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1RY6
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BU of 1ry6 by Molmil
Crystal Structure of Internal Kinesin Motor Domain
Descriptor: INTERNAL KINESIN, SULFATE ION
Authors:Shipley, K, Hekmat-Nejad, M, Turner, J, Moores, C, Anderson, R, Milligan, R, Sakowicz, R, Fletterick, R.
Deposit date:2003-12-19
Release date:2004-04-13
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure of a kinesin microtubule depolymerization machine.
Embo J., 23, 2004
2J8P
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BU of 2j8p by Molmil
NMR structure of C-terminal domain of human CstF-64
Descriptor: CLEAVAGE STIMULATION FACTOR 64 KDA SUBUNIT
Authors:Qu, X, Perez-Canadillas, J.M, Agrawal, S, De Baecke, J, Cheng, H, Varani, G, Moore, C.
Deposit date:2006-10-27
Release date:2006-11-06
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:The C-Terminal Domains of Vertebrate Cstf-64 and its Yeast Orthologue RNA15 Form a New Structure Critical for Mrna 3'-End Processing.
J.Biol.Chem., 282, 2007
2OSR
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BU of 2osr by Molmil
NMR Structure of RRM-2 of Yeast NPL3 Protein
Descriptor: Nucleolar protein 3
Authors:Deka, P, Bucheli, M, Skrisovska, L, Allain, F.H, Moore, C, Buratowski, S, Varani, G.
Deposit date:2007-02-06
Release date:2007-12-18
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Structure of the yeast SR protein Npl3 and Interaction with mRNA 3'-end processing signals.
J.Mol.Biol., 375, 2008
2OSQ
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BU of 2osq by Molmil
NMR Structure of RRM-1 of Yeast NPL3 Protein
Descriptor: Nucleolar protein 3
Authors:Deka, P, Bucheli, M, Skrisovska, L, Allain, F.H, Moore, C, Buratowski, S, Varani, G.
Deposit date:2007-02-06
Release date:2007-12-18
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Structure of the yeast SR protein Npl3 and Interaction with mRNA 3'-end processing signals.
J.Mol.Biol., 375, 2008
4UXT
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BU of 4uxt by Molmil
Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, KINESIN HEAVY CHAIN ISOFORM 5A, ...
Authors:Atherton, J, Farabella, I, Yu, I.M, Rosenfeld, S.S, Houdusse, A, Topf, M, Moores, C.
Deposit date:2014-08-27
Release date:2014-09-24
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (7.4 Å)
Cite:Conserved Mechanisms of Microtubule-Stimulated Adp Release, ATP Binding, and Force Generation in Transport Kinesins.
Elife, 3, 2014
4AQV
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BU of 4aqv by Molmil
Model of human kinesin-5 motor domain (3HQD) and mammalian tubulin heterodimer (1JFF) docked into the 9.7-angstrom cryo-EM map of microtubule-bound kinesin-5 motor domain in the AMPPPNP state.
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, KINESIN-LIKE PROTEIN KIF11, ...
Authors:Goulet, A, Behnke-Parks, W.M, Sindelar, C.V, Rosenfeld, S.S, Moores, C.A.
Deposit date:2012-04-19
Release date:2012-11-21
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (9.7 Å)
Cite:The Structural Basis of Force Generation by the Mitotic Motor Kinesin-5.
J.Biol.Chem., 287, 2012
4UXS
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BU of 4uxs by Molmil
Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, KINESIN-3 MOTOR DOMAIN, ...
Authors:Atherton, J, Farabella, I, Yu, I.M, Rosenfeld, S.S, Houdusse, A, Topf, M, Moores, C.
Deposit date:2014-08-27
Release date:2014-09-24
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (7 Å)
Cite:Conserved Mechanisms of Microtubule-Stimulated Adp Release, ATP Binding, and Force Generation in Transport Kinesins.
Elife, 3, 2014
4UXO
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BU of 4uxo by Molmil
Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, KINESIN-3 MOTOR DOMAIN, ...
Authors:Atherton, J, Farabella, I, Yu, I.M, Rosenfeld, S.S, Houdusse, A, Topf, M, Moores, C.
Deposit date:2014-08-27
Release date:2014-09-24
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (6.3 Å)
Cite:Conserved Mechanisms of Microtubule-Stimulated Adp Release, ATP Binding, and Force Generation in Transport Kinesins.
