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2VAC
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BU of 2vac by Molmil
Structure of N-terminal Actin Depolymerizing Factor homology (ADF-H) domain of human twinfilin-2
Descriptor: 1,2-ETHANEDIOL, TWINFILIN-2, ZINC ION
Authors:Elkins, J.M, Pike, A.C.W, King, O, Salah, E, Savitsky, P, von Delft, F, Weigelt, J, Edwards, A, Arrowsmith, C.H, Sundstrom, M, Knapp, S.
Deposit date:2007-08-30
Release date:2007-10-16
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal Structure of N-Terminal Actin Depolymerizing Factor Homology (Adf-H) Domain of Human Twinfilin-2
To be Published
2VNA
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BU of 2vna by Molmil
Structure of Human Zinc-binding Alcohol Dehydrogenase 1 (ZADH1)
Descriptor: NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PROSTAGLANDIN REDUCTASE 2
Authors:Shafqat, N, Kavanagh, K, Pike, A.C.W, Muniz, J.R.C, Pilka, E, Roos, A.K, Picaud, S, Johansson, C, Smee, C, Fedorov, O, Kochan, G, Edwards, A, Arrowsmith, C.H, Weigelt, J, Bountra, C, von Delft, F, Opperman, U.
Deposit date:2008-02-01
Release date:2009-02-17
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Structure of Human Zinc-Binding Alcohol Dehydrogenase 1 (Zadh1)
To be Published
4O38
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BU of 4o38 by Molmil
Crystal structure of the human cyclin G associated kinase (GAK)
Descriptor: Cyclin-G-associated kinase, GLYCEROL, SUCCINIC ACID
Authors:Zhang, R, Hatzos-Skintges, C, Weger, A, Chaikuad, A, Eswaran, J, Fedorov, O, King, O, von Delft, F, Bountra, C, Arrowsmith, C.H, Weigelt, J, Edwards, A, Knapp, S, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Structural Genomics Consortium (SGC)
Deposit date:2013-12-18
Release date:2014-01-01
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.097 Å)
Cite:Crystal structure of the human cyclin G associated kinase (GAK)
To be Published
4II1
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BU of 4ii1 by Molmil
Crystal structure of the zinc finger of ZGPAT
Descriptor: UNKNOWN ATOM OR ION, ZINC ION, Zinc finger CCCH-type with G patch domain-containing protein
Authors:Bian, C, Tempel, W, Dong, A, Chao, X, Fu, M, Wernimont, A.K, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2012-12-19
Release date:2013-02-13
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Crystal structure of the zinc finger of ZGPAT
to be published
2VN8
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BU of 2vn8 by Molmil
Crystal structure of human Reticulon 4 interacting protein 1 in complex with NADPH
Descriptor: CITRIC ACID, GLYCEROL, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Pike, A.C.W, Guo, K, Elkins, J, Ugochukwu, E, Roos, A.K, Filippakopoulos, P, von Delft, F, Edwards, A, Arrowsmith, C.H, Weigelt, J, Bountra, C, Oppermann, U.
Deposit date:2008-01-31
Release date:2008-03-18
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure of Human Reticulon 4 Interacting Protein 1 in Complex with Nadph
To be Published
3E77
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BU of 3e77 by Molmil
Human phosphoserine aminotransferase in complex with PLP
Descriptor: GLYCEROL, PYRIDOXAL-5'-PHOSPHATE, Phosphoserine aminotransferase
Authors:Lehtio, L, Karlberg, T, Andersson, J, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Dahlgren, L.G, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, A, Johansson, I, Kotenyova, T, Moche, M, Nilsson, M.E, Nordlund, P, Nyman, T, Olesen, K, Persson, C, Sagemark, J, Thorsell, S.G, Tresaugues, L, Van Den Berg, S, Welin, M, Wikstrom, M, Wisniewska, M, Weigelt, J, Schueler, H, Structural Genomics Consortium (SGC)
Deposit date:2008-08-18
Release date:2008-08-26
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Human phosphoserine aminotransferase in complex with PLP
TO BE PUBLISHED
4DYL
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BU of 4dyl by Molmil
F-BAR domain of human FES tyrosine kinase
Descriptor: Tyrosine-protein kinase Fes/Fps
Authors:Ugochukwu, E, Salah, E, Elkins, J, Barr, A, Krojer, T, Filippakopoulos, P, Weigelt, J, Arrowsmith, C.H, Edwards, A, Bountra, C, von Delft, F, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2012-02-29
