5OFR
 
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5OFP
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2WES
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2WEU
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2KP8
 | | Ligand bound to a model peptide that mimics the open fusogenic form | | Descriptor: | 5-{[(4'-methoxybiphenyl-4-yl)methyl][(1S)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl}benzene-1,2,4-tricarboxylic acid, Model peptide | | Authors: | Olejniczak, E.T. | | Deposit date: | 2009-10-09 | | Release date: | 2010-01-19 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Non-peptide entry inhibitors of HIV-1 that target the gp41 coiled coil pocket.
Bioorg.Med.Chem.Lett., 20, 2010
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2GVF
 | | HCV NS3-4A protease domain complexed with a macrocyclic ketoamide inhibitor, SCH419021 | | Descriptor: | (6R,8S,11S)-11-CYCLOHEXYL-N-(1-{[(2-{[(1S)-2-(DIMETHYLAMINO)-2-OXO-1-PHENYLETHYL]AMINO}-2-OXOETHYL)AMINO](OXO)ACETYL}BUTYL)-10,13-DIOXO-2,5-DIOXA-9,12-DIAZATRICYCLO[14.3.1.1~6,9~]HENICOSA-1(20),16,18-TRIENE-8-CARBOXAMIDE, Polyprotein, ZINC ION, ... | | Authors: | Arasappan, A, Njoroge, F.G, Chen, K.X, Venkatraman, S, Parekh, T.N, Gu, H, Pichardo, J, Butkiewicz, N, Prongay, A, Madison, V, Girijavallabhan, V. | | Deposit date: | 2006-05-02 | | Release date: | 2007-01-23 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | P2-P4 macrocyclic inhibitors of hepatitis C virus NS3-4A serine protease.
Bioorg.Med.Chem.Lett., 16, 2006
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2RGU
 | | Crystal structure of complex of human DPP4 and inhibitor | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-3,7-dihydro-1H-purine-2,6-d ione, Dipeptidyl peptidase 4 | | Authors: | Nar, H, Himmelsbach, F, Eckhardt, M. | | Deposit date: | 2007-10-05 | | Release date: | 2007-11-06 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | 8-(3-(R)-Aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydropurine-2,6-dione (BI 1356), a Highly Potent, Selective, Long-Acting, and Orally Bioavailable DPP-4 Inhibitor for the Treatment of Type 2 Diabetes.
J.Med.Chem., 50, 2007
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2V7J
 | | PrnB L-tryptophan complex | | Descriptor: | PRNB, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION, ... | | Authors: | Naismith, J.H. | | Deposit date: | 2007-07-30 | | Release date: | 2007-08-07 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The Second Enzyme in Pyrrolnitrin Biosynthetic Pathway is Related to the Heme-Dependent Dioxygenase Superfamily
Biochemistry, 46, 2007
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2V7I
 | | PrnB native | | Descriptor: | PRNB, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION | | Authors: | Naismith, J.H. | | Deposit date: | 2007-07-30 | | Release date: | 2007-08-07 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | The Second Enzyme in Pyrrolnitrin Biosynthetic Pathway is Related to the Heme-Dependent Dioxygenase Superfamily
Biochemistry, 46, 2007
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2V7M
 | | PrnB 7-Cl-D-tryptophan complex | | Descriptor: | 7-CL-D-TRYPTOPHAN, PHOSPHATE ION, PRNB, ... | | Authors: | Naismith, J.H. | | Deposit date: | 2007-07-30 | | Release date: | 2007-08-07 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The Second Enzyme in Pyrrolnitrin Biosynthetic Pathway is Related to the Heme-Dependent Dioxygenase Superfamily
Biochemistry, 46, 2007
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2V7L
 | | PrnB 7Cl-L-tryptophan complex | | Descriptor: | 7-CHLOROTRYPTOPHAN, PRNB, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Naismith, J.H. | | Deposit date: | 2007-07-30 | | Release date: | 2007-08-07 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | The Second Enzyme in Pyrrolnitrin Biosynthetic Pathway is Related to the Heme-Dependent Dioxygenase Superfamily.
Biochemistry, 46, 2007
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2V7K
 | | PrnB D-tryptophan complex | | Descriptor: | D-TRYPTOPHAN, PRNB, PROTOPORPHYRIN IX CONTAINING FE, ... | | Authors: | Naismith, J.H. | | Deposit date: | 2007-07-30 | | Release date: | 2007-08-07 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | The Second Enzyme in Pyrrolnitrin Biosynthetic Pathway is Related to the Heme-Dependent Dioxygenase Superfamily
Biochemistry, 46, 2007
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1TOP
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2C4U
 | | Crystal structure of the apo form of the 5'-Fluoro-5'-deoxyadenosine synthase enzyme from Streptomyces cattleya | | Descriptor: | 5'-FLUORO-5'-DEOXYADENOSINE SYNTHASE, GLYCEROL | | Authors: | McEwan, A.R, Deng, H, Robinson, D.A, DeLaurentis, W, McGlinchey, R.P, O'Hagan, D, Naismith, J.H. | | Deposit date: | 2005-10-22 | | Release date: | 2006-04-12 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Substrate specificity in enzymatic fluorination. The fluorinase from Streptomyces cattleya accepts 2'-deoxyadenosine substrates.
Org. Biomol. Chem., 4, 2006
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1NCY
 | | TROPONIN-C, COMPLEX WITH MANGANESE | | Descriptor: | MANGANESE (II) ION, SULFATE ION, TROPONIN C | | Authors: | Sundaralingam, M, Rao, S.T. | | Deposit date: | 1996-06-02 | | Release date: | 1997-01-11 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | X-ray structures of Mn, Cd and Tb metal complexes of troponin C.
Acta Crystallogr.,Sect.D, 52, 1996
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1NCZ
 | | TROPONIN C | | Descriptor: | SULFATE ION, TERBIUM(III) ION, TROPONIN C | | Authors: | Sundaralingam, M, Rao, S.T. | | Deposit date: | 1996-06-02 | | Release date: | 1996-12-07 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | X-ray structures of Mn, Cd and Tb metal complexes of troponin C.
Acta Crystallogr.,Sect.D, 52, 1996
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1NCX
 | | TROPONIN C | | Descriptor: | CADMIUM ION, SULFATE ION, TROPONIN C | | Authors: | Sundaralingam, M, Rao, S.T. | | Deposit date: | 1996-06-02 | | Release date: | 1996-12-07 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | X-ray structures of Mn, Cd and Tb metal complexes of troponin C.
Acta Crystallogr.,Sect.D, 52, 1996
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