Loading
PDBj
English日本語简体中文繁體中文한국어
✖
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
9B3T
DownloadVisualize
BU of 9b3t by Molmil
Octameric prenyltransferase domain of linkerless Fusicoccadiene synthase with C2 symmetry without associated cyclase domains
Descriptor: Fusicoccadiene synthase
Authors:Wenger, E.S, Schultz, K, Marmorstein, R, Christianson, D.W.
Deposit date:2024-03-20
Release date:2024-09-25
Last modified:2024-12-04
Method:ELECTRON MICROSCOPY (3.53 Å)
Cite:Engineering substrate channeling in a bifunctional terpene synthase.
Proc.Natl.Acad.Sci.USA, 121, 2024
7KJ8
DownloadVisualize
BU of 7kj8 by Molmil
Wild-type epi-isozizaene synthase: complex with 3 Mg2+ and pamidronate
Descriptor: MAGNESIUM ION, PAMIDRONATE, SULFATE ION, ...
Authors:Ronnebaum, T.A, Gardner, S.M, Christianson, D.W.
Deposit date:2020-10-26
Release date:2020-12-16
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:An Aromatic Cluster in the Active Site of epi -Isozizaene Synthase Is an Electrostatic Toggle for Divergent Terpene Cyclization Pathways.
Biochemistry, 59, 2020
6CSS
DownloadVisualize
BU of 6css by Molmil
Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with cyclopentenylhydroxamate
Descriptor: 1,2-ETHANEDIOL, Hdac6 protein, N-hydroxycyclopent-1-ene-1-carboxamide, ...
Authors:Porter, N.J, Christianson, D.W.
Deposit date:2018-03-21
Release date:2018-05-30
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Entropy as a Driver of Selectivity for Inhibitor Binding to Histone Deacetylase 6.
Biochemistry, 57, 2018
6CSQ
DownloadVisualize
BU of 6csq by Molmil
Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with cyclohexylhydroxamate
Descriptor: Hdac6 protein, N-hydroxycyclohexanecarboxamide, POTASSIUM ION, ...
Authors:Porter, N.J, Christianson, D.W.
Deposit date:2018-03-21
Release date:2018-05-30
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.031 Å)
Cite:Entropy as a Driver of Selectivity for Inhibitor Binding to Histone Deacetylase 6.
Biochemistry, 57, 2018
7SGJ
DownloadVisualize
BU of 7sgj by Molmil
Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with DKFZ-711
Descriptor: 1,2-ETHANEDIOL, 4-[(3-anilino-3-oxopropyl)(methyl)amino]-N-hydroxybutanamide, DI(HYDROXYETHYL)ETHER, ...
Authors:Herbst-Gervasoni, C.J, Christianson, D.W.
Deposit date:2021-10-05
Release date:2022-10-05
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout.
J.Am.Chem.Soc., 144, 2022
7SGI
DownloadVisualize
BU of 7sgi by Molmil
Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with Inhibitor 14
Descriptor: 5-[(2-anilino-2-oxoethyl)(methyl)amino]-N-hydroxypentanamide, PHOSPHATE ION, POTASSIUM ION, ...
Authors:Herbst-Gervasoni, C.J, Christianson, D.W.
Deposit date:2021-10-05
Release date:2022-10-05
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout.
J.Am.Chem.Soc., 144, 2022
6CA2
DownloadVisualize
BU of 6ca2 by Molmil
ENGINEERING THE HYDROPHOBIC POCKET OF CARBONIC ANHYDRASE II
Descriptor: CARBONIC ANHYDRASE II, MERCURY (II) ION, ZINC ION
Authors:Alexander, R.S, Christianson, D.W.
Deposit date:1991-07-09
Release date:1992-07-15
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Engineering the hydrophobic pocket of carbonic anhydrase II.
Biochemistry, 30, 1991
9DM6
DownloadVisualize
BU of 9dm6 by Molmil
Crystal Structure of Danio rerio histone deacetylase 6 catalytic domain 2 complexed with an ethylhydrazide inhibitor
Descriptor: 1,2-ETHANEDIOL, Hdac6 protein, N-[2-(benzylamino)-2-oxoethyl]-4-(dimethylamino)-N-{[4-(2-ethylhydrazine-1-carbonyl)phenyl]methyl}benzamide, ...
Authors:Gaynes, M.N, Watson, P.R, Konig, B, Christianson, D.W.