Elife, 3, 2014
4UXR
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BU of 4uxr by Molmil
Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins
Descriptor: ADENOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Atherton, J, Farabella, I, Yu, I.M, Rosenfeld, S.S, Houdusse, A, Topf, M, Moores, C.
Deposit date:2014-08-27
Release date:2014-09-24
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (7 Å)
Cite:Conserved Mechanisms of Microtubule-Stimulated Adp Release, ATP Binding, and Force Generation in Transport Kinesins.
Elife, 3, 2014
4UY0
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BU of 4uy0 by Molmil
Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins
Descriptor: ADENOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Atherton, J, Farabella, I, Yu, I.M, Rosenfeld, S.S, Houdusse, A, Topf, M, Moores, C.
Deposit date:2014-08-27
Release date:2014-09-24
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (7.7 Å)
Cite:Conserved Mechanisms of Microtubule-Stimulated Adp Release, ATP Binding, and Force Generation in Transport Kinesins.
Elife, 3, 2014
4UXP
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BU of 4uxp by Molmil
Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, KINESIN-3 MOTOR DOMAIN, ...
Authors:Atherton, J, Farabella, I, Yu, I.M, Rosenfeld, S.S, Houdusse, A, Topf, M, Moores, C.
Deposit date:2014-08-27
Release date:2014-09-24
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (6.3 Å)
Cite:Conserved Mechanisms of Microtubule-Stimulated Adp Release, ATP Binding, and Force Generation in Transport Kinesins.
Elife, 3, 2014
4UXY
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BU of 4uxy by Molmil
Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins
Descriptor: ALPHA TUBULIN, BETA TUBULIN, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Atherton, J, Farabella, I, Yu, I.M, Rosenfeld, S.S, Houdusse, A, Topf, M, Moores, C.
Deposit date:2014-08-27
Release date:2014-09-24
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (6.5 Å)
Cite:Conserved Mechanisms of Microtubule-Stimulated Adp Release, ATP Binding, and Force Generation in Transport Kinesins.
Elife, 3, 2014
6YW6
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BU of 6yw6 by Molmil
Cryo-EM structure of the ARP2/3 1B5CL isoform complex.
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, ARPC1B, Actin-related protein 2, ...
Authors:von Loeffelholz, O, Moores, C, Purkiss, A.
Deposit date:2020-04-29
Release date:2020-07-22
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Cryo-EM of human Arp2/3 complexes provides structural insights into actin nucleation modulation by ARPC5 isoforms.
Biol Open, 9, 2020
6YW7
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BU of 6yw7 by Molmil
Cryo-EM structure of the ARP2/3 1A5C isoform complex.
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Actin-related protein 2, Actin-related protein 2/3 complex subunit 1A, ...
Authors:von Loeffelholz, O, Moores, C, Purkiss, A.
Deposit date:2020-04-29
Release date:2020-07-22
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Cryo-EM of human Arp2/3 complexes provides structural insights into actin nucleation modulation by ARPC5 isoforms.
Biol Open, 9, 2020
4AQW
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BU of 4aqw by Molmil
Model of human kinesin-5 motor domain (1II6, 3HQD) and mammalian tubulin heterodimer (1JFF) docked into the 9.5-angstrom cryo-EM map of microtubule-bound kinesin-5 motor domain in the rigor state.
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, KINESIN-LIKE PROTEIN KIF11, ...
Authors:Goulet, A, Behnke-Parks, W.M, Sindelar, C.V, Rosenfeld, S.S, Moores, C.A.
Deposit date:2012-04-19
Release date:2012-11-21
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (9.5 Å)
Cite:The Structural Basis of Force Generation by the Mitotic Motor Kinesin-5.
J.Biol.Chem., 287, 2012
5MM7
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BU of 5mm7 by Molmil
Ustilago maydis kinesin-5 motor domain with N-terminal extension in the AMPPNP state bound to microtubules
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Moores, C.A, von Loeffelholz, O.
Deposit date:2016-12-08
Release date:2018-08-08
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (5.1 Å)
Cite:Cryo-EM structure of the Ustilago maydis kinesin-5 motor domain bound to microtubules.
J.Struct.Biol., 2019
4CK6
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BU of 4ck6 by Molmil
Pseudo-atomic model of microtubule-bound human kinesin-5 motor domain in the ADP.AlFx state, based on cryo-electron microscopy experiment.