Release date:2012-04-04
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:F-BAR domain of human FES tyrosine kinase
TO BE PUBLISHED
4DRZ
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BU of 4drz by Molmil
Crystal structure of human RAB14
Descriptor: CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, Ras-related protein Rab-14
Authors:Wang, J, Tempel, W, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
Deposit date:2012-02-17
Release date:2012-02-29
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of human RAB14
to be published
4E71
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BU of 4e71 by Molmil
Crystal structure of the RHO GTPASE binding domain of Plexin B2
Descriptor: Plexin-B2, SODIUM ION
Authors:Guan, X, Wang, H, Tempel, W, Tong, Y, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Park, H, Structural Genomics Consortium (SGC)
Deposit date:2012-03-16
Release date:2012-03-28
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Crystal structure of the RHO GTPASE binding domain of Plexin B2
to be published
2X7H
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BU of 2x7h by Molmil
Crystal structure of the human MGC45594 gene product in complex with fenoprofen
Descriptor: 1,2-ETHANEDIOL, FENOPROFEN, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Shafqat, N, Yue, W.W, Ugochukwu, E, Niesen, F, Vollmar, M, Chaikuad, A, Pike, A.C.W, von Delft, F, Smee, C, Arrowsmith, C, Weigelt, J, Edwards, A, Bountra, C, Oppermann, U.
Deposit date:2010-02-26
Release date:2010-12-08
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal Structure of the Human Mgc45594 Gene Product in Complex with Fenoprofen
To be Published
2X1H
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BU of 2x1h by Molmil
Crystal structure of the human MGC45594 gene product in complex with raloxifene
Descriptor: 1,2-ETHANEDIOL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2, ...
Authors:Shafqat, N, Yue, W.W, Pike, A.C.W, Niesen, F, Ugochukwu, E, Krojer, T, Chaikuad, A, Smee, C, Arrowsmith, C, Weigelt, J, Edwards, A, Bountra, C, Oppermann, U.
Deposit date:2009-12-24
Release date:2010-11-10
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal Structure of the Human Mgc45594 Gene Product in Complex with Raloxifene
To be Published
4L7P
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BU of 4l7p by Molmil
Human artd3 (parp3) - catalytic domain in complex with inhibitor ME0395
Descriptor: (2E)-N-[(2S)-1-hydroxy-3-phenylpropan-2-yl]-3-(4-oxo-1,4-dihydroquinazolin-2-yl)prop-2-enamide, Poly [ADP-ribose] polymerase 3
Authors:Karlberg, T, Thorsell, A.G, Lindgren, A.E.G, Ekblad, T, Spjut, S, Andersson, C.D, Weigelt, J, Linusson, A, Elofsson, M, Schuler, H.
Deposit date:2013-06-14
Release date:2014-02-19
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Chemical Probes to Study ADP-Ribosylation: Synthesis and Biochemical Evaluation of Inhibitors of the Human ADP-Ribosyltransferase ARTD3/PARP3.
J.Med.Chem., 56, 2013
4L7R
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BU of 4l7r by Molmil
Human artd3 (parp3) - catalytic domain in complex with inhibitor ME0400
Descriptor: N-[(2S)-1-hydroxybutan-2-yl]-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanamide, Poly [ADP-ribose] polymerase 3
Authors:Karlberg, T, Thorsell, A.G, Lindgren, A.E.G, Ekblad, T, Spjut, S, Andersson, C.D, Weigelt, J, Linusson, A, Elofsson, M, Schuler, H.
Deposit date:2013-06-14
Release date:2014-02-19
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Chemical Probes to Study ADP-Ribosylation: Synthesis and Biochemical Evaluation of Inhibitors of the Human ADP-Ribosyltransferase ARTD3/PARP3.
J.Med.Chem., 56, 2013
4L7N
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BU of 4l7n by Molmil
Human artd3 (parp3) - catalytic domain in complex with inhibitor STO1542
Descriptor: 3-(4-oxo-3,4-dihydroquinazolin-2-yl)-N-[(1S)-1-(4-sulfamoylphenyl)ethyl]propanamide, Poly [ADP-ribose] polymerase 3
Authors:Karlberg, T, Thorsell, A.G, Lindgren, A.E.G, Ekblad, T, Spjut, S, Andersson, C.D, Weigelt, J, Linusson, A, Elofsson, M, Schuler, H.
