4WYM
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![BU of 4wym by Molmil](/molmil-images/mine/4wym) | Structural basis of HIV-1 capsid recognition by CPSF6 | Descriptor: | Capsid protein p24, ISOFORM 2 OF CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 6 | Authors: | Battacharya, A, Taylor, A.B, Hart, P.J, Ivanov, D.N. | Deposit date: | 2014-11-17 | Release date: | 2014-12-17 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural basis of HIV-1 capsid recognition by PF74 and CPSF6. Proc.Natl.Acad.Sci.USA, 111, 2014
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4TKP
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![BU of 4tkp by Molmil](/molmil-images/mine/4tkp) | Complex of Ubc13 with the RING domain of the TRIM5alpha retroviral restriction factor | Descriptor: | SULFATE ION, Tripartite motif-containing protein 5, Ubiquitin-conjugating enzyme E2 N, ... | Authors: | Johnson, R, Taylor, A.B, Hart, P.J, Ivanov, D.N. | Deposit date: | 2014-05-27 | Release date: | 2015-07-22 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | RING Dimerization Links Higher-Order Assembly of TRIM5 alpha to Synthesis of K63-Linked Polyubiquitin. Cell Rep, 12, 2015
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6U6Z
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![BU of 6u6z by Molmil](/molmil-images/mine/6u6z) | Human SAMHD1 bound to deoxyribo(TG*TTCA)-oligonucleotide | Descriptor: | DNA polymer TG(PST)TCA, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, ZINC ION | Authors: | Taylor, A.B, Yu, C.H, Ivanov, D.N. | Deposit date: | 2019-08-30 | Release date: | 2020-09-02 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Nucleic acid binding by SAMHD1 contributes to the antiretroviral activity and is enhanced by the GpsN modification. Nat Commun, 12, 2021
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6U6X
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![BU of 6u6x by Molmil](/molmil-images/mine/6u6x) | Human SAMHD1 bound to deoxyribo(C*G*C*C*T)-oligonucleotide | Descriptor: | DNA SC-GS-SC-SC-DT, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, ZINC ION | Authors: | Taylor, A.B, Bhattacharya, A, Wang, Z, Ivanov, D.N. | Deposit date: | 2019-08-30 | Release date: | 2020-09-02 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.58 Å) | Cite: | Nucleic acid binding by SAMHD1 contributes to the antiretroviral activity and is enhanced by the GpsN modification. Nat Commun, 12, 2021
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6U6Y
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![BU of 6u6y by Molmil](/molmil-images/mine/6u6y) | Human SAMHD1 bound to ribo(CGCCU)-oligonucleotide | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, RNA CGCCU, ... | Authors: | Taylor, A.B, Bhattacharya, A, Wang, Z, Ivanov, D.N. | Deposit date: | 2019-08-30 | Release date: | 2020-09-02 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.47 Å) | Cite: | Nucleic acid binding by SAMHD1 contributes to the antiretroviral activity and is enhanced by the GpsN modification. Nat Commun, 12, 2021
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2LM3
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![BU of 2lm3 by Molmil](/molmil-images/mine/2lm3) | Structure of the rhesus monkey TRIM5alpha PRYSPRY domain | Descriptor: | Tripartite motif-containing protein 5 | Authors: | Biris, N, Yang, Y, Taylor, A.B, Tomashevski, A, Guo, M, Hart, P.J, Diaz-Griffero, F, Ivanov, D.N. | Deposit date: | 2011-11-21 | Release date: | 2012-08-08 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structure of the rhesus monkey TRIM5alpha PRYSPRY domain, the HIV capsid recognition module. Proc.Natl.Acad.Sci.USA, 109, 2012
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3UV9
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![BU of 3uv9 by Molmil](/molmil-images/mine/3uv9) | Structure of the rhesus monkey TRIM5alpha deltav1 PRYSPRY domain | Descriptor: | Tripartite motif-containing protein 5 | Authors: | Biris, N, Yang, Y, Taylor, A.B, Tomashevskii, A, Guo, M, Hart, P.J, Diaz-Griffero, F, Ivanov, D. | Deposit date: | 2011-11-29 | Release date: | 2012-08-08 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.549 Å) | Cite: | Structure of the rhesus monkey TRIM5alpha PRYSPRY domain, the HIV capsid recognition module. Proc.Natl.Acad.Sci.USA, 109, 2012
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6OW0
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![BU of 6ow0 by Molmil](/molmil-images/mine/6ow0) | Crystal structure of mithramycin 3-side chain keto-reductase MtmW in complex with NAD+ and PEG | Descriptor: | DI(HYDROXYETHYL)ETHER, GLYCEROL, MtmW, ... | Authors: | Hou, C, Yu, X, Rohr, J, Tsodikov, O.V. | Deposit date: | 2019-05-08 | Release date: | 2019-11-27 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.67 Å) | Cite: | Discovery of a Cryptic Intermediate in Late Steps of Mithramycin Biosynthesis. Angew.Chem.Int.Ed.Engl., 59, 2020
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6OVX
