4F0E

Human ADP-RIBOSYLTRANSFERASE 7 (ARTD7/PARP15), CATALYTIC DOMAIN IN COMPLEX WITH STO1102

Summary for 4F0E

Entry DOI	10.2210/pdb4f0e/pdb
Related	3BLJ 3GEY
Descriptor	Poly [ADP-ribose] polymerase 15, 8-methyl-2-[(pyrimidin-2-ylsulfanyl)methyl]quinazolin-4(1H)-one (3 entities in total)
Functional Keywords	artd, parp, poly (adp-ribose) polymerase, adp-ribose, bal3, b-aggressive lymphoma protein 3, transferase, glycosyltransferase, nucleus, transcription, transcription regulation, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Nucleus (Probable): Q460N3
Total number of polymer chains	4
Total formula weight	92724.15
Authors	Karlberg, T.,Andersson, C.D.,Lindgren, A.,Thorsell, A.G.,Ekblad, T.,Spjut, S.,Weigelt, J.,Elofsson, M.,Linusson, A.,Schuler, H. (deposition date: 2012-05-04, release date: 2012-09-05, Last modification date: 2023-09-13)
Primary citation	Andersson, C.D.,Karlberg, T.,Ekblad, T.,Lindgren, A.E.,Thorsell, A.G.,Spjut, S.,Uciechowska, U.,Niemiec, M.S.,Wittung-Stafshede, P.,Weigelt, J.,Elofsson, M.,Schuler, H.,Linusson, A. Discovery of Ligands for ADP-Ribosyltransferases via Docking-Based Virtual Screening. J.Med.Chem., 55:7706-7718, 2012 Cited by PubMed: 22823910 DOI: 10.1021/jm300746d PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation