7QCQ
 
 | | VHH Z70 in interaction with PHF6 Tau peptide | | Descriptor: | GLYCEROL, Tau 301-312, VHH Z70 | | Authors: | Danis, C, Dupre, E, Zejneli, O, Caillierez, R, Arrial, A, Begard, S, Loyens, A, Mortelecque, J, Cantrelle, F.-X, Hanoulle, X, Rain, J.-C, Colin, M, Buee, L, Landrieu, I. | | Deposit date: | 2021-11-25 | | Release date: | 2021-12-08 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Inhibition of Tau seeding by targeting Tau nucleation core within neurons with a single domain antibody fragment.
Mol.Ther., 30, 2022
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8OP0
 | | VHH Z70 mutant 20 in interaction with PHF6 Tau peptide | | Descriptor: | Tau PHF6 peptide, VHH Z70 mutant 20 | | Authors: | Dupre, E, Mortelecque, J, NGuyen, M, Hanoulle, X, Landrieu, I. | | Deposit date: | 2023-04-06 | | Release date: | 2023-05-31 | | Last modified: | 2024-04-24 | | Method: | X-RAY DIFFRACTION (1.54 Å) | | Cite: | A selection and optimization strategy for single-domain antibodies targeting the PHF6 linear peptide within the tau intrinsically disordered protein.
J.Biol.Chem., 300, 2024
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8PII
 | | VHH Z70 mutant 3 in interaction with PHF6 Tau peptide | | Descriptor: | Microtubule-associated protein tau, VHH Z70 Mutant 3 | | Authors: | Dupre, E, Mortelecque, J, NGuyen, M, Hanoulle, X, Landrieu, I. | | Deposit date: | 2023-06-21 | | Release date: | 2023-07-05 | | Last modified: | 2024-04-24 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | A selection and optimization strategy for single-domain antibodies targeting the PHF6 linear peptide within the tau intrinsically disordered protein.
J.Biol.Chem., 300, 2024
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8OPI
 | | VHH Z70 mutant 1 in interaction with PHF6 Tau peptide | | Descriptor: | PHF6 Tau peptide, VHH Z70 mutant 1 | | Authors: | Dupre, E, Mortelecque, J, NGuyen, M, Hanoulle, X, Landrieu, I. | | Deposit date: | 2023-04-07 | | Release date: | 2023-05-31 | | Last modified: | 2024-04-24 | | Method: | X-RAY DIFFRACTION (1.83 Å) | | Cite: | A selection and optimization strategy for single-domain antibodies targeting the PHF6 linear peptide within the tau intrinsically disordered protein.
J.Biol.Chem., 300, 2024
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