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Goulet, A, Major, J, Jun, Y, Gross, S, Rosenfeld, S, Moores, C.
Deposit date:2013-12-30
Release date:2014-02-05
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (9.2 Å)
Cite:Comprehensive Structural Model of the Mechanochemical Cycle of a Mitotic Motor Highlights Molecular Adaptations in the Kinesin Family.
Proc.Natl.Acad.Sci.USA, 111, 2014
4CK7
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BU of 4ck7 by Molmil
Pseudo-atomic model of microtubule-bound human kinesin-5 motor domain in presence of adp.alfx (NECK-LINKER IN ITS DISCONNECTED CONFORMATION, based on cryo-electron microscopy experiment
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Goulet, A, Major, J, Jun, Y, Gross, S, Rosenfeld, S, Moores, C.
Deposit date:2013-12-30
Release date:2014-02-05
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (9.2 Å)
Cite:Comprehensive Structural Model of the Mechanochemical Cycle of a Mitotic Motor Highlights Molecular Adaptations in the Kinesin Family.
Proc.Natl.Acad.Sci.USA, 111, 2014
4CK5
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BU of 4ck5 by Molmil
Pseudo-atomic model of microtubule-bound human kinesin-5 motor domain in the ADP state, based on cryo-electron microscopy experiment.
Descriptor: ADENOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Goulet, A, Major, J, Jun, Y, Gross, S, Rosenfeld, S, Moores, C.
Deposit date:2013-12-30
Release date:2014-02-05
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (10 Å)
Cite:Comprehensive Structural Model of the Mechanochemical Cycle of a Mitotic Motor Highlights Molecular Adaptations in the Kinesin Family.
Proc.Natl.Acad.Sci.USA, 111, 2014
5MJS
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BU of 5mjs by Molmil
S. pombe microtubule copolymerized with GTP and Mal3-143
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Microtubule integrity protein mal3, ...
Authors:von Loeffelholz, O, Moores, C.
Deposit date:2016-12-01
Release date:2017-12-20
Last modified:2019-10-23
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:Nucleotide- and Mal3-dependent changes in fission yeast microtubules suggest a structural plasticity view of dynamics.
Nat Commun, 8, 2017
5MM4
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BU of 5mm4 by Molmil
Ustilago maydis kinesin-5 motor domain in the AMPPNP state bound to microtubules
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Moores, C.A, von Loeffelholz, O.
Deposit date:2016-12-08
Release date:2018-06-27
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Cryo-EM structure of the Ustilago maydis kinesin-5 motor domain bound to microtubules.
J.Struct.Biol., 2019
7OG3
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BU of 7og3 by Molmil
IRED-88
Descriptor: NAD(P)-dependent oxidoreductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SODIUM ION
Authors:Faller, M, Koch, E.
Deposit date:2021-05-06
Release date:2021-10-06
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.904 Å)
Cite:Machine-Directed Evolution of an Imine Reductase for Activity and Stereoselectivity
Acs Catalysis, 2021
6G76
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BU of 6g76 by Molmil
Phosphorylated RSK4 N-terminal Kinase Domain in complex with AMP-PNP
Descriptor: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Ribosomal protein S6 kinase alpha-6, ZINC ION
Authors:Prischi, F, Ali, M.M.
Deposit date:2018-04-04
Release date:2019-04-17
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (3 Å)
Cite:Repurposed floxacins targeting RSK4 prevent chemoresistance and metastasis in lung and bladder cancer.
Sci Transl Med, 13, 2021
5H7U
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BU of 5h7u by Molmil
NMR structure of eIF3 36-163
Descriptor: Eukaryotic translation initiation factor 3 subunit C
Authors:Nagata, T, Obayashi, E.
Deposit date:2016-11-21
Release date:2017-05-31
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Molecular Landscape of the Ribosome Pre-initiation Complex during mRNA Scanning: Structural Role for eIF3c and Its Control by eIF5.
Cell Rep, 18, 2017
6G78
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BU of 6g78 by Molmil
RSK4 N-terminal Kinase Domain S232E in complex with AMP-PNP
Descriptor: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Ribosomal protein S6 kinase alpha-6
Authors:Prischi, F, Ali, M.M.
Deposit date:2018-04-04
Release date:2019-04-17
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Repurposed floxacins targeting RSK4 prevent chemoresistance and metastasis in lung and bladder cancer.
Sci Transl Med, 13, 2021

 

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