8WSH
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7F43
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7F42
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7F41
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8HQJ
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8J37
| Crystal structure of SARS-Cov-2 main protease K90R mutant in complex with PF00835231 | Descriptor: | 3C-like proteinase nsp5, N-[(2S)-1-({(2S,3S)-3,4-dihydroxy-1-[(3S)-2-oxopyrrolidin-3-yl]butan-2-yl}amino)-4-methyl-1-oxopentan-2-yl]-4-methoxy-1H-indole-2-carboxamide | Authors: | Zhou, X.L, Lin, C, Zou, X.F, Zhang, J, Li, J. | Deposit date: | 2023-04-16 | Release date: | 2024-04-17 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (1.68 Å) | Cite: | Crystal structure of SARS-Cov-2 main protease
K90R mutant in complex with PF00835231 To Be Published
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8J35
| Crystal structure of SARS-Cov-2 main protease G15S mutant in complex with PF00835231 | Descriptor: | 3C-like proteinase nsp5, N-[(2S)-1-({(2S,3S)-3,4-dihydroxy-1-[(3S)-2-oxopyrrolidin-3-yl]butan-2-yl}amino)-4-methyl-1-oxopentan-2-yl]-4-methoxy-1H-indole-2-carboxamide | Authors: | Zhou, X.L, Lin, C, Zou, X.F, Zhang, J, Li, J. | Deposit date: | 2023-04-16 | Release date: | 2024-04-17 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Crystal structure of SARS-Cov-2 main protease
G15S mutant in complex with PF00835231 To Be Published
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8J3A
| Crystal structure of SARS-Cov-2 main protease Y54C mutant in complex with PF00835231 | Descriptor: | 3C-like proteinase nsp5, N-[(2S)-1-({(2S,3S)-3,4-dihydroxy-1-[(3S)-2-oxopyrrolidin-3-yl]butan-2-yl}amino)-4-methyl-1-oxopentan-2-yl]-4-methoxy-1H-indole-2-carboxamide | Authors: | Zhou, X.L, Lin, C, Zou, X.F, Zhang, J, Li, J. | Deposit date: | 2023-04-16 | Release date: | 2024-04-17 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Crystal structure of SARS-Cov-2 main protease
Y54C mutant in complex with PF00835231 To Be Published
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8J38
| Crystal structure of SARS-Cov-2 main protease P132H mutant in complex with PF00835231 | Descriptor: | 3C-like proteinase nsp5, N-[(2S)-1-({(2S,3S)-3,4-dihydroxy-1-[(3S)-2-oxopyrrolidin-3-yl]butan-2-yl}amino)-4-methyl-1-oxopentan-2-yl]-4-methoxy-1H-indole-2-carboxamide | Authors: | Zhou, X.L, Lin, C, Zou, X.F, Zhang, J, Li, J. | Deposit date: | 2023-04-16 | Release date: | 2024-04-17 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | Crystal structure of SARS-Cov-2 main protease
P132H mutant in complex with PF00835231 To Be Published
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8J3B
| Crystal structure of SARS-Cov-2 main protease S46F mutant in complex with PF00835231 | Descriptor: | 3C-like proteinase nsp5, N-[(2S)-1-({(2S,3S)-3,4-dihydroxy-1-[(3S)-2-oxopyrrolidin-3-yl]butan-2-yl}amino)-4-methyl-1-oxopentan-2-yl]-4-methoxy-1H-indole-2-carboxamide | Authors: | Zhou, X.L, Lin, C, Zou, X.F, Zhang, J, Li, J. | Deposit date: | 2023-04-16 | Release date: | 2024-04-17 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | Crystal structure of SARS-Cov-2 main protease
S46F mutant in complex with PF00835231 To Be Published
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8J32
| Crystal structure of SARS-Cov-2 main protease in complex with PF00835231 | Descriptor: | 3C-like proteinase nsp5, N-[(2S)-1-({(2S,3S)-3,4-dihydroxy-1-[(3S)-2-oxopyrrolidin-3-yl]butan-2-yl}amino)-4-methyl-1-oxopentan-2-yl]-4-methoxy-1H-indole-2-carboxamide | Authors: | Zhou, X.L, Lin, C, Zou, X.F, Zhang, J, Li, J. | Deposit date: | 2023-04-16 | Release date: | 2024-04-17 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Crystal structure of SARS-Cov-2 main protease in complex with PF00835231 To Be Published
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8J39
| Crystal structure of SARS-Cov-2 main protease V186F mutant in complex with PF00835231 | Descriptor: | 3C-like proteinase nsp5, N-[(2S)-1-({(2S,3S)-3,4-dihydroxy-1-[(3S)-2-oxopyrrolidin-3-yl]butan-2-yl}amino)-4-methyl-1-oxopentan-2-yl]-4-methoxy-1H-indole-2-carboxamide | Authors: | Zhou, X.L, Lin, C, Zou, X.F, Zhang, J, Li, J. | Deposit date: | 2023-04-16 | Release date: | 2024-04-17 | Method: | X-RAY DIFFRACTION (1.66 Å) | Cite: | Crystal structure of SARS-Cov-2 main protease
V186F mutant in complex with PF00835231 To Be Published