Deposit date:2024-09-12
Release date:2025-02-26
Last modified:2025-03-12
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Exploring Alternative Zinc-Binding Groups in Histone Deacetylase (HDAC) Inhibitors Uncovers DS-103 as a Potent Ethylhydrazide-Based HDAC Inhibitor with Chemosensitizing Properties.
J.Med.Chem., 68, 2025
6CSP
DownloadVisualize
BU of 6csp by Molmil
Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with cyclohexenylhydroxamate
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Porter, N.J, Christianson, D.W.
Deposit date:2018-03-21
Release date:2018-05-30
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.237 Å)
Cite:Entropy as a Driver of Selectivity for Inhibitor Binding to Histone Deacetylase 6.
Biochemistry, 57, 2018
9D2A
DownloadVisualize
BU of 9d2a by Molmil
Crystal structure of (+)-sabinene synthase from Thuja plicata: condition 3
Descriptor: 1,2-ETHANEDIOL, COBALT (II) ION, Sabinene synthase
Authors:Gaynes, M.N, Christianson, D.W.
Deposit date:2024-08-08
Release date:2024-11-27
Last modified:2024-12-11
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Structure and Function of Sabinene Synthase, a Monoterpene Cyclase That Generates a Highly Strained [3.1.0] Bicyclic Product.
Biochemistry, 63, 2024
9D28
DownloadVisualize
BU of 9d28 by Molmil
Crystal structure of (+)-sabinene synthase from Thuja plicata
Descriptor: Sabinene synthase
Authors:Gaynes, M.N, Christianson, D.W.
Deposit date:2024-08-08
Release date:2024-11-27
Last modified:2024-12-11
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Structure and Function of Sabinene Synthase, a Monoterpene Cyclase That Generates a Highly Strained [3.1.0] Bicyclic Product.
Biochemistry, 63, 2024
9D29
DownloadVisualize
BU of 9d29 by Molmil
Crystal structure of (+)-sabinene synthase from Thuja plicata: condition 2
Descriptor: GLYCEROL, SULFATE ION, Sabinene synthase
Authors:Gaynes, M.N, Christianson, D.W.
Deposit date:2024-08-08
Release date:2024-11-27
Last modified:2024-12-11
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:Structure and Function of Sabinene Synthase, a Monoterpene Cyclase That Generates a Highly Strained [3.1.0] Bicyclic Product.
Biochemistry, 63, 2024
6CW8
DownloadVisualize
BU of 6cw8 by Molmil
Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 complexed with RTS-V5
Descriptor: 1,2-ETHANEDIOL, Hdac6 protein, N-(2,2-dimethylpropyl)-N~2~-[4-(hydroxycarbamoyl)benzene-1-carbonyl]-L-asparaginyl-N-benzyl-L-alaninamide, ...
Authors:Osko, J.D, Christianson, D.W.
Deposit date:2018-03-30
Release date:2018-11-21
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery of the First-in-Class Dual Histone Deacetylase-Proteasome Inhibitor.
J. Med. Chem., 61, 2018
6CSR
DownloadVisualize
BU of 6csr by Molmil
Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with phenylhydroxamate
Descriptor: 1,2-ETHANEDIOL, BENZHYDROXAMIC ACID, Hdac6 protein, ...
Authors:Porter, N.J, Christianson, D.W.
Deposit date:2018-03-21
Release date:2018-05-30
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.619 Å)
Cite:Entropy as a Driver of Selectivity for Inhibitor Binding to Histone Deacetylase 6.
Biochemistry, 57, 2018
6DVL
DownloadVisualize
BU of 6dvl by Molmil
Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with DDK-115
Descriptor: Hdac6 protein, N-[2-(cyclohexylamino)-2-oxoethyl]-N-{[4-(hydroxycarbamoyl)phenyl]methyl}-3,5-dimethylbenzamide, POTASSIUM ION, ...
Authors:Porter, N.J, Christianson, D.W.
Deposit date:2018-06-24
Release date:2018-08-29
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Histone Deacetylase 6-Selective Inhibitors and the Influence of Capping Groups on Hydroxamate-Zinc Denticity.
J. Med. Chem., 61, 2018
6DVN
DownloadVisualize
BU of 6dvn by Molmil
Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with DDK-137
Descriptor: 1,2-ETHANEDIOL, Hdac6 protein, N-[2-(benzylamino)-2-oxoethyl]-4-(dimethylamino)-N-{[4-(hydroxycarbamoyl)phenyl]methyl}benzamide, ...
