1O8X
| Mutant tryparedoxin-I Cys43Ala | Descriptor: | TRYPAREDOXIN | Authors: | Alphey, M.S, Bond, C.S, Hunter, W.N. | Deposit date: | 2002-12-09 | Release date: | 2003-04-24 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Tryparedoxins from Crithidia Fasciculata and Trypanosoma Brucei: Photoreduction of the Redox Disulfide Using Synchrotron Radiation and Evidence for a Conformational Switch Implicated in Function J.Biol.Chem., 278, 2003
|
|
5OAJ
| Crystal structure of mutant AChBP in complex with tropisetron (T53F, Q74R, Y110A, I135S, G162E) | Descriptor: | (3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-INDOLE-3-CARBOXYLATE, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Dawson, A, Hunter, W.N, de Souza, J.O, Trumper, P. | Deposit date: | 2017-06-22 | Release date: | 2018-08-01 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.47 Å) | Cite: | Engineering a surrogate human heteromeric alpha / beta glycine receptor orthosteric site exploiting the structural homology and stability of acetylcholine-binding protein. Iucrj, 6, 2019
|
|
5OBG
| Crystal structure of glycine binding protein in complex with strychnine | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ... | Authors: | Dawson, A, Hunter, W.N, Jones, M. | Deposit date: | 2017-06-26 | Release date: | 2018-08-01 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Engineering a surrogate human heteromeric alpha / beta glycine receptor orthosteric site exploiting the structural homology and stability of acetylcholine-binding protein. Iucrj, 6, 2019
|
|
1O8W
| Radiation-reduced Tryparedoxin-I | Descriptor: | TRYPAREDOXIN | Authors: | Alphey, M.S, Bond, C.S, Hunter, W.N. | Deposit date: | 2002-12-09 | Release date: | 2003-08-01 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Tryparedoxins from Crithidia Fasciculata and Trypanosoma Brucei: Photoreduction of the Redox Disulfide Using Synchrotron Radiation and Evidence for a Conformational Switch Implicated in Function J.Biol.Chem., 278, 2003
|
|
5OQ1
| Crystal structure of Serratia marcescens ChiX (used as MR model for superior PDB 5OPZ) | Descriptor: | CHLORIDE ION, ChiX, ZINC ION | Authors: | Owen, R.A, Fyfe, P.K, Lodge, A, Biboy, J, Vollmer, W, Hunter, W.N, Sargent, F. | Deposit date: | 2017-08-10 | Release date: | 2018-01-17 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.34 Å) | Cite: | Structure and activity of ChiX: a peptidoglycan hydrolase required for chitinase secretion by Serratia marcescens. Biochem. J., 475, 2018
|
|
6T9R
| Aplysia californica AChBP in complex with a cytisine derivative | Descriptor: | (1~{R},9~{S})-5-(3-oxidanylpropyl)-7,11-diazatricyclo[7.3.1.0^{2,7}]trideca-2,4-dien-6-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, Acetylcholine binding protein, ... | Authors: | Davis, S, Hunter, W.N. | Deposit date: | 2019-10-28 | Release date: | 2020-02-12 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | The thermodynamic profile and molecular interactions of a C(9)-cytisine derivative-binding acetylcholine-binding protein from Aplysia californica. Acta Crystallogr.,Sect.F, 76, 2020
|
|
3ZFH
| Crystal structure of Pseudomonas aeruginosa inosine 5'-monophosphate dehydrogenase | Descriptor: | CHLORIDE ION, INOSINE 5'-MONOPHOSPHATE DEHYDROGENASE | Authors: | Rao, V.A, Shepherd, S.M, Owen, R, Hunter, W.N. | Deposit date: | 2012-12-11 | Release date: | 2013-01-16 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structure of Pseudomonas Aeruginosa Inosine 5'-Monophosphate Dehydrogenase Acta Crystallogr.,Sect.F, 69, 2013
|
|
3ZPC
| Acinetobacter baumannii RibD, form 1 | Descriptor: | ACETATE ION, PHOSPHATE ION, RIBOFLAVIN BIOSYNTHESIS PROTEIN RIBD, ... | Authors: | Dawson, A, Trumper, P, Chrysostomou, G, Hunter, W.N. | Deposit date: | 2013-02-27 | Release date: | 2013-03-27 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure of Diaminohydroxyphosphoribosylaminopyrimidine Deaminase/5-Amino-6-(5-Phosphoribosylamino)Uracil Reductase from Acinetobacter Baumannii. Acta Crystallogr.,Sect.F, 69, 2013
