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Human CYP11B1 mutant in complex with metyrapone
Descriptor:	CHOLIC ACID, Cytochrome P450 11B1, mitochondrial, ...
Authors:	Mukai, K, Sugimoto, H, Reiko, S, Matsuura, T, Hishiki, T, Kagawa, N.
Deposit date:	2021-02-26
Release date:	2022-01-05
Last modified:	2023-11-29
Method:	X-RAY DIFFRACTION (1.4 Å)
Cite:	Spatially restricted substrate-binding site of cortisol-synthesizing CYP11B1 limits multiple hydroxylations and hinders aldosterone synthesis. Curr Res Struct Biol, 3, 2021

Discovery of (4-Pyrazolyl)-2-Aminopyrimidines as Potent and Selective Inhibitors of Cyclin-Dependent Kinase 2
Descriptor:	1-{(4M)-4-[2-{[1-(cyclopropanesulfonyl)piperidin-4-yl]amino}-5-(trifluoromethyl)pyrimidin-4-yl]-1H-pyrazol-1-yl}-2-methylpropan-2-ol, Cyclin-dependent kinase 2
Authors:	Deller, M.C, Epling, L.B.
Deposit date:	2023-11-02
Release date:	2024-02-14
Last modified:	2024-03-06
Method:	X-RAY DIFFRACTION (1.55 Å)
Cite:	Discovery of (4-Pyrazolyl)-2-aminopyrimidines as Potent and Selective Inhibitors of Cyclin-Dependent Kinase 2. J.Med.Chem., 67, 2024

Crystal structure of the PH domain of Evectin-2 from human complexed with O-phospho-L-serine
Descriptor:	1,2-ETHANEDIOL, PHOSPHOSERINE, Pleckstrin homology domain-containing family B member 2
Authors:	Okazaki, S, Kato, R, Wakatsuki, S.
Deposit date:	2010-05-21
Release date:	2011-05-25
Last modified:	2023-11-01
Method:	X-RAY DIFFRACTION (1 Å)
Cite:	Intracellular phosphatidylserine is essential for retrograde membrane traffic through endosomes Proc.Natl.Acad.Sci.USA, 108, 2011