8QSA
 
 | | Ternary structure of 14-3-3s, C-RAF phosphopeptide (pS259) and compound 86 (1084384) | | Descriptor: | 1-[(5~{R})-2-(4-bromanyl-3-fluoranyl-phenyl)sulfonyl-2,7-diazaspiro[4.4]nonan-7-yl]-2-chloranyl-ethanone, 14-3-3 protein sigma, C-RAF peptide, ... | | Authors: | Konstantinidou, M, Vickery, H, Pennings, M.A.M, Virta, J, Visser, E.J, Oetelaar, M.C.M, Overmans, M, Neitz, J, Ottmann, C, Brunsveld, L, Arkin, M.R. | | Deposit date: | 2023-10-10 | | Release date: | 2025-04-23 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Small molecule stabilization of the 14-3-3sigma/CRAF complex inhibits the MAPK pathway
To Be Published
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8QSF
 | | Ternary structure of 14-3-3s, BRAF phosphopeptide (pS365) and compound 22 (1083853). | | Descriptor: | 14-3-3 protein sigma, BRAF peptide pS365, CHLORIDE ION, ... | | Authors: | Konstantinidou, M, Vickery, H, Pennings, M.A.M, Virta, J, Visser, E.J, Oetelaar, M.C.M, Overmans, M, Neitz, J, Ottmann, C, Brunsveld, L, Arkin, M.R. | | Deposit date: | 2023-10-10 | | Release date: | 2025-04-23 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Small molecule stabilization of the 14-3-3sigma/CRAF complex inhibits the MAPK pathway
To Be Published
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8QS8
 | | Ternary structure of 14-3-3s, C-RAF phosphopeptide (pS259) and compound 78 (1084378) | | Descriptor: | 1-[8-(4-bromophenyl)sulfonyl-5-oxa-2,8-diazaspiro[3.5]nonan-2-yl]-2-chloranyl-ethanone, 14-3-3 protein sigma, C-RAF peptide, ... | | Authors: | Konstantinidou, M, Vickery, H, Pennings, M.A.M, Virta, J, Visser, E.J, Oetelaar, M.C.M, Overmans, M, Neitz, J, Ottmann, C, Brunsveld, L, Arkin, M.R. | | Deposit date: | 2023-10-10 | | Release date: | 2025-04-23 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Small molecule stabilization of the 14-3-3sigma/CRAF complex inhibits the MAPK pathway
To Be Published
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9ML6
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9QLE
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9ML5
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8QS9
 | | Ternary structure of 14-3-3s, C-RAF phosphopeptide (pS259) and compound 83 (1084383) | | Descriptor: | 1-[8-(4-bromanyl-3-fluoranyl-phenyl)sulfonyl-2,8-diazaspiro[3.5]nonan-2-yl]-2-chloranyl-ethanone, 14-3-3 protein sigma, C-RAF peptide pS259, ... | | Authors: | Konstantinidou, M, Vickery, H, Pennings, M.A.M, Virta, J, Visser, E.J, Oetelaar, M.C.M, Overmans, M, Neitz, J, Ottmann, C, Brunsveld, L, Arkin, M.R. | | Deposit date: | 2023-10-10 | | Release date: | 2025-04-23 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Small molecule stabilization of the 14-3-3sigma/CRAF complex inhibits the MAPK pathway
To Be Published
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9N0Z
 | | PP2A-B55 Holoenzyme with B55i | | Descriptor: | B55i inhibitor peptide, Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, ... | | Authors: | Shi, S, Li, X, Alderman, C, Zhao, R. | | Deposit date: | 2025-01-24 | | Release date: | 2025-06-18 | | Last modified: | 2025-07-09 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Cryo-EM structures reveal the PP2A-B55 alpha and Eya3 interaction that can be disrupted by a peptide inhibitor.
