7JVW
| Crystal structure of human histone deacetylase 8 (HDAC8) G320R mutation complexed with M344 | Descriptor: | 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide, Histone deacetylase 8, POTASSIUM ION, ... | Authors: | Osko, J.D, Christianson, D.W, Decroos, C, Porter, N.J, Lee, M. | Deposit date: | 2020-08-24 | Release date: | 2020-12-16 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.40301776 Å) | Cite: | Structural analysis of histone deacetylase 8 mutants associated with Cornelia de Lange Syndrome spectrum disorders. J.Struct.Biol., 213, 2020
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6VNR
| Crystal Structure of Danio rerio Histone Deacetylase 6 Catalytic Domain 2 (CD2) Complexed with Bishydroxamic Acid Inhibitor | Descriptor: | 1,2-ETHANEDIOL, Hdac6 protein, N-hydroxy-1-{[4-(hydroxycarbamoyl)phenyl]methyl}-1H-indole-6-carboxamide, ... | Authors: | Osko, J.D, Porter, N.J, Christianson, D.W. | Deposit date: | 2020-01-29 | Release date: | 2020-05-13 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.94301319 Å) | Cite: | Design and Synthesis of Dihydroxamic Acids as HDAC6/8/10 Inhibitors. Chemmedchem, 15, 2020
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8DSG
| P411-PFA carbene transferase | Descriptor: | 1,2-ETHANEDIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Cytochrome P450-BM3 variant P411-PFA, ... | Authors: | Maggiolo, A.O, Porter, N.J, Zhang, J, Arnold, F.H. | Deposit date: | 2022-07-22 | Release date: | 2023-03-08 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.87 Å) | Cite: | Chemodivergent C(sp 3 )-H and C(sp 2 )-H Cyanomethylation Using Engineered Carbene Transferases. Nat Catal, 6, 2023
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5TD7
| Crystal structure of histone deacetylase 10 | Descriptor: | 7-[(3-aminopropyl)amino]-1,1,1-trifluoroheptane-2,2-diol, PENTAETHYLENE GLYCOL, PHOSPHATE ION, ... | Authors: | Hai, Y, Shinsky, S.A, Porter, N.J, Christianson, D.W. | Deposit date: | 2016-09-17 | Release date: | 2017-05-24 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Histone deacetylase 10 structure and molecular function as a polyamine deacetylase. Nat Commun, 8, 2017
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7UTE
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6DVN
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6PZS
| Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 complexed with JR005 | Descriptor: | 4-[({[(1R,2R,5R)-6,6-dimethylbicyclo[3.1.1]heptan-2-yl]methyl}amino)methyl]-N-hydroxybenzamide, CHLORIDE ION, Hdac6 protein, ... | Authors: | Osko, J.D, Christianson, D.W. | Deposit date: | 2019-08-01 | Release date: | 2020-02-05 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Exploring Structural Determinants of Inhibitor Affinity and Selectivity in Complexes with Histone Deacetylase 6. J.Med.Chem., 63, 2020
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6PZR
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6Q0Z
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6VNQ
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6PZO
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6PZU
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8EUN
| MicroED structure of an Aeropyrum pernix protoglobin metallo-carbene complex | Descriptor: | Protogloblin ApPgb, benzyl[3,3'-(7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-diyl-kappa~4~N~21~,N~22~,N~23~,N~24~)di(propanoato)(2-)]iron | Authors: | Danelius, E, Gonen, T, Unge, J.T. | Deposit date: | 2022-10-19 | Release date: | 2023-04-05 | Last modified: | 2024-05-22 | Method: | ELECTRON CRYSTALLOGRAPHY (2.5 Å) | Cite: | MicroED Structure of a Protoglobin Reactive Carbene Intermediate. J.Am.Chem.Soc., 145, 2023
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8EUM
| MicroED structure of an Aeropyrum pernix protoglobin mutant | Descriptor: | FE (III) ION, IMIDAZOLE, PROTOPORPHYRIN IX CONTAINING FE, ... | Authors: | Danelius, E, Gonen, T, Unge, J.T. | Deposit date: | 2022-10-18 | Release date: | 2023-11-08 | Last modified: | 2024-05-22 | Method: | ELECTRON CRYSTALLOGRAPHY (2.1 Å) | Cite: | MicroED Structure of a Protoglobin Reactive Carbene Intermediate. J.Am.Chem.Soc., 145, 2023
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