7UR9
| SARS-Cov2 Main protease in complex with inhibitor CDD-1845 | Descriptor: | (2P)-2-(isoquinolin-4-yl)-1-[4-(methylamino)-4-oxobutyl]-N-[(1S)-1-(naphthalen-2-yl)ethyl]-1H-benzimidazole-7-carboxamide, 3C-like proteinase nsp5 | Authors: | Lu, S, Palzkill, T. | Deposit date: | 2022-04-21 | Release date: | 2023-07-26 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.16 Å) | Cite: | DNA-encoded chemical libraries yield non-covalent and non-peptidic SARS-CoV-2 main protease inhibitors. Commun Chem, 6, 2023
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7US4
| Sars-Cov2 Main Protease in complex with CDD-1819 | Descriptor: | (2P)-2-(isoquinolin-4-yl)-1-[(1s,3R)-3-(methylcarbamoyl)cyclobutyl]-N-[(1S)-1-(naphthalen-2-yl)ethyl]-1H-benzimidazole-7-carboxamide, 3C-like proteinase | Authors: | Lu, S, Palzkill, T, Matzuk, M.M, Judge, A. | Deposit date: | 2022-04-22 | Release date: | 2023-07-26 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | DNA-encoded chemical libraries yield non-covalent and non-peptidic SARS-CoV-2 main protease inhibitors. Commun Chem, 6, 2023
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7K5C
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7XS4
| Crystal structure of URT1 in complex with AAAU RNA | Descriptor: | RNA (5'-R(*AP*AP*AP*U)-3'), UTP:RNA uridylyltransferase 1 | Authors: | Hu, Q, Zhu, L.R, lv, M.Q, Gong, Q.G. | Deposit date: | 2022-05-12 | Release date: | 2022-09-21 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.846 Å) | Cite: | Molecular mechanism underlying the di-uridylation activity of Arabidopsis TUTase URT1. Nucleic Acids Res., 50, 2022
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7XSQ
| Structure of the Craspase | Descriptor: | CHAT domain protein, RAMP superfamily protein, RNA (34-MER), ... | Authors: | Feng, Y, Zhang, L. | Deposit date: | 2022-05-15 | Release date: | 2022-11-09 | Last modified: | 2022-12-14 | Method: | ELECTRON MICROSCOPY (2.88 Å) | Cite: | Target RNA activates the protease activity of Craspase to confer antiviral defense. Mol.Cell, 82, 2022
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7XSP
| Structure of gRAMP-target RNA | Descriptor: | RAMP superfamily protein, RNA (35-MER), RNA (5'-R(P*GP*GP*GP*GP*CP*AP*GP*AP*AP*AP*AP*UP*UP*GP*G)-3'), ... | Authors: | Feng, Y, Zhang, L.X. | Deposit date: | 2022-05-15 | Release date: | 2022-11-09 | Last modified: | 2022-12-14 | Method: | ELECTRON MICROSCOPY (2.89 Å) | Cite: | Target RNA activates the protease activity of Craspase to confer antiviral defense. Mol.Cell, 82, 2022
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7XT4
| Structure of Craspase-NTR | Descriptor: | CHAT domain protein, RAMP superfamily protein, RNA (34-MER), ... | Authors: | Feng, Y, Zhang, L. | Deposit date: | 2022-05-16 | Release date: | 2022-11-09 | Last modified: | 2022-12-14 | Method: | ELECTRON MICROSCOPY (3.08 Å) | Cite: | Target RNA activates the protease activity of Craspase to confer antiviral defense. Mol.Cell, 82, 2022
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7XSR
| Structure of Craspase-target RNA | Descriptor: | CHAT domain protein, RAMP superfamily protein, RNA (34-MER), ... | Authors: | Feng, Y, Zhang, L. | Deposit date: | 2022-05-15 | Release date: | 2022-11-09 | Last modified: | 2022-12-14 | Method: | ELECTRON MICROSCOPY (2.97 Å) | Cite: | Target RNA activates the protease activity of Craspase to confer antiviral defense. Mol.Cell, 82, 2022
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7XSS
| Structure of Craspase-CTR | Descriptor: | CHAT domain protein, RAMP superfamily protein, RNA (34-MER), ... | Authors: | Feng, Y, Zang, L.X. | Deposit date: | 2022-05-15 | Release date: | 2022-11-09 | Last modified: | 2022-12-14 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Target RNA activates the protease activity of Craspase to confer antiviral defense. Mol.Cell, 82, 2022
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7F75
| Cryo-EM structure of Spx-dependent transcription activation complex | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Lin, W, Feng, Y, Shi, J. | Deposit date: | 2021-06-28 | Release date: | 2021-10-13 | Last modified: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Structural basis of transcription activation by the global regulator Spx. Nucleic Acids Res., 49, 2021
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7XSO
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7CKK
| Structural complex of FTO bound with Dac51 | Descriptor: | 2-{[2,6-dichloro-4-(3,5-dimethyl-1H-pyrazol-4-yl)phenyl]amino}-N-hydroxybenzamide, Alpha-ketoglutarate-dependent dioxygenase FTO, N-OXALYLGLYCINE | Authors: | Yang, C, Gan, J. | Deposit date: | 2020-07-17 | Release date: | 2021-07-21 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance. Cell Metab., 33, 2021
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7DMP
