor: | 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... | Authors: | Zhang, S, Zou, S, Yin, D, Wu, Z, Mao, Y. | Deposit date: | 2021-11-25 | Release date: | 2022-05-04 | Last modified: | 2022-06-01 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | USP14-regulated allostery of the human proteasome by time-resolved cryo-EM. Nature, 605, 2022
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7W3G
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![BU of 7w3g by Molmil](/molmil-images/mine/7w3g) | Structure of USP14-bound human 26S proteasome in substrate-engaged state ED2.0_USP14 | Descriptor: | 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... | Authors: | Zhang, S, Zou, S, Yin, D, Wu, Z, Mao, Y. | Deposit date: | 2021-11-25 | Release date: | 2022-05-04 | Last modified: | 2022-06-01 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | USP14-regulated allostery of the human proteasome by time-resolved cryo-EM. Nature, 605, 2022
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7U4W
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![BU of 7u4w by Molmil](/molmil-images/mine/7u4w) | The ubiquitin-associated domain of human thirty-eight negative kinase-1 flexibly fused to the 1TEL crystallization chaperone via a 2-glycine linker and crystallized at traditional protein concentration | Descriptor: | Transcription factor ETV6,Non-receptor tyrosine-protein kinase TNK1 | Authors: | Nawarathnage, S, Pedroza Romo, M.J, Smith, T, Bunn, D, Stewart, C, Doukov, T, Moody, J.D. | Deposit date: | 2022-03-01 | Release date: | 2023-03-08 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Fusion crystallization reveals the behavior of both the 1TEL crystallization chaperone and the TNK1 UBA domain. Structure, 31, 2023
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7W3K
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![BU of 7w3k by Molmil](/molmil-images/mine/7w3k) | Structure of USP14-bound human 26S proteasome in substrate-inhibited state SD4_USP14 | Descriptor: | 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... | Authors: | Zhang, S, Zou, S, Yin, D, Wu, Z, Mao, Y. | Deposit date: | 2021-11-25 | Release date: | 2022-05-04 | Last modified: | 2022-06-01 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | USP14-regulated allostery of the human proteasome by time-resolved cryo-EM. Nature, 605, 2022
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7W3C
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![BU of 7w3c by Molmil](/molmil-images/mine/7w3c) | Structure of USP14-bound human 26S proteasome in substrate-engaged state ED0_USP14 | Descriptor: | 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... | Authors: | Zhang, S, Zou, S, Yin, D, Wu, Z, Mao, Y. | Deposit date: | 2021-11-25 | Release date: | 2022-05-04 | Last modified: | 2022-06-01 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | USP14-regulated allostery of the human proteasome by time-resolved cryo-EM. Nature, 605, 2022
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7W3F
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![BU of 7w3f by Molmil](/molmil-images/mine/7w3f) | Structure of USP14-bound human 26S proteasome in substrate-engaged state ED1_USP14 | Descriptor: | 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... | Authors: | Zhang, S, Zou, S, Yin, D, Wu, Z, Mao, Y. | Deposit date: | 2021-11-25 | Release date: | 2022-05-04 | Last modified: | 2022-06-01 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | USP14-regulated allostery of the human proteasome by time-resolved cryo-EM. Nature, 605, 2022
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