4BPF
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4BPH
| High resolution crystal structure of Bacillus subtilis DltC | Descriptor: | 4'-PHOSPHOPANTETHEINE, D-ALANINE--POLY(PHOSPHORIBITOL) LIGASE SUBUNIT 2, MAGNESIUM ION | Authors: | Zimmermann, S, Neumann, P, Stubbs, M.T. | Deposit date: | 2013-05-26 | Release date: | 2014-06-11 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | High-Resolution Structures of the D-Alanyl Carrier Protein (Dcp) Dltc from Bacillus Subtilis Reveal Equivalent Conformations of Apo- and Holo-Forms FEBS Lett., 589, 2015
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6TVQ
| Structure of native gp41 derived peptide fusion inhibitor | Descriptor: | Env polyprotein (Fragment), Envelope glycoprotein gp160 | Authors: | Huhmann, S, Nyakatura, E.K, Rohrhofer, A, Schmidt, B, Eichler, J, Moschner, J, Roth, C. | Deposit date: | 2020-01-10 | Release date: | 2021-01-27 | Last modified: | 2023-07-19 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Systematic Evaluation of Fluorination as Modification for Peptide-Based Fusion Inhibitors against HIV-1 Infection. Chembiochem, 22, 2021
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6TVU
| Structure of native gp41 derived peptide fusion inhibitor | Descriptor: | Env polyprotein (Fragment), Transmembrane protein gp41 | Authors: | Huhmann, S, Nyakatura, E.K, Rohrhofer, A, Schmidt, B, Eichler, J, Moschner, J, Roth, C, Koksch, B. | Deposit date: | 2020-01-10 | Release date: | 2021-01-27 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Systematic Evaluation of Fluorination as Modification for Peptide-Based Fusion Inhibitors against HIV-1 Infection. Chembiochem, 22, 2021
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6TVW
| Structure of native gp41 derived peptide fusion inhibitor | Descriptor: | Envelope glycoprotein, Transmembrane protein gp41,Envelope glycoprotein gp160 | Authors: | Huhmann, S, Nyakatura, E.K, Rohrhofer, A, Schmidt, B, Eichler, J, Moschner, J, Roth, C, Koksch, B. | Deposit date: | 2020-01-10 | Release date: | 2021-01-27 | Last modified: | 2024-07-10 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Systematic Evaluation of Fluorination as Modification for Peptide-Based Fusion Inhibitors against HIV-1 Infection. Chembiochem, 22, 2021
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6FHS
| CryoEM Structure of INO80core | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Arp5, ... | Authors: | Eustermann, S, Schall, K, Kostrewa, D, Strauss, M, Hopfner, K. | Deposit date: | 2018-01-15 | Release date: | 2018-04-25 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.754 Å) | Cite: | Structural basis for ATP-dependent chromatin remodelling by the INO80 complex. Nature, 556, 2018
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6FML
| CryoEM Structure INO80core Nucleosome complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Actin related protein 5, ... | Authors: | Eustermann, S, Schall, K, Kostrewa, D, Strauss, M, Hopfner, K. | Deposit date: | 2018-01-31 | Release date: | 2018-04-25 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (4.34 Å) | Cite: | Structural basis for ATP-dependent chromatin remodelling by the INO80 complex. Nature, 556, 2018
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4ZJJ
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4ZJI
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6RAN
| Heterodimeric ABC exporter TmrAB in inward-facing wide conformation | Descriptor: | Multidrug resistance ABC transporter ATP-binding and permease protein, Nanobody Nb9F10 | Authors: | Thomas, C, Januliene, D, Mehdipour, A.R, Hofmann, S, Hummer, G, Moeller, A, Tampe, R. | Deposit date: | 2019-04-06 | Release date: | 2019-07-31 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Conformation space of a heterodimeric ABC exporter under turnover conditions. Nature, 571, 2019
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6RAG
| Heterodimeric ABC exporter TmrAB in inward-facing wide conformation under turnover conditions | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Thomas, C, Januliene, D, Mehdipour, A.R, Hofmann, S, Hummer, G, Moeller, A, Tampe, R. | Deposit date: | 2019-04-06 | Release date: | 2019-07-31 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Conformation space of a heterodimeric ABC exporter under turnover conditions. Nature, 571, 2019
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6RAJ
| Heterodimeric ABC exporter TmrAB in vanadate trapped outward-facing open conformation | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, ADP ORTHOVANADATE, MAGNESIUM ION, ... | Authors: | Thomas, C, Januliene, D, Mehdipour, A.R, Hofmann, S, Hummer, G, Moeller, A, Tampe, R. | Deposit date: | 2019-04-06 | Release date: | 2019-07-31 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Conformation space of a heterodimeric ABC exporter under turnover conditions. Nature, 571, 2019
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6RAH
| Heterodimeric ABC exporter TmrAB in ATP-bound outward-facing open conformation | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Multidrug resistance ABC transporter ATP-binding and permease protein, ... | Authors: | Thomas, C, Januliene, D, Mehdipour, A.R, Hofmann, S, Hummer, G, Moeller, A, Tampe, R. | Deposit date: | 2019-04-06 | Release date: | 2019-07-31 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Conformation space of a heterodimeric ABC exporter under turnover conditions. Nature, 571, 2019
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6RAM
