9GC8
 
 | | Crystal structure of Pseudomonas aeruginosa IspD in complex with C11H12N2O3 | | Descriptor: | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, methyl 2-[(5~{R})-6-methyl-7-oxidanylidene-5~{H}-pyrrolo[3,4-b]pyridin-5-yl]ethanoate | | Authors: | Borel, F, D'Auria, L. | | Deposit date: | 2024-08-01 | | Release date: | 2025-06-11 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Fragment Discovery by X-Ray Crystallographic Screening Targeting the CTP Binding Site of Pseudomonas Aeruginosa IspD.
Angew.Chem.Int.Ed.Engl., 64, 2025
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9G6T
 | | p53-Y220C Core Domain Covalently Bound to 5-Chloro-6-methylpyrazine-2-carbonitrile Soaked at 5 mM | | Descriptor: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5-chloranyl-6-methyl-pyrazine-2-carbonitrile, ... | | Authors: | Stahlecker, J, Klett, T, Stehle, T, Boeckler, F.M. | | Deposit date: | 2024-07-19 | | Release date: | 2025-06-11 | | Method: | X-RAY DIFFRACTION (1.56 Å) | | Cite: | SNAr Reactive Pyrazine Derivatives as p53-Y220C Cleft Binders with Diverse Binding Modes
Drug Des Devel Ther, 2025
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9H4A
 | | Ribonuclease-three Like 4 crystallization and structure determination at room temperature in the CrystalChip | | Descriptor: | Protein NUCLEAR FUSION DEFECTIVE 2 | | Authors: | Engilberge, S, Vincent, R, Coudray, L, Nilles, L, Scheer, H, Ritzenthaler, C, Sauter, C. | | Deposit date: | 2024-10-18 | | Release date: | 2024-12-11 | | Last modified: | 2025-04-16 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Protein crystallization and structure determination at room temperature in the CrystalChip.
Febs Open Bio, 15, 2025
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9HKW
 | | Cryo-EM structure of Pseudomonas aeruginosa tetrameric S-adenosyl-L-homocysteine hydrolase with 3 open and 1 closed subunits | | Descriptor: | ADENOSINE, Adenosylhomocysteinase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | | Authors: | Malecki, P.H, Wozniak, K, Ruszkowski, M, Brzezinski, K. | | Deposit date: | 2024-12-04 | | Release date: | 2025-02-19 | | Method: | ELECTRON MICROSCOPY (2.85 Å) | | Cite: | Cryo-EM structure of Pseudomonas aeruginosa tetrameric S-adenosyl-L-homocysteine hydrolase with 3 open and 1 closed subunits
To Be Published
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9HKY
 | | Cryo-EM structure of Pseudomonas aeruginosa tetrameric S-adenosyl-L-homocysteine hydrolase with 2 open and 2 closed subunits | | Descriptor: | ADENOSINE, Adenosylhomocysteinase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | | Authors: | Malecki, P.H, Wozniak, K, Ruszkowski, M, Brzezinski, K. | | Deposit date: | 2024-12-04 | | Release date: | 2025-02-19 | | Method: | ELECTRON MICROSCOPY (2.89 Å) | | Cite: | Cryo-EM struture of Pseudomonas aeruginosa tetrameric S-adenosyl-L-homocysteine hydrolase with 2 open and 2 closed subunits
To Be Published
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9HKZ
 | | Cryo-EM structure of Pseudomonas aeruginosa tetrameric S-adenosyl-L-homocysteine hydrolase with 2 wide open, 1 open and 1 closed subunits | | Descriptor: | ADENOSINE, Adenosylhomocysteinase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | Authors: | Malecki, P.H, Wozniak, K, Ruszkowski, M, Brzezinski, K. | | Deposit date: | 2024-12-04 | | Release date: | 2025-02-19 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Cryo-EM structure of Pseudomonas aeruginosa tetrameric S-adenosyl-L-homocysteine hydrolase with 2 wide open, 1 open and 1 closed subunits
To Be Published
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9HKX
 | | Cryo-EM structure of Pseudomonas aeruginosa tetrameric S-adenosyl-L-homocysteine hydrolase with 1 open and 3 closed subunits | | Descriptor: | ADENOSINE, Adenosylhomocysteinase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | | Authors: | Malecki, P.H, Wozniak, K, Ruszkowski, M, Brzezinski, K. | | Deposit date: | 2024-12-04 | | Release date: | 2025-02-19 | | Method: | ELECTRON MICROSCOPY (2.83 Å) | | Cite: | Cryo-EM structure of Pseudomonas aeruginosa tetrameric S-adenosyl-L-homocysteine hydrolase with 1 open and 3 closed subunits
To Be Published
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9HKV
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9GR5
 | | The MKAA-RSL - sulfonato-calix[4]arene complex | | Descriptor: | 25,26,27,28-tetrahydroxypentacyclo[19.3.1.1~3,7~.1~9,13~.1~15,19~]octacosa-1(25),3(28),4,6,9(27),10,12,15(26),16,18,21,23-dodecaene-5,11,17,23-tetrasulfonic acid, Fucose-binding lectin protein, beta-D-fructopyranose | | Authors: | Mockler, N.M, Ramberg, K.O, Flood, R.J, Crowley, P.B. | | Deposit date: | 2024-09-10 | | Release date: | 2025-03-05 | | Last modified: | 2025-03-12 | | Method: | X-RAY DIFFRACTION (1.32 Å) | | Cite: | N-Terminal Protein Binding and Disorder-to-Order Transition by a Synthetic Receptor.