J.Biol.Chem., 301, 2025
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8QSG
 | | Ternary structure of 14-3-3s, BRAF phosphopeptide (pS365) and compound 86 (1124384). | | Descriptor: | 1-[(5~{R})-2-(4-bromanyl-3-fluoranyl-phenyl)sulfonyl-2,7-diazaspiro[4.4]nonan-7-yl]-2-chloranyl-ethanone, 14-3-3 protein sigma, BRAF peptide pS365, ... | | Authors: | Konstantinidou, M, Vickery, H, Pennings, M.A.M, Virta, J, Visser, E.J, Oetelaar, M.C.M, Overmans, M, Neitz, J, Ottmann, C, Brunsveld, L, Arkin, M.R. | | Deposit date: | 2023-10-10 | | Release date: | 2025-04-23 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Small molecule stabilization of the 14-3-3sigma/CRAF complex inhibits the MAPK pathway
To Be Published
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9OMA
 | | Cryo-EM structure of PCMTD1-ELOBC-CUL5-RBX2 (CRL5-PCMTD1) | | Descriptor: | Cullin-5, Elongin-B, Elongin-C, ... | | Authors: | Pang, E.Z, Zhao, B, Flowers, C, Oroudjeva, E, Winters, J.B, Pandey, V, Sawaya, M.R, Wohlschlegel, W, Loo, J.A, Rodriguez, J.A, Clarke, S.G. | | Deposit date: | 2025-05-13 | | Release date: | 2025-06-04 | | Last modified: | 2025-06-18 | | Method: | ELECTRON MICROSCOPY (4.14 Å) | | Cite: | Structural basis for L-isoaspartyl-containing protein recognition by the PCMTD1 cullin-RING E3 ubiquitin ligase.
Biorxiv, 2025
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8QSC
 | | Ternary structure of 14-3-3s, ARAF phosphopeptide (pS214) and compound 22 (1083853). | | Descriptor: | 14-3-3 protein sigma, ARAF peptide pS214, CHLORIDE ION, ... | | Authors: | Konstantinidou, M, Vickery, H, Pennings, M.A.M, Virta, J, Visser, E.J, Oetelaar, M.C.M, Overmans, M, Neitz, J, Ottmann, C, Brunsveld, L, Arkin, M.R. | | Deposit date: | 2023-10-10 | | Release date: | 2025-04-23 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Small molecule stabilization of the 14-3-3sigma/CRAF complex inhibits the MAPK pathway
To Be Published
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9NS9
 | | Cryo-EM structure of Gi-coupled FFA2 in complex with TUG-1375 and compound 187 | | Descriptor: | (2R,4R)-2-(2-chlorophenyl)-3-[4-(3,5-dimethyl-1,2-oxazol-4-yl)phenyl]carbonyl-1,3-thiazolidine-4-carboxylic acid, 4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-7-(2-fluorobenzene-1-sulfonyl)-2-methyl-5H-pyrrolo[3,2-d]pyrimidin-6-amine, Free fatty acid receptor 2, ... | | Authors: | Zhang, X, Tikhonova, I, Milligan, G, Zhang, C. | | Deposit date: | 2025-03-16 | | Release date: | 2025-06-25 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Allosteric modulation and biased signalling at free fatty acid receptor 2.
Nature, 2025
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8R7K
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8R7L
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9L3R
 | | Human PI3KDELTA in complex with Zandelisib | | Descriptor: | Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, Zandelisib | | Authors: | Nagiri, C, Aburai, K, Takahashi, Y, Saito, J. | | Deposit date: | 2024-12-19 | | Release date: | 2025-06-11 | | Last modified: | 2025-07-02 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | A long-lasting PI3K delta inhibitor zandelisib forms a water-shielded hydrogen bond with p110 delta and demonstrates sustained inhibitory effects.
Am J Cancer Res, 15, 2025
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8RAU
 | | The crystal structure of DNA-bound human MutSbeta (MSH2/MSH3) in the canonical mismatch bound conformation with ADP bound in MSH2 and MSH3 | | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, DNA (5'-D(*TP*CP*AP*TP*CP*GP*AP*TP*CP*GP*CP*AP*GP*CP*TP*TP*CP*AP*GP*AP*TP*AP*GP*G)-3'), ... | | Authors: | Thomsen, M, Neudegger, T, Thieulin-Pardo, G, Blaesse, M, Costanzi, E, Steinbacher, S, Plotnikov, N.V, Dominguez, C, Iyer, R.R, Wilkinson, H.A, Monteagudo, E, Haque, T.S, Prasad, B.C, Finley, M, Boudet, J, Vogt, T.F, Felsenfeld, D.P. | | Deposit date: | 2023-12-01 | | Release date: | 2025-06-11 | | Last modified: | 2025-07-09 | | Method: | X-RAY DIFFRACTION (2.33 Å) | | Cite: | The crystal structure of DNA-bound human MutSbeta (MSH2/MSH3) in the canonical mismatch bound conformation with ADP bound in MSH2 and MSH3
To Be Published
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8R7J
 | | Cryo-EM structure of the human TREX-2 complex | | Descriptor: | 26S proteasome complex subunit SEM1, Germinal-center associated nuclear protein, PCI domain-containing protein 2 | | Authors: | Hohmann, U, Graf, M, Plaschka, C. | | Deposit date: | 2023-11-25 | | Release date: | 2025-06-11 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | A molecular switch orchestrates the export of human messenger RNA
To Be Published
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8RHW
 | | Crystal Structure of Trypanosoma brucei PTR1 in complex with the cofactor and inhibitor P31 | | Descriptor: | 1-(5-methoxy-1~{H}-benzimidazol-2-yl)guanidine, ACETATE ION, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | Authors: | Pozzi, C, Mangani, S, Landi, G. | | Deposit date: | 2023-12-17 | | Release date: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Identification of Innovative Folate Inhibitors Leveraging the Amino Dihydrotriazine Motif from Cycloguanil for Their Potential as Anti- Trypanosoma brucei Agents.
