4L20
 
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4L21
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4L0Q
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1TLC
 | | THYMIDYLATE SYNTHASE COMPLEXED WITH DGMP AND FOLATE ANALOG 1843U89 | | Descriptor: | 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE, S)-2-(5(((1,2-DIHYDRO-3-METHYL-1-OXOBENZO(F)QUINAZOLIN-9-YL)METHYL)AMINO)1-OXO-2-ISOINDOLINYL)GLUTARIC ACID, THYMIDYLATE SYNTHASE | | Authors: | Weichsel, A, Montfort, W.R, Ciesla, J, Maley, F. | | Deposit date: | 1995-03-07 | | Release date: | 1995-06-03 | | Last modified: | 2018-04-18 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Promotion of purine nucleotide binding to thymidylate synthase by a potent folate analogue inhibitor, 1843U89.
Proc.Natl.Acad.Sci.USA, 92, 1995
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1SI6
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2AT8
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2AT6
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1IKE
 | | Crystal Structure of Nitrophorin 4 from Rhodnius Prolixus Complexed with Histamine at 1.5 A Resolution | | Descriptor: | HISTAMINE, Nitrophorin 4, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Roberts, S.A, Weichsel, A, Qiu, Y, Shelnutt, J.A, Walker, F.A, Montfort, W.R. | | Deposit date: | 2001-05-03 | | Release date: | 2001-10-03 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Ligand-induced heme ruffling and bent no geometry in ultra-high-resolution structures of nitrophorin 4.
Biochemistry, 40, 2001
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1IKJ
 | | 1.27 A CRYSTAL STRUCTURE OF NITROPHORIN 4 FROM RHODNIUS PROLIXUS COMPLEXED WITH IMIDAZOLE | | Descriptor: | IMIDAZOLE, NITROPHORIN 4, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Roberts, S.A, Weichsel, A, Qui, Y, Shelnutt, J.A, Walker, F.A, Montfort, W.R. | | Deposit date: | 2001-05-03 | | Release date: | 2001-10-03 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (1.27 Å) | | Cite: | Ligand-induced heme ruffling and bent no geometry in ultra-high-resolution structures of nitrophorin 4.
Biochemistry, 40, 2001
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1X8O
 | | 1.01 A Crystal Structure Of Nitrophorin 4 From Rhodnius Prolixus Complexed With Nitric Oxide at pH 5.6 | | Descriptor: | NITRIC OXIDE, Nitrophorin 4, PHOSPHATE ION, ... | | Authors: | Kondrashov, D.A, Roberts, S.A, Weichsel, A, Montfort, W.R. | | Deposit date: | 2004-08-18 | | Release date: | 2004-10-05 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (1.01 Å) | | Cite: | Protein functional cycle viewed at atomic resolution: conformational change and mobility in nitrophorin 4 as a function of pH and NO binding
Biochemistry, 43, 2004
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1X8Q
 | | 0.85 A Crystal Structure Of Nitrophorin 4 From Rhodnius Prolixus in Complex with Water at pH 5.6 | | Descriptor: | Nitrophorin 4, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Kondrashov, D.A, Roberts, S.A, Weichsel, A, Montfort, W.R. | | Deposit date: | 2004-08-18 | | Release date: | 2004-10-05 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (0.85 Å) | | Cite: | Protein functional cycle viewed at atomic resolution: conformational change and mobility in nitrophorin 4 as a function of pH and NO binding
Biochemistry, 43, 2004
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1X8P
 | | 0.85 A Crystal Structure Of Nitrophorin 4 From Rhodnius Prolixus Complexed With Ammonia at pH 7.4 | | Descriptor: | AMMONIA, Nitrophorin 4, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Kondrashov, D.A, Roberts, S.A, Weichsel, A, Montfort, W.R. | | Deposit date: | 2004-08-18 | | Release date: | 2004-10-05 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (0.85 Å) | | Cite: | Protein functional cycle viewed at atomic resolution: conformational change and mobility in nitrophorin 4 as a function of pH and NO binding
Biochemistry, 43, 2004
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2HIN
 | | Structure of N15 Cro at 1.05 A: an ortholog of lambda Cro with a completely different but equally effective dimerization mechanism | | Descriptor: | Repressor protein, SULFATE ION | | Authors: | Dubrava, M.S, Ingram, W.M, Roberts, S.A, Weichsel, A, Montfort, W.R, Cordes, M.H. | | Deposit date: | 2006-06-29 | | Release date: | 2007-07-10 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.05 Å) | | Cite: | N15 Cro and lambda Cro: orthologous DNA-binding domains with completely different but equally effective homodimer interfaces.