Authors:Osko, J.D, Christianson, D.W.
Deposit date:2018-06-24
Release date:2018-08-29
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Histone Deacetylase 6-Selective Inhibitors and the Influence of Capping Groups on Hydroxamate-Zinc Denticity.
J. Med. Chem., 61, 2018
7SGG
DownloadVisualize
BU of 7sgg by Molmil
Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with SAHA
Descriptor: DI(HYDROXYETHYL)ETHER, OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE, PHOSPHATE ION, ...
Authors:Herbst-Gervasoni, C.J, Christianson, D.W.
Deposit date:2021-10-05
Release date:2022-10-05
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout.
J.Am.Chem.Soc., 144, 2022
9E2I
DownloadVisualize
BU of 9e2i by Molmil
Variediene synthase with six cyclases
Descriptor: Variediene synthase
Authors:Wenger, E.S, Christianson, D.W.
Deposit date:2024-10-22
Release date:2025-05-21
Method:ELECTRON MICROSCOPY (3.18 Å)
Cite:Variediene synthase with six cyclases
To Be Published
9E2M
DownloadVisualize
BU of 9e2m by Molmil
Variediene synthase with one cyclase (conformation 3)
Descriptor: PYROPHOSPHATE 2-, Variediene synthase
Authors:Wenger, E.S, Christianson, D.W.
Deposit date:2024-10-22
Release date:2025-05-21
Method:ELECTRON MICROSCOPY (2.98 Å)
Cite:Variediene synthase hexameric prenyltransferase core
To Be Published
7SGK
DownloadVisualize
BU of 7sgk by Molmil
Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with DKFZ-728
Descriptor: N-(2-{[4-(hydroxyamino)-4-oxobutyl](methyl)amino}ethyl)benzamide, PHOSPHATE ION, POTASSIUM ION, ...
Authors:Herbst-Gervasoni, C.J, Christianson, D.W.
Deposit date:2021-10-05
Release date:2022-10-05
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout.
J.Am.Chem.Soc., 144, 2022
9E2H
DownloadVisualize
BU of 9e2h by Molmil
Variediene synthase hexameric prenyltransferase core
Descriptor: Variediene synthase
Authors:Wenger, E.S, Christianson, D.W.
Deposit date:2024-10-22
Release date:2025-05-21
Method:ELECTRON MICROSCOPY (2.77 Å)
Cite:Variediene synthase hexameric prenyltransferase core
To Be Published
9E2L
DownloadVisualize
BU of 9e2l by Molmil
Variediene synthase with one cyclase (conformation 2)
Descriptor: PYROPHOSPHATE 2-, Variediene synthase
Authors:Wenger, E.S, Christianson, D.W.
Deposit date:2024-10-22
Release date:2025-05-21
Method:ELECTRON MICROSCOPY (3.08 Å)
Cite:Variediene synthase with one cyclase (conformation 2)
To Be Published
9E2J
DownloadVisualize
BU of 9e2j by Molmil
Variediene synthase with five cyclases
Descriptor: Variediene synthase
Authors:Wenger, E.S, Christianson, D.W.
Deposit date:2024-10-22
Release date:2025-05-21
Method:ELECTRON MICROSCOPY (3.59 Å)
Cite:Variediene synthase with five cyclases
To Be Published
9E2K
DownloadVisualize
BU of 9e2k by Molmil
Variediene synthase with one cyclase (conformation 1)
Descriptor: PYROPHOSPHATE 2-, Variediene synthase
Authors:Wenger, E.S, Christianson, D.W.
Deposit date:2024-10-22
Release date:2025-05-21
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Variediene synthase hexameric prenyltransferase core
To Be Published
9CBH
DownloadVisualize
BU of 9cbh by Molmil
Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with p-Aminomethyl Phenylthioketone
Descriptor: 1-[4-(aminomethyl)phenyl]-2-sulfanylethan-1-one, PHOSPHATE ION, POTASSIUM ION, ...
Authors:Goulart Stollmaier, J, Christianson, D.W.
Deposit date:2024-06-19
Release date:2024-09-11
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Design, Synthesis, and Structural Evaluation of Acetylated Phenylthioketone Inhibitors of HDAC10.
Acs Med.Chem.Lett., 15, 2024

238582

건을2025-07-09부터공개중

PDB statisticsPDBj update infoContact PDBjnumon