Biochemistry, 64, 2025
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9H1A
 | | Crystal structure of Angiotensin-1 converting enzyme N-domain in complex with dual ACE/NEP inhibitor AD014 | | Descriptor: | (2~{S},5~{R})-5-(3-hydroxyphenyl)-1-[2-[[(2~{S})-3-(4-hydroxyphenyl)-2-sulfanyl-propanoyl]amino]ethanoyl]pyrrolidine-2-carboxylic acid, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Cozier, G.E, Acharya, K.R. | | Deposit date: | 2024-10-09 | | Release date: | 2025-04-16 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Design of Novel Mercapto-3-phenylpropanoyl Dipeptides as Dual Angiotensin-Converting Enzyme C-Domain-Selective/Neprilysin Inhibitors.
J.Med.Chem., 68, 2025
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9H1C
 | | Crystal structure of Angiotensin-1 converting enzyme C-domain in complex with dual ACE/NEP inhibitor AD014 | | Descriptor: | (2~{S},5~{R})-5-(3-hydroxyphenyl)-1-[2-[[(2~{S})-3-(4-hydroxyphenyl)-2-sulfanyl-propanoyl]amino]ethanoyl]pyrrolidine-2-carboxylic acid, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Cozier, G.E, Acharya, K.R. | | Deposit date: | 2024-10-09 | | Release date: | 2025-04-16 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Design of Novel Mercapto-3-phenylpropanoyl Dipeptides as Dual Angiotensin-Converting Enzyme C-Domain-Selective/Neprilysin Inhibitors.
J.Med.Chem., 68, 2025
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9H1E
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9H1B
 | | Crystal structure of Angiotensin-1 converting enzyme N-domain in complex with dual ACE/NEP inhibitor AD015 | | Descriptor: | (2~{S},5~{R})-5-(4-methylphenyl)-1-[2-[[(2~{S})-3-phenyl-2-sulfanyl-propanoyl]amino]ethanoyl]pyrrolidine-2-carboxylic acid, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Cozier, G.E, Acharya, K.R. | | Deposit date: | 2024-10-09 | | Release date: | 2025-04-16 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Design of Novel Mercapto-3-phenylpropanoyl Dipeptides as Dual Angiotensin-Converting Enzyme C-Domain-Selective/Neprilysin Inhibitors.
J.Med.Chem., 68, 2025
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9I2S
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9FUO
 | | Crystal structure of SNAr1.3 (K39A) | | Descriptor: | CHLORIDE ION, Chain A, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Roberts, G.R, Leys, D. | | Deposit date: | 2024-06-26 | | Release date: | 2025-01-29 | | Last modified: | 2025-03-26 | | Method: | X-RAY DIFFRACTION (1.81 Å) | | Cite: | Engineered enzymes for enantioselective nucleophilic aromatic substitutions.
Nature, 639, 2025
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9GP2
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9G65
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9FYV
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9H0N
 | | Fucosylated Lacto-N-biose binding protein from Bifidobacterium longum subsp. infantis in complex with Galacto-N-biose | | Descriptor: | Extracellular solute-binding protein, family 1, SODIUM ION, ... | | Authors: | Jensen, M, Hansen, M.E, Sakanaka, H, Slotboom, D.J, Abou Hachem, M, Morth, J.P. | | Deposit date: | 2024-10-08 | | Release date: | 2025-07-02 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Uptake of fucosylated type I human milk oligosaccharide blocks by Bifidobacterium longum subsp. infantis
Mbio, 2025
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9H0O
 | | Fucosylated Lacto-N-biose binding protein from Bifidobacterium longum subsp. infantis in complex with Lacto-N-biose | | Descriptor: | CALCIUM ION, Extracellular solute-binding protein, family 1, ... | | Authors: | Jensen, M, Hansen, M.E, Sakanaka, H, Slotboom, D.J, Abou Hachem, M, Morth, J.P. | | Deposit date: | 2024-10-08 | | Release date: | 2025-07-02 | | Method: | X-RAY DIFFRACTION (2.14 Å) | | Cite: | Uptake of fucosylated type I human milk oligosaccharide blocks by Bifidobacterium longum subsp. infantis
Mbio, 2025
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9H0P
 | | Fucosylated Lacto-N-biose binding protein from Bifidobacterium longum subsp. infantis in complex with H1 trisaccharide | | Descriptor: | Extracellular solute-binding protein, family 1, alpha-L-fucopyranose-(1-2)-beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-alpha-D-glucopyranose | | Authors: | Jensen, M, Hansen, M.E, Sakanaka, H, Slotboom, D.J, Abou Hachem, M, Morth, J.P. | | Deposit date: | 2024-10-08 | | Release date: | 2025-07-02 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Uptake of fucosylated type I human milk oligosaccharide blocks by Bifidobacterium longum subsp. infantis
Mbio, 2025
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9FMX
 | | Aerolysin Y221G - prepore | | Descriptor: | Aerolysin | | Authors: | Iacovache, I, Zuber, B. | | Deposit date: | 2024-06-07 | | Release date: | 2025-02-12 | | Last modified: | 2025-02-19 | | Method: | ELECTRON MICROSCOPY (2.2 Å) | | Cite: | Aerolysin Nanopore Structures Revealed at High Resolution in a Lipid Environment.
J.Am.Chem.Soc., 147, 2025
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9G59
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9GJU
 | | Structure of replicating Nipah Virus RNA Polymerase Complex - RNA-bound state | | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Phosphoprotein, ... | | Authors: | Sala, F, Ditter, K, Dybkov, O, Urlaub, H, Hillen, H.S. | | Deposit date: | 2024-08-22 | | Release date: | 2025-03-05 | | Last modified: | 2025-03-19 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Structural basis of Nipah virus RNA synthesis.
Nat Commun, 16, 2025
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9HZ0
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