4D1E
 
 | | THE CRYSTAL STRUCTURE OF HUMAN MUSCLE ALPHA-ACTININ-2 | | Descriptor: | ALPHA-ACTININ-2 | | Authors: | Pinotsis, N, Salmazo, A, Sjoeblom, B, Gkougkoulia, E, Djinovic-Carugo, K. | | Deposit date: | 2014-05-01 | | Release date: | 2014-12-10 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | The Structure and Regulation of Human Muscle Alpha-Actinin
Cell(Cambridge,Mass.), 159, 2014
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3LUE
 | | Model of alpha-actinin CH1 bound to F-actin | | Descriptor: | Actin, cytoplasmic 1, Alpha-actinin-3 | | Authors: | Galkin, V.E, Orlova, A, Salmazo, A, Djinovic-Carugo, K, Egelman, E.H. | | Deposit date: | 2010-02-17 | | Release date: | 2010-04-28 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (15 Å) | | Cite: | Opening of tandem calponin homology domains regulates their affinity for F-actin.
Nat.Struct.Mol.Biol., 17, 2010
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8V42
 | | Structure of Human Vaccinia-related Kinase 1 (VRK1) Bound to ACH000400 | | Descriptor: | (7S)-2-(3,5-difluoro-4-hydroxyanilino)-7-methyl-5-[(1,2-oxazol-5-yl)methyl]-8-(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5H)-one, DI(HYDROXYETHYL)ETHER, SULFATE ION, ... | | Authors: | Counago, R.M, de Souza, G.P, Azevedo, A, Guimaraes, C, Mascarello, A, Gama, F, Ferreira, M, Arruda, P. | | Deposit date: | 2023-11-28 | | Release date: | 2024-09-04 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Novel Dihydropteridinone Derivatives As Potent Inhibitors of the Understudied Human Kinases Vaccinia-Related Kinase 1 and Casein Kinase 1 delta / epsilon.
J.Med.Chem., 67, 2024
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5NL6
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5NL7
 | | The crystal structure of the Actin Binding Domain (ABD) of alpha actinin from Entamoeba histolytica | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, Calponin homology domain protein putative | | Authors: | Pinotsis, N, Djinovic-Carugo, K, Khan, M.B. | | Deposit date: | 2017-04-04 | | Release date: | 2018-05-16 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.48 Å) | | Cite: | Calcium modulates the domain flexibility and function of an alpha-actinin similar to the ancestral alpha-actinin.
Proc.Natl.Acad.Sci.USA, 117, 2020
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6SL7
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6SL3
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6SL2
 | | ALPHA-ACTININ FROM ENTAMOEBA HISTOLYTICA | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, Calponin homology domain protein putative, ... | | Authors: | Pinotsis, N, Khan, M.B, Djinovic-Carugo, K. | | Deposit date: | 2019-08-18 | | Release date: | 2020-08-26 | | Last modified: | 2020-11-04 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Calcium modulates the domain flexibility and function of an alpha-actinin similar to the ancestral alpha-actinin.
Proc.Natl.Acad.Sci.USA, 117, 2020
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