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![BU of 6ovx by Molmil](/molmil-images/mine/6ovx) | Crystal structure of mithramycin 3-side chain keto-reductase MtmW in complex with NAD+, P422 form | Descriptor: | GLYCEROL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Putative side chain reductase | Authors: | Hou, C, Yu, X, Rohr, J, Tsodikov, O.V. | Deposit date: | 2019-05-08 | Release date: | 2019-11-27 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Discovery of a Cryptic Intermediate in Late Steps of Mithramycin Biosynthesis. Angew.Chem.Int.Ed.Engl., 59, 2020
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5VA4
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![BU of 5va4 by Molmil](/molmil-images/mine/5va4) | |
4QNB
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![BU of 4qnb by Molmil](/molmil-images/mine/4qnb) | |
7LTT
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![BU of 7ltt by Molmil](/molmil-images/mine/7ltt) | SAMHD1(113-626) H206R D207N R366C | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, MAGNESIUM ION | Authors: | Temple, J.T, Bowen, N.E. | Deposit date: | 2021-02-20 | Release date: | 2021-11-24 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural and functional characterization explains loss of dNTPase activity of the cancer-specific R366C/H mutant SAMHD1 proteins. J.Biol.Chem., 297, 2021
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7LU5
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![BU of 7lu5 by Molmil](/molmil-images/mine/7lu5) | SAMHD1(113-626) H206R D207N R366H | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | Authors: | Temple, J.T, Bowen, N.E. | Deposit date: | 2021-02-20 | Release date: | 2021-11-24 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.57 Å) | Cite: | Structural and functional characterization explains loss of dNTPase activity of the cancer-specific R366C/H mutant SAMHD1 proteins. J.Biol.Chem., 297, 2021
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7JSL
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![BU of 7jsl by Molmil](/molmil-images/mine/7jsl) | |
7JSA
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![BU of 7jsa by Molmil](/molmil-images/mine/7jsa) | |
6OVQ
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![BU of 6ovq by Molmil](/molmil-images/mine/6ovq) | Crystal structure of mithramycin 3-side chain keto-reductase MtmW | Descriptor: | GLYCEROL, Putative Side chain reductase | Authors: | Hou, C, Yu, X, Rohr, J, Tsodikov, O.V. | Deposit date: | 2019-05-08 | Release date: | 2019-11-27 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Discovery of a Cryptic Intermediate in Late Steps of Mithramycin Biosynthesis. Angew.Chem.Int.Ed.Engl., 59, 2020
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5JW2
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![BU of 5jw2 by Molmil](/molmil-images/mine/5jw2) | Crystal structure of mithramycin analogue MTM SA-Phe in complex with a 10-mer DNA AGGGATCCCT | Descriptor: | DNA (5'-D(*AP*GP*GP*GP*AP*TP*CP*CP*CP*T)-3'), Plicamycin, mithramycin analogue MTM SA-Phe, ... | Authors: | Hou, C, Rohr, J, Tsodikov, O.V. | Deposit date: | 2016-05-11 | Release date: | 2016-09-14 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structures of mithramycin analogues bound to DNA and implications for targeting transcription factor FLI1. Nucleic Acids Res., 44, 2016
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5JVT
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![BU of 5jvt by Molmil](/molmil-images/mine/5jvt) | |
5JVW
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![BU of 5jvw by Molmil](/molmil-images/mine/5jvw) | Crystal structure of mithramycin analogue MTM SA-Trp in complex with a 10-mer DNA AGAGGCCTCT. | Descriptor: | DNA (5'-D(*AP*GP*AP*GP*GP*CP*CP*TP*CP*T)-3'), Plicamycin, mithramycin analogue MTM SA-Trp, ... | Authors: | Hou, C, Rohr, J, Tsodikov, O.V. | Deposit date: | 2016-05-11 | Release date: | 2016-09-14 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structures of mithramycin analogues bound to DNA and implications for targeting transcription factor FLI1. Nucleic Acids Res., 44, 2016
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5JW0
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![BU of 5jw0 by Molmil](/molmil-images/mine/5jw0) | Crystal structure of mithramycin analogue MTM SA-Phe in complex with a 10-mer DNA AGGGTACCCT | Descriptor: | DNA (5'-D(P*AP*GP*GP*GP*TP*AP*CP*CP*CP*T)-3'), Plicamycin, mithramycin analogue MTM SA-Phe, ... | Authors: | Hou, C, Rohr, J, Tsodikov, O.V. | Deposit date: | 2016-05-11 | Release date: | 2016-09-14 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structures of mithramycin analogues bound to DNA and implications for targeting transcription factor FLI1. Nucleic Acids Res., 44, 2016
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7ZUD
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![BU of 7zud by Molmil](/molmil-images/mine/7zud) | Crystal structure of HIV-1 capsid IP6-CPSF6 complex | Descriptor: | Capsid protein p24, Cleavage and polyadenylation specificity factor subunit 6, INOSITOL HEXAKISPHOSPHATE | Authors: | Nicastro, G, Taylor, I.A. | Deposit date: | 2022-05-12 | Release date: | 2022-07-27 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.93 Å) | Cite: | CP-MAS and Solution NMR Studies of Allosteric Communication in CA-assemblies of HIV-1. J.Mol.Biol., 434, 2022
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