Deposit date:2013-06-14
Release date:2014-02-19
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Chemical Probes to Study ADP-Ribosylation: Synthesis and Biochemical Evaluation of Inhibitors of the Human ADP-Ribosyltransferase ARTD3/PARP3.
J.Med.Chem., 56, 2013
4L7L
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BU of 4l7l by Molmil
Human artd3 (parp3) - catalytic domain in complex with inhibitor ME0368
Descriptor: DIMETHYL SULFOXIDE, N-[(2S)-1-hydroxy-3-phenylpropan-2-yl]-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanamide, Poly [ADP-ribose] polymerase 3
Authors:Karlberg, T, Thorsell, A.G, Lindgren, A.E.G, Ekblad, T, Spjut, S, Andersson, C.D, Weigelt, J, Linusson, A, Elofsson, M, Schuler, H.
Deposit date:2013-06-14
Release date:2014-02-19
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Chemical Probes to Study ADP-Ribosylation: Synthesis and Biochemical Evaluation of Inhibitors of the Human ADP-Ribosyltransferase ARTD3/PARP3.
J.Med.Chem., 56, 2013
4L7U
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BU of 4l7u by Molmil
Human artd3 (parp3) - catalytic domain in complex with inhibitor ME0398
Descriptor: Poly [ADP-ribose] polymerase 3, methyl N-[3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanoyl]-L-phenylalaninate
Authors:Karlberg, T, Thorsell, A.G, Lindgren, A.E.G, Ekblad, T, Spjut, S, Andersson, C.D, Weigelt, J, Linusson, A, Elofsson, M, Schuler, H.
Deposit date:2013-06-14
Release date:2014-02-19
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Chemical Probes to Study ADP-Ribosylation: Synthesis and Biochemical Evaluation of Inhibitors of the Human ADP-Ribosyltransferase ARTD3/PARP3.
J.Med.Chem., 56, 2013
4L6Z
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BU of 4l6z by Molmil
Human artd3 (parp3) - catalytic domain in complex with inhibitor STO1168
Descriptor: 3-(4-oxo-3,4-dihydroquinazolin-2-yl)-N-[(1S)-1-(pyridin-4-yl)ethyl]propanamide, DIMETHYL SULFOXIDE, Poly [ADP-ribose] polymerase 3
Authors:Karlberg, T, Thorsell, A.G, Lindgren, A.E.G, Ekblad, T, Spjut, S, Andersson, C.D, Weigelt, J, Linusson, A, Elofsson, M, Schuler, H.
Deposit date:2013-06-13
Release date:2014-02-19
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Chemical Probes to Study ADP-Ribosylation: Synthesis and Biochemical Evaluation of Inhibitors of the Human ADP-Ribosyltransferase ARTD3/PARP3.
J.Med.Chem., 56, 2013
4L7O
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BU of 4l7o by Molmil
Human artd3 (parp3) - catalytic domain in complex with inhibitor STO1542
Descriptor: DIMETHYL SULFOXIDE, N-{(1S)-1-[4-(1H-imidazol-1-yl)phenyl]ethyl}-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanamide, Poly [ADP-ribose] polymerase 3
Authors:Karlberg, T, Thorsell, A.G, Lindgren, A.E.G, Ekblad, T, Spjut, S, Andersson, C.D, Weigelt, J, Linusson, A, Elofsson, M, Schuler, H.
Deposit date:2013-06-14
Release date:2014-02-19
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Chemical Probes to Study ADP-Ribosylation: Synthesis and Biochemical Evaluation of Inhibitors of the Human ADP-Ribosyltransferase ARTD3/PARP3.