Protein Sci., 17, 2008
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2FTO
 | | Y94F mutant of thymidylate synthase bound to thymidine-5'-phosphate and 10-propargyl-5,8-dideazafolid acid | | Descriptor: | 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, PHOSPHATE ION, THYMIDINE-5'-PHOSPHATE, ... | | Authors: | Roberts, S.A, Montfort, W.R. | | Deposit date: | 2006-01-24 | | Release date: | 2006-05-02 | | Last modified: | 2021-10-20 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structure of the Y94F mutant of Escherichia coli thymidylate synthase.
ACTA CRYSTALLOGR.,SECT.F, 62, 2006
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1KOI
 | | CRYSTAL STRUCTURE OF NITROPHORIN 4 FROM RHODNIUS PROLIXUS COMPLEXED WITH NITRIC OXIDE AT 1.08 A RESOLUTION | | Descriptor: | NITRIC OXIDE, NITROPHORIN 4, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Roberts, S.A, Weichsel, A, Qiu, Y, Shelnutt, J.A, Walker, F.A, Montfort, W.R. | | Deposit date: | 2001-05-03 | | Release date: | 2002-01-09 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.08 Å) | | Cite: | Ligand-induced heme ruffling and bent no geometry in ultra-high-resolution structures of nitrophorin 4.
Biochemistry, 40, 2001
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1KV7
 | | Crystal Structure of CueO, a multi-copper oxidase from E. coli involved in copper homeostasis | | Descriptor: | COPPER (II) ION, CU-O-CU LINKAGE, PROBABLE BLUE-COPPER PROTEIN YACK | | Authors: | Roberts, S.A, Weichsel, A, Grass, G, Thakali, K, Hazzard, J.T, Tollin, G, Rensing, C, Montfort, W.R. | | Deposit date: | 2002-01-25 | | Release date: | 2002-02-06 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Crystal structure and electron transfer kinetics of CueO, a multicopper oxidase required for copper homeostasis in Escherichia coli.
Proc.Natl.Acad.Sci.USA, 99, 2002
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1YWA
 | | 0.9 A Structure of NP4 from Rhodnius Prolixus complexed with CO at pH 5.6 | | Descriptor: | CARBON MONOXIDE, PHOSPHATE ION, PROTOPORPHYRIN IX CONTAINING FE, ... | | Authors: | Maes, E.M, Weichsel, A, Roberts, S.A, Montfort, W.R. | | Deposit date: | 2005-02-17 | | Release date: | 2005-10-04 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (0.89 Å) | | Cite: | Ultrahigh Resolution Structures of Nitrophorin 4: Heme Distortion in Ferrous CO and NO Complexes
Biochemistry, 44, 2005
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1YWC
 | | Structure of the ferrous CO complex of NP4 from Rhodnius Prolixus at pH 7.0 | | Descriptor: | CARBON MONOXIDE, PROTOPORPHYRIN IX CONTAINING FE, nitrophorin 4 | | Authors: | Maes, E.M, Weichsel, A, Roberts, S.A, Montfort, W.R. | | Deposit date: | 2005-02-17 | | Release date: | 2005-10-04 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1 Å) | | Cite: | Ultrahigh Resolution Structures of Nitrophorin 4: Heme Distortion in Ferrous CO and NO Complexes
Biochemistry, 44, 2005
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1Y21
 | | Crystal Structure of Cimex Nitrophorin NO Complex | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, NITRIC OXIDE, PROTOPORPHYRIN IX CONTAINING FE, ... | | Authors: | Weichsel, A, Maes, E.M, Andersen, J.F, Valenzuela, J.G, Shokhireva, T.K, Walker, F.A, Montfort, W.R. | | Deposit date: | 2004-11-19 | | Release date: | 2004-11-30 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Heme-assisted S-nitrosation of a proximal thiolate in a nitric oxide transport protein.