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8J34
| Crystal structure of MERS main protease in complex with PF00835231 | Descriptor: | N-[(2S)-1-({(2S,3S)-3,4-dihydroxy-1-[(3S)-2-oxopyrrolidin-3-yl]butan-2-yl}amino)-4-methyl-1-oxopentan-2-yl]-4-methoxy-1H-indole-2-carboxamide, ORF1a | Authors: | Zhou, X.L, Lin, C, Zou, X.F, Zhang, J, Li, J. | Deposit date: | 2023-04-16 | Release date: | 2024-04-17 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of MERS main protease in complex with PF00835231 To Be Published
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8J36
| Crystal structure of SARS-Cov-2 main protease M49I mutant in complex with PF00835231 | Descriptor: | 3C-like proteinase nsp5, N-[(2S)-1-({(2S,3S)-3,4-dihydroxy-1-[(3S)-2-oxopyrrolidin-3-yl]butan-2-yl}amino)-4-methyl-1-oxopentan-2-yl]-4-methoxy-1H-indole-2-carboxamide | Authors: | Zhou, X.L, Lin, C, Zou, X.F, Zhang, J, Li, J. | Deposit date: | 2023-04-16 | Release date: | 2024-05-01 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Crystal structure of SARS-Cov-2 main protease
M49I mutant in complex with PF00835231 To Be Published
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7C2Y
| The crystal structure of COVID-2019 main protease in the apo state | Descriptor: | 3C-like proteinase | Authors: | Zhou, X.L, Zhong, F.L, Lin, C, Zhou, H, Hu, X.H, Wang, Q.S, Li, J, Zhang, J. | Deposit date: | 2020-05-10 | Release date: | 2020-09-02 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | COVID-2019 main protease in the apo state To Be Published
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7VBF
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7VBE
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8WSK
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8WSJ
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7DR8
| Crystal structure of MERS-CoV 3CL protease in spacegroup P212121 | Descriptor: | 3C-like proteinase | Authors: | Zhang, Y.T, Gao, H.X, Zhou, H, Zhong, F.L, Hu, X.H, Zhou, X.L, Lin, C, Wang, Q.S, Li, J, Zhang, J. | Deposit date: | 2020-12-26 | Release date: | 2021-12-29 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.338149 Å) | Cite: | Crystal structure of MERS-CoV 3CL protease in spacegroup P212121 To Be Published
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7VBD
| Crystal structure of SARS-Cov-2 nucleocapsid N-terminal domain (NTD) protein,pH8.0 | Descriptor: | Nucleoprotein | Authors: | Zeng, P, Zhou, X.L, Zhong, F.L, Li, J, Zhang, J. | Deposit date: | 2021-08-31 | Release date: | 2022-08-31 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Crystal structure of SARS-Cov-2 nucleocapsid N-terminal domain (NTD) protein,pH8.0 To Be Published
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7WQI
| Crystal structure of SARS coronavirus main protease in complex with PF07304814 | Descriptor: | 3C-like proteinase, [(3~{S})-3-[[(2~{S})-2-[(4-methoxy-1~{H}-indol-2-yl)carbonylamino]-4-methyl-pentanoyl]amino]-2-oxidanylidene-4-[(3~{R})-2-oxidanylidene-3,4-dihydropyrrol-3-yl]butyl] dihydrogen phosphate | Authors: | Lin, C, Zhong, F.L, Zhou, X.L, Zeng, P, Zhang, J, Li, J. | Deposit date: | 2022-01-25 | Release date: | 2023-01-25 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Crystal structure of SARS coronavirus main protease in complex with PF07304814 To Be Published
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7DRA
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7YDG
| Crystal structure of human SARS2 catalytic domain with a disease related mutation | Descriptor: | Serine--tRNA ligase, mitochondrial | Authors: | Wu, S, Li, P, Zhou, X.L, Fang, P. | Deposit date: | 2022-07-04 | Release date: | 2022-11-02 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Selective degradation of tRNASer(AGY) is the primary driver for mitochondrial seryl-tRNA synthetase-related disease. Nucleic Acids Res., 50, 2022
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7YDF
| Crystal structure of human SARS2 catalytic domain | Descriptor: | Serine--tRNA ligase, mitochondrial | Authors: | Wu, S, Li, P, Zhou, X.L, Fang, P. | Deposit date: | 2022-07-04 | Release date: | 2022-11-02 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Selective degradation of tRNASer(AGY) is the primary driver for mitochondrial seryl-tRNA synthetase-related disease. Nucleic Acids Res., 50, 2022
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