J.Med.Chem., 56, 2013
2VR2
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BU of 2vr2 by Molmil
Human Dihydropyrimidinase
Descriptor: CHLORIDE ION, DIHYDROPYRIMIDINASE, ZINC ION
Authors:Welin, M, Karlberg, T, Andersson, J, Arrowsmith, C.H, Berglund, H, Busam, R.D, Collins, R, Dahlgren, L.G, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Herman, M.D, Johansson, I, Kallas, A, Kotenyova, T, Lehtio, L, Moche, M, Nilsson, M.E, Nyman, T, Persson, C, Sagemark, J, Svensson, L, Thorsell, A.G, Tresaugues, L, Van Den Berg, S, Weigelt, J, Wikstrom, M, Nordlund, P, Structural Genomics Consortium (SGC)
Deposit date:2008-03-25
Release date:2008-04-01
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The Crystal Structure of Human Dihydropyrimidinase
To be Published
4E74
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BU of 4e74 by Molmil
Crystal structure of the RHO GTPASE BINDING DOMAIN of Plexin A4A
Descriptor: Plexin-A4, UNKNOWN ATOM OR ION
Authors:Guan, X, Wang, H, Tempel, W, Dong, A, Tong, Y, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Park, H, Structural Genomics Consortium (SGC)
Deposit date:2012-03-16
Release date:2012-03-28
Last modified:2024-11-27
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Crystal structure of the RHO GTPASE BINDING DOMAIN of Plexin A4A
to be published
4F1L
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BU of 4f1l by Molmil
Human Artd8 (Parp14, Bal2) - catalytic domain in complex with inhibitor A16(Z)
Descriptor: (2Z)-4-[(3-carbamoylphenyl)amino]-4-oxobut-2-enoic acid, NITRATE ION, Poly [ADP-ribose] polymerase 14
Authors:Karlberg, T, Andersson, C.D, Lindgren, A, Spjut, S, Thorsell, A.G, Ekblad, T, Weigelt, J, Elofsson, M, Linusson, A, Schuler, H.
Deposit date:2012-05-07
Release date:2012-09-05
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery of Ligands for ADP-Ribosyltransferases via Docking-Based Virtual Screening.
J.Med.Chem., 55, 2012
4F1Q
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BU of 4f1q by Molmil
Human Artd8 (Parp14, Bal2) - catalytic domain in complex with A16(E)
Descriptor: (2E)-4-[(3-carbamoylphenyl)amino]-4-oxobut-2-enoic acid, NITRATE ION, Poly [ADP-ribose] polymerase 14
Authors:Karlberg, T, Andersson, C.D, Lindgren, A, Spjut, S, Thorsell, A.G, Ekblad, T, Weigelt, J, Elofsson, M, Linusson, A, Schuler, H.
Deposit date:2012-05-07
Release date:2012-09-05
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Discovery of Ligands for ADP-Ribosyltransferases via Docking-Based Virtual Screening.
J.Med.Chem., 55, 2012
4FMW
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BU of 4fmw by Molmil
Crystal structure of methyltransferase domain of human RNA (guanine-9-) methyltransferase domain containing protein 2
Descriptor: 1,2-ETHANEDIOL, POTASSIUM ION, RNA (guanine-9-)-methyltransferase domain-containing protein 2, ...
Authors:Dong, A, Zeng, H, Loppnau, P, Tempel, W, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Wu, H, Structural Genomics Consortium (SGC)
Deposit date:2012-06-18
Release date:2012-08-22
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of methyltransferase domain of human RNA (guanine-9-) methyltransferase domain containing protein 2
TO BE PUBLISHED
2VUX
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BU of 2vux by Molmil
Human ribonucleotide reductase, subunit M2 B
Descriptor: FE (III) ION, RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2 B
Authors:Welin, M, Moche, M, Andersson, J, Arrowsmith, C.H, Berglund, H, Busam, R.D, Collins, R, Dahlgren, L.G, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Herman, M.D, Johansson, A, Johansson, I, Kallas, A, Karlberg, T, Kotenyova, T, Lehtio, L, Nilsson, M.E, Nyman, T, Persson, C, Sagemark, J, Schueler, H, Svensson, L, Thorsell, A.G, Tresaugues, L, van Den Berg, S, Weigelt, J, Wikstrom, M, Nordlund, P, Structural Genomics Consortium (SGC)
Deposit date:2008-05-31
Release date:2008-07-15
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Human Ribonucleotide Reductase, Subunit M2 B
To be Published
4F0E
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BU of 4f0e by Molmil
Human ADP-RIBOSYLTRANSFERASE 7 (ARTD7/PARP15), CATALYTIC DOMAIN IN COMPLEX WITH STO1102
Descriptor: 8-methyl-2-[(pyrimidin-2-ylsulfanyl)methyl]quinazolin-4(1H)-one, Poly [ADP-ribose] polymerase 15
Authors:Karlberg, T, Andersson, C.D, Lindgren, A, Thorsell, A.G, Ekblad, T, Spjut, S, Weigelt, J, Elofsson, M, Linusson, A, Schuler, H.
Deposit date:2012-05-04
Release date:2012-09-05
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Discovery of Ligands for ADP-Ribosyltransferases via Docking-Based Virtual Screening.
J.Med.Chem., 55, 2012

238582

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