Proc.Natl.Acad.Sci.Usa, 102, 2005
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1YWB
 | | 0.9 A Structure of NP4 from Rhodnius Prolixus complexed with NO at pH 5.6 | | Descriptor: | NITRIC OXIDE, PHOSPHATE ION, PROTOPORPHYRIN IX CONTAINING FE, ... | | Authors: | Maes, E.M, Weichsel, A, Roberts, S.A, Montfort, W.R. | | Deposit date: | 2005-02-17 | | Release date: | 2005-10-04 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (0.97 Å) | | Cite: | Ultrahigh Resolution Structures of Nitrophorin 4: Heme Distortion in Ferrous CO and NO Complexes
Biochemistry, 44, 2005
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1ZEQ
 | | 1.5 A Structure of apo-CusF residues 6-88 from Escherichia coli | | Descriptor: | Cation efflux system protein cusF | | Authors: | Loftin, I.R, Franke, S, Roberts, S.A, Weichsel, A, Heroux, A, Montfort, W.R, Rensing, C, McEvoy, M.M. | | Deposit date: | 2005-04-19 | | Release date: | 2005-08-02 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | A Novel Copper-Binding Fold for the Periplasmic Copper Resistance Protein CusF.
Biochemistry, 44, 2005
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1YWD
 | | 1.08 A Structure of Ferrous NP4 (aquo complex) | | Descriptor: | PROTOPORPHYRIN IX CONTAINING FE, nitrophorin 4 | | Authors: | Maes, E.M, Weichsel, A, Roberts, S.A, Montfort, W.R. | | Deposit date: | 2005-02-17 | | Release date: | 2005-10-04 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.08 Å) | | Cite: | Ultrahigh Resolution Structures of Nitrophorin 4: Heme Distortion in Ferrous CO and NO Complexes
Biochemistry, 44, 2005
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1X8N
 | | 1.08 A Crystal Structure Of Nitrophorin 4 From Rhodnius Prolixus Complexed With Nitric Oxide at pH 7.4 | | Descriptor: | NITRIC OXIDE, Nitrophorin 4, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Kondrashov, D.A, Roberts, S.A, Weichsel, A, Montfort, W.R. | | Deposit date: | 2004-08-18 | | Release date: | 2004-10-05 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.08 Å) | | Cite: | Protein functional cycle viewed at atomic resolution: conformational change and mobility in nitrophorin 4 as a function of pH and NO binding
Biochemistry, 43, 2004
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2TSR
 | | THYMIDYLATE SYNTHASE FROM RAT IN TERNARY COMPLEX WITH DUMP AND TOMUDEX | | Descriptor: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE, TOMUDEX | | Authors: | Sotelo-Mundo, R.R, Ciesla, J, Dzik, J.M, Rode, W, Maley, F, Maley, G, Hardy, L.W, Montfort, W.R. | | Deposit date: | 1998-06-19 | | Release date: | 1999-02-16 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal structures of rat thymidylate synthase inhibited by Tomudex, a potent anticancer drug.
Biochemistry, 38, 1999
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2VF0
 | | CRYSTAL STRUCTURE OF THE THYMIDYLATE SYNTHASE K48Q COMPLEXED WITH 5NO2DUMP AND BW1843U89 | | Descriptor: | 2'-DEOXY-5-NITROURIDINE 5'-MONOPHOSPHATE, S)-2-(5(((1,2-DIHYDRO-3-METHYL-1-OXOBENZO(F)QUINAZOLIN-9-YL)METHYL)AMINO)1-OXO-2-ISOINDOLINYL)GLUTARIC ACID, SULFATE ION, ... | | Authors: | Sotelo-Mundo, R.R, Arreola, R, Maley, F, Montfort, W.R. | | Deposit date: | 2007-10-27 | | Release date: | 2007-12-04 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Role of an Invariant Lysine Residue in Folate Binding on Escherichia Coli Thymidylate Synthase: Calorimetric and Crystallographic Analysis of the K48Q Mutant.
Int.J.Biochem.Cell Biol., 40, 2008
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