|
|
3ZPG
| Acinetobacter baumannii RibD, form 2 | Descriptor: | ACETATE ION, CACODYLATE ION, CHLORIDE ION, ... | Authors: | Dawson, A, Trumper, P, Chrysostomou, G, Hunter, W.N. | Deposit date: | 2013-02-27 | Release date: | 2013-03-27 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Structure of Diaminohydroxyphosphoribosylaminopyrimidine Deaminase/5-Amino-6-(5-Phosphoribosylamino)Uracil Reductase from Acinetobacter Baumannii. Acta Crystallogr.,Sect.F, 69, 2013
|
|
3ZIB
| Rap2a protein (SMA2265) from Serratia marcescens | Descriptor: | RAP2A SMA2265 | Authors: | Srikannathasan, V, O'Rourke, P.E.F, Rao, V.A, English, G, Coulthurst, S.J, Hunter, W.N. | Deposit date: | 2013-01-08 | Release date: | 2013-06-19 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural Basis for Type Vi Secreted Peptidoglycan Dl-Endopeptidase Function, Specificity and Neutralization in Serratia Marcescens Acta Crystallogr.,Sect.D, 69, 2013
|
|
3ZBH
| |
4ANN
| Crystal Structure Staphylococcus aureus ESSB cytoplasmic fragment | Descriptor: | ESSB | Authors: | Zoltner, M, Fyfe, P.K, Palmer, T, Hunter, W.N. | Deposit date: | 2012-03-21 | Release date: | 2012-05-23 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.05 Å) | Cite: | Characterization of Staphylococcus Aureus Essb, an Integral Membrane Component of the Type Vii Secretion System: Atomic Resolution Crystal Structure of the Cytoplasmic Segment. Biochem.J., 449, 2013
|
|
4ANO
| Crystal Structure Geobacillus thermodenitrificans EssB cytoplasmic fragment | Descriptor: | CHLORIDE ION, ESSB, SODIUM ION | Authors: | Zoltner, M, Fyfe, P, Hunter, W.N. | Deposit date: | 2012-03-21 | Release date: | 2012-12-05 | Last modified: | 2013-11-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The Architecture of Essb, an Integral Membrane Component of the Type Vii Secretion System. Structure, 21, 2013
|
|
4AGS
| Leishmania TDR1 - a unique trimeric glutathione transferase | Descriptor: | 1,2-ETHANEDIOL, GLUTATHIONE, THIOL-DEPENDENT REDUCTASE 1 | Authors: | Fyfe, P.K, Westrop, G.D, Silva, A.M, Coombs, G.H, Hunter, W.N. | Deposit date: | 2012-01-31 | Release date: | 2012-07-04 | Last modified: | 2012-08-01 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Leishmania Tdr1 Structure, a Unique Trimeric Glutathione Transferase Capable of Deglutathionylation and Antimonial Prodrug Activation. Proc.Natl.Acad.Sci.USA, 109, 2012
|
|
4A5O
| Crystal structure of Pseudomonas aeruginosa N5, N10- methylenetetrahydrofolate dehydrogenase-cyclohydrolase (FolD) | Descriptor: | BIFUNCTIONAL PROTEIN FOLD, DI(HYDROXYETHYL)ETHER, GLYCEROL | Authors: | Eadsforth, T.C, Gardiner, M, Maluf, F.V, McElroy, S, James, D, Frearson, J, Gray, D, Hunter, W.N. | Deposit date: | 2011-10-26 | Release date: | 2011-11-16 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Assessment of Pseudomonas Aeruginosa N(5),N(10)-Methylenetetrahydrofolate Dehydrogenase - Cyclohydrolase as a Potential Antibacterial Drug Target. Plos One, 7, 2012
|
|
4AIR
| Leishmania major cysteine synthase | Descriptor: | CHLORIDE ION, Cysteine synthase, FGA-FGA-FGA-FGA, ... | Authors: | Fyfe, P.K, Westrop, G.D, Coombs, G.H, Hunter, W.N. | Deposit date: | 2012-02-13 | Release date: | 2012-02-29 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure of Leishmania Major Cysteine Synthase. Acta Crystallogr.,Sect.F, 68, 2012
|
|
4A26
| The crystal structure of Leishmania major N5,N10- methylenetetrahydrofolate dehydrogenase/cyclohydrolase | Descriptor: | CHLORIDE ION, PUTATIVE C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC | Authors: | Eadsforth, T.C, Cameron, S, Hunter, W.N. | Deposit date: | 2011-09-22 | Release date: | 2011-10-26 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The Crystal Structure of Leishmania Major N(5),N(10)-Methylenetetrahydrofolate Dehydrogenase/Cyclohydrolase and Assessment of a Potential Drug Target. Mol.Biochem.Parasitol., 181, 2012