| Heterodimeric ABC exporter TmrAB under turnover conditions in asymmetric unlocked return conformation with wider opened intracellular gate | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Thomas, C, Januliene, D, Mehdipour, A.R, Hofmann, S, Hummer, G, Moeller, A, Tampe, R. | Deposit date: | 2019-04-06 | Release date: | 2019-07-31 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Conformation space of a heterodimeric ABC exporter under turnover conditions. Nature, 571, 2019
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6RAK
| Heterodimeric ABC exporter TmrAB in vanadate trapped outward-facing occluded conformation | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, ADP ORTHOVANADATE, MAGNESIUM ION, ... | Authors: | Thomas, C, Januliene, D, Mehdipour, A.R, Hofmann, S, Hummer, G, Moeller, A, Tampe, R. | Deposit date: | 2019-04-06 | Release date: | 2019-07-31 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Conformation space of a heterodimeric ABC exporter under turnover conditions. Nature, 571, 2019
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6RAI
| Heterodimeric ABC exporter TmrAB in ATP-bound outward-facing occluded conformation | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Multidrug resistance ABC transporter ATP-binding and permease protein, ... | Authors: | Thomas, C, Januliene, D, Mehdipour, A.R, Hofmann, S, Hummer, G, Moeller, A, Tampe, R. | Deposit date: | 2019-04-06 | Release date: | 2019-07-31 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Conformation space of a heterodimeric ABC exporter under turnover conditions. Nature, 571, 2019
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6RAL
| Heterodimeric ABC exporter TmrAB under turnover conditions in asymmetric unlocked return conformation | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Thomas, C, Januliene, D, Mehdipour, A.R, Hofmann, S, Hummer, G, Moeller, A, Tampe, R. | Deposit date: | 2019-04-06 | Release date: | 2019-07-31 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Conformation space of a heterodimeric ABC exporter under turnover conditions. Nature, 571, 2019
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6RAF
| Heterodimeric ABC exporter TmrAB in inward-facing narrow conformation under turnover conditions | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Anti-vesicular stomatitis virus N VHH, ... | Authors: | Thomas, C, Januliene, D, Mehdipour, A.R, Hofmann, S, Hummer, G, Moeller, A, Tampe, R. | Deposit date: | 2019-04-06 | Release date: | 2019-07-31 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Conformation space of a heterodimeric ABC exporter under turnover conditions. Nature, 571, 2019
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6S90
| BTK in complex with an inhibitor | Descriptor: | 4-~{tert}-butyl-~{N}-[2-methyl-3-[6-[4-(4-methylpiperazin-1-yl)carbonylphenyl]-7~{H}-pyrrolo[2,3-d]pyrimidin-4-yl]phenyl]benzamide, Tyrosine-protein kinase BTK | Authors: | Gutmann, S, Hinniger, A. | Deposit date: | 2019-07-11 | Release date: | 2019-09-18 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | Design of Potent and Selective Covalent Inhibitors of Bruton's Tyrosine Kinase Targeting an Inactive Conformation. Acs Med.Chem.Lett., 10, 2019
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5IS5
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5IU2
| Discovery of imidazoquinolines as a novel class of potent, selective and in vivo efficacious COT kinase inhibitors | Descriptor: | Mitogen-activated protein kinase kinase kinase 8, N-[2-(morpholin-4-yl)ethyl]-6-(8-phenyl-1H-imidazo[4,5-c][1,7]naphthyridin-1-yl)-1,3-benzothiazol-2-amine | Authors: | Gutmann, S, Hinniger, A. | Deposit date: | 2016-03-17 | Release date: | 2016-08-24 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Discovery of Imidazoquinolines as a Novel Class of Potent, Selective, and in Vivo Efficacious Cancer Osaka Thyroid (COT) Kinase Inhibitors. J.Med.Chem., 59, 2016
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2KQC
| Second PBZ domain of human APLF protein | Descriptor: | Aprataxin and PNK-like factor, ZINC ION | Authors: | Neuhaus, D, Eustermann, S, Brockmann, C, Yang, J. | Deposit date: | 2009-11-04 | Release date: | 2010-01-19 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structures of the two PBZ domains from human APLF and their interaction with poly(ADP-ribose). Nat.Struct.Mol.Biol., 17, 2010
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2KQB
| First PBZ domain of human APLF protein | Descriptor: | Aprataxin and PNK-like factor, ZINC ION | Authors: | Neuhaus, D, Eustermann, S, Brockmann, C, Yang, J. | Deposit date: | 2009-11-04 | Release date: | 2010-01-19 | Last modified: | 2024-05-08 | Method: | SOLUTION NMR | Cite: | Solution structures of the two PBZ domains from human APLF and their interaction with poly(ADP-ribose). Nat.Struct.Mol.Biol., 17, 2010
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2KQD
| First PBZ domain of human APLF protein in complex with ribofuranosyladenosine | Descriptor: | ADENOSINE, Aprataxin and PNK-like factor, ZINC ION, ... | Authors: | Neuhaus, D, Eustermann, S, Brockmann, C, Yang, J. | Deposit date: | 2009-11-04 | Release date: | 2010-01-19 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Solution structures of the two PBZ domains from human APLF and their interaction with poly(ADP-ribose). Nat.Struct.Mol.Biol., 17, 2010
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2KQE
| Second PBZ domain of human APLF protein in complex with ribofuranosyladenosine | Descriptor: | ADENOSINE, Aprataxin and PNK-like factor, ZINC ION, ... | Authors: | Neuhaus, D, Eustermann, S, Brockmann, C, Yang, J. | Deposit date: | 2009-11-04 | Release date: | 2010-01-19 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Solution structures of the two PBZ domains from human APLF and their interaction with poly(ADP-ribose). Nat.Struct.Mol.Biol., 17, 2010
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