| Mouse radial spoke complex | Descriptor: | Radial spoke head 1 homolog, Radial spoke head protein 4 homolog A, Radial spoke head protein 9 homolog | Authors: | Zheng, W, Cong, Y. | Deposit date: | 2020-12-05 | Release date: | 2021-07-21 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Distinct architecture and composition of mouse axonemal radial spoke head revealed by cryo-EM Proc.Natl.Acad.Sci.USA, 118, 2021
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7DTK
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7DTJ
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7XPR
| Crystal structrue of SeMet-MtdL:GDP | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Transglycosylse | Authors: | Li, F.D, He, C. | Deposit date: | 2022-05-05 | Release date: | 2023-03-29 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structures of the NDP-pyranose mutase belonging to glycosyltransferase family 75 reveal residues important for Mn 2+ coordination and substrate binding. J.Biol.Chem., 299, 2023
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7XPT
| Crystal structrue of MtdL:GDP:Mn soaked with GDP-Glc | Descriptor: | GDP-ALPHA-D-GLUCOSE, MANGANESE (II) ION, Transglycosylse | Authors: | Li, F.D, He, C. | Deposit date: | 2022-05-05 | Release date: | 2023-03-29 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structures of the NDP-pyranose mutase belonging to glycosyltransferase family 75 reveal residues important for Mn 2+ coordination and substrate binding. J.Biol.Chem., 299, 2023
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7XPS
| Crystal structrue of MtdL:GDP:Mn | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, Transglycosylse | Authors: | Li, F.D, He, C. | Deposit date: | 2022-05-05 | Release date: | 2023-03-29 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structures of the NDP-pyranose mutase belonging to glycosyltransferase family 75 reveal residues important for Mn 2+ coordination and substrate binding. J.Biol.Chem., 299, 2023
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7XPU
| crystal structure of MtdL-S228A-His soaked GDP-Fucp and Mn | Descriptor: | GLYCEROL, GUANOSINE-5'-DIPHOSPHATE-BETA-L-FUCOPYRANOSE, MANGANESE (II) ION, ... | Authors: | Li, F.D, He, C. | Deposit date: | 2022-05-05 | Release date: | 2023-03-29 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structures of the NDP-pyranose mutase belonging to glycosyltransferase family 75 reveal residues important for Mn 2+ coordination and substrate binding. J.Biol.Chem., 299, 2023
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7XPV
| crysteal structure of MtdL-S228A-His soaked with GDP-Fucf and Mn | Descriptor: | MANGANESE (II) ION, Transglycosylse, [[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanyl-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{S},3~{S},4~{S},5~{R})-3,4-bis(oxidanyl)-5-[(1~{S})-1-oxidanylethyl]oxolan-2-yl] hydrogen phosphate | Authors: | Li, F.D, He, C. | Deposit date: | 2022-05-05 | Release date: | 2023-03-29 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structures of the NDP-pyranose mutase belonging to glycosyltransferase family 75 reveal residues important for Mn 2+ coordination and substrate binding. J.Biol.Chem., 299, 2023
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7FIA
| Structure of AcrIF23 | Descriptor: | AcrIF23 | Authors: | Ren, J, Yue, F. | Deposit date: | 2021-07-30 | Release date: | 2022-07-27 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.13 Å) | Cite: | Structural and mechanistic insights into the inhibition of type I-F CRISPR-Cas system by anti-CRISPR protein AcrIF23. J.Biol.Chem., 298, 2022
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2FFL
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6I8L
| Crystal structure of Spindlin1 in complex with the inhibitor TD001851a | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, 5'-(cyclopropylmethoxy)-6'-[3-(1,3-dihydroisoindol-2-yl)propoxy]spiro[cyclopentane-1,3'-indole]-2'-amine, ... | Authors: | Johansson, C, Fagan, V, Brennan, P.E, Sorrell, F.J, Krojer, T, Arrowsmith, C.H, Bountra, C, Edwards, A, Oppermann, U.C.T. | Deposit date: | 2018-11-20 | Release date: | 2018-12-05 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function. J.Med.Chem., 62, 2019
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8IPM
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8IPK
| The structure of human mitochondrial methyltransferase METTL15 with SAM | Descriptor: | 12S rRNA N4-methylcytidine (m4C) methyltransferase, GLYCEROL, S-ADENOSYLMETHIONINE | Authors: | Lv, M.Q, Zhou, W.W. | Deposit date: | 2023-03-14 | Release date: | 2024-01-03 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural insights into the specific recognition of mitochondrial ribosome-binding factor hsRBFA and 12 S rRNA by methyltransferase METTL15. Cell Discov, 10, 2024
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