|
|
3ZFI
| Rap1a protein (SMA2260) from Serratia marcescens | Descriptor: | RAP1A PROTEIN | Authors: | Srikannathasan, V, O'Rourke, P.E.F, Rao, V.A, English, G, Coulthurst, S.J, Hunter, W.N. | Deposit date: | 2012-12-11 | Release date: | 2013-06-19 | Last modified: | 2019-05-08 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | Structural Basis for Type Vi Secreted Peptidoglycan Dl-Endopeptidase Function, Specificity and Neutralization in Serratia Marcescens Acta Crystallogr.,Sect.D, 69, 2013
|
|
4A1R
| The Structure of Serratia marcescens Lip, a membrane bound component of the Type VI Secretion System. | Descriptor: | 1,2-ETHANEDIOL, LIP, SODIUM ION | Authors: | Rao, V.A, Shepherd, S.M, English, G, Coulthurst, S.J, Hunter, W.N. | Deposit date: | 2011-09-19 | Release date: | 2011-10-05 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | The Structure of Serratia Marcescens Lip, a Membrane-Bound Component of the Type Vi Secretion System Acta Crystallogr.,Sect.F, 67, 2011
|
|
4AX2
| New Type VI-secreted toxins and self-resistance proteins in Serratia marcescens | Descriptor: | 1,2-ETHANEDIOL, IODIDE ION, RAP1B | Authors: | English, G, Trunk, K, Rao, V.A, Srikannathasan, V, Fritsch, M.J, Guo, M, Hunter, W.N, Coulthurst, S.J. | Deposit date: | 2012-06-07 | Release date: | 2012-09-19 | Last modified: | 2013-07-17 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | New Secreted Toxins and Immunity Proteins Encoded within the Type Vi Secretion System Gene Cluster of Serratia Marcescens Mol.Microbiol., 86, 2012
|
|
4B6I
| |
3H4V
| Selective screening and design to identify inhibitors of leishmania major pteridine reductase 1 | Descriptor: | METHYL 1-(4-{[(2,4-DIAMINOPTERIDIN-6-YL)METHYL]AMINO}BENZOYL)PIPERIDINE-4-CARBOXYLATE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Pteridine reductase 1 | Authors: | Mcluskey, K, Gibellini, F, Hunter, W.N. | Deposit date: | 2009-04-21 | Release date: | 2009-05-05 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development Proc.Natl.Acad.Sci.USA, 105, 2008
|
|
3GN2
| Structure of Pteridine Reductase 1 (PTR1) from TRYPANOSOMA BRUCEI in ternary complex with cofactor (NADP+) and inhibitor (DDD00066730) | Descriptor: | 1-(3,4-dichlorobenzyl)-1H-benzimidazol-2-amine, ACETATE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Tulloch, L.B, Brenk, R, Hunter, W.N. | Deposit date: | 2009-03-16 | Release date: | 2009-12-29 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | One scaffold, three binding modes: novel and selective pteridine reductase 1 inhibitors derived from fragment hits discovered by virtual screening. J.Med.Chem., 52, 2009
|
|
3JQ7
| Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 6-phenylpteridine-2,4,7-triamine (DX2) | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 6-phenylpteridine-2,4,7-triamine, ACETATE ION, ... | Authors: | Tulloch, L.B, Hunter, W.N. | Deposit date: | 2009-09-06 | Release date: | 2009-12-08 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure-based design of pteridine reductase inhibitors targeting african sleeping sickness and the leishmaniases. J.Med.Chem., 53, 2010
|
|
3JQF
| Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 1,3,5-triazine-2,4,6-triamine (AX2) | Descriptor: | (4S,5S)-1,2-DITHIANE-4,5-DIOL, 1,3,5-triazine-2,4,6-triamine, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ... | Authors: | Tulloch, L.B, Hunter, W.N. | Deposit date: | 2009-09-06 | Release date: | 2009-12-08 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structure-based design of pteridine reductase inhibitors targeting african sleeping sickness and the leishmaniases. J.Med.Chem., 53, 2010
|
|