Acs Infect Dis., 10, 2024
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8RHX
 | | Crystal Structure of Trypanosoma brucei PTR1 in complex with the cofactor and inhibitor P32 | | Descriptor: | 1-[4,6-bis(chloranyl)-1~{H}-benzimidazol-2-yl]guanidine, ACETATE ION, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | Authors: | Pozzi, C, Mangani, S, Landi, G. | | Deposit date: | 2023-12-17 | | Release date: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (1.48 Å) | | Cite: | Identification of Innovative Folate Inhibitors Leveraging the Amino Dihydrotriazine Motif from Cycloguanil for Their Potential as Anti- Trypanosoma brucei Agents.
Acs Infect Dis., 10, 2024
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8RHY
 | | Crystal Structure of Trypanosoma brucei PTR1 in complex with the cofactor and inhibitor P34 | | Descriptor: | 1-[5,6-bis(chloranyl)-1~{H}-benzimidazol-2-yl]guanidine, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Pteridine reductase | | Authors: | Pozzi, C, Mangani, S, Landi, G. | | Deposit date: | 2023-12-17 | | Release date: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (1.86 Å) | | Cite: | Identification of Innovative Folate Inhibitors Leveraging the Amino Dihydrotriazine Motif from Cycloguanil for Their Potential as Anti- Trypanosoma brucei Agents.
Acs Infect Dis., 10, 2024
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9ML4
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9ML7
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9L1X
 | | hDEK-nucleosome complex (conformation 1) | | Descriptor: | 601 DNA (189-MER), 601 DNA_R (189-MER), Histone H2A type 1-B/E, ... | | Authors: | Liu, Y, Wang, C, Huang, H. | | Deposit date: | 2024-12-16 | | Release date: | 2025-05-07 | | Last modified: | 2025-06-25 | | Method: | ELECTRON MICROSCOPY (2.69 Å) | | Cite: | DEK-nucleosome structure shows DEK modulates H3K27me3 and stem cell fate.
Nat.Struct.Mol.Biol., 2025
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9LBN
 | | The composite cryo-EM structure of the head-to-tail connector and head-proximal tail components of bacteriophage phiXacJX1 | | Descriptor: | adaptor protein gp5, portal protein gp1, stopper protein gp6, ... | | Authors: | Guo, M, Wang, A, Zheng, Y, Liu, C, Shao, Q, Fang, Q. | | Deposit date: | 2025-01-03 | | Release date: | 2025-05-07 | | Last modified: | 2025-06-18 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Cryo-EM structures of a Xanthomonas phage: Insights into viral architecture and implications for the model phage HK97.
Structure, 33, 2025
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9VG5
 | | NMR Solution Structure of the Monomeric Catalytic C-terminal Lobe of the E6AP HECT E3 Ubiquitin Ligase | | Descriptor: | Ubiquitin-protein ligase E3A | | Authors: | Dag, C, Lambert, M, Lohr, F, Lee, W, Kazar, A.E, Dotsch, V. | | Deposit date: | 2025-06-12 | | Release date: | 2025-06-25 | | Method: | SOLUTION NMR | | Cite: | NMR Solution Structure of the Monomeric Catalytic C-terminal Lobe of the E6AP HECT E3 Ubiquitin Ligase
To Be Published
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